Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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Aseptic Non-union of Long Bone Fractures in the Lower Limb : Clinical Outcomes of Treatment with a Locking Plate

Fujiwara Tomohiro, Noda Tomoyuki, Nishiyama Takeshi, Nakahara Ryuichi, Saiga Kenta, Shimamura Yasunori, Ozaki Toshifumi, Kahara Naoaki, Miyazawa Shinichi, Takagi Yasushi

The Journal of the Chugoku-Shikoku Orthopaedic Association 22 ( 2 ) 355 - 361 2010

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

The development of the locking plate has allowed considerable progress in the treatment of fractures, but few studies have evaluated its usefulness for the treatment of aseptic non-union. We have treated 15 cases of aseptic non-union of long bones in the lower limb (femur : 5, tibia : 10, including 3 periprosthetic non-unions) using locking plates. The initial treatments were external fixation in 1 case, intramedullary nailing in 2, conventional plating in 5, locking plating in 4, and use of a cast only in 3. Nine cases were hypertrophic non-unions and 5 were atrophic non-unions. Union was achieved in all cases, although one case showed correction loss and 5 showed delayed union. These results were quite good, and allowed us to conclude that the locking plate is useful for the treatment of aseptic non-union of bones in the lower limb. Because the degree of bone defect and deformity differs in individual cases, detailed preoperative planning and choice of an appropriate operative technique are needed to achieve good results.

DOI： 10.11360/jcsoa.22.355

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Treatment for fractures of the distal femur using with polyaxial locking plate

SAITO Taichi

The Central Japan Journal of Orthopaedic Surgery & Traumatology 53 ( 4 ) 821 - 822 2010

Continuous femoral nerve block for total knee arthroplasty

YOKOYAMA Yusuke

The Central Japan Journal of Orthopaedic Surgery & Traumatology 53 ( 4 ) 881 - 882 2010

A Case of Valgus Knee Deformity with Patellar Dislocation Caused by Infantile Septic Arthritis

Saito Taichi, Mitani Shigeru, Miyake Yoshiaki, Tetsunaga Tomonori, Ozaki Toshifumi, Endo Hirosuke

The Journal of the Chugoku-Shikoku Orthopaedic Association 22 ( 2 ) 343 - 348 2010

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

We report a case of valgus knee deformity with patellar dislocation caused by infantile septic arthritis. The patient, a boy, had a congenital heart malformation. He had developed infantile septic arthritis of the knee joint at 1 month of age, and the distal lateral epiphysis of the femur had been affected. At 6 years of age, valgus deformity appeared, and therefore we performed deformity correction and leg lengthening with an Ilizarov fixator. However, the deformity recurred and the patella became dislocated laterally 3 years after initial surgery. In a second operation, we performed osteotomy at two sites of the femur. Distally, we corrected the valgus deformity and reduced the patella by changing the rotation of the femur and overlapping the medial soft tissue. Proximally, we corrected the retroversion and performed lengthening on a gradual basis. In the left leg, the preoperative mLDFA was 110° and the postoperative mLDFA was improved to 90°. As the deformity will likely relapse because of the patientｾs age, we plan to achieve realignment again by corrective surgery.

DOI： 10.11360/jcsoa.22.343

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Case Report : Treatment for Retro-odontoid Pseudotumor with Posterior Fusion

Shiozaki Yasuyuki, Sugimoto Yoshihisa, Misawa Haruo, Tanaka Masato, Ozaki Toshifumi

The Journal of the Chugoku-Shikoku Orthopaedic Association 22 ( 2 ) 317 - 321 2010

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

Retro-odontoid pseudotumor is an inflammatory mass most frequently associated with rheumatoid arthritis and dialysis. Recently, some case reports of retro-odontoid pseudotumor without instability have been published. Here we describe a 63-year-old man who was admitted to our hospital with numbness of the left upper extremity and walking disturbance. MRI showed a large retro-odontoid pseudotumor and severe compression of the spinal cord at the C1 level. The patient underwent C1 laminectomy, posterior occipital-C2 fusion and tumor resection via a transdural approach. Postoperative MRI showed that the retro-odontoid pseudotumor had been partially removed, but this was enough to obtain sufficient decompression of the spinal cord. Neurological symptoms were markedly improved after surgery.

DOI： 10.11360/jcsoa.22.317

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Short-term follow-up of hip transposition using external fixator after resection of pelvic tumor

FUJIWARA Tomohiro

The Central Japan Journal of Orthopaedic Surgery & Traumatology 53 ( 4 ) 937 - 938 2010

10P-D-1 Supporting System for Diagnosis of Child Hip Joint by X-ray images

HONDA Mitsugi, ARITA Seizaburo, MITANI Shigeru, TAKEDA Yoshihiro, OZAKI Toshifumi, INOUE Tatsuya, INAMURA Keiji, KANAZAWA Susumu

Proceedings of the Annual Conference of Biomedical Fuzzy Systems Association 23 225 - 226 2010

Language：Japanese Publisher：Biomedical Fuzzy Systems Association

It is important to diagnose developmental dislocation of the hip (DDH) by X-ray images. The aim of this study was to construct a diagnostic support system for DDH based on clinical findings obtained from the X-ray images of 154 female infants with confirmed diagnoses made by orthopedists. The Min-Max method of nonlinear analysis was applied to construct the diagnostic support system based on the measurement of four items in X-ray images : the outward displacement rate, upward displacement rate, OE angle, and a angle. This system was then applied to the data, we obtained good results that matched the confirmed diagnoses of orthopedists with an accuracy of 85.9%.

DOI： 10.24466/pacbfsa.23.0_225

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Short-term result of congenital club foot treated with achillotectomy

KANAZAWA Tomoko

The Central Japan Journal of Orthopaedic Surgery & Traumatology 53 ( 6 ) 1249 - 1250 2010

The short term results of Chiari pelvic osteotomy combined with femoral varus osoteotomy for the advanced coxaosteoarthritis

ENDO Hirosuke

The Central Japan Journal of Orthopaedic Surgery & Traumatology 53 ( 4 ) 943 - 944 2010

A Pilot Study of the Physical Characteristics and Thermal Effects of Mud compared with Bentonite

WATANABE Masutaka, MITSUNOBU Fumihiro, OZAKI Toshifumi, SENDA Masuo, MORISHITA Tsugutake, TAKAGI Toru

The Japanese Journal of Rehabilitation Medicine 47 ( 9 ) 620 - 625 2010

Language：Japanese Publisher：The Japanese Association of Rehabilitation Medicine

Design : A pilot, comparative study was conducted. Background : Heat wraps using bentonite (HWb) are commonly used in thermotherapy. In the Okayama University Misasa Medical Center, heat wraps using mud (HWm) produced by mixing soil with boiling water have also been used. The subjective thermal effects of HWm on patients with osteoarthritis of the knee have been reported. However, the objective thermal effects of HWm have not been examined. As such, the physicochemical thermal effects of HWm were analyzed and compared with those of HMb. Methods : The thermal effects of HWm and HWb were investigated regarding heat radiation, conduction, capacity and moisture content. Heat radiation and conduction were measured by changes in temperature of the heat wraps, in addition heat conduction was also assessed by blood flow in body surfaces (N=7). Heat capacity and moisture content were measured with a Differential Scanning Calorimeter. Results: Heat radiation and heat conduction of HWm were significantly greater than those of HWb (p<0.001). The specific heat capacity of HWm was 2.0 J/g/°C, and was 1.7 J/g/°C for HWb. Moisture content of HWm and HWb were 0.6 mg/g and 0.3 mg/g, respectively. Conclusion : Heat radiation, conduction and capacity of HWm are superior to those of HWb. Moreover, the moisture content in HWm is greater than that of HWb. These results indicate that the thermal effects of HWm would have more be physicochemical usefulness.

DOI： 10.2490/jjrmc.47.620

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Other Link： https://jlc.jst.go.jp/DN/JALC/00356689331?from=CiNii

Min-max methods of attribute probabilities for the child hip joint diagnosis based on X-ray images

ARITA Seizaburo, HONDA Mitsugi, MITANI Shigeru, AZUMA Yoshiharu, TAKEDA Yoshihiro, OZAKI Toshifumi, INOUE Tatsuya, INAMURA Keiji, KANAZAWA Susumu

Journal of Biomedical Fuzzy Systems Association 12 ( 1 ) 1 - 8 2010

Language：Japanese Publisher：Biomedical Fuzzy Systems Association

A diagnostic logic which outputs multiple items from multiple input items was constructed using nonlinear multivariate analysis, and applied for the diagnosis of child hip joints on X-ray images. Regarding the outward displacement rates, upward displacement rates, OE angles, and α angles as input and the diagnoses of dislocation of the hip, acetabular dysplasia, and normal hip joint as output, the attribute probability functions were introduced into the system, and diagnoses were made based on the synergism of 2 items and the Min-Max assessment. X-ray imaging data of 110 child hip joints were investigated. The data were divided into 2 groups: data for system construction and verification, and the diagnostic accuracy of the system was investigated. On applying the system to the verification data, diagnostic accuracy rate was 92.9%. The developed diagnostic system may be useful for the diagnosis of child hip joints.

DOI： 10.24466/jbfsa.12.1_1

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Other Link： http://search.jamas.or.jp/link/ui/2011109479

CTベースナビゲーションシステムを用いたセメントレスTHAの術前計画精度とインプラント選択

藤原一夫, 三谷茂, 遠藤裕介, 鉄永智紀, 皆川寛, 尾崎敏文

日本人工関節学会誌 39 90 - 91 2009.12

Language：Japanese Publisher：(一社)日本人工関節学会

CTベースナビゲーションシステムを用いたセメントレス人工股関節全置換術の術前計画精度とインプラント選択について検討した。セメントレスTHAのうち、JMM社製AMS HAカップおよびPerFix910ステムを使用した88例90股を対象とした。変形性股関節症78例80股、関節リウマチ7例7股、大腿骨頸部骨折3例3股であった。実際に使用されたカップは術前計画と比べ+2mm、-2mm、-4mmの症例がそれぞれ、1股、5股、1股で、83股(92.2%)が計画通りであった。術後CTにてマイナスサイズの症例では偏心設置であり、計画通りのインプラント設置が可能なスペースが残存し、合計89股(98.9%)で正確な術前計画となった。ステム側は術前計画より+2サイズ、+1サイズ、-1サイズの症例がそれぞれ2股、21股、9股で、58股(64.4%)が計画通りであった。

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転子部骨折後の人工骨頭置換術施行後早期に高度の臼蓋欠損をきたした1例

三宅由晃, 遠藤裕介, 三谷茂, 鉄永智紀, 皆川寛, 藤原一夫, 尾崎敏文

日本人工関節学会誌 39 514 - 515 2009.12

Language：Japanese Publisher：(一社)日本人工関節学会

83歳女。81歳時に転倒して左大腿骨転子部骨折を負い、近医で髄内釘による骨接合術を施行されたが、術後6週で髄内釘のラグスクリューがカットアウトし、他院で人工骨頭置換術を施行された。術後2年経過時に臼蓋の高度欠損と破壊をきたし、亜脱臼となったため当科に紹介され、人工股関節全置換術を行った。臼蓋欠損の原因として、カットアウトしたラグスクリューにより臼蓋後上方の軟骨下骨が損傷を受けたことが考えられた。

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人工股関節再置換術における自己血貯血量に関する検討

鉄永智紀, 三谷茂, 遠藤裕介, 藤原一夫, 皆川寛, 尾崎敏文

日本人工関節学会誌 39 222 - 223 2009.12

Language：Japanese Publisher：(一社)日本人工関節学会

当科では股関節手術に際し可能な限り自己血輸血を行っている。今回、人工股関節再置換術施行例の周術期出血量を調査することで、同手術における適正な自己血貯血量について検討した。対象は、2002〜2008年に同手術を行った症例のうち感染例と透析患者を除く52例とし、臼蓋側・大腿骨側とも再置換した群(22例;以下T群)、臼蓋側のみ再置換した群(24例;以下C群)、人工骨頭置換術後の再置換群(6例;以下B群)の3群に分けて検討した。その結果、周術期出血量から求めた手術血液準備量(SBOE)をもとに算出した適正自己血貯血量は、術後Hbを10g/dlと設定するとT群7.2単位、C群0.8単位、B群5.7単位であり、術後Hbを8g/dlと設定するとT群4.6単位、C群0単位、B群3.4単位であった。C群においては貯血前Hb値とSBOEとの間に弱い相関が認められ、貯血前Hb値が自己血貯血量の一指標となる可能性が示唆された。

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Neurofibromatosis type Iに合併した脊柱側彎症に対して後方固定術を施行した1例

齋藤太一, 杉本佳久, 田中雅人, 三澤治夫, 高畑智宏, 林隆宏, 尾崎敏文

岡山医学会雑誌 121 ( 3 ) 233 - 233 2009.12

自然退縮を認めた骨軟骨腫の2例

藤原智洋, 国定俊之, 井谷智, 森本裕樹, 尾崎敏文

岡山医学会雑誌 121 ( 3 ) 233 - 233 2009.12

Cervical Cord Injury in Patients With Ankylosed Spines Progressive Paraplegia in Two Patients After Posterior Fusion Without Decompression Reviewed

Yoshihisa Sugimoto, Yasuo Ito, Masato Tanaka, Masao Tomioka, Yasuhiro Hasegawa, Kie Nakago, Yukihisa Yagata, Toshifumi Ozaki

SPINE 34 ( 23 ) E861 - E863 2009.11

Language：English Publishing type：Research paper (scientific journal) Publisher：LIPPINCOTT WILLIAMS & WILKINS

Study Design. Case report and clinical discussion.
Objective. To describe technical pitfall to treat 2 cervical cord injuries, including dislocations in patients with ankylosed spine due to diffuse idiopathic skeletal hyperostosis (DISH) or ossification of the posterior longitudinal ligament (OPLL).
Summary of Background Data. DISH and OPLL are disease processes similar in pathology, which can lead to unexpected fractures due to low-energy trauma. In reported cases of fracture of the ankylosed spine in patients with DISH or OPLL, increasing lever arm and a grossly unstable fracture occurred. However, the actual surgical intervention for these fractures and spinal cord injuries was not discussed.
Methods. We report 2 cervical cord injuries, including dislocations in patients with ankylosed spine due to DISH or OPLL.
Results. Two patients underwent posterior fusion without decompression; however, postoperative progressive paraplegia still occurred. There were 3 points in common: these patients had ankylosed spines due to DISH or OPLL; they were elderly and had spinal canal stenosis; and after undergoing posterior fusion without decompression, their bilateral, lower extremity palsies worsened after surgery. Cervical alignment was slightly different after posterior fusion, and this change concentrated in one segment because adjacent vertebral bodies were ankylosed, and thus, immoveable. Additionally, this stress caused infolding of the ligamentum flavum with resultant spinal cord compression.
Conclusion. In these cases, we recommend posterior fusion and decompression such as laminoplasty to avoid worsening palsy.

DOI： 10.1097/BRS.0b013e3181bb89fc

Web of Science

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化膿性膝関節炎後の膝蓋骨脱臼を伴った大腿骨変形に対する矯正術を行った1例

斎藤太一, 遠藤裕介, 三谷茂, 鉄永智紀, 尾崎敏文

中国・四国整形外科学会雑誌 21 ( 3 ) 477 - 477 2009.10

ロッキングプレートによる下肢長幹骨非感染性偽関節の治療成績

藤原智洋, 野田知之, 島村安則, 中原龍一, 雑賀建多, 門田康孝, 尾崎敏文

中国・四国整形外科学会雑誌 21 ( 3 ) 479 - 479 2009.10

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. Reviewed International journal

Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, Taniguchi N, Hashimoto M, Tsuchiya M, Ozaki T, Lotz M, Bedford MT, Asahara H

BMC developmental biology 9 47 - 47 2009.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Chondrogenesis and subsequent endochondral ossification are processes tightly regulated by the transcription factor Sox9 (SRY-related high mobility group-Box gene 9), but molecular mechanisms underlying this activity remain unclear. Here we report that coactivator-associated arginine methyltransferase 1 (CARM1) regulates chondrocyte proliferation via arginine methylation of Sox9. RESULTS: CARM1-null mice display delayed endochondral ossification and decreased chondrocyte proliferation. Conversely, cartilage development of CARM1 transgenic mice was accelerated. CARM1 specifically methylates Sox9 at its HMG domain in vivo and in vitro. Arg-methylation of Sox9 by CARM1 disrupts interaction of Sox9 with beta-catenin, regulating Cyclin D1 expression and cell cycle progression of chondrocytes. CONCLUSION: These results establish a role for CARM1 as an important regulator of chondrocyte proliferation during embryogenesis.

DOI： 10.1186/1471-213X-9-47

PubMed

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