Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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手術治療単独で悪性転化をきたした二次性悪性骨巨細胞腫の2例

藤原智洋, 国定俊之, 武田健, 魚谷弘二, 杉生和久, 尾崎敏文

中部日本整形外科災害外科学会雑誌 58 ( 春季学会 ) 221 - 221 2015.3

O-armによる術中CT撮影とナビゲーションシステムを用いて手術を行った類骨骨腫の1例

魚谷弘二, 武田健, 藤原智洋, 山川泰明, 国定俊之, 尾崎敏文

中部日本整形外科災害外科学会雑誌 58 ( 春季学会 ) 217 - 217 2015.3

有痛性dorsal defect of the patellaの一例

三宅孝昌, 藤原智洋, 武田健, 山川泰明, 国定俊之, 尾崎敏文

中部日本整形外科災害外科学会雑誌 58 ( 春季学会 ) 301 - 301 2015.3

【整形外科領域における集学的診療体制の構築】整形外科腫瘍領域(肉腫)における集学的治療

国定俊之, 武田健, 藤原智洋, 魚谷弘二, 杉生和久, 尾崎敏文

整形・災害外科 58 ( 3 ) 303 - 313 2015.3

骨盤腫瘍の外科的治療戦略骨盤腫瘍の治療方針

国定俊之, 武田健, 藤原智洋, 杉原進介, 尾崎敏文

日本整形外科学会雑誌 89 ( 2 ) S355 - S355 2015.3

骨肉腫患者における血中circulating miRNAの特定と臨床経過との相関

藤原智洋, 根津悠, 吉田晶, 魚谷弘二, 杉生和久, 大森敏規, 山川泰明, 武田健, 国定俊之, 川井章, 尾崎敏文

日本整形外科学会雑誌 89 ( 2 ) S139 - S139 2015.3

テロメラーゼ依存型腫瘍融解ウイルス治療とゾレドロネート併用療法の骨肉腫に対する前臨床的検討

山川泰明, 長谷井嬢, 藤原智洋, 武田健, 国定俊之, 尾崎敏文

中部日本整形外科災害外科学会雑誌 58 ( 春季学会 ) 175 - 175 2015.3

水道水による手術時手洗いは骨軟部腫瘍切除後感染に影響するか

武田健, 国定俊之, 魚谷弘二, 杉生和久, 藤原智洋, 尾崎敏文

中部日本整形外科災害外科学会雑誌 58 ( 春季学会 ) 110 - 110 2015.3

自然退縮を認めた骨軟骨腫の2例

大森敏規, 藤原智洋, 武田健, 国定俊之, 尾崎敏文

中部日本整形外科災害外科学会雑誌 58 ( 春季学会 ) 216 - 216 2015.3

思春期特発性側彎症Lenke type 1 curveに対する装具療法の予後不良因子頂椎回矯正に着目して

山根健太郎, 田中雅人, 杉本佳久, 荒瀧慎也, 瀧川朋亨, 鉄永倫子, 篠原健介, 魚谷弘二, 渡邊典之, 尾崎敏文

Journal of Spine Research 6 ( 3 ) 617 - 617 2015.3

頸椎不安定性を有する関節リウマチ患者に対する頸椎固定術当科における過去10年間の動向

杉本佳久, 田中雅人, 荒瀧慎也, 瀧川朋亨, 鉄永倫子, 山根健太郎, 篠原健介, 魚谷弘二, 渡邉典行, 尾崎敏文

Journal of Spine Research 6 ( 3 ) 702 - 702 2015.3

軟骨無形成症による脊椎後彎症に対してVCRを併用し矯正固定術を行った3例

魚谷弘二, 瀧川朋亨, 渡邉典行, 篠原健介, 山根健太郎, 荒瀧慎介, 杉本佳久, 田中雅人, 尾崎敏文

Journal of Spine Research 6 ( 3 ) 379 - 379 2015.3

Growing rod法での金属強度の違いによるimplant折損パターンについて

篠原健介, 瀧川朋亨, 魚谷弘二, 渡邊典行, 山根健太郎, 鉄永倫子, 荒瀧慎也, 杉本佳久, 田中雅人, 皿井孝明, 廣岡孝彦, 尾崎敏文

Journal of Spine Research 6 ( 3 ) 727 - 727 2015.3

MRI of Rheumatoid Arthritis: Comparing the Outcome Measures in Rheumatology Clinical Trials (OMERACT) Scoring and Volume of Synovitis for the Assessment of Biologic Therapy Reviewed

Ryuichi Nakahara, Keiichiro Nishida, Kenzo Hashizume, Ryouzou Harada, Takahiro Machida, Masahiro Horita, Aiji Ohtsuka, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 69 ( 1 ) 29 - 35 2015.2

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

The outcome measures in rheumatology clinical trials (OMERACT) scores are the most mature quantitation system for rheumatoid arthritis (RA) on magnetic resonance imaging (MRI). Direct measuring techniques of synovial volume have been reported with good reproducibility, although few reports have demonstrated the changes of these measures in response to treatment. To assess these clinical responses, we evaluated the correlation of the changes of clinical activity score 28-joints disease activity score (DAS28-CRP) with the changes of OMERACT scores and with synovial volume measurements. Eight RA patients who were treated by biologic agents were examined with MRI of the dominant affected wrist and finger joints before and one year after the treatment. The total OMERACT score was reduced from 48.0 to 41.3, and synovial volume was reduced from 15.4 to 8.8 milliliters. Positive correlations were seen between the changes of DAS28-CRP and the changes of OMERACT synovitis score (r = 0.27), OMERACT total score (r = 0.43) and synovial volume (r = 0.30). Limited to synovium assessment, synovial volume showed a better correlation with DAS28-CRP than the OMERACT synovitis score. On the other hand, the OMERACT total score showed a higher correlation with DAS28-CRP than synovial volume, probably because the OMERACT total score includes scores for bone erosion and bone edema as well.

Web of Science

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MicroRNAs in Bone and Soft Tissue Sarcomas and Their Value as Biomarkers Reviewed

Tomohiro Fujiwara, Yu Fujita, Yutaka Nezu, Akira Kawai, Toshifumi Ozaki, Takahiro Ochiya

Epigenetic Biomarkers and Diagnostics 613 - 642 2015.1

Language：English Publishing type：Part of collection (book) Publisher：Elsevier Inc.

Bone and soft tissue sarcomas are malignant neoplasms that are histologically and genetically heterogeneous, and various subtypes of them have been identified. Evidence of microRNA (miRNA) dysregulation in bone and soft tissue sarcomas has been recently described. miRNA dysregulation that is associated with genetic abnormalities unique to the specific subtypes of sarcomas, functionally important, or correlated with clinical prognosis has been gradually identified. Furthermore, the discovery of circulating miRNAs in patient blood has accelerated interest in their potential to transform clinical applications. Considering the lack of useful bone and soft tissue sarcoma biomarkers, the discovery of miRNA dysregulation may provide a diagnostic method that can be used at early disease stages to detect tumors, predict tumor response to chemotherapy, or identify prognoses. Such interventions would address some of the most important challenges in sarcoma management. In this review, we summarize the emerging evidence of miRNA dysregulation in bone and soft tissue sarcomas and discuss their potential as novel biomarkers and therapeutics.

DOI： 10.1016/B978-0-12-801899-6.00030-9

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Stem selection of total hip arthroplasty for femoral head deformity in developmental dysplasia of the hip

KAGAWA Yohei

The Central Japan Journal of Orthopaedic Surgery & Traumatology 58 ( 6 ) 1107 - 1108 2015

The effects of prevention of VTE using oral direct FXa inhibitor after total hip arthroplasty

FUJII Yosuke

The Central Japan Journal of Orthopaedic Surgery & Traumatology 58 ( 4 ) 649 - 650 2015

Total hip arthroplasty for the DDH cases, femoral head deformity and discrepancy

ENDO Hirosuke

The Central Japan Journal of Orthopaedic Surgery & Traumatology 58 ( 4 ) 679 - 680 2015

Modification of the cell adhesion and hydrophilic characteristics of poly(ether-ether-ketone) by 172-nm Xenon excimer radiation Reviewed

Yukimasa Okada, Takayuki Furumatsu, Shinichi Miyazawa, Masataka Fujii, Hiroyuki Takahashi, Hiroomi Kimura, Toshifumi Ozaki, Nobuhiro Abe

BIO-MEDICAL MATERIALS AND ENGINEERING 25 ( 2 ) 169 - 175 2015

Language：English Publishing type：Research paper (scientific journal) Publisher：IOS PRESS

BACKGROUND: Poly-ether-ether-ketone (PEEK) has biomechanical and chemical properties that are excellent for biomedical applications; however, PEEK adhesion to bone or chondral tissue proceeds slowly due to poor hydrophilicity and other surface characteristics.
OBJECTIVE: We investigated the structural change, hydrophilicity, and cytocompatibility of a PEEK surface after 172-nm xenon excimer UV-irradiation.
METHODS: The surface characteristics before and after irradiation were evaluated by contact angle and ATR-FTIR measurements. Mouse osteoblast-like cells (MC3T3-E1) were cultured on PEEK plates and collected after 6, 12 and 24 h for cell adhesion analysis by crystal violet staining (CVS) and scanning electron microscopy (SEM).
RESULTS: UV-irradiation improved PEEK surface hydrophilicity, as indicated by a significant drop in water contact angle (p < 0.05). Irradiated PEEK showed additional peaks around 3370 cm(-1) and 1720 cm(-1), highlighting the generation of hydroxyl and carbonyl groups. CVS and SEM revealed improved adhesion to the PEEK surface after UV-irradiation.
CONCLUSION: Our results suggest that 172-nm UV-irradiated PEEK may be used in biomedical applications that require good cell adhesion.

DOI： 10.3233/BME-151267

Web of Science

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Automatic method to determine anterior pelvic plane of pelvis Reviewed

T. Inoue, K. Fujiwara, Y. Fujii, N. Abe, T. Ozaki, Y. Nakajima, N. Sugita, M. Mitsuishi, Z. Chen

Japanese Journal of Clinical Biomechanics 36 145 - 150 2015

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Papers - OZAKI Toshifumi