Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

Division display 921 - 940 of about 1,746 ／ All the affair displays >>

Inhibitory effect of JAK inhibitor on mechanical stress-induced protease expression by human articular chondrocytes. International journal

Takahiro Machida, Keiichiro Nishida, Yoshihisa Nasu, Ryuichi Nakahara, Masatsugu Ozawa, Ryozo Harada, Masahiro Horita, Ayumu Takeshita, Daisuke Kaneda, Aki Yoshida, Toshifumi Ozaki

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 66 ( 11 ) 999 - 1009 2017.11

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To investigate whether janus kinase (JAK) inhibitor exhibits a chondro-protective effect against mechanical stress-induced expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) and matrix metalloproteinase (MMPs) in human chondrocytes. MATERIALS AND METHODS: Normal human articular chondrocytes were seeded onto stretch chambers and incubated with or without tofacitinib (1000 nM) for 12 h before mechanical stimulation or cytokine stimulation. Uni-axial cyclic tensile strain (CTS) (0.5 Hz, 10% elongation, 30 min) was applied and the gene expression levels of type II collagen α1 chain (COL2A1), aggrecan (ACAN), ADAMTS4, ADAMTS5, MMP13, and runt-related transcription factor 2 (RUNX-2) were examined by real-time polymerase chain reaction. Nuclear translocation of RUNX-2 and nuclear factor-κB (NF-κB) was examined by immunocytochemistry, and phosphorylation of mitogen-activated protein kinase (MAPK) and signaling transducer and activator of transcription (STAT) 3 was examined by western blotting. The concentration of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in the supernatant was examined by enzyme-linked immunosorbent assay. RESULTS: COL2A1 and ACAN gene expression levels were decreased by CTS, but these catabolic effects were canceled by tofacitinib. Tofacitinib significantly down-regulated CTS-induced expression of ADAMTS4, ADAMTS5, MMP13, and RUNX2, and the release of IL-6 in supernatant by chondrocytes. Tofacitinib also reduced CTS-induced nuclear translocation of RUNX-2 and NF-κB, and phosphorylation of MAPK and STAT3. CONCLUSION: Tofacitinib suppressed mechanical stress-induced expression of ADAMTS4, ADAMTS5, and MMP13 by human chondrocytes through inhibition of the JAK/STAT and MAPK cascades.

DOI： 10.1007/s00011-017-1083-x

PubMed

researchmap

Tibial eminence width can predict the presence of complete discoid lateral meniscus: A preliminary study.

Tomohito Hino, Takayuki Furumatsu, Masataka Fujii, Yuya Kodama, Shinichi Miyazawa, Yusuke Kamatsuki, Kazuki Yamada, Toshifumi Ozaki

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 22 ( 6 ) 1084 - 1088 2017.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: To compare the plain knee radiograph finding of tibial eminence width between knees with complete discoid lateral meniscus, incomplete discoid lateral meniscus, and normal lateral meniscus. MATERIALS AND METHODS: The study included 27 knees with discoid lateral meniscus, including 13 knees with complete discoid lateral meniscus and 14 knees with incomplete discoid lateral meniscus. A control group of 14 knees with normal lateral meniscus was also included. Tibial eminence width and the lateral slope angle of the medial tibial eminence were assessed using plain frontal knee radiographs. Individual differences in knee size were corrected by dividing tibial eminence width by tibial width to obtain the tibial eminence width percentage. RESULTS: Mean tibial eminence width and tibial eminence width percentage in the complete discoid lateral meniscus group was significant larger than other groups. Mean lateral slope angle in the complete discoid lateral meniscus group was significantly smaller than other groups. A tibial eminence width cut-off of 13.9 mm showed a sensitivity and specificity of 100% and 83%, respectively. A tibial eminence width percentage cut-off of 18.8% showed a sensitivity and specificity of 100% and 90%, respectively. A lateral slope angle cut-off of 27.1° showed a sensitivity and specificity of 71% and 83%, respectively. CONCLUSION: There were clear differences in tibial eminence width, tibial eminence width percentage, and lateral slope angle between the complete discoid lateral meniscus group and the other groups. The plain radiographic parameters identified by this study could be useful for complete discoid lateral meniscus screening. STUDY DESIGN: Clinical.

DOI： 10.1016/j.jos.2017.07.011

PubMed

researchmap

側彎症手術を行った重症脳性麻痺患者における健康関連QOL調査の試み

小田孔明, 瀧川朋亨, 杉本佳久, 田中雅人, 尾崎敏文

中部日本整形外科災害外科学会雑誌 60 ( 6 ) 1049 - 1050 2017.11

Arthroscopic Repair of the Medial Meniscus Radial/Oblique Tear Prevents the Progression of Meniscal Extrusion in Mildly Osteoarthritic Knees Reviewed

Takayuki Furumatsu, Yuya Kodama, Yusuke Kamatsuki, Tomohito Hino, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 71 ( 5 ) 413 - 418 2017.10

Tensile strength of the pullout repair technique for the medial meniscus posterior root tear: a porcine study. International journal

Masataka Fujii, Takayuki Furumatsu, Haowei Xue, Shinichi Miyazawa, Yuya Kodama, Tomohito Hino, Yusuke Kamatsuki, Toshifumi Ozaki

International orthopaedics 41 ( 10 ) 2113 - 2118 2017.10

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The purpose of this study was to compare the load-to-failure of different common suturing techniques with a new technique for the medial meniscus posterior root tear (MMPRT). METHODS: Thirty porcine medial menisci were randomly assigned to three suturing techniques used for transtibial pullout repair of the MMPRT (n = 10 per group). Three different meniscal suture configurations were studied: the two simple suture (TSS) technique, the conventional modified Mason-Allen suture (MMA) technique, and the new MMA technique using the FasT-Fix combined with the Ultrabraid (F-MMA). The ultimate failure load was tested using a tensile testing machine. RESULTS: The MMA and F-MMA groups demonstrated significantly higher failure loads than the TSS group (P = 0.0003 and P = 0.0005, respectively). No significant differences were observed between the MMA and F-MMA groups (P = 0.734). CONCLUSIONS: The ultimate failure load was significantly greater in the F-MMA than the TSS group and similar to the conventional MMA technique.

DOI： 10.1007/s00264-017-3561-8

PubMed

researchmap

人工肘関節置換術(TEA)後の尺骨神経障害の治療と神経伝導検査

堅山佳美, 千田益生, 兼田大輔, 日野知仁, 池田吉宏, 尾崎敏文

臨床神経生理学 45 ( 5 ) 421 - 421 2017.10

関節リウマチ肘に対するlinked人工肘関節(PROSNAP)の治療成績の検討

沖田駿治, 西田圭一郎, 渡辺雅仁, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 那須義久, 尾崎敏文

日本関節病学会誌 36 ( 3 ) 367 - 367 2017.10

深層学習を用いた関節リウマチ患者の超音波画像分類における動画データ利用

中原龍一, 西田圭一郎, 木曽洋平, 大橋秀樹, 兼田大輔, 竹下歩, 那須義久, 尾崎敏文

日本関節病学会誌 36 ( 3 ) 366 - 366 2017.10

関節リウマチ新時代の手術療法 50歳未満のRA患者に対する人工肘関節全置換術

西田圭一郎, 沖田駿治, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 大橋秀基, 木曽洋平, 尾崎敏文, 橋詰謙三

日本関節病学会誌 36 ( 3 ) 362 - 362 2017.10

中足骨遠位斜め骨切り短縮術を行った関節リウマチ外側趾のX線学的経時変化

大橋秀基, 西田圭一郎, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 木曽洋平, 沖田駿治, 渡辺雅仁, 尾崎敏文

日本関節病学会誌 36 ( 3 ) 360 - 360 2017.10

関節リウマチ前足部手術における足長変化に関する検討

木曽洋平, 那須義久, 渡辺雅仁, 沖田瞬治, 大橋秀基, 兼田大輔, 竹下歩, 堀田昌宏, 中原龍一, 雑賀健多, 西田圭一郎, 尾崎敏文

日本関節病学会誌 36 ( 3 ) 359 - 359 2017.10

関節リウマチ前足部変形における外側趾中足骨短縮骨切りが外反母趾角に与える影響

那須義久, 渡辺雅仁, 木曽洋平, 沖田駿治, 大橋基広, 兼田大輔, 竹下歩, 中原龍一, 西田圭一郎, 尾崎敏文

日本関節病学会誌 36 ( 3 ) 358 - 358 2017.10

外側型肘離断性骨軟骨炎に対する膝外側壁を含む骨軟骨柱移植術

島村安則, 内野崇彦, 名越充, 島村好信, 中道亮, 野田知之, 西田圭一郎, 尾崎敏文

日本肩関節学会抄録集 44回 161 - 161 2017.10

リトルリーグショルダーに対する抵抗下外旋テストの有用性

内野崇彦, 島村安則, 島村好信, 中道亮, 名越充, 野田知之, 尾崎敏文

日本肩関節学会抄録集 44回 334 - 334 2017.10

地方都市における希少がん標準的化学療法の取り組み骨軟部腫瘍化学療法の現状

山根弘路, 越智宣昭, 本多宣裕, 山岸智子, 中川望, 長崎泰有, 国定俊之, 藤原智洋, 長谷井嬢, 尾崎敏文, 瀧川奈義夫

日本癌治療学会学術集会抄録集 55回 P42 - 4 2017.10

Role of zoledronic acid in oncolytic virotherapy: Promotion of antitumor effect and prevention of bone destruction. Reviewed

Yamakawa Y, Tazawa H, Hasei J, Osaki S, Omori T, Sugiu K, Komatsubara T, Uotani K, Fujiwara T, Yoshida A, Kunisada T, Urata Y, Kagawa S, Ozaki T, Fujiwara T

Cancer science 108 ( 9 ) 1870 - 1880 2017.9

がん免疫療法の一段の進化へむけて腫瘍浸潤免疫細胞の代謝は抗腫瘍免疫応答を制御する

鵜殿平一郎, 榮川伸吾, 國定勇希, 上原健敬, 渡邉元嗣, 木村裕司, 佐々木朗, 尾崎敏文, 豊岡伸一, 藤原俊義

日本癌学会総会記事 76回 S10 - 5 2017.9

胸部食道癌術後症例の誤嚥性肺炎のリスク要因の検討

池田吉宏, 日野知仁, 兼田大輔, 堅山佳美, 千田益生, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 54 ( 秋季特別号 ) S274 - S274 2017.9

関節リウマチ治療手術のタイミングと工夫リウマチ肘関節に対する人工関節置換術の適応とインプラント選択

那須義久, 西田圭一郎, 尾崎敏文

中部日本整形外科災害外科学会雑誌 60 ( 秋季学会 ) 55 - 55 2017.9

骨肉腫細胞内と分泌エクソソーム内におけるmicroRNA発現の相違と患者血清エクソソーム内の発現と臨床的相関性

清野正普, 藤原智洋, 吉田晶, 森田卓也, 横尾賢, 小松原将, 望月雄介, 出宮浩二, 長谷井嬢, 国定俊之, 尾崎敏文

日本癌学会総会記事 76回 P - 2045 2017.9

　 PREV - NEXT 　

< OZAKI Toshifumi >

Papers - OZAKI Toshifumi