Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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関節リウマチの手術上肢関節リウマチ(RA)に対するSauve-Kapandji法の治療成績

金澤智子, 橋詰謙三, 西田圭一郎, 中原龍一, 斉藤太一, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 55回・20回 383 - 383 2011.6

関節リウマチの手術上肢 RA手関節に対する部分固定術の術後成績

斉藤太一, 西田圭一郎, 橋詰謙三, 中原龍一, 金澤智子, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 55回・20回 312 - 312 2011.6

幹細胞研究の骨・軟部腫瘍学への応用骨肉腫のがん幹細胞様性質を司る分子機構の解明

藤原智洋, 高橋陵宇, 小坂展慶, 竹下文隆, 川井章, 尾崎敏文, 落谷孝広

日本整形外科学会雑誌 85 ( 6 ) S823 - S823 2011.6

【患者さんといっしょに読める整形外科病態生理32 はじめてマニュアル】肩〜手指鎖骨骨折

島村安則, 野田知之, 中原龍一, 尾崎敏文

整形外科看護 ( 2011春季増刊 ) 10 - 17 2011.5

Increased level of heme oxygenase-1 in rheumatoid arthritis synovial fluid Reviewed

Ai Kitamura, Keiichiro Nishida, Takamitsu Komiyama, Hideyuki Doi, Yasutaka Kadota, Aki Yoshida, Toshifumi Ozaki

MODERN RHEUMATOLOGY 21 ( 2 ) 150 - 157 2011.4

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

We investigated the expression and localization of heme oxygenase-1 (HO-1) in synovial fluid and synovial tissue, and examined the stimulation of HO-1 production in rheumatoid synovial fibroblasts (RASFs). Synovial fluid samples were obtained from knee joints of 20 rheumatoid arthritis (RA) and 20 osteoarthritis (OA) patients, and concentration of HO-1 and matrix metalloproteinase-3 (MMP-3) were measured by enzyme-linked immunosorbent assay (ELISA). Synovial tissues obtained from RA or OA patients during total knee arthroplasty (TKA) were used for immunohistochemical analysis of HO-1. HO-1 production by RASFs in response to various cytokines was examined by ELISA. HO-1 levels in synovial fluid were higher in the RA group than in the OA group with significant difference (P < 0.001), and correlated with serum C-reactive protein (CRP) level (r = 0.80, P < 0.01) in the RA group. Higher levels of HO-1 were seen in the RA-L group (Larsen grade III-V) than in the RA-E (Larsen grade 0-II) group (P < 0.001). There was weak correlation between the levels of HO-1 protein and MMP-3 in synovial fluid in the RA group (r = 0.31, P < 0.01), while no positive correlation was observed in OA. Positive immunoreaction for HO-1 was observed in cells of synovial tissue including synovial fibroblasts and cells in synovial pannus. HO-1 protein levels in cultured media of RASFs were increased by stimulation by interleukin-1 beta at 6 h and tumor necrosis factor-alpha at 12 h, but suppressed by interferon-gamma at 12 and 24 h. These results indicated that HO-1 expression in synovial tissue might be stimulated by inflammatory cytokines. The correlation of HO-1 concentration in synovial fluid with serum CRP and MMP-3 in joint fluid indicated that HO-1 might be useful as a marker of joint inflammation in RA patients.

DOI： 10.1007/s10165-010-0372-9

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掌側プレート固定を行った橈骨遠位端骨折における抜釘術の重要性

島村安則, 井上円加, 小澤正嗣, 斎藤太一, 金澤智子, 中原龍一, 雑賀建多, 野田知之, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 23 ( 1 ) 258 - 258 2011.4

ハンドル外傷による舟状骨骨折の1例

金澤智子, 島村安則, 西田圭一郎, 斎藤太一, 中原龍一, 雑賀建多, 野田知之, 尾崎敏文

中国・四国整形外科学会雑誌 23 ( 1 ) 253 - 253 2011.4

大腿骨基部骨折を合併した大腿骨頭すべり症の一例

尾崎修平, 遠藤裕介, 三宅由晃, 藤原一夫, 野田知之, 尾崎敏文

岡山医学会雑誌 123 ( 1 ) 73 2011.4

RA手関節に対する部分固定術の術後成績

斎藤太一, 西田圭一郎, 橋詰謙三, 島村安則, 尾崎敏文

日本手外科学会雑誌 28 ( 1 ) S138 - S138 2011.3

硬組織接着性多糖誘導体リン酸化プルランの開発

高畑智宏, 塩崎泰之, 吉田靖弘, 三澤治夫, 杉本佳久, 田中雅人, 尾崎敏文

Journal of Spine Research 2 ( 3 ) 647 - 647 2011.3

Anterior transposition of the ulnar nerve with endoscopic assistance Reviewed

T. Konishiike, K. Nishida, M. Ozawa, T. Ozaki

Journal of Hand Surgery: European Volume 36 ( 2 ) 126 - 129 2011.2

Language：English Publishing type：Research paper (scientific journal)

We treated 20 patients with cubital tunnel syndrome by anterior transposition of the ulnar nerve with endoscopic assistance. Five elbows were classified preoperatively as McGowan's stage 1, 11 as stage 2 and four as stage 3. Excellent outcomes were obtained in nine and good in eight patients. Three patients had fair results. Improvement of symptoms occurred in all patients. There were no serious complications. All ulnar nerves remained anteriorly transposed.

DOI： 10.1177/1753193410381675

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Anatomical and functional segments of the deltoid muscle Reviewed

Yoshimasa Sakoma, Hirotaka Sano, Nobuhisa Shinozaki, Yoshiaki Itoigawa, Nobuyuki Yamamoto, Toshifumi Ozaki, Eiji Itoi

Journal of Anatomy 218 ( 2 ) 185 - 190 2011.2

Language：English Publishing type：Research paper (scientific journal)

Previous studies showed that the insertion of the intramuscular tendons of the deltoid muscle formed three discrete lines. The purpose of the present study was to establish a new dividing method of the deltoid muscle into various anatomical segments based on the distribution of the intramuscular tendons with their insertions (anatomical study). We further hoped to clarify the relationship between the anatomical segments and their activity pattern assessed by positron emission tomography with [18F]-2-fluoro-deoxyglucose (FDG-PET
PET study). Sixty cadaveric shoulders were investigated in the anatomical study. Three tendinous insertions of the deltoid muscle to the humerus were identified. Then, the intramuscular tendons were traced from their humeral insertions to the proximal muscular origins. The extent of each anatomical segment of the muscle including its origin and insertion was determined through careful dissection. Six healthy volunteers were examined using FDG-PET for the PET study. PET images were obtained after exercise of elevation in the scapular plane. On the PET images, margins of each anatomical segment of the deltoid muscle were determined using magnetic resonance images. Then, the standardized uptake value in each segment was calculated to quantify its activity. The anatomical study demonstrated that the deltoid muscle was divided into seven segments based on the distribution of its intramuscular tendons. The PET study revealed that the intake of FDG was not uniform in the deltoid muscle. The area with high FDG intake corresponded well to the individual muscular segments separated by the intramuscular tendons. We conclude that the deltoid muscle has seven anatomical segments, which seem to represent the functional units of this muscle. © 2010 The Authors. Journal of Anatomy © 2010 Anatomical Society of Great Britain and Ireland.

DOI： 10.1111/j.1469-7580.2010.01325.x

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軟部腫瘍の良悪性鑑別におけるTI-201腫瘍シンチグラフィの有用性

佐藤修平, 稲井良太, 原田聡介, 新家崇義, 郷原英夫, 奥村能啓, 国定俊之, 尾崎敏文, 金澤右

日本医学放射線学会学術集会抄録集 70回 S365 - S366 2011.2

骨髄炎に対する抗菌薬含有セメント髄内釘による治療成績の検討

金澤智子, 野田知之, 島村安則, 西山武, 雑賀建多, 中原龍一, 尾崎敏文

日本骨・関節感染症学会雑誌 24 43 - 46 2011.2

Language：Japanese Publisher：(一社)日本骨・関節感染症学会

骨折治療後に生じた長管骨骨髄炎に対して抗菌薬含有セメント髄内釘または抗菌薬含有セメントロッドによる治療を行った7例の成績を報告した。男性6例、女性1例、年齢16〜81歳、罹患部位は大腿骨5例、脛骨2例、起因菌はMRSAが6例、不明1例であった。治療成績は6例(86%)で感染の沈静化が得られ、治療開始時に骨癒合していなかった5例中3例(60%)で骨癒合が得られた。代表例1例を提示した。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J04867&link_issn=&doc_id=20110214090009&doc_link_id=%2Fey4kotsu%2F2010%2F002400%2F009%2F0043-0046%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fey4kotsu%2F2010%2F002400%2F009%2F0043-0046%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

骨端線障害後の下肢遺残変形に対して矯正術を行った2例

斎藤太一, 尾崎敏文, 遠藤裕介, 三谷茂

日本創外固定・骨延長学会雑誌 22 13 - 16 2011.2

Language：Japanese Publisher：日本創外固定・骨延長学会

骨端線障害後の下肢遺残変形に対し、Ilizarov創外固定器による複数回の矯正術を行った2症例について検討した。症例1(10歳男児)は1歳時の化膿性膝関節炎、症例2(14歳男児)は6歳時の交通事故により骨端線障害が生じていた。6歳時と9歳時に、Ilizarov創外固定器を用いて矯正骨切りと脚延長を行った。しかし変形は再発し、2度目の手術を9歳時と13歳時に行った。2例とも、Ilizarov創外固定器を用いて良好なアライメントと脚長差の補正が得られたが、若年での骨端線障害における遺残変形に対する骨端線閉鎖術、もしくは解除術なしでの変形矯正術は、複数回の手術を要すると思われた。

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硬組織接着性多糖誘導体リン酸化プルランによる薬剤徐放能の検討

塩崎泰之, 高畑智宏, 吉田靖弘, 杉本佳久, 三澤治夫, 吉田晶, 田中雅人, 尾崎敏文

日本整形外科学会雑誌 85 ( 2 ) S109 - S109 2011.2

硬組織接着性多糖誘導体リン酸化プルランの開発

高畑智宏, 塩崎泰之, 吉田靖弘, 杉本佳久, 三澤治夫, 吉田晶, 田中雅人, 尾崎敏文

日本整形外科学会雑誌 85 ( 2 ) S108 - S108 2011.2

Toolpath generator for multi-axis medical machine tool to optimize cutting tool posture and position before skin incision Reviewed

Nawata W, Sugita N, Nakajima Y, Kato T, Fujiwara K, Abe N, Ozaki T, Suzuki M, Mitsuishi M

Proceedings of the 6th International Conference on Leading Edge Manufacturing in 21st Century, LEM 2011 2011

Publishing type：Research paper (international conference proceedings)

A robotic system has been developed for Minimally Invasive Surgery (MIS) in Total Knee Arthroplasty (TKA). In MIS TKA, it is imperative to achieve high accuracy of bone cutting and short skin incision. However, MIS TKA has a challenging issue as to the tool insertion into the small incision area. Moreover, an inappropriate incision causes inability of bone cutting or interference between tool and skin. Therefore, tool path generation method was developed based on the optimized incision placement. The experiments with model and swine legs showed that we could successfully implement the operation within 80 mm incision in clinical use.

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Other Link： http://orcid.org/0000-0002-1369-0747

Toolpath strategy based on geometric model for multi-axis medical machine tool Reviewed

Sugita N, Nakano T, Abe N, Fujiwara K, Ozaki T, Suzuki M, Mitsuishi M

CIRP Annals - Manufacturing Technology 60 ( 1 ) 419 - 424 2011

Publishing type：Research paper (scientific journal)

Toolpath generation for a multi-axis medical machine tool is a challenging task. In surgical procedures, it is difficult to apply industrial CAM technology owing to the requirement for quick toolpath generation and the likelihood of tool interference with complex structures of the target area. The objectives of this study are to optimize the initial position and posture of the cutting tool for performing the ideal skin incision and to minimize contact between the cutting tool and the surrounding area. We propose a novel toolpath strategy based on geometric models. It can be potentially applied to general machine-assisted surgeries. © 2011 CIRP.

DOI： 10.1016/j.cirp.2011.03.030

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Other Link： http://orcid.org/0000-0002-1369-0747

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells. Reviewed

Tetsunaga T, Nishida K, Furumatsu T, Naruse K, Hirohata S, Yoshida A, Saito T, Ozaki T

Osteoarthritis Cartilage 19 ( 2 ) 222 - 232 2011

Publishing type：Research paper (scientific journal)

Objective: To investigate the mechanism of mechanical stress-induced expression and regulation of aggrecanases and examine the role of runt-related transcription factor 2 (RUNX-2) in chondrocyte-like cells. Methods: SW1353 cells were seeded onto stretch chambers at a concentration of 5×104cells/chamber, and a uni-axial cyclic tensile strain (CTS) (0.5Hz, 10% stretch) was applied for 30min. Total RNA was extracted, reverse transcribed, and analyzed by polymerase chain reaction (PCR) and real-time PCR. RUNX-2 overexpression and small interfering RNA (siRNA) targeting RUNX-2 were used to investigate the role of RUNX-2 in CTS-induced gene expression. The involvement of diverse mitogen-activated protein kinase (MAPK) pathways in the activation of RUNX-2, MMP-13 and ADAMTS-5 during CTS was examined by Western blotting. Results: CTS induced expression of RUNX-2, MMP-13, ADAMTS-4, -5, and -9. Overexpression of RUNX-2 up-regulated expression of MMP-13 and ADAMTS-5, whereas RUNX-2 siRNA resulted in significant down-regulation of mechanically-induced MMP-13 and ADAMTS-5 expression. CTS induced activation of p38 MAPK, and CTS induction of RUNX-2, MMP-13 and ADAMTS-5 mRNA was down-regulated by the selective p38 MAPK inhibitor SB203580 but not by the p44/42 MAPK inhibitor U0126, or the JNK MAPK inhibitor JNK inhibitor II. Conclusions: RUNX-2 might have a role as a key downstream mediator of p38's ability to regulate mechanical stress-induced MMP-13 and ADAMTS-5 expression. © 2010 Osteoarthritis Research Society International.

DOI： 10.1016/j.joca.2010.11.004

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Papers - OZAKI Toshifumi