Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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骨・軟部腫瘍における新規分子・細胞標的粘液線維肉腫における分泌型microRNA-1260bは腫瘍周囲微小環境に作用し浸潤を促進する

森田卓也, 藤原智洋, 吉田晶, 清野正普, 横尾賢, 小松原将, 望月雄介, 長谷井嬢, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 92 ( 8 ) S1709 - S1709 2018.8

吉田晶, 藤原智洋, 魚谷弘二, 森田卓也, 清野正普, 横尾賢, 長谷井嬢, 中田英二, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 92 ( 8 ) S1813 - S1813 2018.8

Complete tear of the lateral meniscus posterior root is associated with meniscal extrusion in anterior cruciate ligament deficient knees. Reviewed International journal

Kamatsuki Y, Furumatsu T, Fujii M, Kodama Y, Miyazawa S, Hino T, Ozaki T

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 36 ( 7 ) 1894 - 1900 2018.7

Language：English Publishing type：Research paper (scientific journal)

This study aimed to evaluate the relationship between preoperative lateral meniscal extrusion (LME) and arthroscopic findings of lateral meniscus posterior root tear (LMPRT) in knees with anterior cruciate ligament (ACL) tear. Thirty-five knees that had LMPRTs with concomitant ACL tears on arthroscopy were evaluated. Patients were divided into two groups, partial and complete root tears, via arthroscopic findings at the time of ACL reconstruction. For comparison, we added two groups, using the same database; 20 normal knees (normal group) and 20 ACL-injured knees without LM injury (intact LM group). We retrospectively measured preoperative LMEs using magnetic resonance imaging (MRI). Twenty-three knees had partial LMPRTs. Complete LMPRTs were observed in 12 knees. The average LME was -0.1 ± 0.4 mm in the normal group, 0.2 ± 0.5 mm in the intact LM group, 0.4 ± 0.8 mm in the partial LMPRT group, and 2.0 ± 0.6 mm in the complete LMPRT group. A significant difference in preoperative LMEs was observed between the complete LMPRT group and the other groups (p < 0.001). The receiver operating curve analysis, which distinguishes a partial tear from a complete tear, identified an optimal cut-off point of 1.1 mm for preoperative LME. This LME cut-off had a sensitivity of 100% and specificity of 83% for complete LMPRT. We found that preoperative LMEs were larger in complete LMPRTs associated with ACL injuries than in partial LMPRTs. Our results suggest that preoperative MRI-detected LME may be a useful indicator for estimating LMPRT severity in ACL-injured knees. LEVEL OF EVIDENCE: Retrospective comparative study level IV. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1894-1900, 2018.

DOI： 10.1002/jor.23861

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関節リウマチ前足部手術における術式別のTUGおよびJSSF-RA scaleの検討とX線学的解析

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 大橋秀基, 木曽洋平, 沖田駿治, 松橋美波, 尾崎敏文

関節の外科 45 ( 2 ) 96 - 96 2018.7

リウマチ性疾患治療中に発症し診断に難渋した手指屈筋腱腱鞘滑膜炎の3例

沖田駿治, 那須義久, 松橋美波, 渡辺雅仁, 木曽洋平, 大橋秀基, 中原龍一, 西田圭一郎, 尾崎敏文

日本骨・関節感染症学会プログラム・抄録集 41回 126 - 126 2018.7

上肢:上腕骨骨幹部骨折上腕骨骨幹部骨折における最小侵襲プレート骨接合術(MIPO)による手術治療

島村安則, 野田知之, 山川泰明, 斎藤太一, 内野崇彦, 中原龍一, 尾崎敏文

骨折 40 ( Suppl. ) S15 - S15 2018.7

Medial meniscus posterior root tear induces pathological posterior extrusion of the meniscus in the knee-flexed position: An open magnetic resonance imaging analysis Reviewed

S. Masuda, T. Furumatsu, Y. Okazaki, Y. Kodama, T. Hino, Y. Kamatsuki, S. Miyazawa, T. Ozaki

Orthopaedics and Traumatology: Surgery and Research 104 ( 4 ) 485 - 489 2018.6

Medial meniscus posterior root tear induces pathological posterior extrusion of the meniscus in the knee-flexed position: An open magnetic resonance imaging analysis Reviewed

S. Masuda, T. Furumatsu, Y. Okazaki, Y. Kodama, T. Hino, Y. Kamatsuki, S. Miyazawa, T. Ozaki

Revue de Chirurgie Orthopedique et Traumatologique 104 ( 4 ) 339 2018.6

Les l?sions de la racine post?rieure du m?nisque m?dial induisent une extrusion m?niscale post?rieure anormale en semi-flexion Reviewed International journal

Masuda S, Furumatsu T, Okazaki Y, Kodama Y, Hino T, Kamatsuki Y, Miyazawa S, Ozaki T

Revue de Chirurgie Orthopedique et Traumatologique, Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil Moteur, Revue d'orthope?die et de chirurgie de l'appareil moteur 104 ( 4 ) 2018.6

中高齢者原発性悪性骨腫瘍に対する補助化学療法の検討 JCOG骨軟部腫瘍グループアンケート結果より

永野昭仁, 松本誠一, 川井章, 大隈知威, 平賀博明, 松本嘉寛, 西田佳弘, 米本司, 保坂正美, 高橋満, 吉川秀樹, 尾崎敏文, 淺沼邦洋, 中紀文, 江森誠人, 久保忠彦, 川島寛之, 河本旭哉, 横山良平, 筑紫聡

日本整形外科学会雑誌 92 ( 6 ) S1408 - S1408 2018.6

骨肉腫の細胞内外microRNA-25-3p発現異常の腫瘍学的意義

吉田晶, 藤原智洋, 魚谷弘二, 森田卓也, 清野正普, 横尾賢, 長谷井嬢, 中田英二, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 92 ( 6 ) S1460 - S1460 2018.6

骨転移治療に対する院内コンセンサス形成整形外科としての骨転移への関わりがん専門病院の立場から

杉原進介, 魚谷弘二, 中田英二, 尾崎敏文

日本整形外科学会雑誌 92 ( 6 ) S1509 - S1509 2018.6

Utility of Bayesian Single-Arm Design in New Drug Application for Rare Cancers in Japan: A Case Study of Phase 2 Trial for Sarcoma Reviewed

Akihiro Hirakawa, Tadaaki Nishikawa, Kan Yonemori, Taro Shibata, Kenichi Nakamura, Masashi Ando, Takafumi Ueda, Toshifumi Ozaki, Kenji Tamura, Akira Kawai, Yasuhiro Fujiwara

Therapeutic Innovation and Regulatory Science 52 ( 3 ) 334 - 338 2018.5

骨粗鬆性骨折患者における骨粗鬆治療薬の骨折予防効果システマティックレビュー

斎藤太一, 島村安則, 千田益生, 尾崎敏文

運動器リハビリテーション 29 ( 2 ) 249 - 249 2018.5

Relationship between displacement of the psoas major muscle and spinal alignment in patients with adult spinal deformity Reviewed

Yoshiaki Oda, Tomoyuki Takigawa, Ryo Ugawa, Yasuyuki Shiozaki, Haruo Misawa, Yoshihisa Sugimoto, Masato Tanaka, Toshifumi Ozaki

Asian Spine Journal 12 ( 2 ) 335 - 342 2018.4

Clinical and Functional Significance of Intracellular and Extracellular microRNA-25-3p in Osteosarcoma. Reviewed

Yoshida A, Fujiwara T, Uotani K, Morita T, Kiyono M, Yokoo S, Hasei J, Nakata E, Kunisada T, Ozaki T

Acta medica Okayama 72 ( 2 ) 165 - 174 2018.4

Language：English Publishing type：Research paper (scientific journal)

Although there is considerable evidence indicating that the dysregulation of microRNAs (miRNAs) in malignant tumors plays a role in tumor development, the overall function of miRNAs and their clinicopathological significance are not well understood. In this retrospective analysis of 45 biopsy specimens from osteosarcoma (OS) patients, we investigated the functional and clinical significance of miR-25-3p in OS, which we previously identified as a highly expressed miRNA in OS patients' serum. We observed that miR-25-3p dysregulation in human OS tissues was negatively correlated with the clinical prognosis, whereas the expression level of its target gene, Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3), was positively correlated with the clinical prognosis. Endogenous miR-25-3p upregulation promoted tumor growth, invasion, and drug resistance, which was consistent with DKK3 silencing in OS cells. In addition, secretory miR-25-3p was embedded in tumor-derived exosomes, where it promoted capillary formation and the invasion of vascular endothelial cells. Overall, our results show that miR-25-3p has intracellular and extracellular oncogenic functions as well as clinicopathological relevance in OS, indicating its potential as a novel diagnostic and therapeutic tool for the clinical management of this disease.

DOI： 10.18926/AMO/55857

PubMed

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【運動器画像診療の最前線】部位別・疾患別画像診療の最前線骨腫瘍の画像診療

中田英二, 国定俊之, 長谷井嬢, 藤原智洋, 尾崎敏文

関節外科 37 ( 4月増刊 ) 130 - 143 2018.4

足関節脱臼骨折後遺残変形に対し腓骨延長を行った2例

雑賀建多, 大橋秀基, 堀田昌宏, 出宮光二, 横尾賢, 内野崇彦, 清野正普, 望月雄介, 小松原将, 吉村将秀, 中道亮, 山川泰明, 齋藤太一, 野田知之, 尾崎敏文

中国・四国整形外科学会雑誌 30 ( 1 ) 163 - 163 2018.4

脊椎に原発した骨肉腫の5例

塩崎泰之, 瀧川朋亨, 三澤治夫, 尾崎敏文, 中田英二, 国定俊之

中国・四国整形外科学会雑誌 30 ( 1 ) 79 - 82 2018.4

MiRNA-133a-5p inhibits the expression of osteoblast differentiation-associated markers by targeting the 3′ UTR of RUNX2 Reviewed

Wei Zhang, Yonggang Wu, Yasuyuki Shiozaki, Yoshihisa Sugimoto, Tomoyuki Takigawa, Masato Tanaka, Akihiro Matsukawa, Toshifumi Ozaki

DNA and Cell Biology 37 ( 3 ) 199 - 209 2018.3

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