Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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軟部肉腫に対するp53発現テロメラーゼ依存型腫瘍融解アデノウイルスの放射線効果増強

小松原将, 田澤大, 望月雄介, 杉生和久, 大森敏規, 山川泰明, 尾崎修平, 長谷井嬢, 藤原智洋, 国定俊之, 浦田泰生, 尾崎敏文, 藤原俊義

日本癌学会総会記事 76回 J - 2008 2017.9

Ewing肉腫におけるエクソソームを標的とした体液診断法の確立

吉田晶, 藤原智洋, 魚谷弘二, 岩田慎太郎, 吉岡祐亮, 植田幸嗣, 森田卓也, 清野正普, 横尾賢, 長谷井嬢, 国定俊之, 落谷孝広, 尾崎敏文

日本癌学会総会記事 76回 P - 1289 2017.9

粘液線維肉腫由来エクソソーム中microRNAプロファイリングの特定と機能解析

森田卓也, 藤原智洋, 吉田晶, 清野正晋, 横尾賢, 長谷井嬢, 国定俊之, 尾崎敏文

日本癌学会総会記事 76回 P - 2295 2017.9

転写因子Mohawkは椎間板線維輪の維持、再生に重要である

中道亮, 尾崎敏文

中部日本整形外科災害外科学会雑誌 60 ( 秋季学会 ) 254 - 254 2017.9

重症脳性麻痺患者におけるgrowth spurt中の側彎症進行調査

小田孔明, 瀧川朋亨, 塩崎泰之, 三澤治夫, 赤澤啓史, 尾崎敏文

中国・四国整形外科学会雑誌 29 ( 3 ) 350 - 350 2017.9

関節リウマチ患者の環軸椎亜脱臼に対する固定術式の検討

三澤ハルオ, 瀧川朋亨, 塩崎泰之, 小田孔明, 宇川諒, 尾崎敏文

中部日本整形外科災害外科学会雑誌 60 ( 秋季学会 ) 184 - 184 2017.9

頸椎に生じた骨軟骨腫の1例

村岡聡介, 小田孔明, 塩崎泰之, 瀧川朋亨, 三澤治夫, 尾崎敏文

中部日本整形外科災害外科学会雑誌 60 ( 秋季学会 ) 216 - 216 2017.9

Cervical Spine Osteoradionecrosis Reviewed

Masato Tanaka, Yoshihisa Sugimoto, Tomoyuki Takigawa, Yoshihiro Kimata, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 71 ( 4 ) 345 - 349 2017.8

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

Osteoradionecrosis (ORN), a well-known complication of radiotherapy in the mandibular bone, is very rare in the cervical spine. The authors report the result of a 3-year follow-up of a 63-year-old female patient with ORN of the cervical spine. The patient had a history of laryngeal carcinoma and was treated with chemotherapy and radiation therapy with a total of 120 Gy. Eight years later, she developed acute, severe neck pain due to cervical spine necrosis. The authors performed vascularized fibular bone graft and posterior pedicle screw fixation to reconstruct her cervical spine. The patient was successfully treated with surgery, and cervical alignment was preserved. She had neither neurological deficits nor severe neck pain at her final follow-up 3 years later. Delaying treatment of ORN may be life threatening, so the early diagnosis of this condition is important for patients who receive radiotherapy. Otolaryngologists and spine surgeons should understand this potential complication to speed diagnosis and treatment as early as possible.

DOI： 10.18926/AMO/55312

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An Analysis of the Characteristics and Improved Use of Newly Developed CT-based Navigation System in Total Hip Arthroplasty.

Yosuke Fujii, Kazuo Fujiwara, Tomonori Tetsunaga, Takamasa Miyake, Kazuki Yamada, Hirosuke Endo, Nobuhiro Abe, Naohiko Sugita, Mamoru Mitsuishi, Takayuki Inoue, Yoshio Nakashima, Toshifumi Ozaki

Acta medica Okayama 71 ( 4 ) 279 - 289 2017.8

Language：English Publishing type：Research paper (scientific journal)

We developed a surface matching-type computed tomography (CT)-based navigation system for total hip arthroplasty (the N-navi; TEIJIN NAKASHIMA MEDICAL, Okayama, Japan). In the registration step, surface matching was performed with digitizing points on the pelvic bone surface after coarse paired matching. In the present study, we made model bones from the CT data of patients whose acetabular shapes had various deformities. We measured the distances and angles after surface matching from the fiducial points and evaluated the ability to correct surface-matching registration on each pelvic form, using several areas and numbers of points. When the surface-matching points were taken on the superior area of the acetabulum, the correction was easy for the external direction, but it was difficult to correct for the anterior and proximal directions. The correction was difficult for external and proximal directions on the posterior area. Each area of surface-matching points has particular directions that are easily corrected and other directions that are difficult to correct. The shape of the pelvis also affected the correction ability. Our present findings suggest that checking the position after coarse paired matching and choosing the surface-matching area and points that are optimal to correct will improve the accuracy of total hip arthroplasty and reduce surgical times.

DOI： 10.18926/AMO/55304

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Location of the tibial tunnel aperture affects extrusion of the lateral meniscus following reconstruction of the anterior cruciate ligament. International journal

Yuya Kodama, Takayuki Furumatsu, Shinichi Miyazawa, Masataka Fujii, Takaaki Tanaka, Hiroto Inoue, Toshifumi Ozaki

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 35 ( 8 ) 1625 - 1633 2017.8

Language：English Publishing type：Research paper (scientific journal)

The anterior root of the lateral meniscus provides functional stability to the meniscus. In this study, we evaluated the relationship between the position of the tibial tunnel and extrusion of the lateral meniscus after anterior cruciate ligament reconstruction, where extrusion provides a proxy measure of injury to the anterior root. The relationship between extrusion and tibial tunnel location was retrospectively evaluated from computed tomography and magnetic resonance images of 26 reconstructed knees, contributed by 25 patients aged 17-31 years. A measurement grid was used to localize the position of the tibial tunnel based on anatomical landmarks identified from the three-dimensional reconstruction of axial computed tomography images of the tibial plateaus. The reference point-to-tibial tunnel distance (mm) was defined as the distance from the midpoint of the lateral edge of the grid to the posterolateral aspect of the tunnel aperture. The optimal cutoff of this distance to minimize post-operative extrusion was identified using receiver operating curve analysis. Extrusion of the lateral meniscus was positively correlated to the reference point-to-tibial tunnel distance (r 2 = 0.64; p < 0.001), with a cutoff distance of 5 mm having a sensitivity to extrusion of 83% and specificity of 93%. The mean extrusion for a distance >5 mm was 0.40 ± 0.43 mm, compared to 1.40 ± 0.51 mm for a distance ≤5 mm (p < 0.001). Therefore, a posterolateral location of the tibial tunnel aperture within the footprint of the anterior cruciate ligament decreases the reference point-to-tibial tunnel distance and increases extrusion of the lateral meniscus post-reconstruction. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1625-1633, 2017.

DOI： 10.1002/jor.23450

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Residual Femoral Deformity and Femoroacetabular Impingement after Intertrochanteric Osteotomy for Slipped Capital Femoral Epiphysis.

Yosuke Fujii, Hirosuke Endo, Shigeru Mitani, Hirofumi Akazawa, Tomonori Tetsunaga, Takamasa Miyake, Kazuki Yamada, Kiyoshi Aoki, Toshifumi Ozaki

Acta medica Okayama 71 ( 4 ) 315 - 323 2017.8

Language：English Publishing type：Research paper (scientific journal)

We retrospectively reviewed 29 hips in which intertrochanteric osteotomies were performed for severe slipped capital femoral epiphyses. Mean age at surgery: 12.6 years. Mean follow-up period: 6 years. At the final follow-up evaluation, one patient had coxalgia, and six hips showed a limited range of motion. A pistol-grip deformity was observed in 13 hips, osteoarthritis in two hips, and a bump existed in 19 hips on the latest radiographs. Gradual remodeling of the bumps was observed post-operatively in 22 hips. The mean α and β angles and offset α and β improved over time. The remodeling proceeded rapidly for 1 year post-surgery. We compared hips classified as β angles of ≥ 63° to < 63° at the final follow-up evaluation, the mean β angle 1 year post-surgery, and the mean ratio of improvement of the β angle per year from 1 year post-surgery to the final follow up, which differed significantly. Nearly all of the patients who underwent intertrochanteric osteotomies had residual morphologic abnormalities, but few had clinical symptoms. The β angle 1 year post-surgery and the ratio of remodeling of the bump from 1 year post-surgery to the final follow-up can be regarded as a potential predictor of morphologic results after intertrochanteric osteotomy.

DOI： 10.18926/AMO/55308

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軟骨細胞によるIL-1β誘導性蛋白分解酵素発現に対する脂肪由来抽出液の影響

大橋秀基, 那須義久, 竹下歩, 兼田大輔, 木曽洋平, 沖田駿治, 渡辺雅仁, 中原龍一, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1758 - S1758 2017.8