Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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周術期の管理エタネルセプト使用症例の周術期感染頻度の検討

中原龍一, 西田圭一郎, 金澤智子, 斎藤太一, 橋詰謙三, 尾崎敏文

日本関節病学会誌 29 ( 3 ) 340 - 340 2010.10

【肩関節・肩甲帯部疾患病態・診断・治療の現状】治療保存的治療と手術的治療の現状骨折と脱臼鎖骨骨折鎖骨骨幹部骨折に対するプレート固定法前下方プレート法、minimally invasive plate osteosynthesis法

島村安則, 野田知之, 中原龍一, 雑賀建多, 西山武, 尾崎敏文

別冊整形外科 ( 58 ) 71 - 75 2010.10

Language：Japanese Publisher：(株)南江堂

2007年より鎖骨骨幹部骨折に対してプレート固定による手術的治療を行った症例は42例であった。そのうち、初期の32例に対してはanteroinferior plating法(AP法)を、2009年からの10例は、AP法を応用したminimally invasive plate osteosynthesis法(MIPO法)を施行した。AP法、MIPO法ともに全例において骨癒合が得られ、JOAスコア、DASHスコアともに良好な改善が得られた。MIPO法はAP法に比較して、早期に疼痛の軽減が得られている印象であった。AP法は従来の手術法に比べて早期に社会復帰が可能となる有用な方法であるが、さらにMIPO法はAP法のメリットに加えて整容面や骨折部の血流温存といった面でも有利であり、手術・保存的治療双方のメリットを併せ持つ優れた治療法であると考えられた。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J04037&link_issn=&doc_id=20101104480015&doc_link_id=10.15106%2FJ04037.2011097692&url=https%3A%2F%2Fdoi.org%2F10.15106%2FJ04037.2011097692&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

関節病に対する上肢人工関節置換術関節リウマチ肘関節破壊に対するJACE型人工肘関節置換術の中期成績

橋詰謙三, 西田圭一郎, 中原龍一, 斎藤太一, 金澤智子, 尾崎敏文

日本関節病学会誌 29 ( 3 ) 409 - 409 2010.10

Multicenter Phase II trial assessing effectiveness of imatinib mesylate on relapsed or refractory KIT-positive or PDGFR-positive sarcoma Reviewed

Hideshi Sugiura, Yasuhiro Fujiwara, Masashi Ando, Akira Kawai, Akira Ogose, Toshifumi Ozaki, Ryohei Yokoyama, Toru Hiruma, Takeshi Ishii, Hideo Morioka, Hideo Mugishima

JOURNAL OF ORTHOPAEDIC SCIENCE 15 ( 5 ) 654 - 660 2010.9

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER TOKYO

Imatinib myselate is a molecularly targeted drug that inhibits Abl tyrosine kinase, as well as type III tyrosine kinase receptors such as platelet-derived growth factor receptor (PDGFR), KIT, colony-stimulating factor 1 receptor (CSF-1R), and discoidin domain receptor (DDR). Ph1 chromosome-positive chronic myeloid leukemias (CMLs), KIT-positive gastrointestinal stromal tumors (GISTs), and PDGFR-positive dermatofibrosarcoma protuberans (DFSP) have been reported to be responsive to imatinib treatment. We conducted a multicenter Phase II trial of imatinib in patients with relapsed or refractory KIT-positive (excluding GISTs) or PDGFR-positive sarcomas.
Patient ages ranged from 12 and 75 years. Eligibility criteria included (1) metastatic sarcomas with a definitive diagnosis based on histopathology or that were completely unresectable and locally advanced; (2) relapsed or refractory cases that had completed standard treatment; and (3) a tumor confirmed by immunohistochemical staining to be KIT- or PDGFR-positive. A 600-mg dose of imatinib was administered to patients once a day, with each patient receiving six courses of the drug and each course lasting 4 weeks. In cases categorized as stable or progressive, the imatinib dose was increased to 800 mg/day administered twice daily.
A total of 25 patients who met the eligibility criteria were enrolled in the trial; 22 were evaluated for response. The response rate with a 600 mg/day dose of imatinib was 4.5% (0 complete response, 1 partial response). There were no other objective responses after increasing imatinib to 800 mg/day (0/10). We estimated 50% progression-free survival to be 61.0 days for an imatinib dose of 600 mg/day based on the Kaplan-Meier method. Side effects of imatinib were generally similar to those observed in previous clinical trials.
Our results did not indicate effectiveness of imatinib monotherapy at a dose of 600 or 800 mg/day in patients with relapsed or refractory KIT-positive (excluding GISTs) or PDGFR-positive sarcomas. Our findings suggest the need to evaluate the synergistic effect of combination therapy with other anticancer drugs.

DOI： 10.1007/s00776-010-1506-9

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橈骨遠位端骨折に対する掌側プレートによる長母指屈筋腱断裂の3例

金澤智子, 島村安則, 野田知之, 西山武, 斎藤太一, 尾崎敏文

中部日本整形外科災害外科学会雑誌 53 ( 秋季学会 ) 177 - 177 2010.9

鎖骨骨幹部粉砕骨折に対するMIPOによる治療経験

島村安則, 野田知之, 西山武, 中原龍一, 雑賀建多, 斉藤太一, 門田康孝, 尾崎敏文

中国・四国整形外科学会雑誌 22 ( 2 ) 494 - 495 2010.9

三次元実体石膏模型を利用して治療した反復性肩関節脱臼の1例

井上円加, 中原龍一, 斎藤太一, 金澤智子, 島村安則, 小澤正嗣, 阿部信寛, 野田知之, 西田圭一郎, 尾崎敏文

肩関節 35 ( 1 ) 176 - 176 2010.9

鎖骨骨幹部骨折に対する前下方プレート法による治療成績

島村安則, 野田知之, 中原龍一, 金澤智子, 井上円加, 斎藤太一, 小澤正嗣, 雑賀建多, 西田圭一郎, 尾崎敏文

肩関節 35 ( 1 ) 75 - 75 2010.9

肩鎖関節脱臼に合併した外傷性肩関節前方不安定症の1例

島村安則, 阿部信寛, 野田知之, 雑賀建多, 斎藤太一, 金澤智子, 井上円加, 小澤正嗣, 中原龍一, 尾崎敏文

肩関節 35 ( 1 ) 189 - 189 2010.9

より安全な掌側ロッキングプレート固定術の実施をめざした橈骨遠位端掌側部の解剖学的・組織学的研究

今谷潤也, 清水弘毅, 近藤秀則, 林正典, 秋田恵一, 尾崎敏文

日本整形外科学会雑誌 84 ( 8 ) S1339 - S1339 2010.8

良性嚢胞性骨腫瘍の画像診断 FEGNO-MASHICは正しいか

郷原英夫, 稲井良太, 加藤勝也, 佐藤修平, 新家崇義, 国定俊之, 尾崎敏文, 金澤右

日本医学放射線学会秋季臨床大会抄録集 46回 S539 - S540 2010.8

The 2009 Okayama Medical Association Awards: TGF-β-Smad3 pathway activates Sox9-dependent chondrogenesis

Journal of Okayama Medical Association 122 ( 2 ) 95 - 99 2010.8

Guidelines: Orthopaedic surgery: Japanese guidelines for coxarthrosis

Journal of Okayama Medical Association 122 ( 2 ) 159 - 162 2010.8

ヒト軟骨細胞様細胞においてADAMTS-5はRUNX-2を介してメカノセンシティブに機能するアグリカナーゼである

鉄永智紀, 西田圭一郎, 古松毅之, 斎藤太一, 成瀬恵治, 尾崎敏文

日本整形外科学会雑誌 84 ( 8 ) S1230 - S1230 2010.8

NCB Distal Femurプレートによる大腿骨遠位部骨折の治療経験

斎藤太一, 野田知之, 島村安則, 中原龍一, 雑賀健多, 尾崎敏文

岡山医学会雑誌 122 ( 2 ) 178 - 178 2010.8

THA cup再置換術後に早期破綻した1例に対する治療経験

藤原智洋, 遠藤裕介, 三谷茂, 尾崎敏文, 藤原一夫

岡山医学会雑誌 122 ( 2 ) 177 - 177 2010.8

骨肉腫におけるがん幹細胞の同定と解析(Identification and characterization of tumor-initiating cells in osteosarcoma)

藤原智洋, 高橋陵宇, 竹下文隆, 尾崎敏文, 川井章, 落谷孝広

日本癌学会総会記事 69回 488 - 488 2010.8

Computed tomography fluoroscopy-guided placement of iliosacral screws in patients with unstable posterior pelvic fractures Reviewed

Toshihiro Iguchi, Ken-Ichi Ogawa, Takeshi Doi, Koji Miyasho, Kazuo Munetomo, Takao Hiraki, Toshifumi Ozaki, Susumu Kanazawa

SKELETAL RADIOLOGY 39 ( 7 ) 701 - 705 2010.7

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

The purpose of this study was to evaluate retrospectively the safety and effectiveness of the computed tomography (CT) fluoroscopy-guided placement of iliosacral screws in patients with unstable posterior pelvic fractures.
Six patients (four women and two men; mean age 55.8 years; range 35-77 years) with unstable posterior pelvic fractures underwent iliosacral screw placement under CT fluoroscopy guidance between November 2007 and August 2008. Unstable pelvic ring injury (AO types B and C) was the indication for this procedure.
In all the six patients except one, CT fluoroscopy-guided placement had been technically successful. In one patient, a second screw had been inserted, with a tilt to the caudal site, and slightly advanced into the extrasacral body; afterward, it could be exchanged safely for a shorter screw. Five patients and one patient underwent placement of two screws and one screw, respectively. The mean duration of the procedure was 15.0 min (range 9-30 min) per screw; the duration was 12.3 min and 18.2 min for the first and second screws, respectively. No complications requiring treatment occurred during or after the procedure. The mean clinical and radiologic follow-up period was 14 months (range 6-21 months). All pelvic injuries had healed satisfactorily, without complication, and all patients are now doing well clinically and can walk.
CT fluoroscopy-guided placement of iliosacral screws is a safe and effective treatment in patients with unstable posterior pelvic fractures.

DOI： 10.1007/s00256-009-0826-3

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鎖骨骨幹部骨折に対するMIPOによる治療経験

島村安則, 野田知之, 中原龍一, 斎藤太一, 金澤智子, 長谷井嬢, 雑賀建多, 井上円加, 尾崎敏文

骨折 32 ( Suppl. ) S82 - S82 2010.7

ロッキングプレートによるTKA周囲大腿骨骨折の治療経験

斎藤太一, 野田知之, 島村安則, 寺田忠司, 西山武, 中原龍一, 雑賀健多, 尾崎敏文

骨折 32 ( Suppl. ) S129 - S129 2010.7

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