Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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Prognostic and therapeutic factors influencing the clinical outcome of metastatic Ewing sarcoma family of tumors: A retrospective report from the Japan Ewing Sarcoma Study Group. International journal

Katsutsugu Umeda, Takako Miyamura, Kenji Yamada, Hideki Sano, Ako Hosono, Minako Sumi, Hajime Okita, Takuya Kamio, Naoko Maeda, Hiroyuki Fujisaki, Ryoji Jyoko, Atsuko Watanabe, Yosuke Hosoya, Daiichiro Hasegawa, Satoshi Takenaka, Shunsuke Nakagawa, Motoaki Chin, Toshifumi Ozaki

Pediatric blood & cancer 68 ( 3 ) e28844 2021.3

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The prognosis of patients with metastatic Ewing sarcoma family of tumors (ESFT) remains poor. PROCEDURE: We retrospectively analyzed 57 patients diagnosed with metastatic ESFT between 2000 and 2018 to identify prognostic and therapeutic factors affecting the clinical outcome. RESULTS: The 3-year overall survival (OS) rate of the entire cohort was 46.8% (95% confidence interval [CI], 33.0-59.4%). Treatment-related death was not observed. Multivariate analysis identified stem cell transplantation (SCT), response to first-line chemotherapy, and bone metastasis as independent risk factors for OS. Objective response rate to first-line chemotherapy was 65.1% in the 43 evaluable patients. There was no significant difference in the response to different types of first-line chemotherapy. Among patients with lung metastasis alone, the 3-year OS rate was higher in 13 patients who received local treatment than in four who did not, although the difference was not significant. CONCLUSIONS: One possible reason for the high OS rates was the absence of treatment-related mortality even in patients receiving SCT, which could be attributed to advances in the management of post-SCT complications. Novel first-line chemotherapy strategies need to be established to improve the disease status prior to SCT in a higher proportion of patients.

DOI： 10.1002/pbc.28844

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大腿骨頸部前捻角に左右差はあるか 3D計測による検討

佐藤浩平, 野田知之, 近藤宏也, 畑利彰, 上原健敬, 齋藤太一, 雑賀建多, 島村安則, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S1125 - S1125 2021.3

不安定型骨盤輪損傷に対するCTナビゲーションガイド下スクリュー固定の治療成績

上原健敬, 野田知之, 畑利彰, 佐藤浩平, 近藤宏也, 齋藤太一, 島村安則, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S1116 - S1116 2021.3

寛骨臼骨折におけるroof-arc angle計測の妥当性の検討単純X線写真計測と3D計測の比較と術後臨床評価との関連性

近藤宏也, 上原健敬, 佐藤浩平, 畑利彰, 根津智史, 松橋美波, 齋藤太一, 島村安則, 野田知之, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S1116 - S1116 2021.3

The trend of treatment and conveyance system for upper extremity replantation in Japan: A nationwide population-based study from the Japan trauma data bank.

Taichi Saito, Satoshi Nezu, Minami Matsuhashi, Ryuichi Nakahara, Yasunori Shimamura, Tomoyuki Noda, Tetsuya Yumoto, Atsunori Nakao, Toshifumi Ozaki

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 26 ( 2 ) 271 - 275 2021.3

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: In Japan, microsurgical skill development and a system to transfer patients to an appropriate hospital for upper extremity amputation have been promoted; however, information about trends of replantation is limited. Therefore, the aim of this study was to clarify the trends in the treatment for upper extremity amputation using the Japan Trauma Data Bank (JTDB). METHODS: Data derived from JTDB (2004-2015) were used to quantify trends in the volume of replantation for upper extremity amputation including finger amputation. Trauma was diagnosed based on the Abbreviated Injury Scale code; a subgroup of patients who underwent replantation was delineated. We investigated patient demographics, infection rate, and characteristics of treating facilities. RESULTS: A total of 1240 patients underwent upper extremity amputation. Among these, 510 (41.1%) underwent replantation, and the rate of replantation did not change over the study period. The average age of patients who underwent or did not undergo replantation was 45.5 and 47.2 years, respectively. The proportion of the patients who were transferred to another hospital for treatment significantly decreased between 2004 (28.5%) and 2015 (16.3%) (P < 0.01). Time taken for transfer from the accident site to hospitals increased. The rate of patients who underwent replantation differed among different hospitals; however, higher-volume hospitals were more likely to perform replantation. CONCLUSION: The rate of patients transferred to another hospital decreased between 2004 and 2015; however, the rate of patients who underwent replantation remained unchanged. This suggests that the number of patients who were transported directly from the accident site to an appropriate hospital has increased, whereas the indication for care in each hospital remains unchanged. Common criteria for amputations are needed to address the differing rates of replantation among hospitals.

DOI： 10.1016/j.jos.2020.03.006

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An MRI-based suspension bridge sign can predict an arthroscopically favorable meniscal healing following the medial meniscus posterior root repair.

Takayuki Furumatsu, Yuki Okazaki, Takaaki Hiranaka, Yuya Kodama, Yusuke Kamatsuki, Yoshiki Okazaki, Ximing Zhang, Toshifumi Ozaki

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 26 ( 2 ) 237 - 242 2021.3

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Medial meniscus (MM) posterior root repairs show favorable clinical outcomes in patients with MM posterior root tears (MMPRTs). However, there is no useful magnetic resonance imaging (MRI) finding to determine a functionally good meniscal healing following MM posterior root repairs. We hypothesized that a characteristic postoperative MRI finding can predict a good meniscal healing following pullout repairs. The aim of this study was to investigate a clinical usefulness of several MRI findings for estimating an actual meniscal healing following MMPRT repairs. METHODS: Fifty eight patients who had a posteromedial painful popping of the injured knee and underwent an arthroscopic pullout repair for the MMPRT were included. Arthroscopic meniscal healing was assessed according to the Furumatsu scoring system at 1 year postoperatively. We evaluated postoperative MRI-based meniscal healing using signal intensity, continuity, suspension bridge-like sign of the MM posterior root, and MM medial extrusion on coronal images. Postoperative clinical outcome evaluations were performed at second-look arthroscopy. RESULTS: Twenty three patients showed good arthroscopic healing scores (≥7 points). Thirty five patients had moderate/poor arthroscopic healing scores (<7 points). At 1-year follow-up period, clinical outcome scores were significantly higher in the good healing group than in the moderate/poor healing group. A characteristic meniscal shape, termed "suspension bridge sign", was highly observed in the good meniscal healing group (83%) compared with in the moderate/poor healing group (26%, P < 0.001). High signal intensity and continuity of the MM posterior root and MM medial extrusion showed no differences between both groups. CONCLUSIONS: Our study demonstrated that the MRI-based suspension bridge sign can predict an arthroscopically favorable meniscal healing following the MM posterior root repair. The suspension bridge-like MRI finding of the MM would be a useful indicator to evaluate the actual meniscal healing in patients who underwent pullout repairs for MMPRTs.

DOI： 10.1016/j.jos.2020.03.012

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生物学的製剤と手術当科におけるリウマチ外科手術1569例の患者背景

那須義久, 堀田佳史, 渡辺雅仁, 松橋美波, 中原龍一, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 343 - 343 2021.3

慢性疼痛患者におけるロコモティブシンドローム有病率とその特徴

辻寛謙, 鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S934 - S934 2021.3

慢性疼痛患者の自己効力感は介護者の介護負担度に影響を与える

辻寛謙, 鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S919 - S919 2021.3

寛骨臼回転骨切り術前後での三次元的大腿骨頭移動はADLに影響するか

鉄永智紀, 山田和希, 佐藤嘉洋, 廣瀬一樹, 鉄永倫子, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S972 - S972 2021.3

成人脊椎変形術後の固定隣接椎体骨折に術前胸椎CTハンスフィールド値が与える影響

山根健太郎, 三澤治夫, 小田孔明, 鉄永倫子, 辻寛謙, 高尾真一郎, 梶木裕矢, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S1012 - S1012 2021.3

不安定型骨盤輪損傷に対するCTナビゲーションガイド下スクリュー固定の治療成績

上原健敬, 野田知之, 畑利彰, 佐藤浩平, 近藤宏也, 齋藤太一, 島村安則, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S1116 - S1116 2021.3

寛骨臼骨折におけるroof-arc angle計測の妥当性の検討単純X線写真計測と3D計測の比較と術後臨床評価との関連性

近藤宏也, 上原健敬, 佐藤浩平, 畑利彰, 根津智史, 松橋美波, 齋藤太一, 島村安則, 野田知之, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S1116 - S1116 2021.3

若手整形外科医が知っておくべき骨折治療法下肢骨折に対するプレート固定の適応と限界

野田知之, 上原健敬, 島村安則, 佐藤浩平, 畑利彰, 近藤宏也, 根津智史, 松橋美波, 齋藤太一, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S573 - S573 2021.3

大腿骨頸部前捻角に左右差はあるか 3D計測による検討

佐藤浩平, 野田知之, 近藤宏也, 畑利彰, 上原健敬, 齋藤太一, 雑賀建多, 島村安則, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S1125 - S1125 2021.3

Growing rod挿入術の矯正率予想

小田孔明, 三澤治夫, 山根健太郎, 鉄永倫子, 辻寛謙, 高尾真一郎, 梶木裕矢, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S1022 - S1022 2021.3

骨折を伴ったリウマチ肘に対するPROSNAPを用いた人工肘関節全置換術の治療成績

堀田佳史, 西田圭一郎, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 602 - 602 2021.3

関節リウマチ超音波検査におけるデジタルカメラ画像とAIを用いたボディーマーク付与

中原龍一, 西田圭一郎, 那須義久, 渡辺雅仁, 松橋美波, 堀田佳史, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 555 - 555 2021.3

生物学的製剤と手術当科におけるリウマチ外科手術1569例の患者背景

那須義久, 堀田佳史, 渡辺雅仁, 松橋美波, 中原龍一, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 343 - 343 2021.3

Medial meniscus posterior root repairs: A comparison among three surgical techniques in short-term clinical outcomes and arthroscopic meniscal healing scores.

Takayuki Furumatsu, Takaaki Hiranaka, Yuki Okazaki, Keisuke Kintaka, Yuya Kodama, Yusuke Kamatsuki, Toshifumi Ozaki

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2021.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Medial meniscus (MM) posterior root repairs lead to favorable clinical outcomes in patients with MM posterior root tears (MMPRTs). However, there are few comparative studies in evaluating the superiority among several pullout repair techniques such as modified Mason-Allen suture, simple stitch, and concomitant posteromedial pullout repair. We hypothesized that an additional pullout suture at the MM posteromedial part would have clinical advantages in transtibial pullout repairs of the MMPRTs. The aim of this study was to compare the clinical usefulness among several types of pullout repair techniques in patients with MMPRTs. METHODS: Eighty-three patients who underwent arthroscopic pullout repairs of the MMPRTs were investigated. Patients were divided into three groups using different pullout repair techniques: a modified Mason-Allen suture using FasT-Fix all-inside meniscal repair device (F-MMA, n = 28), two simple stitches (TSS, n = 30), and TSS concomitant with posteromedial pullout repair using all-inside meniscal repair device (TSS-PM, n = 25). Postoperative clinical outcomes and semi-quantitative arthroscopic meniscal healing scores (0-10 points) were evaluated at second-look arthroscopies. RESULTS: No significant differences among the three groups were observed in patient demographics and preoperative clinical scores, except for preoperative Lysholm scores. At second-look arthroscopies, there were no significant differences among the three techniques in postoperative clinical outcomes and meniscal healing scores. CONCLUSIONS: This study demonstrated that the TSS-PM pullout repair technique did not show better scores in postoperative clinical outcomes and meniscal healings compared with the F-MMA and TSS techniques. Our results suggest that the concomitant posteromedial pullout suture may have no clinical advantage in the conventional pullout repairs for the patients with MMPRTs.

DOI： 10.1016/j.jos.2020.11.013

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