Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

Division display 541 - 560 of about 1,743 ／ All the affair displays >>

生物学的製剤の使用は手術部位感染と創傷治癒遅延のリスク因子となるか

木曽洋平, 西田圭一郎, 原田遼三, 那須義久, 中原龍一, 堀田佳史, 浪花崇一, 尾崎敏文

関節の外科 49 ( 2 ) 59 - 59 2022

Randomized placebo-controlled double-blind phase II study of zaltoprofen for patients with diffuse-type and unresectable localized tenosynovial giant cell tumors: The REALIZE study. International journal

Akihiko Takeuchi, Makoto Endo, Akira Kawai, Yoshihiro Nishida, Ryu Terauchi, Akihiko Matsumine, Hisaki Aiba, Tomoki Nakamura, Susumu Tandai, Toshifumi Ozaki, Manabu Hoshi, Daiki Kayano, Miho Okuda, Norio Yamamoto, Katsuhiro Hayashi, Shinji Miwa, Kentaro Igarashi, Kenichi Yoshimura, Akihiro Nomura, Toshinori Murayama, Hiroyuki Tsuchiya

Frontiers in oncology 12 900010 - 900010 2022

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: A tenosynovial giant cell tumor (TGCT) is a locally aggressive benign neoplasm arising from intra- or extra-articular tissue, categorized as localized (L-TGCT, solitary lesion) and diffuse (D-TGCT, multiple lesions) TGCT. Surgical excision is the mainstay of the treatment, and a high local recurrence rate of approximately 50% has been reported. We focused on zaltoprofen, a nonsteroidal anti-inflammatory drug that can activate peroxisome proliferator-activated receptor gamma (PPARγ) and inhibit the proliferation of TGCT stromal cells. Therefore, we conducted a randomized trial to evaluate the safety and effectiveness of zaltoprofen in patients with D-TGCTs or unresectable L-TGCTs. METHODS: This randomized, placebo-controlled, double-blind, multicenter trial evaluated the safety and efficacy of zaltoprofen. In the treatment group, zaltoprofen (480 mg/day) was administered for 48 weeks; the placebo group received similar dosages without zaltoprofen. The primary outcome was progression-free rate (PFR) 48 weeks after treatment administration. Disease progression was defined as the following conditions requiring surgical intervention: 1) repetitive joint swelling due to hemorrhage, 2) joint range of motion limitation, 3) invasion of the adjacent cartilage or bone, 4) severe joint space narrowing, and 5) increased tumor size (target lesion). RESULTS: Forty-one patients were allocated to the zaltoprofen (n=21) or placebo (n=20) groups. The PFR was not significant between the zaltoprofen group and the placebo group at 48 weeks (84.0% and 90.0%, respectively; p=0.619). The mean Japanese Orthopedic Association knee score significantly improved from baseline to week 48 in the zaltoprofen group (85.38 versus 93.75, p=0.027). There was a significant difference between the values at 48 weeks of placebo and zaltoprofen group (p=0.014). One severe adverse event (grade 3 hypertension) was observed in the zaltoprofen group. DISCUSSION: This is the first study to evaluate the efficacy and safety of zaltoprofen in patients with TGCT. No significant differences in PFR were observed between the groups at 48 weeks. Physical function significantly improved after zaltoprofen treatment. The safety profile of zaltoprofen was acceptable. This less invasive and safer treatment with zaltoprofen, compared to surgical removal, could be justified as a novel approach to treating TGCT. Further analysis of long-term administration of zaltoprofen should be considered in future studies. CLINICAL TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trials Registry, identifier (UMIN000025901).

DOI： 10.3389/fonc.2022.900010

PubMed

researchmap

BAPGAN: GAN-based bone age progression of femur and phalange x-ray images.

Shinji Nakazawa, Changhee Han, Joe Hasei, Ryuichi Nakahara, Toshifumi Ozaki

Medical Imaging: Computer-Aided Diagnosis 2022

The impact of system and diagnostic errors for medical litigation outcomes in orthopedic surgery.

Norio Yamamoto, Takashi Watari, Ayako Shibata, Tomoyuki Noda, Toshifumi Ozaki

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2021.12

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Medical litigation resulting from medical errors has a negative impact on health economics for both patients and medical practitioners. In medical litigation involving orthopedic surgeons, we aimed to identify factors contributing to plaintiff victory (orthopedic surgeon loss) through a comprehensive assessment. METHODS: This retrospective study included 166 litigation claims against orthopedic surgeons using a litigation database in Japan. We evaluated the sex and age of the patient (plaintiff), initial diagnosis, diagnostic error, system error, the time and place of each claim that led to malpractice litigation, the institution's size, and clinical outcomes. The main outcome was the litigation outcome (acceptance or rejection) in the final judgment. Acceptance meant that the orthopedic surgeon lost the malpractice lawsuit. We conducted multivariable logistic regression analyses to examine the association of factors with an accepted claim. RESULTS: The median age of the patients was 42 years, and 65.7% were male. The litigation outcome of 85 (51.2%) claims was acceptance. The adjusted median indemnity paid was $151,818. The multivariable analysis showed that diagnostic error, system error, sequelae, inadequate medical procedure, and follow-up observation were significantly associated with the orthopedic surgeon losing the lawsuit. In particular, claims involving diagnostic errors were more likely to be acceptance claims, in which the orthopedic surgeon lost (adjusted odds ratio 16.7, 95% confidence intervals: 4.7 to 58.0, p < 0.001). All of the claims in which the orthopedic surgeon lost were associated with a diagnostic or system error, with the most common one being system error. CONCLUSIONS: System errors and diagnostic errors were significantly associated with acceptance claims (orthopedic surgeon losses). Since these are modifiable factors, it is necessary to take measures not only for individual physicians but also for the overall medical management system to enhance patient safety and reduce the litigation risk of orthopedic surgeons.

DOI： 10.1016/j.jos.2021.11.006

PubMed

researchmap

Relationship between clinical outcomes and nerve conduction studies before and after surgery in patients with carpal tunnel syndrome International journal

Masato Ise, Taichi Saito, Yoshimi Katayama, Ryuichi Nakahara, Yasunori Shimamura, Masanori Hamada, Masuo Senda, Toshifumi Ozaki

BMC Musculoskeletal Disorders 22 ( 1 ) 882 - 882 2021.12

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

<title>Abstract</title><sec>
<title>Background</title>
Nerve conduction study (NCS) is the only useful test for objective assessment of carpal tunnel syndrome (CTS). However, the relationship between pre- and postoperative NCS and clinical outcomes was unclear. This study aimed to determine whether pre- and postoperative (6 months) NCS could predict patient-oriented and motor outcomes (6 and 12 months postoperatively) in patients with CTS.

</sec><sec>
<title>Method</title>
Of the 85 patients with CTS, 107 hands were analyzed from March 2011 to March 2020. All patients underwent open carpal tunnel release and were examined using the disabilities of the arm, shoulder and hand (DASH) questionnaire and grip strength (GS) preoperatively and 6 and 12 months postoperatively. Moreover, NCS was examined preoperatively and 6 months postoperatively. Distal motor latency (DML) and sensory conduction velocity (SCV) were the parameters used for NCS. The correlation coefficient between NCS and DASH or GS was calculated. A receiver operating characteristic curve was utilized to determine the NCS threshold value to predict DASH and GS improvement.

</sec><sec>
<title>Results</title>
The average scores of GS preoperatively and 6 and 12 months postoperatively were 21.3, 22.3, and 22.8, respectively. On the other hand, the average scores of DASH preoperatively and 6 and 12 months postoperatively were 28.8, 18.3, and 12.2, respectively. The average NCS scores (DML and SCV) preoperatively/6 months postoperatively were 7.3/5.4 and 27.8/36.7, respectively. Preoperative NCS did not correlate with DASH and GS. Postoperative SCV correlated with the change in grip strength (6–12 months, <italic>r</italic> = 0.67; 0–12 months, <italic>r</italic> = 0.60) and DASH (0–12 months, <italic>r</italic> = 0.77). Moreover, postoperative DML correlated with the change in DASH (6–12 months, <italic>r</italic> = − 0.33; 0–12 months, <italic>r</italic> = − 0.59). The prediction for the improvement of GS/DASH achieved a sensitivity of 50.0%/66.7% and a specificity of 100%/100%, at an SCV cutoff score of 38.5/45.0 or above. The prediction for improvement of GS/DASH achieved a sensitivity of 83.3%/66.7% and a specificity of 100%/66.7% at a DML cutoff score of 4.4/4.4 or below.

</sec><sec>
<title>Conclusion</title>
NCS at 6 months postoperatively can be used to predict the improvement of clinical outcome after 6 months postoperatively in patients with CTS.

</sec>

DOI： 10.1186/s12891-021-04771-y

PubMed

researchmap

Other Link： https://link.springer.com/article/10.1186/s12891-021-04771-y/fulltext.html

A characteristic MRI finding to diagnose a partial tear of the medial meniscus posterior root: an ocarina sign

Takayuki Furumatsu, Takaaki Hiranaka, Keisuke Kintaka, Yuki Okazaki, Naohiro Higashihara, Masanori Tamura, Toshifumi Ozaki

Knee Surgery & Related Research 33 ( 1 ) 2021.12

Authorship：Last author Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

<title>Abstract</title><sec>
<title>Background</title>
Diagnosing partial tears of the medial meniscus (MM) posterior root is difficult. The aim of this study was to evaluate diagnostic values involved in conventional magnetic resonance imaging (MRI) features of MM posterior root tears (MMPRTs) and find other MRI-based findings in patients with partial MMPRTs.

</sec><sec>
<title>Methods</title>
Eighteen patients who had arthroscopically confirmed partial MMPRTs were included. As a control, 18 patients who underwent partial meniscectomy for other types of MM tears were evaluated. Isolated partial MMPRTs were classified into the following three types: type A, accurate partial stable tear (cleavage < 1/2 of root width); type B, bridged unstable root tear (cleavage ≥ 1/2 of root width); type C, complex horn tear expanded to the root. Conventional MRI-based findings of MMPRTs were evaluated between two groups (<italic>n</italic> = 23). Posterior root irregularity, bone marrow spot, and ocarina-like appearance showing several condensed circles in triangular meniscal horn (ocarina sign) were also evaluated.

</sec><sec>
<title>Results</title>
Posterior root irregularity and bone marrow spot were frequently observed in the partial MMPRTs (47.8%), compared with the other MM tears (<italic>P</italic> = 0.007 and 0.023, respectively). The ocarina sign was detected in 69.6% of patients with partial MMPRTs. A significant difference between two groups was observed in a positive ratio of ocarina sign (<italic>P</italic> < 0.001). Types A, B, and C of the partial tear/damage were observed in three, eight, and seven patients, respectively. The ocarina sign was the most common MRI finding in each type of partial MMPRT.

</sec><sec>
<title>Conclusions</title>
This study demonstrated that a characteristic MRI finding, “ocarina sign,” was frequently observed in patients with partial tear/damage of the MM posterior root. The ocarina sign was the most common MRI finding in several types of partial MMPRTs. Our results suggest that the ocarina sign may be useful to diagnose unnoticed partial MMPRTs.

<italic>Level of evidence:</italic> IV, retrospective comparative study.

</sec>

DOI： 10.1186/s43019-021-00120-4

researchmap

Other Link： https://link.springer.com/article/10.1186/s43019-021-00120-4/fulltext.html

股関節痛を契機に診断された強直性脊椎炎の1例

山田和希, 那須義久, 鉄永智紀, 佐藤嘉洋, 廣瀬一樹, 中原龍一, 西田圭一郎, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 2 ) 166 - 170 2021.12

Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(一社)日本小児整形外科学会

股関節痛を契機に診断に至った、強直性脊椎炎:ankylosing spondylitis(以下、AS)の1例を経験したので報告する。症例は16歳男子で、右股関節痛のため近医を受診した。大腿骨寛骨臼インピンジメントの診断で当科に紹介された。当科初診時、右股関節痛は安静時と夜間に強く、運動時には感じなかった。右股関節の可動域制限を認め疼痛誘発テストは陽性であった。詳細に問診したところ、過去に腰臀部痛と両股関節痛を繰り返していた。単純X線では左仙腸関節に硬化像を認め、MRIでは右股関節水腫と両仙腸関節周囲の骨髄浮腫像を認めた。血液検査では炎症反応が上昇し、HLA-B27は陽性であった。ASと診断し、疾患活動性が高かったため、Infliximabの適応とした。治療は奏効し、現在も継続している。詳細な病歴聴取により早期の診断と治療が行えたため、短期の成績ではあるが経過良好であった。(著者抄録)

researchmap

骨盤骨折に伴った腰仙骨神経叢損傷の1例

伊勢真人, 本郷匡一, 堅山佳美, 濱田全紀, 千田益生, 池田吉宏, 茂山幸雄, 徳弘昭博, 尾崎敏文

末梢神経 32 ( 2 ) 346 - 346 2021.12

Novel Technique for Removing a Well-Fixed Cemented Cup with a Dedicated Original Device during Revision Total Hip Arthroplasty: Surgical Technique.

Hirosuke Endo, Kazuki Yamada, Tomonori Testunaga, Takayuki Furumatsu, Shigeru Mitani, Toshifumi Ozaki

Acta medica Okayama 75 ( 6 ) 751 - 754 2021.12

Language：English

The improved cemented cup technique has attained excellent long-term results in primary total hip arthroplasty. When cup revision surgery was performed, the cemented cup, which was loosened at the bone-cement interface, was easily removed. However, with a well-fixed bone-cement interface, it remains difficult to remove the cemented cup for a revision in the event of a recurring dislocation. In addition, protrusions in the cement can cause unpredictable bone defects. A new removal device was created and used successfully to remove a well-fixed cemented cup safely and efficiently. This report introduces the device and the technique used in cemented cup removal.

DOI： 10.18926/AMO/62817

PubMed

researchmap

The Japanese Version of the Patient-Rated Elbow Evaluation is a Useful Outcome Measure that Potentially Reflects Hand Function in Patients with Rheumatoid Arthritis who Underwent Total Elbow Arthroplasty. International journal

Ryozo Harada, Keiichiro Nishida, Yoshiyuki Matsuyama, Kenzo Hashizume, Takuro Wada, Yoshihisa Nasu, Ryuichi Nakahara, Masahiro Horita, Masuo Senda, Toshifumi Ozaki

Modern rheumatology 32 ( 6 ) 1041 - 1046 2021.11

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: We examined the relationship between The Japanese version of Patient-Related Elbow Evaluation (PREE-J) and other established subjective and objective outcome measures in Japanese patients with rheumatoid arthritis (RA) who underwent total elbow arthroplasty (TEA). PATIENTS AND METHODS: This study involved 46 elbows of 40 RA patients. We collected clinical data one year after surgery, including the PREE-J, the Mayo Elbow Performance Score (MEPS), Disability of the Arm, Shoulder, and Hand (DASH), and Hand20. The correlation and responsiveness to PREE-J were evaluated compared with other outcome measures pre-and postoperatively. RESULTS: Almost all outcome measures were improved significantly after surgery. Preoperative PREE-J was significantly correlated with preoperative DASH, Hand20, and MEPS. Interestingly, postoperative PREE-J did not correlate with postoperative MEPS. Multiple regression analyses revealed that preoperative grip strength (B = -0.09; 95% CI -0.17 to -0.01, p = 0.03) and preoperative Hand20 (B = 0.31, 95% CI 0.03 - 0.58, p = 0.03) were significant factors those might influenced the postoperative PREE-J. CONCLUSIONS: The PREE-J was shown to correlate well with other preoperative outcome measures among the RA patients included in the current study. The postoperative PREE-J after TEA was influenced by the preoperative grip strength and function of the hand.

DOI： 10.1093/mr/roab100

PubMed

researchmap

The effect of mechanical stress on enthesis homeostasis in a rat Achilles enthesis organ culture model

Taichi Saito, Ryo Nakamichi, Aki Yoshida, Takaaki Hiranaka, Yuki Okazaki, Satoshi Nezu, Minami Matsuhashi, Yasunori Shimamura, Takayuki Furumatsu, Keiichiro Nishida, Toshifumi Ozaki

Journal of Orthopaedic Research 40 ( 8 ) 1872 - 1882 2021.11

What are the Results of Resection of Forearm Soft Tissue Sarcoma?

Eiji Nakata, Tomohiro Fujiwara, Toshiyuki Kunisada, Ryuichi Nakahara, Toshiyuki Watanabe, Toshifumi Ozaki

2021.11

Publisher：Research Square Platform LLC

Abstract

Only few reports have assessed the characteristics and oncological and functional outcomes of forearm soft tissue sarcomas (STS). Then, we aimed to investigate the clinical features and survival-related factors for forearm STS who underwent surgical excision at our institution. There were 38 patients. Fourteen patients (41%) were referred to our institution after an unplanned excision and tumor size and grade were significantly associated with the receipt of it. The postoperative median Musculoskeletal Tumor Society rating scale (MSTS) score was 28. Bone resection or major nerve palsy was the only factor influencing the postoperative MSTS score (P < 0.001). There was no significant difference in MSTS scores according to the reconstruction procedures (the use of flap or tendon reconstruction). The 5-year local recurrence-free survival (LRFS) rate was 86%. Univariate analysis revealed that the histological diagnosis of myxofibrosarcoma was the only factor that influenced LRFS (P = 0.047). The 5-year metastasis-free survival rate was 77%. The 5-year overall survival (OS) rate was 94%. Age was the only factor that influenced OS (P = 0.01). In conclusion, reconstruction of the skin and tendon can compensate for function. Careful follow-up is important, especially in patients with myxofibrosarcoma, due to its likelihood of local recurrence.

DOI： 10.21203/rs.3.rs-1028963/v1

researchmap

Other Link： https://www.researchsquare.com/article/rs-1028963/v1.html

Factors affecting the quality of life of patients with painful spinal bone metastases

Yoshiteru Akezaki, Eiji Nakata, Masato Kikuuchi, Shinsuke Sugihara, Yoshimi Katayama, Haruki Katayama, Masanori Hamada, Toshifumi Ozaki

Healthcare (Switzerland) 9 ( 11 ) 2021.11

Authorship：Last author Publishing type：Research paper (scientific journal)

This study examined changes in the quality of life (QOL), as well as the factors affecting QOL, among patients with painful spinal bone metastases without paralysis for 1 month after radiotherapy. Methods: This study included 79 participants (40 male and 39 female; median age, 65 (42–88) years) who had undergone radiotherapy for painful spinal bone metastases without paralysis. Patients’ age, sex, activities of daily living (Barthel index), pain, spinal instability (spinal instability neoplastic score [SINS]), and QOL (EORTC QLQ-C30) were investigated. Results: Having an unstable SINS score was a positive factor for global health status (p < 0.05). The improvement in activities of daily living and response to pain were positive factors for physical function (p < 0.05). A positive effect on emotional function was confirmed among female patients (p < 0.05). Conclusion: Engaging in rehabilitation along with radiotherapy leads to improvements in QOL for patients with spinal bone metastases.

DOI： 10.3390/healthcare9111499

Scopus

researchmap

AIを用いた単純X線画像における骨端線変化の自動生成

中原龍一, 西田圭一郎, 長谷井嬢, 中澤慎二, 韓昌煕, 藏品豊, 那須義久, 尾崎敏文

日本関節病学会誌 40 ( 3 ) 308 - 308 2021.11

良性腫瘍に対する低侵襲治療類骨骨種に対するRFA

冨田晃司, 馬越紀行, 宇賀麻由, 藤原智洋, 松井裕輔, 中田英二, 生口俊浩, 国定俊之, 平木隆夫, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 3 ) S39 - S39 2021.11

AIを用いた単純X線画像における骨端線変化の自動生成

中原龍一, 西田圭一郎, 長谷井嬢, 中澤慎二, 韓昌煕, 藏品豊, 那須義久, 尾崎敏文

日本関節病学会誌 40 ( 3 ) 308 - 308 2021.11

良性腫瘍に対する低侵襲治療術中CTナビゲーションを用いた類骨骨腫に対する低侵襲手術

藤原智洋, 国定俊之, 中田英二, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 3 ) S38 - S38 2021.11

発育性股関節形成不全に対するSalter innominate osteotomyの短期成績

廣瀬一樹, 鉄永智紀, 山田和希, 佐藤嘉洋, 小浦卓, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 3 ) S84 - S84 2021.11

腰仙椎の癒合がpincer lesionの原因と考えられた若年アスリートに発症した大腿骨寛骨臼インピンジメントの1例

山田和希, 鉄永智紀, 佐藤嘉洋, 廣瀬一樹, 小浦卓, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 3 ) S131 - S131 2021.11

麻痺性側彎側彎症を伴う重症脳性麻痺児のQOL評価

小田孔明, 三澤治夫, 鉄永倫子, 魚谷弘二, 赤澤啓史, 青木清, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 3 ) S19 - S19 2021.11

　 PREV - NEXT 　

< OZAKI Toshifumi >

Papers - OZAKI Toshifumi