Faculty Profiles - OZAKI Toshifumi

Kensuke Toriumi, Yuta Onodera, Toshiyuki Takehara, Tatsufumi Mori, Joe Hasei, Kanae Shigi, Natsumi Iwawaki, Toshifumi Ozaki, Masao Akagi, Mahito Nakanishi, Takeshi Teramura

iScience 26 ( 7 ) 106946 - 106946 2023.7

Language：English Publishing type：Research paper (scientific journal)

Mesenchymal stem cells (MSCs) are used as a major source for cell therapy, and its application is expanding in various diseases. On the other hand, reliable method to evaluate quality and therapeutic properties of MSC is limited. In this study, we focused on TWIST1 that is a transcription factor regulating stemness of MSCs and found that the transmembrane protein LRRC15 tightly correlated with the expression of TWIST1 and useful to expect TWIST1-regulated stemness of MSCs. The LRRC15-positive MSC populations in human and mouse bone marrow tissues highly expressed stemness-associated transcription factors and therapeutic cytokines, and showed better therapeutic effect in bleomycin-induced pulmonary fibrosis model mice. This study provides evidence for the important role of TWIST1 in the MSC stemness, and for the utility of the LRRC15 protein as a marker to estimate stem cell quality in MSCs before cell transplantation.

DOI： 10.1016/j.isci.2023.106946

PubMed

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Influence of Janus kinase inhibitors on early postoperative complications in patients with rheumatoid arthritis undergoing orthopaedic surgeries

Keiichiro Nishida, Ryozo Harada, Yoshihisa Nasu, Shuichi Naniwa, Ryuichi Nakahara, Yoshifumi Hotta, Noriyuki Shimizu, Deting Lin, Toshifumi Ozaki

Modern Rheumatology 34 ( 3 ) 466 - 473 2023.6

Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

ABSTRACT

Objective

We retrospectively reviewed the records of rheumatoid arthritis (RA) patients who underwent orthopaedic surgery to examine the influence of the perioperative use of Janus kinase (JAK) inhibitors on early postoperative complications.

Patients and Methods

Thirty-two patients with RA under disease control with JAK inhibitors who underwent 49 orthopaedic procedures were included in the study. Patient records after surgery were investigated for surgical site infection (SSI), delayed wound healing (DWH), a flare-up of the disease, preoperative and postoperative absolute lymphocyte counts (ALCs), venous thromboembolism, and other postoperative complications.

Results

JAK inhibitors were continued during the perioperative period in 31 procedures. In the remaining 18 procedures, JAK inhibitors were discontinued perioperatively with a mean discontinuation period of 2.4 days. No instances of SSI were identified in any patient during at least 90 days’ follow-up, while DWH was seen in one patient. Disease flare-up was noted in two patients after 3 and 9 days of discontinuation of JAK inhibitors, respectively. The ALCs significantly decreased on postoperative Day 1 (P &lt; .0001), and there was a significant correlation between pre- and post-one-day ALCs (r = 0.75, P &lt; .0001).

Conclusion

JAK inhibitors seem to be safe during the perioperative period of orthopaedic surgery.

DOI： 10.1093/mr/road047

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Other Link： https://academic.oup.com/mr/article-pdf/34/3/466/57109151/road047.pdf

悪性末梢神経鞘腫瘍における治療標的PRRX1の同定と新規創薬開発の可能性

たき平将太, 山田大祐, 岡本真幸, 高尾知佳, 中田英二, 板野拓人, 藤原智洋, 国定俊之, 尾崎敏文, 宝田剛志

日本整形外科学会雑誌 97 ( 6 ) S1428 - S1428 2023.6

非転位型の橈骨遠位端骨折において骨折部位,Lister結節形状は長母指伸筋腱断裂に影響する

斎藤太一, 近藤秀則, 福岡史朗, 佐藤浩平, 畑利彰, 中道亮, 依光正則, 島村安則, 尾崎敏文

骨折 45 ( Suppl. ) S301 - S301 2023.6

術前化学療法を併用した四肢高悪性度肉腫に対する局所再発の臨床病理学的背景 JCOG0304副次的解析

筑紫聡, 田仲和宏, 国定俊之, 町田龍之介, 竹中聡, 川井章, 片桐浩久, 比留間徹, 松本嘉寛, 土屋弘行, 中山ロバート, 畠野宏史, 江森誠人, 吉田新一郎, 大幸英至, 坂本昭夫, 今西淳悟, 喜多亮介, 尾崎敏文, 岩本幸英

日本整形外科学会雑誌 97 ( 6 ) S1459 - S1459 2023.6

腫瘍軟部腫瘍に対する放射線治療後の病的大腿骨骨折術後感染に対する治療戦略

斎藤太一, 上原健敬, 中道亮, 依光正則, 島村安則, 野田知之, 尾崎敏文

日本骨・関節感染症学会プログラム・抄録集 46回 82 - 82 2023.6

The clinical and radiographic outcomes of type 2 medial meniscus posterior root tears following transtibial pullout repair. Reviewed International journal

Takaaki Hiranaka, Takayuki Furumatsu, Yusuke Yokoyama, Keisuke Kintaka, Naohiro Higashihara, Masanori Tamura, Koki Kawada, Haowei Xue, Masanori Hamada, Toshifumi Ozaki

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 31 ( 6 ) 2323 - 2330 2023.6

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The aim of this study was to compare the clinical outcomes of different subtypes of type 2 medial meniscus posterior root tears following transtibial pullout repair. METHODS: In total, 147 patients (mean age: 66.2 ± 8.3 years) who were diagnosed with type 2 medial meniscus posterior root tears and underwent transtibial pullout repair were included. Patients were divided into 2A (n = 31), 2B (n = 90), and 2C (n = 26) groups according to tear type. Clinical outcomes were assessed pre-operatively and at second-look arthroscopy using the Knee injury and Osteoarthritis Outcome Score. The meniscal healing status was evaluated at second-look arthroscopy. Medial meniscus extrusion was calculated using magnetic resonance imaging pre-operatively and at second-look arthroscopy. RESULTS: No significant differences in pre-operative or post-operative clinical scores were observed between each subtype, although clinical scores improved post-operatively for each subtype. Significant differences were noted in the anteroposterior width of the bridging tissues at second-look arthroscopy (2A, 7.1 ± 1.2; 2B, 6.2 ± 1.7; and 2C, 6.2 ± 1.7 mm; p = 0.045); type 2A tears were the widest. There was a significant difference in post-operative medial meniscus extrusion (2A, 3.2 ± 0.9; 2B, 4.0 ± 1.2; and 2C, 4.0 ± 1.4 mm; p = 0.004) and its progression (2A, 0.7 ± 0.6; 2B, 1.2 ± 0.8; and 2C, 1.2 ± 0.8 mm; p = 0.008), and type 2A tears were the shortest. CONCLUSION: Although there was no significant difference in the post-operative clinical scores among different type 2 tears in the short term, type 2A tears showed better healing and medial meniscus extrusion progression prevention, thus indicating the usefulness of classifying tear type in estimating post-operative outcomes. LEVEL OF EVIDENCE: III.

DOI： 10.1007/s00167-022-07293-9

PubMed

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