Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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Ewing肉腫における腫瘍由来exosomeを標的としたliquid biopsy法の確立

魚谷弘二, 藤原智洋, 吉田晶, 岩田慎太郎, 森田卓也, 清野正普, 長谷井嬢, 国定俊之, 吉岡祐亮, 植田幸嗣, 落谷孝広, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1713 - S1713 2017.8

ドキソルビシン耐性骨肉腫細胞に対するp53発現腫瘍融解アデノウイルスによるMDR1発現抑制を介した薬剤耐性克服機序の検討

杉生和久, 田澤大, 望月雄介, 小松原将, 大森敏規, 山川泰明, 吉田晶, 長谷井嬢, 藤原智洋, 国定俊之, 浦田泰生, 藤原俊義, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1523 - S1523 2017.8

p53発現腫瘍融解アデノウイルスによる軟部肉腫に対する放射線治療併用効果の検討

小松原将, 望月雄介, 杉生和久, 大森敏規, 長谷井嬢, 吉田晶, 藤原智洋, 国定俊之, 浦田泰生, 田澤大, 藤原俊義, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1499 - S1499 2017.8

悪性骨・軟部腫瘍転移制御への道粘液線維肉腫における分泌型microRNAは腫瘍の浸潤性と関連しているか

森田卓也, 藤原智洋, 魚谷弘二, 吉田晶, 清野正普, 杉生和久, 小松原将, 望月雄介, 長谷井嬢, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1709 - S1709 2017.8

骨肉腫細胞内と分泌エクソソーム内におけるmicroRNA発現プロファイリングの相違と患者循環エクソソーム内の発現評価

清野正普, 藤原智洋, 魚谷弘二, 吉田晶, 森田卓也, 杉生和久, 小松原将, 望月雄介, 長谷井嬢, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1525 - S1525 2017.8

腫瘍融解ウイルスの骨・軟部腫瘍組織に対する感染効率の評価

吉田晶, 魚谷弘二, 藤原智洋, 長谷井嬢, 森田卓也, 清野正普, 杉生和久, 小松原将, 望月雄介, 国定俊之, 藤原俊義, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1823 - S1823 2017.8

青年期の肘関節弛緩性に対して年齢が与える影響についての検討

内野崇彦, 島村安則, 島村好信, 名越充, 中道亮, 井上博登, 雑賀建多, 古松毅之, 野田知之, 尾崎敏文

日本整形外科スポーツ医学会雑誌 37 ( 4 ) 561 - 561 2017.8

スノーボードによる稀な陳旧性肘関節側方脱臼の一例

清水健志, 島村安則, 内野崇彦, 中道亮, 野田知之, 尾崎敏文

日本整形外科スポーツ医学会雑誌 37 ( 4 ) 447 - 447 2017.8

思春期特発性側彎症における体幹体表変形の三次元的評価

小田孔明, 瀧川朋亨, 中原龍一, 宇川諒, 塩崎泰之, 杉本佳久, 鉄永倫子, 田中雅人, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1809 - S1809 2017.8

脊柱変形手術時の運動誘発電位モニタリングにおけるanesthetic fade現象の検討

宇川諒, 瀧川朋亨, 小田孔明, 塩崎泰之, 鉄永倫子, 杉本佳久, 三澤治夫, 田中雅人, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1733 - S1733 2017.8

A giraffe neck sign of the medial meniscus: A characteristic finding of the medial meniscus posterior root tear on magnetic resonance imaging.

Takayuki Furumatsu, Masataka Fujii, Yuya Kodama, Toshifumi Ozaki

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 22 ( 4 ) 731 - 736 2017.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The posterior root ligament of the medial meniscus (MM) has a critical role in regulating the MM movement. An accurate diagnosis of the MM posterior root tear (MMPRT) using magnetic resonance imaging (MRI) is important for preventing sequential osteoarthritis following the MMPRT. However, diagnosis of the MMPRT is relatively difficult even after using several characteristic MRI findings. The aim of this study was to identify a useful meniscal body sign of the MMPRT for improving diagnostic MRI reading. METHODS: Eighty-five patients who underwent surgical treatments for the MMPRT (39 knees) and other types of MM tears (49 knees) were included. The presence of characteristic MRI findings such as cleft sign, ghost sign, radial tear sign, medial extrusion sign, and new meniscal body shape-oriented "giraffe neck sign" was evaluated in 120 MRI examinations. RESULTS: Giraffe neck signs were observed in 81.7% of the MMPRTs and in 3.3% of other MM tears. Cleft, ghost, and radial tear signs were highly positive in the MMPRTs compared with other MM tears. Medial extrusion signs were frequently observed in both groups. Coexistence rates of any 2 MRI signs, except for medial extrusion sign, were 91.7% in the MMPRT group and 5% in other MM tears. CONCLUSIONS: This study demonstrated that a new characteristic MRI finding "giraffe neck sign" was observed in 81.7% of the MMPRT. Our results suggest that the combination of giraffe neck, cleft, ghost, and radial tear signs may be important for an accurate diagnostic MRI reading of the MMPRT.

DOI： 10.1016/j.jos.2017.03.013

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The distribution of vascular endothelial growth factor in human meniscus and a meniscal injury model.

Zhichao Lu, Takayuki Furumatsu, Masataka Fujii, Ami Maehara, Toshifumi Ozaki

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 22 ( 4 ) 715 - 721 2017.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The meniscus plays an important role in controlling the complex biomechanics of the knee. Meniscus injury is common in the knee joint. The perimeniscal capillary plexus supplies the outer meniscus, whereas the inner meniscus is composed of avascular tissue. Angiogenesis factors, such as vascular endothelial growth factor (VEGF), have important roles in promoting vascularization of various tissues. VEGF-mediated neovascularization is beneficial to the healing of injured tissues. However, the distribution and angiogenic role of VEGF remains unclear in the meniscus and injured meniscus. We hypothesized that VEGF could affect meniscus cells and modulate the meniscus healing process. METHODS: Menisci were obtained from total knee arthroplasty patients. Meniscal injury was created ex vivo by a microsurgical blade. VEGF mRNA and protein expression were detected by the polymerase chain reaction and immunohistochemical analyses, respectively. RESULTS: In native meniscal tissue, the expression of VEGF and HIF-1α mRNAs could not be detected. However, VEGF and HIF-1α mRNAs were found in cultured meniscal cells (VEGF: outer > inner; HIF-1α: outer = inner). Injury increased mRNA levels of both VEGF and HIF-1α, with the increase being greatest in the outer area. Immunohistochemical analyses revealed that VEGF protein was detected mainly in the outer region and around injured areas of the meniscus. However, VEGF concentrations were similar between inner and outer menisci-derived media. CONCLUSIONS: This study demonstrated that both the inner and outer regions of the meniscus contained VEGF. HIF-1α expression and VEGF deposition were high in injured meniscal tissue. Our results suggest that injury stimulates the expression of HIF-1α and VEGF that may be preserved in the extracellular matrix as the healing stimulator of damaged meniscus, especially in the outer meniscus.

DOI： 10.1016/j.jos.2017.02.006

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関節リウマチ患者のボディイメージに対する手術治療の影響

堀田昌宏, 西田圭一郎, 橋詰謙三, 那須義久, 中原龍一, 林充, 尾崎敏文

関節の外科 44 ( 2 ) 67 - 67 2017.7

足関節・足部最良の機能再建とQOL向上を目指して関節リウマチ前足部手術における足長変化に関する検討

木曽洋平, 那須義久, 渡辺雅仁, 沖田駿治, 大橋秀基, 竹下歩, 兼田大輔, 堀田昌宏, 中原龍一, 雑賀健多, 西田圭一郎, 尾崎敏文

関節の外科 44 ( 2 ) 36 - 36 2017.7

鎖骨骨幹部骨折に対する最小侵襲プレート骨接合術(MIPO) 患者適合型プレベンディング法による手術手技

島村安則, 野田知之, 山川泰明, 吉村将秀, 内野崇彦, 中道亮, 島村好信, 中原龍一, 尾崎敏文

骨折 39 ( Suppl. ) S371 - S371 2017.7

Discrimination between Malignant and Benign Vertebral Fractures Using Magnetic Resonance Imaging. International journal

Tomoyuki Takigawa, Masato Tanaka, Yoshihisa Sugimoto, Tomoko Tetsunaga, Keiichiro Nishida, Toshifumi Ozaki

Asian spine journal 11 ( 3 ) 478 - 483 2017.6

Language：English Publishing type：Research paper (scientific journal)

STUDY DESIGN: Retrospective analysis using magnetic resonance imaging (MRI). PURPOSE: To identify MRI features that could discriminate benign from malignant vertebral fractures. OVERVIEW OF LITERATURE: Discrimination between benign and malignant vertebral fractures remains challenging, particularly in patients with osteoporosis and cancer. Presently, the most sensitive means of detecting and assessing fracture etiology is MRI. However, published reports have focused on only one or a few discriminators. METHODS: Totally, 106 patients were assessed by MRI within six weeks of sustaining 114 thoracic and/or lumbar vertebral fractures (benign, n=65; malignant, n=49). The fractures were pathologically confirmed if malignant or clinically diagnosed if benign and were followed up for a minimum of six months. Seventeen features were analyzed in all fractures' magnetic resonance images. Single parameters were analyzed using the chi-square test; a logit model was established using multivariate logistic regression analysis. RESULTS: The chi-square test revealed 11 malignant and 4 benign parameters. Multivariate logistic regression analysis selected (i) posterior wall diffuse protrusion (odds ratio [OR], 48; 95% confidence interval [CI], 4.2-548; p=0.002), (ii) pedicle involvement (OR, 21; 95% CI, 2.0-229; p=0.01), (iii) posterior involvement (OR, 21; 95% CI, 1.5-21; p=0.02), and (iv) band pattern (OR, 0.047; 95% CI, 0.0005-4.7; p=0.19). The logit model was expressed as P=1/[1+exp (x)], x=-3.88×(i)-3.05×(ii)-3.02×(iii)+3.05×(iv)+5.00, where P is the probability of malignancy. The total predictive value was 97.3%. The only exception was multiple myeloma with features of a benign fracture. CONCLUSIONS: Although each MRI feature had a different meaning with a variable differentiation power, combining them led to an accurate diagnosis. This study identified the most relevant MRI features that would be helpful in discriminating benign from malignant vertebral fractures.

DOI： 10.4184/asj.2017.11.3.478

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Accuracy of pedicle screw insertion in posterior scoliosis surgery: a comparison between intraoperative navigation and preoperative navigation techniques. International journal

Wei Zhang, Tomoyuki Takigawa, YongGang Wu, Yoshihisa Sugimoto, Masato Tanaka, Toshifumi Ozaki

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 26 ( 6 ) 1756 - 1764 2017.6

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: This study was conducted to compare the efficacy and accuracy of intraoperative navigation (O-arm or Arcadis navigation) and preoperative CT-based navigation in adolescent idiopathic scoliosis (AIS) surgery. METHODS: Sixty-seven patients with scoliosis were grouped according to the method of navigation used in their fixation surgeries. A total of 492 pedicle screws were implanted in 27 patients using intraoperative navigation, and 626 screws were implanted in 40 patients using preoperative navigation. We analyzed the postoperative CT images for pedicle violations using the Gertzbein classification. RESULTS: There was no statistical difference in the accuracy of pedicle screw placement between two groups. However, in the apical region (the apex ± 2 vertebrae), the accuracy of safe pedicle screw placement (grades 0, 1) was significantly higher in the intraoperative navigation group than in the preoperative navigation group (94.8 vs 89.2%, respectively; P = 0.035). Intraoperative navigation significantly diminished medial perforation compared to preoperative navigation (P = 0.027), and the number of screws per vertebra that could be placed in the apical region was significantly higher in intraoperative navigation group (P < 0.001). In addition, the time required for the registration procedure and insertion of one pedicle screw was 11.3 ± 2.1 min in the preoperative group, but significantly decreased to 5.1 ± 1.1 min in the intraoperative group (P < 0.001). CONCLUSIONS: Both preoperative CT-based and intraoperative navigation systems provide sufficient accuracy and safety in pedicle screw insertion for AIS surgery. Intraoperative navigation systems facilitate pedicle screw insertion in the apical region and reduce registration time during AIS surgery which improves the efficacy and accuracy of pedicle screw insertion.

DOI： 10.1007/s00586-016-4930-5

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全人工肘関節置換術(TEA)後の尺骨神経障害

堅山佳美, 千田益生, 兼田大輔, 日野知仁, 池田吉宏, 尾崎敏文

運動器リハビリテーション 28 ( 2 ) 174 - 174 2017.6

粘液線維肉腫患者における分泌型microRNAの特定

森田卓也, 藤原智洋, 魚谷弘二, 吉田晶, 清野正晋, 杉生和久, 小松原将, 望月雄介, 長谷井嬢, 国定俊之, 落合孝広, 尾崎敏文

日本整形外科学会雑誌 91 ( 6 ) S1394 - S1394 2017.6

術中CTナビゲーションシステムの良性骨腫瘍手術における有用性

藤原智洋, 国定俊之, 長谷井嬢, 森田卓也, 小松原将, 清野正普, 望月雄介, 吉田晶, 尾崎敏文

日本整形外科学会雑誌 91 ( 6 ) S1290 - S1290 2017.6

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Papers - OZAKI Toshifumi