Faculty Profiles - OZAKI Toshifumi

Scoliosis correction surgery for patients with McCune-Albright syndrome using pedicle screws: a report of two cases with different characteristics and a review of the literature Reviewed

Kentaro Yamane, Masato Tanaka, Yoshihisa Sugimoto, Haruo Misawa, Toshifumi Ozaki

EUROPEAN SPINE JOURNAL 24 ( 7 ) 1362 - 1367 2015.7

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

Scoliosis can occur secondary to McCune-Albright syndrome (MAS); it can be progressive and sometimes requires surgical treatment. It is still unclear if pedicle screw (PS) fixation in these patients with poor bone quality can be considered an effective treatment for scoliosis. The purpose of this study is to report two MAS patients with spinal fibrous dysplasia (FD) who underwent scoliosis surgeries with the PS system.
Case 1: a 12-year-old girl. Standing posteroanterior radiographs revealed a 58A degrees right curve from T7 to L2. Computed tomography (CT) showed small areas of FD throughout the spine. A posterior spinal arthrodesis from T4 to L3 using PS fixation was performed with a CT-based navigation system. Case 2: a 26-year-old woman. Radiographs in the standing position revealed a right 87A degrees curve from T8 to L2 and a 55A degrees kyphosis from T8 to T12. CT images showed multiple areas of severe spinal FD causing angular deformity and collapse of vertebral bodies. The patient underwent posterior spinal arthrodesis from T8 to her pelvis using a CT-based navigation system for PS fixation.
Superior scoliosis corrections were obtained using PS instrumentation, attaining complete bony union in both cases without major complications. However, Case 2 had some technical difficulties in treating due to the multiple large FD lesions.
PS fixation can be considered an effective treatment for correcting scoliosis and maintaining the correction at follow-up in MAS patients with poor bone quality. However, great care must be taken when performing correction and follow-up.

DOI： 10.1007/s00586-015-3813-5

Web of Science

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Perioperative chemotherapy with ifosfamide and doxorubicin for high-grade soft tissue sarcomas in the extremities (JCOG0304). Reviewed International journal

Tanaka K, Mizusawa J, Fukuda H, Araki N, Chuman H, Takahashi M, Ozaki T, Hiruma T, Tsuchiya H, Morioka H, Hatano H, Iwamoto Y

Japanese journal of clinical oncology 45 ( 6 ) 555 - 561 2015.6

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The efficacy of perioperative chemotherapy for soft tissue sarcomas is controversial and only a few prospective studies of pre-operative chemotherapy for soft tissue sarcomas in the extremities have been reported. We therefore carried out Phase II study of perioperative chemotherapy for patients with soft tissue sarcomas in the extremities. METHODS: Patients with Stage III non-round cell soft tissue sarcomas in the extremities were eligible. The patients were treated with pre-operative chemotherapy consisting doxorubicin 60 mg/m(2) and ifosfamide 10 g/m(2) for three courses. After the tumor resection, two additional courses of the same regimen were carried out. RESULTS: A total of 72 patients were enrolled and 70 patients were eligible. The median age of the patients was 49 years. The major pathological subtypes were synovial sarcoma in 20 and undifferentiated pleomorphic sarcoma in 17 patients. The protocol treatments were completed in 74% of the eligible cases. The 2 and 5-year progression-free survival rates were 75.7% (95% CI, 63.9-84.1%) and 63.8% (95% CI, 51.3-73.9%), respectively. The 5-year overall survival was 82.6% (95% CI, 71.3-89.7%). There was no treatment-related death. Grade 3 or 4 hematological toxicities (leukopenia and neutropenia) were observed in most of the patients. CONCLUSIONS: Although the toxicities of the regimen were significant, pre-operative chemotherapy followed by post-operative chemotherapy using doxorubicin and high-dose ifosfamide was feasible. The outcome of the trial for the patients with high-grade soft tissue sarcomas in the extremities was favorable, and this regimen is promising for further investigation. This trial was registered at the UMIN Clinical Trials Registry (www.umin.ac.jp/ctr/) as C000000096.

DOI： 10.1093/jjco/hyv042

PubMed

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骨肉腫における全生存率を予測する予後予測ノモグラムの開発

小倉浩一, 藤原智洋, 松居宏樹, 康永秀生, 平賀博明, 石井猛, 米本司, 鴨田博人, 尾崎敏文, 小澤英史, 西田佳弘, 森岡秀夫, 比留間徹, 角永茂樹, 上田孝文, 荒木信人, 中紀文, 津田祐輔, 河野博隆, 川井章

日本整形外科学会雑誌 89 ( 6 ) S1329 - S1329 2015.6

大腿骨遠位骨幹部骨折偽関節に対する骨移植併用exchange nailingの治療経験

小松原将, 野田知之, 杉生和久, 堀田昌宏, 上原健敬, 山川泰明, 雑賀建多, 中原龍一, 木浪陽, 尾崎敏文

骨折 37 ( Suppl. ) S89 - S89 2015.6

脆弱性骨折に対するトータルケアーの現状と理想大腿骨近部骨折に対する外科的治療の最前線(手術手技の工夫)

野田知之, 吉村将秀, 上原健敬, 島村安則, 尾崎敏文, 山川泰明

骨折 37 ( Suppl. ) S19 - S19 2015.6

若年男性の横隔神経伝導速度の左右差についての検討

堅山佳美, 千田益生, 上原健敬, 尾崎敏文

運動器リハビリテーション 26 ( 2 ) 241 - 241 2015.6

上腕骨骨幹部骨折における最小侵襲プレート骨接合術(MIPO)による治療成績

島村安則, 野田知之, 山川泰明, 中原龍一, 木浪陽, 上原健敬, 吉村将秀, 竹下歩, 島村好信, 尾崎敏文

骨折 37 ( Suppl. ) S263 - S263 2015.6

大腿骨ステム周囲骨折に対するロッキングプレートの治療経験

児玉有弥, 野田知之, 島村安則, 木浪陽, 中原龍一, 雑賀建多, 山川泰明, 上原健敬, 杉生和久, 尾崎敏文

骨折 37 ( Suppl. ) S191 - S191 2015.6

仙骨骨巨細胞腫に対する治療戦略

藤原智洋, 国定俊之, 武田健, 山川泰明, 大森敏規, 上原健敬, 魚谷弘二, 杉生和久, 尾崎敏文

日本整形外科学会雑誌 89 ( 6 ) S1308 - S1308 2015.6

マウス骨肉腫におけるmyeloid derived suppressor cellsとmetforminの作用

上原健敬, 榮川伸吾, 杉生和久, 魚谷弘二, 大森敏規, 山川泰明, 吉田晶, 藤原智洋, 武田健, 国定俊之, 鵜殿平一郎, 尾崎敏文

日本整形外科学会雑誌 89 ( 6 ) S1238 - S1238 2015.6

骨腫瘍切除後の骨欠損に対する配向連通気孔構造を有する新しい人工骨移植の治療成績

武田健, 国定俊之, 小松原将, 森田卓也, 杉生和久, 魚谷弘二, 大森敏規, 上原健敬, 藤原智洋, 尾崎敏文

日本整形外科学会雑誌 89 ( 6 ) S1209 - S1209 2015.6

足関節開放脱臼骨折に対してVAF flapを用いて治療した2例

堀田昌宏, 雑賀建多, 野田知之, 尾崎敏文, 木浪陽, 斎藤太一

骨折 37 ( 3 ) 829 - 832 2015.6

Language：Japanese Publisher：(一社)日本骨折治療学会

足関節開放脱臼骨折2例に対してvenoaccompanying artery fasciocutaneous(以下、VAF)flapを用いて治療した。症例1は49歳男性で、右足関節開放脱臼骨折(Gustilo type IIIB、AO44-B3)に対して、受傷から4時間半後に緊急で洗浄デブリドマンおよび創外固定施行、受傷後11日目に内固定し、受傷後17日目にVAF flapを施行。症例2は60歳男性で、右足関節開放脱臼骨折(Gustilo type IIIB、AO44-B3)に対して、受傷から6時間半後に緊急で洗浄デブリドマンおよび創外固定施行。受傷後11日目に内固定とVAF flapを施行。2例とも元の生活活動に復帰し経過良好であった。足関節開放骨折に対して当科では、まず洗浄・デブリドマン・創外固定を施行し、次に二期的に徹底したデブリドマンを行い、可能な限り同時に骨軟部組織再建を施行するという治療方針を立てている。今回2例とも骨接合に併用してVAF flapを用いて治療し、良好な足関節の機能を獲得することができた。足関節開放骨折Gustilo type IIIBに対し、皮弁挙上部の軟部組織損傷を認めなければVAF flapは有用であった。(著者抄録)

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