Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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岡山大学病院における難治性慢性痛に対する新しい試み痛みリエゾン外来

鉄永倫子, 田中雅人, 杉本佳久, 瀧川朋亨, 尾崎敏文, 太田晴之, 千田益夫, 西江宏行, 石川慎一, 溝渕知司, 井上真一郎

日本整形外科学会雑誌 87 ( 2 ) S504 - S504 2013.3

骨・軟部腫瘍骨軟部腫瘍におけるmicroRNAの最新の知見と臨床応用への挑戦

藤原智洋, 川井章, 小坂展慶, 尾崎敏文, 落谷孝広

癌と化学療法 40 ( 3 ) 305 - 313 2013.3

寛骨臼骨折に対する観血的整復内固定術後合併症についての検討

土井武, 竹下歩, 小田孔明, 野田知之, 尾崎敏文

日本整形外科学会雑誌 87 ( 3 ) S626 - S626 2013.3

Multiple Regression Analysis for Grading and Prognosis of Cubital Tunnel Syndrome: Assessment of Akahori's Classification Reviewed

Masutaka Watanabe, Seizaburo Arita, Hiroyuki Hashizume, Mitsugi Honda, Keiichiro Nishida, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 67 ( 1 ) 35 - 44 2013.2

Comparison between normal and loose fragment chondrocytes in proliferation and redifferentiation potential Reviewed

Kenichiro Sakata, Takayuki Furumatsu, Shinichi Miyazawa, Yukimasa Okada, Masataka Fujii, Toshifumi Ozaki

INTERNATIONAL ORTHOPAEDICS 37 ( 1 ) 159 - 165 2013.1

Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes

Saito T., Nishida K., Furumatsu T., Yoshida A., Ozawa M., Ozaki T.

Osteoarthritis and Cartilage 21 ( 1 ) 165 - 174 2013.1

Total Hip Arthroplasty for Hip Ankylosis due to Juvenile Idiopathic Arthritis : A Case Report

Harada Ryozo, Fujiwara Kazuo, Misawa Haruo, Miyake Yoshiaki, Okada Yoshiki, Ozaki Toshifumi, Endo Hirosuke

The Journal of the Chugoku-Shikoku Orthopaedic Association 25 ( 1 ) 13 - 17 2013

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

In patients with variable changes in pelvic inclination, total hip arthroplasty (THA) is required for accurate cup installation to prevent dislocation. Here we reported the use of THA for hip ankylosis due to juvenile idiopathic arthritis (JIA) and variable pelvic inclination with changes in posture. The patient was a 55-year-old woman, who had received medical treatment for JIA until the age of 14 year. She had been examined two years previously for bilateral leg pain and gait disturbance. Clinically, the lumbar spine had degenerative changes and the left hip joint was ankylosed at a 50-degree -flexed position, causing severe lordosis of the pelvis and lumbar spine and more severe lordosis during changes in posture. We treated the lumbar spine by laminectomy, and then THA was performed under a navigation system. Postoperatively, the patient was relieved of her symptoms and her ambulatory ability was improved. Anteversion of the pelvis with changes in posture remains, but the large femoral head has ensured that no dislocation has occurred up to the present. In cases of variable pelvic inclination due to changes in posture, use of a navigation system is useful intraoperatively for accurate cup installation, and a large femoral head matches any postoperative changes in pelvic inclination.

DOI： 10.11360/jcsoa.25.13

CiNii Article

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Other Link： http://search.jamas.or.jp/link/ui/2013299772

Comparative Analysis of Tunnel Position Between Transtibial and Outside-In Double-Bundle Anterior Cruciate Ligament Reconstruction

Fujii Masataka, Furumatsu Takayuki, Miyazawa Shinichi, Okada Yukimasa, Ozaki Toshifumi, Abe Nobuhiro

The Journal of the Chugoku-Shikoku Orthopaedic Association 25 ( 1 ) 73 - 77 2013

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

The present study was conducted to evaluate the femoral and tibial tunnel positions created by the transtibial and outside-in techniques, and to assess the difference in clinical outcome between the two techniques after anterior cruciate ligament (ACL) reconstruction. The study included 45 patients who underwent ACL reconstruction using either the transtibial (n=15) or outside-in (n=30) technique. Computed tomography scans of the treated knees were performed two weeks after surgery, and three-dimensional surface models were then produced. The positions of the femoral tunnels were measured by the quadrant method. Tibial tunnel aperture centers were measured in the anterior-to-posterior and medial-to-lateral directions on the tibial plateau. The clinical outcomes were measured in terms of range of motion, the Lachman test, pivot shift test, KT-2000 arthrometry, and Lysholm score at 6 months after surgery. On the femoral side, outside-in technique can create tunnels more accurately at the anatomic ACL footprint center than the transtibial technique. On the tibial side, the bone tunnel positions for the transtibial and outside-in techniques were both significantly closer to the tunnel position that was indicated by data from previous studies. There were no significant differences between the two groups in any of the physical parameters determined, or the Lysholm score. The outside-in technique showed more accurate positioning of the femoral tunnels than the transtibial technique. It was difficult to create two femoral tunnels using the transtibial technique because the positions of the femoral tunnels are defined by the direction of the tibial tunnel. The present findings suggest that the outside-in technique is useful because it can create accurate positioning of the femoral tunnels independently.

DOI： 10.11360/jcsoa.25.73

CiNii Article

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Other Link： http://search.jamas.or.jp/link/ui/2013299783

A new navigation system for minimally invasive total knee arthroplasty. Reviewed

Yokoyama Y, Abe N, Fujiwara K, Suzuki M, Nakajima Y, Sugita N, Mitsuishi M, Nakashima Y, Ozaki T

Acta medica Okayama 67 ( 6 ) 351 - 358 2013

Management of lumbar artery injury related to pedicle screw insertion. Reviewed

Sugimoto Y, Tanaka M, Gobara H, Misawa H, Kunisada T, Ozaki T

Acta medica Okayama 67 ( 2 ) 113 - 116 2013

Language：English Publishing type：Research paper (scientific journal)

We report on 2 patients who experienced injury to one of their lumbar arteries related to pedicle screw misplacement. In this report, the lumbar pedicle screw holes were made laterally with resultant injury to the lumbar artery. During surgery, arterial bleeding was controlled with pressure and gauze; however, the patients experienced vital shock after surgery. Vital shock ensued and they were rescued by catheter embolization. If patients receiving lumbar instrumentation surgery experience severe anemia or vital shock postoperatively, the surgeon should assume lumbar artery injury as a differential diagnosis.

DOI： 10.18926/AMO/49670

PubMed

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外科的摘出および定位放射線治療が有用であった転移性滑膜肉腫の1例

大谷理浩, 市川智継, 黒住和彦, 柳井広之, 国定俊之, 尾崎敏文, 伊達勲

Neurological Surgery 41 ( 3 ) 255 - 262 2013

Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. Reviewed International journal

Yasuyuki Shiozaki, Takashi Kitajima, Tetsuro Mazaki, Aki Yoshida, Masato Tanaka, Akihiro Umezawa, Mariko Nakamura, Yasuhiro Yoshida, Yoshihiro Ito, Toshifumi Ozaki, Akihiro Matsukawa

International journal of nanomedicine 8 1349 - 60 2013

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Bone defects and nonunions are major clinical skeletal problems. Growth factors are commonly used to promote bone regeneration; however, the clinical impact is limited because the factors do not last long at a given site. The introduction of tissue engineering aimed to deter the diffusion of these factors is a promising therapeutic strategy. The purpose of the present study was to evaluate the in vivo osteogenic capability of an engineered bone morphogenetic protein-4 (BMP4) fusion protein. METHODS: BMP4 was fused with a nanosized carrier, collagen-binding domain (CBD), derived from fibronectin. The stability of the CBD-BMP4 fusion protein was examined in vitro and in vivo. Osteogenic effects of CBD-BMP4 were evaluated by computer tomography after intramedullary injection without a collagen-sponge scaffold. Recombinant BMP-4, CBD, or vehicle were used as controls. Expressions of bone-related genes and growth factors were compared among the groups. Osteogenesis induced by CBD-BMP4, BMP4, and CBD was also assessed in a bone-defect model. RESULTS: In vitro, CBD-BMP4 was retained in a collagen gel for at least 7 days while BMP4 alone was released within 3 hours. In vivo, CBD-BMP4 remained at the given site for at least 2 weeks, both with or without a collagen-sponge scaffold, while BMP4 disappeared from the site within 3 days after injection. CBD-BMP4 induced better bone formation than BMP4 did alone, CBD alone, and vehicle after the intramedullary injection into the mouse femur. Bone-related genes and growth factors were expressed at higher levels in CBD-BMP4-treated mice than in all other groups, including BMP4-treated mice. Finally, CBD-BMP4 potentiated more bone formation than did controls, including BMP4 alone, when applied to cranial bone defects without a collagen scaffold. CONCLUSION: Altogether, nanocarrier-CBD enhanced the retention of BMP4 in the bone, thereby promoting augmented osteogenic responses in the absence of a scaffold. These results suggest that CBD-BMP4 may be clinically useful in facilitating bone formation.

DOI： 10.2147/IJN.S44124

PubMed

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The clinical manifestations of lumbar disease are correlated with self-rating depression scale scores Reviewed

Tomoko Tetsunaga, Haruo Misawa, Masato Tanaka, Yoshihisa Sugimoto, Tomonori Tetsunaga, Tomoyuki Takigawa, Toshifumi Ozaki

Journal of Orthopaedic Science 18 ( 3 ) 374 - 379 2013

Histological analysis of failed cartilage repair after marrow stimulation for the treatment of large cartilage defect in medial compartmental osteoarthritis of the knee Reviewed

Kenichiro Sakata, Takayuki Furumatsu, Nobuhiro Abe, Shinichi Miyazawa, Yoshimasa Sakoma, Toshifumi Ozaki

Acta Medica Okayama 67 ( 1 ) 65 - 74 2013

Development of dysphagia and trismus developed after c1-2 posterior fusion in extended position Reviewed

Haruo Misawa, Masato Tanaka, Yoshihisa Sugimoto, Kouichiro Koshimune, Toshifumi Ozaki

Acta Medica Okayama 67 ( 3 ) 185 - 190 2013

Novel chondrogenic and chondroprotective effects of the natural compound harmine Reviewed

Hara, Emilio Satoshi, Ono, Mitsuaki, Kubota, Satoshi, Sonoyama, Wataru, Oida, Yasutaka, Hattori, Takako, Nishida, Takashi, Furumatsu, Takayuki, Ozaki, Toshifumi, Takigawa, Masaharu, Kuboki, Takuo

Biochimie 95 ( 2 ) 374 - 381 2013

The management of total hip arthroplasty for dislocated hip

ENDO Hirosuke

The Central Japan Journal of Orthopaedic Surgery & Traumatology 56 ( 1 ) 25 - 26 2013

Recovery of Motor Function in Patients with Subaxial Cervical Spine Injury Relevant to the Fracture Pattern Reviewed

Yasuyuki Shiozaki, Yasuo Ito, Yoshihisa Sugimoto, Masao Tomioka, Tetsuya Shimokawa, Tetsuro Mazaki, Koichiro Koshimune, Masato Tanaka, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 66 ( 6 ) 469 - 473 2012.12

Surgical Treatment for Congenital Kyphosis Correction Using Both Spinal Navigation and a 3-dimensional Model Reviewed

Yoshihisa Sugimoto, Masato Tanaka, Ryuichi Nakahara, Haruo Misawa, Toshiyuki Kunisada, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 66 ( 6 ) 499 - 502 2012.12

メカニカルストレスによる軟骨基質分解酵素発現に対するヒストン脱アセチル化酵素阻害剤の抑制効果

斎藤太一, 西田圭一郎, 古松毅之, 小澤正嗣, 金澤智子, 原田遼三, 尾崎敏文

移植 47 ( 6 ) 499 - 499 2012.12

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