Faculty Profiles - OZAKI Toshifumi

当科における滑膜肉腫の治療成績

藤原智洋, 森本裕樹, 井谷智, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 84 ( 6 ) S998 - S998 2010.6

Operative treatment for pincer type femoroacetabular impingement:a case report. Reviewed

Endo H, Noda T, Mitani S, Nakahara R, Tetsunaga T, Kunisada T, Ozaki T

Acta medica Okayama 64 ( 2 ) 149 - 154 2010.4

Language：English Publishing type：Research paper (scientific journal)

Femoroacetabular impingement (FAI) is a condition characterized by the impingement of the femur and acetabulum. In Japan, this disorder has become recognized gradually. Here we report a rare case of surgically treated FAI, associated with an osseous protrusion on the acetabulum of a 30-year-old female. Plain computed tomography (CT) and reconstructive 3D-CT images clearly demonstrated an anterolateral bony protrusion. Hip arthroscopy showed no degeneration of the cartilage on either the femoral or acetabular side, but degeneration at the edge of labrum was observed in the region of the bony protrusion. The complete removal of the bony protrusion under hip arthroscopy was thus considered impracticable, and a small skin incision was therefore made anteriorly to approach the acetabulum. The Short-Form 36-Item Health Survey (SF-36) revealed improvement in all scores.

DOI： 10.18926/AMO/32853

PubMed

The effect of service dogs on the improvement of health-related quality of life Reviewed

Mai Shintani, Masuo Senda, Tomoko Takayanagi, Yoshimi Katayama, Kazunari Furusawa, Tamami Okutani, Masaki Kataokani, Toshifumi Ozaki

Acta Medica Okayama 64 ( 2 ) 109 - 113 2010.4

Language：English Publishing type：Research paper (scientific journal)

To assess the effects of service dogs on health-related quality of life (HRQOL), we conducted a survey of 10 service dog owners using SF-36v2 (Medical Outcomes Study 36 Item Short-Form Health Survey Version 2.0) and compared it with a matched control group of people with physical disabilities who did not have service dogs but were eligible for one. The scores for mental health and role emotional of service dog owners were relatively high, and their mental component summary was higher than the general population norm. These results indicate that service dogs affect the mentality of their owners. The comparison with the control group indicated that service dogs alleviate the mental burden of daily activities, and subjectively improved the physical functioning of their owners. This study showed that service dogs have positive functional and mental effects on their disabled owners. © 2010 by Okayama University Medical School.

PubMed

掌側ロッキングプレートを用いて加療した橈骨遠位部骨折における抜釘術の検討

化膿性膝関節炎後の膝蓋骨脱臼を伴った大腿骨変形に対する矯正術を行った1例

斎藤太一, 遠藤裕介, 三谷茂, 鉄永智紀, 尾崎敏文

岡山医学会雑誌 122 ( 1 ) 86 - 86 2010.4

島村安則, 斎藤太一, 金澤智子, 中原龍一, 雑賀建多, 野田知之, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 22 ( 1 ) 199 - 199 2010.4

生物学的製剤使用下の手術治療について生物学的製剤の限界

西田圭一郎, 橋詰謙三, 門田康孝, 中原龍一, 斎藤太一, 尾崎敏文

日本整形外科学会雑誌 84 ( 3 ) S228 - S228 2010.3

掌側ロッキングプレートを用いて加療した橈骨遠位部骨折における抜釘術の検討

島村安則, 斎藤太一, 野田知之, 西田圭一郎, 尾崎敏文

日本手の外科学会雑誌 27 ( 1 ) S138 - S138 2010.3

生物学的製剤時代における手術の変遷画像診断と外科的治療画像からみた手術の適応とタイミングどの時期に手術が必要か

西田圭一郎, 橋詰謙三, 中原龍一, 門田康孝, 那須義久, 斎藤太一, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 54回・19回 219 - 219 2010.3

関節リウマチに対する手術療法の進歩と今後関節リウマチに対する上肢手術の進歩と今後

西田圭一郎, 橋詰謙三, 門田康孝, 中原龍一, 斎藤太一, 尾崎敏文

日本整形外科学会雑誌 84 ( 3 ) S231 - S231 2010.3

Anterior cruciate ligament-derived cells have high chondrogenic potential Reviewed

Takayuki Furumatsu, Motomi Hachioji, Kenta Saiga, Naoki Takata, Yusuke Yokoyama, Toshifumi Ozaki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 391 ( 1 ) 1142 - 1147 2010.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE

Anterior cruciate ligament (ACL)-derived cells have a character different from medial collateral ligament (MCL)-derived cells. However, the critical difference between ACL and MCL is still unclear in their healing Potential and cellular response. The objective of this study was to investigate the mesenchymal differentiation property of each ligament-derived cell. Both ligament-derived cells differentiated into adipogenic, osteogenic, and chondrogenic lineages. In chondrogenesis, ACL-derived cells had the higher chondrogenic property than MCL-derived cells. The chondrogenic marker genes, Sox9 and alpha 1(II) collagen (Col2a1), were induced faster in ACL-derived pellets than in MCL-derived pellets. Sox9 expression preceded the increase of Col2a1 in both pellet-cultured cells. However, the expression level of Sox9 and a ligament/tendon transcription factor Scleraxis did not parallel the increase of Col2a1 expression along with chondrogenic induction. The present Study demonstrates that the balance between Sox9 and Scleraxis have an important role in the chondrogenic differentiation of ligament-derived cells. (C) 2009 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.bbrc.2009.12.044

Web of Science

Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription Reviewed

Takayuki Furumatsu, Chisa Shukunami, Michiyo Amemiya-Kudo, Hitoshi Shimano, Toshifumi Ozaki

International Journal of Biochemistry and Cell Biology 42 ( 1 ) 148 - 156 2010.1

Language：English Publishing type：Research paper (scientific journal)

During musculoskeletal development, Sry-type HMG box 9 (Sox9) has a crucial role in mesenchymal condensation and chondrogenesis. On the other hand, a tissue-specific basic helix-loop-helix (bHLH) transcription factor Scleraxis (Scx) regulates the differentiation of tendon and ligament progenitors. Whereas these two transcription factors cooperatively participate in the determination of cellular lineages, the precise interaction between Sox9 and Scx remains unclear. We have previously demonstrated that the Sox9-dependent transcription is synergistically activated by several Sox9-associating molecules, such as p300 and Smad3, on chromatin. In this study, we investigated the function of Scx in the Sox9-dependent transcription. The expression of α1(II) collagen (Col2a1) gene was stimulated by an appropriate transduction of Sox9 and Scx. Scx and its partner E47, which dimerizes with other bHLH proteins, cooperatively enhanced the Sox9-dependent transcription in luciferase reporter assays. Coactivator p300 synergistically increased the activity of Sox9-regulated reporter gene, which contains promoter and enhancer regions of Col2a1, in the presence of Scx and E47. Immunoprecipitation analyses revealed that Scx and E47 formed a transcriptional complex with Sox9 and p300. Scx/E47 heterodimer also associated with a conserved E-box sequence (CAGGTG) in the Col2a1 promoter on chromatin. These findings suggest that Scx and E47 might modulate the primary chondrogenesis by associating with the Sox9-related transcriptional complex, and by binding to the conserved E-box on Col2a1 promoter. © 2009 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.biocel.2009.10.003

PubMed

Bone Repair Using a Hybrid Scaffold of Self-Assembling Peptide PuraMatrix and Polyetheretherketone Cage in Rats Reviewed

Hiroyuki Nakahara, Haruo Misawa, Aid Yoshida, Takayuki Hayashi, Masato Tanaka, Takayuki Furumatsu, Noriaki Tanaka, Naoya Kobayashi, Toshifumi Ozaki

CELL TRANSPLANTATION 19 ( 6-7 ) 791 - 797 2010

Language：English Publishing type：Research paper (scientific journal) Publisher：COGNIZANT COMMUNICATION CORP

Self-assembling peptide scaffold (SAPS) is well known to have very good bone conduction properties. However, the intensity of SAPS is too weak to actually use it for a clinical bone regeneration. Therefore, we have produced a hybrid scaffold system that involves fabricating a cage from polyetheretherketone (PEEK) that has high intensity, filling the interior of this cage with SAPS, and then transplanted this hybrid scaffold to bone defects in rat femurs. After 28 days, soft X-ray radiographs and histological assessment revealed that good new bone formation was clearly observed in the defects transplanted the PEEK cage with SAPS, but not in the PEEK cage only. The PEEK cage maintained a form and osteoconduction ability of internal SAPS, and SAPS promoted bone formation inside the PEEK; therefore, each was in charge of intensity and bone regeneration separately. The present study suggests that hybrid scaffolds made from PEEK cages and SAPS can be useful tools for the regeneration of load-bearing bones, based on the idea that it should be possible to develop ideal bone filler materials by combining the strength of artificial bone with the bone regeneration and bone conduction properties of SAPS.

DOI： 10.3727/096368910X508906

Web of Science

Interference free surgical tool-path generation in multi-axis bone milling robot Reviewed

Sugita N, Nakano T, Nakajima Y, Fujiwara K, Abe N, Ozaki T, Suzuki M, Mitsuishi M

2010 3rd IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, BioRob 2010 790 - 795 2010

Publishing type：Research paper (international conference proceedings)

Tool interference causes serious damage to surrounding soft tissue in minimally invasive orthopedic surgery with a milling robot. The objective of this study is to avoid the collision of cutting tool with complicated shapes, and a novel approach of interference-free toolpath generation in a short intraoperative time is proposed. In order to resolve this issue, we propose the following two methods: intraoperative modeling of soft tissues as an interference area and interference-free toolpath generation based on the model. A model is constructed to represent the opening area and the internal tissues by using a 3-dimensional optical position sensor to measure them. Based on the constructed model, interference-free toolpath is immediately determined by the preliminary definition of evacuating direction. The effectiveness of the proposed method is evaluated with artificial models on the system that the authors have developed so far. A tool contact force against the model was measured by a force sensor mounted on the cutting tool. The result revealed that the tool interference was greatly reduced by implementing the proposed method. © 2010 IEEE.

DOI： 10.1109/BIOROB.2010.5627008

Optimal control of cutting feed rate in the robotic milling for total knee arthroplasty Reviewed

Other Link： http://orcid.org/0000-0002-1369-0747

Inoue T, Sugita N, Mitsuishi M, Saito T, Nakajima Y, Yokoyama Y, Fujiwara K, Abe N, Ozaki T, Suzuki M, Kuramoto K, Nakashima Y, Tanimoto K

2010 3rd IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, BioRob 2010 215 - 220 2010

Publishing type：Research paper (international conference proceedings)

For the total knee arthroplasty, we developed the robotic system, such as the cutting feed rate is controlled depending on the hardness of the bone tissue predicted on the basis of the medical image. Since the cutting force is reduced by this system, the displacement of the bone is minimized during the bone cutting process. Therefore it makes a possibility to fix the target bone using "safer" and "less-invasive fixation technique. © 2010 IEEE.

DOI： 10.1109/BIOROB.2010.5626940

Short-term Results of CentPillar Total Hip Arthroplasty

Other Link： http://orcid.org/0000-0002-1369-0747

Tetsunaga Tomonori, Mitani Shigeru, Fujiwara Kazuo, Ozaki Toshifumi, Endo Hirosuke

The Journal of the Chugoku-Shikoku Orthopaedic Association 22 ( 2 ) 449 - 453 2010

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

The present study examined the short-term results of CentPillar cementless total hip arthroplasty (THA) using the GB HA and TMZF HA stems. We treated 31 patients during the period between January 2005 and June 2009. The average age of the patients at the time of surgery was 54 years, and the average postoperative follow-up period was 13 months. Early stem subsidence after surgery was significantly less frequent for the TMZF HA stem than for the GB HA stem. In particular, early stem subsidence was detected in cases of varus or valgus stem alignment. The change in stem alignment after surgery using the TMZF HA stem was smaller than that for the GB HA stem. There was no significant difference in the stem-occupation rate in the canal between the two stem types. The average Japanese Orthopaedic Association hip score improved significantly after surgery with both types of stem. The CentPillar TMZF HA stem achieved initial stability of the proximal femur as a result of smaller stem subsidence by coating the PureFix HA with plasma spray.

DOI： 10.11360/jcsoa.22.449

Two Cases of Old Femoral Neck Fracture

Tamura Ryu, Kano Takeshi, Fujiwara Kazuo, Endo Hirosuke, Ozaki Toshifumi

The Journal of the Chugoku-Shikoku Orthopaedic Association 22 ( 2 ) 285 - 288 2010

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

We report two cases with old femoral neck fracture. One patient was an 80-year-old woman who had fallen down 6 months previously. The other patient was an 88-year-old man who had fallen down 4 months previously. Both patients had severe flexion contracture in their hip joints, and X-rays examinations showed severe old femoral neck fractures. Surgery was performed using bipolar hemiarthroplasty. This procedure was chosen in consideration of the patients' age and the presence of several risk factors related to their general condition. As the contracture was severe in the first case, we performed release of the soft tissues, especially in the area of the rectus femoris. After surgery, both patients regained full extension of their hip joints, and were able to start standing and walking exercise one week after the operation. Their ADL scores were obviously improved in comparison with those before surgery. We think that the release of soft tissue is useful in order to improve the contracture of the hip joint with old femoral neck fracture.

DOI： 10.11360/jcsoa.22.285

Posterior Dislocation of the Hip while Sprinting : A Case Report

Miyake Yoshiaki, Mitani Shigeru, Endo Hirosuke, Ozaki Toshifumi, Fujiwara Kazuo

The Journal of the Chugoku-Shikoku Orthopaedic Association 22 ( 2 ) 363 - 367 2010

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

Hip dislocation is mostly caused by high-energy injury, and only rarely by athletic injury. Here we report a 17-year-old boy who suffered hip dislocation while sprinting. When he suddenly stopped after the sprint burst, posterior dislocation of the hip and anterior wall fracture of the acetabulum occurred. The hip is generally displaced posteriorly with the hip flexed, adducted, and internally rotated. Posterior wall fracture of the acetabulum sometimes occurs when the hip is less flexed. Although some authors have reported posterior dislocation with posterior wall fracture, there has been no previous report of posterior dislocation with anterior wall fracture. In the present case, the femoral neck might have impinged against the anterior acetabulum wall with the hip flexed, adducted, and internally rotated. In this position, an axial load would have been added to the hip joint, resulting in posterior dislocation and anterior wall fracture. We examined the hip joint by MRI in 5 months after the injury, and no osteonecrosis of the femoral head was evident. Careful follow-up will be necessary because hip dislocation often results in osteonecrosis even in cases of low-energy injury.

DOI： 10.11360/jcsoa.22.363

Giant Cell Tumor of the Sacrum Treated with Selective Intra-Arterial Embolization : A Case Report

Sasaki Tsuyoshi, Morimoto Yuki, Ozaki Toshifumi, Kunisada Toshiyuki, Gobara Hideo

The Journal of the Chugoku-Shikoku Orthopaedic Association 22 ( 2 ) 267 - 272 2010

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

Giant cell tumor (GCT) of the sacrum is rare and difficult to treat, although several treatment modalities have been reported. Here we report a patient with sacral GCT who underwent selective intra-arterial embolization.<br>The patient, a 23-year-old woman, had been treated with curettage alone at a local hospital. However, 4 months after surgery, MRI showed recurrence of the tumor, and the patient was referred to our hospital for further treatment.<br>After discussion with her and her family, they accepted intra-arterial embolization of the tumor vessels. Embolization using a temporary embolic agent reduced the size of the tumor and the level of serum acid phosphatase (ACP). However, both the tumor size and the level of ACP increased a few months after the procedure. Therefore, embolization was performed using an embolic agent consisting of spherical particles. MRI showed a marked reduction of tumor size 1 month after the last embolization, and the level of serum ACP also fell to less than the standard value.<br>Embolization using a spherical-particulate embolic agent can be an effective treatment for sacral GCT.

DOI： 10.11360/jcsoa.22.267