Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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肉腫におけるがんゲノム医療の現状と未来がん遺伝子パネル検査から同定されるGermline Findingsへの対応

二川摩周, 中田英二, 藤原智洋, 国定俊之, 平沢晃, 尾崎敏文

日本整形外科学会雑誌 97 ( 2 ) S446 - S446 2023.3

Musculoskeletal Tumor 骨・軟部腫瘍骨・軟部腫瘍におけるがん遺伝子プロファイリング検査骨・軟部腫瘍診療におけるがん遺伝子パネルの役割

中田英二, 藤原智洋, 国定俊之, 尾崎敏文, 豊岡伸一, 遠西大輔, 山本英喜, 二宮貴一朗, 冨田秀太, 平沢晃, 二川摩周, 田端雅弘

癌と化学療法 50 ( 3 ) 314 - 320 2023.3

成長期の関節疾患治療アップデート上腕骨小頭離断性骨軟骨炎の手術治療

島村安則, 斉藤太一, 中道亮, 尾崎敏文

日本整形外科学会雑誌 97 ( 2 ) S505 - S505 2023.3

TSS法へのall-inside sutureの追加は内側半月板逸脱体積の抑制効果に乏しい

金高圭甫, 古松毅之, 横山裕介, 田村優典, 川田紘己, 尾崎敏文

中部日本整形外科災害外科学会雑誌 66 ( 春季学会 ) 250 - 250 2023.3

内側半月板後根断裂に対する経脛骨pullout修復術男女別比較

東原直裕, 古松毅之, 横山裕介, 金高圭甫, 田村優典, 川田紘己, 尾崎敏文

日本整形外科学会雑誌 97 ( 3 ) S577 - S577 2023.3

内側半月板後根断裂に対するpullout修復術術後早期からの部分荷重および可動域訓練は治療成績を悪化させない

田村優典, 古松毅之, 横山裕介, 金高圭甫, 東原直裕, 川田紘己, 尾崎敏文

日本整形外科学会雑誌 97 ( 3 ) S856 - S856 2023.3

内側半月板後根プルアウト修復術関節裂隙の狭小化はどの程度進行するのか

川田紘己, 古松毅之, 田村優典, Xue Haowei, 東原直裕, 金高圭甫, 横山裕介, 尾崎敏文

日本整形外科学会雑誌 97 ( 3 ) S571 - S571 2023.3

TSS法へのall-inside sutureの追加は内側半月板逸脱の抑制効果に乏しい

金高圭甫, 古松毅之, 横山裕介, 東原直裕, 田村優典, 川田紘己, 尾崎敏文

日本整形外科学会雑誌 97 ( 3 ) S575 - S575 2023.3

内側半月板後根プルアウト修復術後における関節裂隙狭小化の定量的評価

川田紘己, 古松毅之, 横山裕介, 金高圭甫, 東原直裕, 尾崎敏文

中部日本整形外科災害外科学会雑誌 66 ( 春季学会 ) 250 - 250 2023.3

Vertebral body collapse after radiotherapy for spinal metastases. International journal

Eiji Nakata, Ryuichi Nakahara, Haruyoshi Katayama, Takuto Itano, Shinsuke Sugihara, Toshifumi Ozaki

Oncology letters 25 ( 3 ) 109 - 109 2023.3

Language：English Publishing type：Research paper (scientific journal)

Spinal metastases are common in patients with advanced stages of cancer and frequently cause vertebral body collapse (VBC). Although conventional radiotherapy (RT) is used for spinal metastases, the rates of occurrence of new VBC and progression of VBC at RT initiation have not been fully investigated. The present retrospective study assessed VBC and its associated risk factors after RT over time and evaluated new VBC and progression of VBC in patients who presented with VBC at RT initiation. The study evaluated 177 patients who received RT for vertebral metastases without paralysis between July 2012 and November 2016. Radiological responses of the irradiated vertebrae were assessed using computed tomography. Follow-up assessments were performed at RT initiation and 1, 2, 3, 4 and 6 months after RT. New VBC occurred in 12% of patients with no prior VBC within 1 month of RT. Multivariate analysis revealed that numeric rating scale (NRS) score (≥4) [relative risk (RR), 27.1; 95% confidence interval (CI), 1.86 to 394.9; P=0.016] was associated with the occurrence of new VBC at the 1 month follow-up time point. VBC progression occurred in 51% of the patients with collapse at RT initiation. Multivariate analysis revealed that bone quality (lytic metastases) (RR, 3.1; 95% CI, 1.28 to 7.70; P=0.013), NRS score (≥4) (RR, 3.0; 95% CI, 1.18 to 7.45; P=0.021) and tumor involvement of posterolateral elements of the spine (RR, 2.7; 95% CI, 1.03 to 7.29; P=0.04) were associated with the progression of VBC at the 1 month follow-up time point. The current study findings suggested that clinicians should pay attention to the factors that predict the occurrence of new VBC and VBC progression to ensure proper evaluation of conservative treatment effectiveness and facilitate the determination of patients who need close monitoring.

DOI： 10.3892/ol.2023.13695

PubMed

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骨巨細胞腫に対するデノスマブのde-escalationの有効性

板野拓人, 中田英二, 藤原智洋, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 97 ( 3 ) S959 - S959 2023.3