Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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MIS手術におけるロッキングプレートの応用上肢骨折における最小侵襲プレート骨接合術(MIPO)による治療成績

島村安則, 中原龍一, 井上円加, 斉藤太一, 金澤智子, 小澤正嗣, 中道亮, 山川泰明, 野田知之, 尾崎敏文, 橋詰博行, 島村好信

日本最小侵襲整形外科学会誌 12 ( 1 ) 84 - 84 2012.11

Dual Energy CTを用いた骨抽出性能の向上

中原龍一, 西田圭一郎, 金澤智子, 原田遼三, 小澤正嗣, 斎藤太一, 橋詰謙三, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 243 - 243 2012.10

当科における人工肩関節置換術(TSA)の治療成績の検討

金澤智子, 西田圭一郎, 橋詰謙三, 島村安則, 中原龍一, 斉藤太一, 小澤正嗣, 那須義久, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 317 - 317 2012.10

岡山大学病院における難治性慢性疼痛に対する新しい試み痛み・リエゾン外来

鉄永倫子, 田中雅人, 尾崎敏文, 西江宏行, 石川慎一, 溝渕知司, 井上真一郎, 宮脇卓也, 太田晴之, 千田益夫

中国・四国整形外科学会雑誌 24 ( 3 ) 486 - 486 2012.10

RAにおけるSwansonとAvantaによるMP人工指関節置換術の治療成績

原田遼三, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 317 - 317 2012.10

人工関節再置換術原因と成否のポイント<パート1.肘 TEA> 岡山大式人工肘関節再置換術例の検討

西田圭一郎, 橋詰謙三, 中原龍一, 斎藤太一, 金澤智子, 小澤正嗣, 原田遼三, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 314 - 314 2012.10

大腿骨遠位骨幹部骨折偽関節の治療経験

山川泰明, 野田知之, 井上円加, 金澤智子, 長谷井嬢, 斎藤太一, 中原龍一, 島村安則, 尾崎敏文, 木浪陽, 皆川寛, 高城康師, 川上和秀

中国・四国整形外科学会雑誌 24 ( 3 ) 503 - 503 2012.10

関節リウマチの足関節、中後足部変形に対する治療成績

小澤正嗣, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 原田遼三, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 371 - 371 2012.10

バイオ製剤使用のストラテジー並びにバイオ製剤無効例への対応と展望 Bio製剤効果不十分例に対する整形外科手術の有効性

西田圭一郎, 金澤智子, 中原龍一, 橋詰謙三, 斎藤太一, 小澤正嗣, 原田遼三, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 259 - 259 2012.10

Tc-99m DMSA (V) scintigraphy for evaluation in patients with cartilaginous bone tumor

T. Shinya, S. Sato, A. Alafate, H. Gobara, K. Kato, T. Kunisada, T. Ozaki, S. Kanazawa

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 39 S473 - S474 2012.10

MicroRNA-21 correlates with tumorigenesis in malignant peripheral nerve sheath tumor (MPNST) via programmed cell death protein 4 (PDCD4) Reviewed

Satoru Itani, Toshiyuki Kunisada, Yuki Morimoto, Aki Yoshida, Tsuyoshi Sasaki, Sachio Ito, Mamoru Ouchida, Shinsuke Sugihara, Kenji Shimizu, Toshifumi Ozaki

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 138 ( 9 ) 1501 - 1509 2012.9

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

We investigated the miRNA profile in peripheral nerve tumors and clarified the involvement of miRNA in the development and progression of MPNST in comparison with neurofibroma (NF). In addition, we attempted to seek associations between the miRNA and their potential targets in MPNST.
Global miRNA expression profiling was investigated for clinical samples of 6 MPNSTs and 6 NFs. As detected by profiling analysis, the expressions of miR-21 in clinical samples of 12 MPNSTs, 11 NFs, and 5 normal nerves, and 3 MPNST cell lines were compared using quantitative real-time reverse transcription PCR. MPNST cell line (YST-1) was transfected with miR-21 inhibitor to study its effects on cell proliferation, caspase activity, and the expression of miR-21 targets.
Analysis of miRNA expression profiles in MPNST and NF revealed significantly altered expression levels of nine miRNAs, one of those, miR-21, and its putative target, programmed cell death protein 4 (PDCD4), were selected for further studies. miR-21 expression level in MPNST was significantly higher than that in NF (P < 0.05). In MPNST cells, transfection of miR-21 inhibitor significantly increased caspase activity (P < 0.01), significantly suppressed cell growth (P < 0.05), and upregulated protein level of PDCD4, indicating that miR-21 inhibitor could induce cell apoptosis of MPNST cells.
These results suggest that miR-21 plays an important role in MPNST tumorigenesis and progression through its target, PDCD4. MiR-21 and PDCD4 may be candidate novel therapeutic targets against the development or progression of MPNSTs.

DOI： 10.1007/s00432-012-1223-1

Web of Science

PubMed

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Resection of the entire first rib for fibrous dysplasia using a combined posterior-transmanubrial approach. Reviewed

Furukawa M, Soh J, Toyooka S, Ozaki T, Miyoshi S

General thoracic and cardiovascular surgery 60 ( 9 ) 584 - 586 2012.9

Language：English Publishing type：Research paper (scientific journal)

A 27-year-old woman presented with pain of the left anterior chest of 2-year duration. Chest X-ray revealed a mass in the upper-left lung field and chest computed tomography (CT) a 6-cm first-rib tumor. CT-guided biopsy was performed and the tumor diagnosed as fibrous dysplasia. Because of continued pain, surgery was deemed necessary. Surgery began with the use of the posterior approach in the prone position to expose the first thoracic vertebra and detach the first rib at the costotransverse joint. After transitioning to the spine position, the transmanubrial approach was used to resect the tumor en bloc with the left first rib. Histological examination revealed the tumor to be fibrous dysplasia. Postoperative recovery was uneventful. The outcomes of this case suggest that the combined posterior-transmanubrial approach described here is a safe, successful approach for first-rib resection of a space-occupying tumor that yields good cosmetic results.

DOI： 10.1007/s11748-012-0044-0

PubMed

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下腿骨幹部骨折術後非感染性偽関節の治療戦略

藤原智洋, 野田知之, 中原龍一, 島村安則, 尾崎敏文, 寺田忠司

骨折 34 ( 3 ) 702 - 706 2012.9

Language：Japanese Publisher：(一社)日本骨折治療学会

下腿骨幹部骨折術後非感染性偽関節の治療にはインプラント選択を含めた再内固定方法、骨欠損および変形への対処法など様々な問題点が存在する。当科で経験した5例を検討した。全例男性、手術時平均年齢は46歳、偽関節タイプおよび前回手術法は肥厚型3例(プレート固定1例、血管柄付き骨移植2例)、萎縮型2例(創外固定1例、髄内釘固定1例)。偽関節手術法は、髄内釘固定および髄内釘入れ替えを2例、ロッキングプレート固定を3例に実施し、偽関節部新鮮化・骨移植を4例、部分腓骨切除を併用した変形矯正を3例に行った。全例に骨癒合が得られ、矯正位は良好であった。本偽関節に対しては、適切な手術手技による髄内釘入れ替えを第一選択とし、血管柄付き骨移植後などの髄腔狭小・閉鎖例にはロッキングプレート固定を第二選択として適応し、変形や骨欠損に対する部分腓骨切除や自家骨移植などの併用により治療成績の向上が期待できる。(著者抄録)

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Radiographic remodeling of the shoulder joint in a patient with rheumatoid arthritis after 4 years of treatment with etanercept Reviewed

Toshifumi Ozaki, Kenzo Hashizume, Ryuichi Nakahara, Keiichiro Nishida

MODERN RHEUMATOLOGY 22 ( 4 ) 635 - 637 2012.8

Segmental Pedicle Screw Fixation for a Scoliosis Patient with Post-laminectomy and Post-irradiation Thoracic Kyphoscoliosis of Spinal Astrocytoma Reviewed

Masato Tanaka, Yoshihiro Sugimoto, Haruo Misawa, Tomoyuki Takigawa, Toshiyuki Kunisada, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 66 ( 4 ) 363 - 368 2012.8

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

Spinal deformity is an important clinical manifestation after surgery for spinal cord tumors. One-third of patients who receive laminectomies and irradiation of the spinal column develop scoliosis, kyphosis, or kyphoscoliosis. Recent reports indicate good results after scoliosis surgery using segmental pedicle screws and a navigation system, but these reported studies have not included surgery for post-laminectomy kyphosis. Hooks and wires are ineffective in such patients who undergo laminectomy, and there are also high perioperative risks with insertion of pedicle screws because landmarks have been lost. Here, we report on the 5-year follow-up of a 13-year-old male patient with post-laminectomy and post-irradiation thoracic kyphoscoliosis after surgical treatment of spinal astrocytoma. Posterior segmental pedicle screw fixation was performed safely using a computer-assisted technique. The authors present the first case report for treatment of this condition using a navigation system.

DOI： 10.18926/AMO/48692

Web of Science

PubMed

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An anatomical study of the watershed line on the volar, distal aspect of the radius: Implications for plate placement and avoidance of tendon ruptures Reviewed

Junya Imatani, Keiichi Akita, Kumiko Yamaguchi, Hirotaka Shimizu, Hidenori Kondou, Toshifumi Ozaki

Journal of Hand Surgery 37 ( 8 ) 1550 - 1554 2012.8

Language：English Publishing type：Research paper (scientific journal)

Purpose: The watershed line is a useful surgical landmark for positioning a volar locking plate. Implants placed on or distal to it can impinge on flexor tendons and cause injury. However, the details of the anatomy of this line are unclear. We studied macroscopically and histologically the structures of the volar aspect of the distal radius. Methods: We studied 20 distal forearm regions of 10 cadavers (5 males and 5 females
mean age, 79 y [range, 56-88 y]) to clarify the details of the watershed line. In 16 specimens, we investigated the macroscopic appearance of the volar aspect of the radius and the relationships among the bone, the volarradiocarpal ligaments, and the pronator quadratus. Histological analyses were performed in 4 specimens of 2 cadavers to examine the morphology of the margin of the bony structures. Results: In the medial half of the distal volar radius, 2 lines were identified by direct macroscopic visualization
one was the proximal line that corresponded to the distal ridge of the pronator fossa, and the other was the distal line, which was more prominent. A medial bony prominence was situated on the distal line. In the lateral half, the distal and proximal lines of the medial half merged to form a single line. A lateral prominence was situated on this line. Conclusions: The watershed line might not be a distinct line, and it corresponds to the distal margin of the pronator fossa in the lateral half of the volar radius and to a hypothetical line between the distal and proximal lines in the medial half. The medial and lateral bony prominences on the volar radius should be key structures for accurate plate placement to avoid flexor tendon injury. Clinical relevance: The present study suggests bony landmarks for positioning a volar locking plate. © 2012 American Society for Surgery of the Hand.

DOI： 10.1016/j.jhsa.2012.05.011

Scopus

PubMed

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FAI治療に対する3Dボーンモデルの有用性

遠藤裕介, 岡田芳樹, 中原龍一, 藤原一夫, 三宅由晃, 尾崎敏文, 三谷茂

Hip Joint 38 110 - 113 2012.8

Language：Japanese Publisher：日本股関節学会

観血的治療を施行したfemoroacetabular impingement患者2例(症例1:34歳男、症例2:22歳男)において、術前のCTデータより3Dボーンモデルを作成し、それを参考にして臼蓋側と大腿骨側のトリミングを行った。術前のボーンモデルにおける関節可動域は外転0°回旋0°における最大屈曲角度が症例1で77°、症例2が73°であり、外転0°屈曲60°における最大内旋角度はそれぞれ20°、10°であった。術後に作成したボーンモデルによる関節可動域は最大屈曲角度が症例1で80°、症例2が76°、最大内旋角度はそれぞれ28°、14°であった。術後の両症例平均角度は屈曲で3°、内旋で5°改善した。X線評価ではCE角が術前平均37°から27°、α角は69°から43°となった。両症例とも術後6週時には可動域は術前と同程度に回復しており、安静時痛は消失してインピンジメントテストは陰性であった。術後3ヵ月からの負担の軽いスポーツ活動を許可している。

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メカニカルストレスによる軟骨基質分解酵素発現に対するヒストン脱アセチル化酵素阻害薬の抑制効果

斎藤太一, 西田圭一郎, 古松毅之, 小澤正嗣, 金澤智子, 原田遼三, 尾崎敏文

日本整形外科学会雑誌 86 ( 8 ) S1219 - S1219 2012.8

新規microRNA阻害剤による骨肉腫に対する前臨床試験

藤原智洋, 小坂展慶, 吉岡祐亮, 萩原啓太郎, 竹下文隆, 窪田大介, 川井章, 尾崎敏文, 落谷孝広

日本整形外科学会雑誌 86 ( 8 ) S1313 - S1313 2012.8

microRNA機能阻害によるがん幹細胞制御を目的とした骨肉腫に対する新規治療戦略(A Novel Therapeutic Strategy against Tumor-initiating Cells of Osteosarcoma: microRNA Inhibition with Current Treatment)

藤原智洋, 小坂展慶, 高橋陵宇, 吉岡祐亮, 萩原啓太郎, 竹下文隆, 窪田大介, 近藤格, 川井章, 尾崎敏文, 落合孝広

日本癌学会総会記事 71回 273 - 273 2012.8

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Papers - OZAKI Toshifumi