Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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腫瘍 ⑵ 骨転移の画像診断

中田英二, 國定俊之, 藤原智洋, 尾﨑敏文

関節外科 43 143 - 154 2024.4

内側半月板後根プルアウト修復術膝内側関節裂隙狭小化の縦断的評価

川田紘己, 古松毅之, 横山裕介, 東原直裕, 田村優典, 尾崎敏文

中部日本整形外科災害外科学会雑誌 67 ( 春季学会 ) 86 - 86 2024.4

岡山大学病院における脊椎内視鏡補助下手術の現状

魚谷弘二, 鉄永倫子, 篠原健介, 小田孔明, 尾崎敏文

中国・四国整形外科学会雑誌 36 ( 1 ) 173 - 173 2024.4

骨接合術を行い椎間可動域の温存を試みたが椎体間固定術を要した椎弓根骨折の1例

小田孔明, 三澤治夫, 鉄永倫子, 魚谷弘二, 志渡澤央和, 植田昌敬, 鷹取亮, 尾崎敏文

中国・四国整形外科学会雑誌 36 ( 1 ) 93 - 97 2024.4

胸椎後縦靱帯骨化症に対する脊椎手術後に生じた下肢麻痺に対してステロイド大量療法にて改善が得られた一例

篠原健介, 魚谷弘二, 小田孔明, 尾崎敏文

中部日本整形外科災害外科学会雑誌 67 ( 春季学会 ) 246 - 246 2024.4

【小児整形外科up-to-date】体幹疾患環軸関節回旋位固定環軸関節回旋位固定のup-to-date

魚谷弘二, 鉄永倫子, 篠原健介, 小田孔明, 尾崎敏文

別冊整形外科 ( 85 ) 154 - 159 2024.4

Language：Japanese Publisher：(株)南江堂

＜文献概要＞はじめに環軸関節回旋位固定(atlantoaxial rotatory fixation:AARF)は,主に上気道炎などの後に斜頸を起こし受診することが多い.急性期に適切な治療を行えば経過は一般的に良好であるが,斜頸の見過ごしや治療の適切なタイミングを逃すと環軸関節の癒合や変形をきたし,難治例となる.難治例となった場合には外科的介入が主に行われてきたが,近年ではhalo fixationを数ヵ月行うことで環軸関節のリモデリングを狙うという治療戦略もとられている.本稿ではAARFに関する知識の整理と最近の知見をまとめ,報告する.

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2024&ichushi_jid=J04037&link_issn=&doc_id=20240517380031&doc_link_id=10.15106%2Fj_besei85_154&url=https%3A%2F%2Fdoi.org%2F10.15106%2Fj_besei85_154&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

広範な脊椎強直を伴うL5/S1シャルコー脊椎の1例

植田昌敬, 小田孔明, 魚谷弘二, 鉄永倫子, 篠原健介, 尾崎敏文

中部日本整形外科災害外科学会雑誌 67 ( 春季学会 ) 119 - 119 2024.4

腰椎脊柱管内硬膜外嚢腫により右下肢痛を呈した一例

坂田慎一郎, 篠原健介, 魚谷弘二, 小田孔明, 尾崎敏文

中部日本整形外科災害外科学会雑誌 67 ( 春季学会 ) 122 - 122 2024.4

p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression.

Tadashi Komatsubara, Hiroshi Tazawa, Joe Hasei, Toshinori Omori, Kazuhisa Sugiu, Yusuke Mochizuki, Koji Demiya, Aki Yoshida, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Shunsuke Kagawa, Toshifumi Ozaki, Toshiyoshi Fujiwara

Acta medica Okayama 78 ( 2 ) 151 - 161 2024.4

Language：English Publishing type：Research paper (scientific journal)

Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors' growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.

DOI： 10.18926/AMO/66924

PubMed

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Longitudinal changes in medial meniscus extrusion and clinical outcomes following pullout repair for medial meniscus posterior root tears: a 3-year evaluation. International journal

Koki Kawada, Takayuki Furumatsu, Yusuke Yokoyama, Naohiro Higashihara, Masanori Tamura, Toshifumi Ozaki

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 2024.3

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: We aimed to evaluate the longitudinal changes in medial meniscus extrusion (MME) and clinical scores at multiple time points up to 3 years after pullout repair for medial meniscus posterior root tears (MMPRTs). METHODS: This retrospective case series study included 64 patients who underwent pullout repair for MMPRTs and four MRI evaluations (preoperatively and at 3 months, 1 year, and 3 years postoperatively). MME was measured during the same time points. Clinical scores were assessed four times: preoperatively and at 1, 2, and 3 years postoperatively. Additionally, a multivariate analysis was performed on the change in MME (ΔMME) from the preoperative measurement point to 3 years postoperatively. RESULTS: The ΔMME per month from the preoperative measurement point to 3 months postoperatively, from 3 months to 1 year postoperatively, and from 1 to 3 years postoperatively were 0.30, 0.05, and 0.01 mm/month, respectively. All clinical scores significantly improved 3 years postoperatively (p < 0.001). In a multiple regression analysis for ΔMME from the preoperative measurement point to 3 years postoperatively, sex significantly affected the outcome (p = 0.039). CONCLUSION: Following pullout repair for MMPRTs with well-aligned lower extremities, although MME progression could not be entirely prevented, the rate of progression decreased over time, and clinical scores improved. In particular, MME progressed markedly during the first 3 months postoperatively. Additionally, sex had a significant influence on MME progression, suggesting that males may be able to expand the indications of pullout repair for MMPRTs.

DOI： 10.1007/s00590-024-03889-8

PubMed

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An osteoinductive surface by adhesive bone morphogenetic protein-2 prepared using the bioorthogonal approach for tight binding of titanium with bone. Reviewed International journal

Xueli Ren, Hironori Tsuji, Takahiko Uchino, Izumi Kono, Takashi Isoshima, Akimitsu Okamoto, Noriyuki Nagaoka, Toshifumi Ozaki, Akihiro Matsukawa, Hideyuki Miyatake, Yoshihiro Ito

Journal of materials chemistry. B 12 ( 12 ) 3006 - 3014 2024.3

Language：English Publishing type：Research paper (scientific journal)

Inorganic biomaterials are used in various orthopedic and dental implants. Nevertheless, they cause clinical issues such as loosening of implants and patient morbidity. Therefore, inspired by mussel adhesive proteins, we aimed to design an adhesive and dimer-forming highly active bone morphogenetic protein-2 (BMP-2) using bioorthogonal chemistry, in which recombinant DNA technology was combined with enzymatic modifications, to achieve long-term osseointegration with titanium. The prepared BMP-2 exhibited substantially higher binding activity than wild-type BMP-2, while the adhered BMP-2 was more active than soluble BMP-2. Therefore, the adhesive BMP-2 was immobilized onto titanium wires and screws and implanted into rat bones, and long-term osteogenesis was evaluated. Adhesive BMP-2 promoted the mechanical binding of titanium to bones, enabling efficient bone regeneration and effective stabilization of implants. Thus, such adhesive biosignaling proteins can be used in regenerative medicine.

DOI： 10.1039/d3tb02838k

PubMed

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Signal intensity of repaired posterior roots after transtibial pullout repair for medial meniscus posterior root tears in stable knees: Magnetic resonance imaging evaluations at 3 years postoperatively. Reviewed International journal

Koki Kawada, Takayuki Furumatsu, Yusuke Yokoyama, Naohiro Higashihara, Masanori Tamura, Toshifumi Ozaki

The Knee 48 22 - 29 2024.3

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Only a few studies have assessed signal intensity after pullout repair for medial meniscus posterior root (MMPR) tears (MMPRTs) based on mid-term magnetic resonance imaging (MRI) evaluations. Therefore, this study aimed to assess the quantitative signal intensity of repaired posterior roots over time, up to 3 years postoperatively, and the related factors. METHODS: This study included 36 patients who underwent pullout repair for MMPRTs and MRI examinations using the same MRI system. The signal intensity of the repaired posterior roots was quantitatively evaluated using the signal-to-noise quotient (SNQ). Medial meniscus extrusion (MME), the SNQ for MMPR, and clinical scores were assessed over 3 years postoperatively. RESULTS: MME progressed over time until 3 years postoperatively, and its progression during this period was 1.61 ± 1.44 mm. The SNQ for MMPR decreased over time until 3 years postoperatively, and the change in the SNQ from 3 months to 3 years postoperatively (ΔSNQ) was 2.69 ± 1.69. All clinical scores significantly improved (p < 0.001). ΔSNQ was significantly correlated with body weight (correlation coefficient = -0.424, p = 0.010) and body mass index (correlation coefficient = -0.330, p = 0.050). However, ΔSNQ was not significantly correlated with preoperative or postoperative clinical scores. CONCLUSION: After pullout repair for MMPRTs, MME progressed to 3 years postoperatively. However, the signal intensity of the repaired posterior roots decreased, and clinical scores improved over time until 3 years postoperatively. Patient weight and body mass index were significantly correlated with the reduced signal intensity of the repaired posterior roots, suggesting that weight assessment in patients with MMPRTs is crucial. LEVEL OF EVIDENCE: IV.

DOI： 10.1016/j.knee.2024.02.014

PubMed

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PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours

Shota Takihira, Daisuke Yamada, Tatsunori Osone, Tomoka Takao, Masakiyo Sakaguchi, Michiyuki Hakozaki, Takuto Itano, Eiji Nakata, Tomohiro Fujiwara, Toshiyuki Kunisada, Toshifumi Ozaki, Takeshi Takarada

British Journal of Cancer 130 ( 9 ) 1493 - 1504 2024.3

Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

Paired related-homeobox 1 (PRRX1) is a transcription factor in the regulation of developmental morphogenetic processes. There is growing evidence that PRRX1 is highly expressed in certain cancers and is critically involved in human survival prognosis. However, the molecular mechanism of PRRX1 in cancer malignancy remains to be elucidated.

Methods

PRRX1 expression in human Malignant peripheral nerve sheath tumours (MPNSTs) samples was detected immunohistochemically to evaluate survival prognosis. MPNST models with PRRX1 gene knockdown or overexpression were constructed in vitro and the phenotype of MPNST cells was evaluated. Bioinformatics analysis combined with co-immunoprecipitation, mass spectrometry, RNA-seq and structural prediction were used to identify proteins interacting with PRRX1.

Results

High expression of PRRX1 was associated with a poor prognosis for MPNST. PRRX1 knockdown suppressed the tumorigenic potential. PRRX1 overexpressed in MPNSTs directly interacts with topoisomerase 2 A (TOP2A) to cooperatively promote epithelial-mesenchymal transition and increase expression of tumour malignancy-related gene sets including mTORC1, KRAS and SRC signalling pathways. Etoposide, a TOP2A inhibitor used in the treatment of MPNST, may exhibit one of its anticancer effects by inhibiting the PRRX1–TOP2A interaction.

Conclusion

Targeting the PRRX1–TOP2A interaction in malignant tumours with high PRRX1 expression might provide a novel tumour-selective therapeutic strategy.

DOI： 10.1038/s41416-024-02632-8

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Other Link： https://www.nature.com/articles/s41416-024-02632-8

非転位型の橈骨遠位端骨折において骨折部位,Lister結節形状は長母指伸筋腱断裂に影響する

斎藤太一, 近藤秀則, 古谷友希, 中道亮, 島村安則, 西田圭一郎, 今谷潤也, 尾崎敏文

日本整形外科学会雑誌 98 ( 3 ) S781 - S781 2024.3