Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

Division display 1,521 - 1,540 of about 1,743 ／ All the affair displays >>

Comparison between loose fragment chondrocytes and condyle fibrochondrocytes in cellular proliferation and redifferentiation. Reviewed

Takata N, Furumatsu T, Abe N, Naruse K, Ozaki T

J Orthop Sci 16 ( 5 ) 589 - 597 2011

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Loose fragments in spontaneous osteonecrosis of the knee (SONK) are usually removed by surgical treatment. However, the healing potential of osteonecrotic loose fragments and their clinical availability, for example as a cell source for cartilage repair and tissue engineering, have not been investigated. The objective of this study was to evaluate the cellular proliferation and redifferentiation ability of loose fragment chondrocytes for the treatment of SONK. METHODS: Cells were obtained from the remaining cartilage of chondral loose fragments or fibrocartilaginous tissue under the affected femoral condyle in SONK. The proliferation activity of loose fragment-derived chondrocytes and condyle-derived fibrochondrocytes was evaluated. In-vitro differentiation ability was assessed by PCR and histological analysis. RESULTS: The deposition of proteoglycans and type II collagen were maintained in loose fragments. However, loose fragment-derived chondrocytes had lower proliferating activity than condyle-derived fibrochondrocytes. Chondrogenic redifferentiation ability was lower in loose fragment chondrocytes than in condyle fibrochondrocytes. Differentiation towards adipogenic and osteogenic lineages was not observed in loose fragment chondrocytes. On the other hand, lipid vacuoles were detected in fibrochondrocytes after adipogenic treatment. CONCLUSIONS: This study demonstrated that loose fragment-derived chondrocytes in SONK had lower potential than fibrochondrocytes in cellular proliferation and redifferentiation. Our experimental results suggest that osteonecrotic loose fragments might have restricted cellular properties in the healing of SONK-related osteochondral defects.

DOI： 10.1007/s00776-011-0128-1

PubMed

researchmap

Treatment of Torn Lateral Discoid Meniscus:— Comparison of Meniscal Repair Group and Subtotal Meniscectomy Group —

Takata Naoki, Furumatsu Takayuki, Miyazawa Shinichi, Yokoyama Yusuke, Okada Yukimasa, Ozaki Toshifumi, Abe Nobuhiro

The Journal of the Chugoku-Shikoku Orthopaedic Association 23 ( 2 ) 261 - 265 2011

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

Arthroscopic treatment has been widely performed for tears of the lateral discoid meniscus. However, this frequently results in total meniscectomy in cases of degenerative peripheral tear. We performed meniscal suturing of residual peripheral tears after subtotal meniscectomy to preserve the function of the meniscus. Methods : We treated 15 knees of 15 patients (4 males and 11 females) with symptomatic lateral discoid meniscus tears. The mean age of the patients at surgery was 18.7 years (range, 7 to 37 years), and the mean follow-up period was 2.7 years (range, 12 to 65 months). We retrospectively compared the clinical results and the incidence rate of osteochondritis dissecans (OCD) in the peripheral repair group with those in the subtotal meniscectoy group. Clinical results were assessed on the basis of the Japanese Orthopaedic Association (JOA) score. Results : Eight patients underwent arthroscopic partial meniscectomy alone. In the remaining 7 patients with degenerative peripheral tears, meniscal repair was performed after subtotal meniscectomy to avoid total meniscectomy. All of the patients had excellent JOA scores at the final follow-up point. None of them required additional surgery for re-tear. The incidence of OCD was 14% in the partial meniscectomy group, whereas OCD was not found in the peripheral repair group. Conclusion : Our results demonstrate the short-term efficacy of arthroscopic partial meniscectomy in conjunction with peripheral repair in cases of degenerative peripheral tear of lateral discoid meniscus.

DOI： 10.11360/jcsoa.23.261

CiNii Article

researchmap

Comparison between Fondaparinux and Enoxaparin in Early Administration after Total Knee Arthroplasty

Okada Yukimasa, Furumatsu Takayuki, Itani Satoru, Saiga Kenta, Takata Naoki, Yokoyama Yusuke, Ozaki Toshifumi, Abe Nobuhiro

The Journal of the Chugoku-Shikoku Orthopaedic Association 23 ( 2 ) 399 - 403 2011

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

Background: The validity of fondaparinux and enoxaparin has been reported in the prevention of deep vein thronbosis and pulmonary embolism (DVT/PE) after total knee arthroplasty (TKA). We compared the effectiveness of early administration of these two drugs after TKA. Methods: We studied 32 patients who underwent TKA in the period between May 2009 and May 2010. The operations were performed under general anesthesia and femoral nerve block, using an air tourniquet, and using cements for implant fixation. The patients were divided in two groups, use of 2.5mg fondaparinux once daily (Fa group), and use of 2000IU of enoxaparin twice daily (Ex group). The initial dose was administered between 12 and 21 hours after surgery and continued for 14 days. We compared the incidence of DVT/PE, bleeding complications, D dimer level, and hemoglobin (Hb) loss. Results: DVT/PE occurred in 6 patients (38%) in the Fa group, and 3 (19%) in the Ex group. Bleeding complications occurred in none of the Fa group and 4 (25%) in the Ex group. There were no significant differences in D dimer level and Hb loss. Conclusion: Our results indicate that enoxaparin decreases the incidence of DVT/PE compared with fondaparinux, but increases the bleeding complications.

DOI： 10.11360/jcsoa.23.399

CiNii Article

researchmap

Deep venous thrombosis and pulmonary embolism after pelvic and acetabular fracture

MAZAKI Tetsuro

The Central Japan Journal of Orthopaedic Surgery & Traumatology 54 ( 3 ) 469 - 470 2011

Corrective osteotomy for severe kyophosis in ankylosing spondylitis: One case report

MAZAKI Tetsuro

The Central Japan Journal of Orthopaedic Surgery & Traumatology 54 ( 6 ) 1231 - 1232 2011

The long term results over 25 years follow-up of Charnley total hip arthroplasty

TETSUNAGA Tomonori

The Central Japan Journal of Orthopaedic Surgery & Traumatology 54 ( 5 ) 1017 - 1018 2011

A case report of atypical femoral shaft farcture: the medullary cavity was obstructed at the fracture site

OSAKI Shuhei

The Central Japan Journal of Orthopaedic Surgery & Traumatology 54 ( 5 ) 951 - 952 2011

Total hip arthroplasty with femoral shortening osteotomy for a patient treated by Schanz osteotomy

INOUE Madoka

The Central Japan Journal of Orthopaedic Surgery & Traumatology 54 ( 5 ) 1009 - 1010 2011

Well leg compartment syndrome following radical cystectomy: A case report

OKADA Yoshiki

The Central Japan Journal of Orthopaedic Surgery & Traumatology 54 ( 4 ) 869 - 870 2011

Radiological outcome after medial patellofemoral ligament reconstruction using Endobutton fixation

YOKOYAMA Yusuke

The Central Japan Journal of Orthopaedic Surgery & Traumatology 54 ( 4 ) 731 - 732 2011

The functional outcome after subtotal scaplectomy for chondrosarcoma: two case reports

OKADA Yoshiki

The Central Japan Journal of Orthopaedic Surgery & Traumatology 54 ( 1 ) 41 - 42 2011

Minimally invasive plate osteosynthesis for osteofibrous dysplasia of the tibia: a case report. Reviewed International journal

Nakahara H, Kunisada T, Noda T, Ozaki T

Journal of orthopaedic surgery (Hong Kong) 18 ( 3 ) 374 - 377 2010.12

Language：English Publishing type：Research paper (scientific journal)

Osteofibrous dysplasia occurs most frequently in the tibia and may result in deformity and pathological fracture. We report one such case in a 6-year-old girl who underwent minimally invasive plate osteosynthesis using a locking compression plate. The varus deformity of the tibia was manually corrected, and the plate was inserted without extensive surgical exposure. At 20-week follow-up, the fracture had healed completely, and she had returned to normal daily living. At 3-year follow-up, radiographs showed no progression of the varus deformity. Minimally invasive plate osteosynthesis is useful for treatment of pathological fractures caused by osteofibrous dysplasia. It preserves blood flow at the fracture site, leading to good bone healing and stability to prevent further deformity and an early return to daily activity.

DOI： 10.1177/230949901001800325

PubMed

researchmap

Centpillar stemで著明なゆるみを生じた1例

長谷井嬢, 遠藤裕介, 鉄永智紀, 藤原一夫, 三谷茂, 尾崎敏文

日本人工関節学会誌 40 724 - 725 2010.12

Language：Japanese Publisher：(一社)日本人工関節学会

54歳女。変形性股関節症で、10年前に右股関節に対しセメントTHAを施行し、今回、左股関節に対しTHAを施行した。Cup挿入にはnavigationを使用し、Stemは術前CTプランニングと同サイズをnavigation非使用で術中骨折等の合併症なく挿入した。術後2日で荷重歩行を開始し、術後1週のCTで骨折などは認めず経過良好であったが、術後2週で2mmのsubsidenceを認めた。荷重制限は行わず、術後3週でT字杖一本歩行で自宅退院し経過観察していたところ、徐々に骨萎縮が進行し、術後1年では著明な跛行およびX線上約4mmのsubsidenceと大腿骨の膨化を認めた。再置換術は希望されず、更に術後2年では約2cmのsubsidenceが生じ、術後2年6ヵ月にはステム遠位部での骨形成がみられた。術後2年以降、subsidenceの進行は認めていない。

researchmap

長橈側手根伸筋(ECRL)腱を用いて母指手根中手骨(CM)関節形成術を行った1例

井上円加, 西田圭一郎, 橋詰謙三, 島村安則, 中原龍一, 斉藤太一, 金澤智子, 尾崎敏文

岡山医学会雑誌 122 ( 3 ) 279 - 279 2010.12

パルス洗浄が人工股関節全置換術術後成績に与える影響についての検討

鉄永智紀, 三谷茂, 藤原一夫, 遠藤裕介, 三宅由晃, 尾崎敏文

日本人工関節学会誌 40 234 - 235 2010.12

Language：Japanese Publisher：(一社)日本人工関節学会

セメントレスTHAの術中にパルス洗浄を行った群(25例)と行わなかった群(25例)とで手術成績を比較検討した。評価項目は「手術時間」「術中出血量」「術後合併症」「術後の血液検査所見」「JOAスコア」とした。検討の結果、いずれの項目にも有意な群間差は認められなかった。

researchmap

ケルブールプレートと人工骨を併用した臼蓋再置換術THAの短期成績の検討

遠藤裕介, 三谷茂, 藤原一夫, 三宅由晃, 鉄永智紀, 国定俊之, 尾崎敏文

日本人工関節学会誌 40 102 - 103 2010.12

Language：Japanese Publisher：(一社)日本人工関節学会

2000年〜2007年に人工骨とケルブールプレート併用の臼蓋側再置換術(THA)を施行した骨欠損症37例中2年以上経過観察できた30例30関節(男性5例、女性25例、44〜78歳・平均66歳)を対象に、短期成績について検討した。前回手術は人工骨頭置換術(BHA)2例、人工股関節置換術(THA)28例で前回手術からの経過観察期間は平均15年(2〜26年)、再置換の理由は無菌性のゆるみ27例、感染2例、脱臼1例、平均追跡期間は4年6ヵ月(2〜9年)であった。術前のAAOS分類はIが5股、IIが2股、IIIが20股、IVが3股であった。術直後のX線像におけるケルブールプレートのフックの設置位置は14股(46%)に外側設置を認め、荷重部の移植骨の厚みは平均15mm(0〜27mm)であった。最終調査時迄に遅発性感染を2例に認め、スクリューのゆるみ・破損を6股(20%)に認めた。カップの内方への移動を7股(23%)に認め移動距離は平均7.2mm(1〜20mm)であった。JOAスコアは術前平均50点から最終観察時平均77点と改善した。感染例2例を除く28股においてカップの移動を生じた5股と問題のなかった23股を比較検討したが両群に術前の平均年齢、BMIに差はなく成績不良群には術前AAOS分類でタイプIVが2股存在した。成績不良群は全例荷重部にブロックを使用せずに人工骨顆粒のみを使用していた。荷重部の移植骨の厚みには有意差は認めず、プレートの設置状態が良好であった15股中2股に成績不良を認めた。

researchmap

大腿骨頸部外骨腫にともなう変形性股関節症の1例

金澤智子, 藤原一夫, 遠藤裕介, 鉄永智紀, 尾崎敏文, 三谷茂

日本人工関節学会誌 40 726 - 727 2010.12

Language：Japanese Publisher：(一社)日本人工関節学会

47歳男。44歳時より誘因なく右股関節痛が出現し、前医でのX線で右大腿骨頭の変形を指摘されたが、臼蓋側の変形は軽度で、関節裂隙の狭小化も僅かであった。MRIでは正常骨皮質と連続した有茎性の腫瘤を認め、周囲組織の信号変化はなかった。大腿骨頸部に発生した外骨腫の診断で保存加療を受けたが、右股関節痛が増悪し、腫瘍増大も疑われたため当科紹介受診した。受診時には歩行時痛、著明な可動域制限を認め、X線で関節裂隙は狭小化し、臼蓋側にも骨硬化と骨嚢胞を認めた。CT・MRIでは大腿骨頸部前外側に有茎性の骨性隆起を認め、周囲組織との信号変化は認めなかった。タリウムシンチグラムでは、early phase、delayed phase共に集積の亢進は認めなかった。以上より変形性股関節症と診断し、人工股関節置換術を施行した。組織学的所見では大腿骨頸部に認めた骨性隆起に軟骨様の組織を認め、軟骨帽の一部であったと考えられた。術後経過は良好で、術後4ヵ月時でJOA scoreは34点から83点に改善しており、ROMも著明改善し、1時間程度の独歩が可能であった。

researchmap

Combined use of bFGF and GDF-5 enhances the healing of medial collateral ligament injury Reviewed

Kenta Saiga, Takayuki Furumatsu, Aki Yoshida, Shin Masuda, Shota Takihira, Nobuhiro Abe, Toshifumi Ozaki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 402 ( 2 ) 329 - 334 2010.11

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE

Basic fibroblast growth factor (bFGF) and growth and differentiation factor (GDF)-5 stimulate the healing of medial collateral ligament (MCL) injury. However, the effect of isolated and combined use of bFGF/GDF-5 remains still unclear. We investigated cellular proliferation and migration responding to bFGF/GDF-5 using rabbit MCL fibroblasts. Rabbit MCL injury was treated by bFGF and/or GDF-5 with peptide hydrogels. Gene expression and deposition of collagens in healing tissues were evaluated. bFGF/GDF-5 treatment additively enhanced cell proliferation and migration. bFGF/GDF-5 hydrogels stimulated Col1a1 expression without increasing Col3a1 expression. Combined use of bFGF/GDF-5 stimulated type I collagen deposition and the reorganization of fiber alignment, and induced better morphology of fibroblasts in healing MCLs. Our study indicates that combined use of bFGF/GDF-5 might enhance MCL healing by increasing proliferation and migration of MCL fibroblasts, and by regulating collagen synthesis and connective fiber alignment. (C) 2010 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.bbrc.2010.10.026

Web of Science

researchmap

Clinical application of a pedicle nail system with polymethylmethacrylate for osteoporotic vertebral fracture Reviewed

Keiya Yamana, Masato Tanaka, Yoshihisa Sugimoto, Tomoyuki Takigawa, Toshifumi Ozaki, Hitoshi Konishi

EUROPEAN SPINE JOURNAL 19 ( 10 ) 1643 - 1650 2010.10

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

The instrumentation of the osteoporotic spine may sometimes result in failure due to the loosening or pullout of the conventional pedicle screw. Moreover, augmentation of screws with polymethylmethacrylate (PMMA) has risks of complications. We developed a new and original pedicle nail system with PMMA for osteoporotic vertebral fractures. A clinical evaluation of this novel pedicle nail system utilized in patients with an osteoporotic vertebral collapse was performed to determine the effectiveness and safety of this technique. Thirty-four elderly patients who suffered from osteoporotic compression fractures were treated by posterolateral fusion using the pedicle nail system. The mean follow-up period was 37 months. Of the 25 patients with neurological symptoms, two patients improved two stages at the Frankel level. Fifteen patients improved one stage at the Frankel level, and eight other patients improved, however, their improvement did not exceed a Frankel level. Nine cases with neuralgia symptoms improved from 4.4 to 2.2 points on average on the Denis pain scale (p < 0.01). The fusion rate was 94% as determined by X-rays of flexion and extension, and the correction of the compression fracture site was maintained well. A pedicle nail system stabilizes the spinal column with osteoporosis and reduces the instrumentation failure. The technique for the insertion of the pedicle nail reduces complication from cement augmentation. The authors speculate that the strategy using the pedicle nail system for osteoporotic spine may be effective and safe when the surgery is performed through a posterior approach.

DOI： 10.1007/s00586-010-1402-1

Web of Science

researchmap

RA上肢変形の治療関節リウマチ(RA)に対するSauve-Kapandji(S-K)法の治療成績

金澤智子, 橋詰謙三, 西田圭一郎, 中原龍一, 斎藤太一, 尾崎敏文

日本関節病学会誌 29 ( 3 ) 398 - 398 2010.10

　 PREV - NEXT 　

< OZAKI Toshifumi >

Papers - OZAKI Toshifumi