Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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踵骨骨折に対する外側小切開による骨接合術の治療成績ロッキングプレート固定とスクリュー固定の比較

佐藤浩平, 野田知之, 福岡史朗, 近藤宏也, 畑利彰, 上原健敬, 横尾賢, 吉村将秀, 尾崎敏文

骨折 43 ( Suppl. ) S251 - S251 2021.7

上原健敬, 野田知之, 福岡史朗, 佐藤浩平, 畑利彰, 近藤宏也, 齋藤太一, 雑賀建多, 島村安則, 尾崎敏文

骨折 43 ( Suppl. ) S248 - S248 2021.7

Subjective and Objective Outcomes of Surgery for Rheumatoid Forefoot Deformities Under the Current Treatment Paradigm. International journal

Masahiro Horita, Keiichiro Nishida, Daisuke Kaneda, Kenzo Hashizume, Yoshihisa Nasu, Ryuichi Nakahara, Kenta Saiga, Hideki Ohashi, Masahito Watanabe, Toshifumi Ozaki

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 61 ( 1 ) 53 - 59 2021.6

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

We investigated the clinical outcomes of surgical procedures for the treatment of forefoot deformities in patients with rheumatoid arthritis. Twenty feet in 16 women (mean age 62.1 years) underwent corrective osteotomy of the first metatarsal bone with shortening oblique osteotomy of the lesser metatarsophalangeal joints (joint-preservation group), while 13 feet in 12 women (mean age 67.4 years) underwent arthrodesis of the first metatarsophalangeal joint with resection arthroplasty of the lesser metatarsophalangeal joints (joint-sacrifice group); mean follow-up for each group was 25.8 and 23.8 months, respectively. The mean total Japanese Society for Surgery of the Foot (JSSF) scale improved significantly from 64.2 to 89.2 in the joint-preservation group (p < .001), and from 54.2 to 74.2 in the joint-sacrifice group (p = .003). In the joint-preservation group, the postoperative range of motion (ROM) of the joint, walking ability, and activities of daily living scores of the JSSF scale were significantly higher than those in the joint-sacrifice group (p = .001, p = .001, and p = .019, respectively). There were no differences in the subscale scores of the self-administered foot evaluation questionnaire between 2 groups either pre- or postoperatively. No differences in the postoperative complications were found between 2 groups. Although the joint-sacrificing procedure resulted in lower objective outcomes than the joint-preserving procedure regarding the ROM of the joint, the walking ability, and the level of activities of daily living, both procedures resulted in similar treatment outcomes when evaluated by the subjective measures.

DOI： 10.1053/j.jfas.2021.06.008

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Transtibial pullout repair techniques using two simple stitches for medial meniscus posterior root tear can prevent the progression of medial meniscus extrusion and obtain successful outcomes. International journal

Takaaki Hiranaka, Takayuki Furumatsu, Shinichi Miyazawa, Yuki Okazaki, Keisuke Kintaka, Yuya Kodama, Yusuke Kamatsuki, Toshifumi Ozaki

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 2021.6

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Transtibial pullout repairs using two simple stitches (TSS) and a combination of TSS with posteromedial pullout repair (TSS + PMP) using an all-inside meniscal repair device have been reported previously for the treatment of medial meniscus (MM) posterior root tears. This study aimed to investigate the postoperative clinical outcomes of these techniques including MM extrusion (MME). METHODS: Fifty-two patients who underwent transtibial pullout repair were investigated and divided into TSS (n = 27) and TSS + PMP (n = 25) groups. The clinical outcomes were assessed using the Lysholm knee score and Knee Injury and Osteoarthritis Outcome Score 1 year postoperatively and compared between two groups. MME was measured using magnetic resonance imaging at 1 year postoperatively and compared between two groups. RESULTS: A significant improvement in each clinical score was observed in both groups, and no significant difference was seen in clinical outcomes. Moreover, no significant difference in postoperative MME was observed in both groups (TSS and TSS + PMP: 3.5 mm and 3.8 mm, respectively). Though no significant progression of MME was observed in TSS group, a significant progression of it was observed in TSS + PMP group postoperatively. CONCLUSIONS: This study demonstrated that both techniques improved clinical outcomes in the short-term postoperative period. However, MME was progressed significantly in TSS + PMP group 1 year postoperatively, which indicated that PMP might not be a useful additional procedure for reducing the postoperative MME.

DOI： 10.1007/s00590-021-03035-8

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Adrenergic signaling promotes the expansion of cancer stem-like cells of malignant peripheral nerve sheath tumors. International journal

Rongsheng Huang, Atsushi Fujimura, Eiji Nakata, Shota Takihira, Hirofumi Inoue, Soichiro Yoshikawa, Takeshi Hiyama, Toshifumi Ozaki, Atsunori Kamiya

Biochemical and biophysical research communications 557 199 - 205 2021.6

Language：English Publishing type：Research paper (scientific journal)

Malignant peripheral nerve sheath tumor (MPNST), a highly malignant tumor that arises in peripheral nerve tissues, is known to be highly resistant to radiation and chemotherapy. Although there are several reports on genetic mutations and epigenetic changes that define the pathogenesis of MPNST, there is insufficient information regarding the microenvironment that contributes to the malignancy of MPNST. In the present study, we demonstrate that adrenaline increases the cancer stem cell population in MPNST. This effect is mediated by adrenaline stimulation of beta-2 adrenergic receptor (ADRB2), which activates the Hippo transducer, YAP/TAZ. Inhibition and RNAi experiments revealed that inhibition of ADRB2 attenuated the adrenaline-triggered activity of YAP/TAZ and subsequently attenuated MPNST cells stemness. Furthermore, ADRB2-YAP/TAZ axis was confirmed in the MPNST patients' specimens. The prognosis of patients with high levels of ADRB2 was found to be significantly worse. These data show that adrenaline exacerbates MPNST prognosis and may aid the development of new treatment strategies for MPNST.

DOI： 10.1016/j.bbrc.2021.03.172

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Clinical outcome of patients with recurrent or refractory localized Ewing's sarcoma family of tumors: A retrospective report from the Japan Ewing Sarcoma Study Group. International journal

Katsutsugu Umeda, Takako Miyamura, Kenji Yamada, Hideki Sano, Ako Hosono, Minako Sumi, Hajime Okita, Tadashi Kumamoto, Akira Kawai, Junya Hirayama, Ryoji Jyoko, Akihisa Sawada, Hideki Nakayama, Yosuke Hosoya, Naoko Maeda, Nobuyuki Yamamoto, Chihaya Imai, Daiichiro Hasegawa, Motoaki Chin, Toshifumi Ozaki

Cancer reports (Hoboken, N.J.) 4 ( 3 ) e1329 2021.6

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Patients with Ewing's sarcoma family of tumors (ESFT) who experience relapse or progression have a poor prognosis. AIM: This study aimed to identify the prognostic and therapeutic factors affecting overall survival (OS) of patients with recurrent or refractory localized ESFT. METHODS AND RESULTS: Thirty-eight patients with localized ESFT who experienced first relapse or progression between 2000 and 2018 were retrospectively reviewed. The 5-year OS rate of the entire cohort was 48.3% (95% confidence interval, 29.9%-64.5%). Multivariate analysis of OS identified time to relapse or progression, but not stem cell transplantation (SCT), as the sole independent risk factor (hazard ratio, 35.8; P = .002). Among 31 patients who received salvage chemotherapy before local treatment, 21 received chemotherapy regimens that are not conventionally used for newly diagnosed ESFT. The objective response rate to first-line salvage chemotherapy was 55.2% in the 29 evaluable patients. Time to relapse or progression was significantly associated with response to first-line salvage chemotherapy (P = .006). CONCLUSIONS: The present study fails to demonstrate significant clinical benefit of SCT for recurrent or refractory localized ESFT. Recently established chemotherapy regimens may increase the survival rate of patients with recurrent or refractory localized ESFT while attenuating the beneficial effect of SCT.

DOI： 10.1002/cnr2.1329

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骨・軟部腫瘍のgermline findingsに対する遺伝子医療部門の取り組み

二川摩周, 中田英二, 十川麗美, 加藤芙美乃, 浦川優作, 河内麻里子, 山本英喜, 国定俊之, 平沢晃, 尾崎敏文

日本整形外科学会雑誌 95 ( 6 ) S1251 - S1251 2021.6

がんロコモの現状と課題がんロコモ発生予防のための院内システムの構築

中田英二, 堅山佳美, 明崎禎輝, 濱田全紀, 国定俊之, 藤原智洋, 千田益生, 尾崎敏文

日本整形外科学会雑誌 95 ( 6 ) S1241 - S1241 2021.6

がんロコモの現状と課題遠隔転移のないがん患者における周術期のがんロコモの発生率とそのリスクファクター

堅山佳美, 中田英二, 明崎禎輝, 千田益生, 国定俊之, 濱田全紀, 尾崎敏文

日本整形外科学会雑誌 95 ( 6 ) S1298 - S1298 2021.6

DDH治療後の腸腰筋断面積の検討

佐藤嘉洋, 鉄永智紀, 山田和希, 廣瀬一樹, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 1 ) 44 - 46 2021.6

人工知能による骨肉腫X線像読影システム

長谷井嬢, 中原龍一, 板野拓人, 沖田駿治, 三宅孝昌, 杉本佳久, 木浪陽, 藤原一夫, 臼井正明, 尾崎敏文

日本整形外科学会雑誌 95 ( 6 ) S1250 - S1250 2021.6

前腕に発生した肉腫の治療成績

畑利彰, 佐藤浩平, 近藤宏也, たき平将太, 藤原智洋, 中田英二, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 95 ( 6 ) S1354 - S1354 2021.6

骨肉腫における腫瘍関連マクロファージの臨床病理学的意義

近藤宏也, 藤原智洋, 吉田晶, 佐藤浩平, 畑利彰, たき平将太, 中田英二, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 95 ( 6 ) S1410 - S1410 2021.6

肉腫の心臓転移

板野拓人, 中田英二, 国定俊之, 藤原智洋, 尾崎敏文

日本整形外科学会雑誌 95 ( 6 ) S1389 - S1389 2021.6

がん遺伝子パネルによる肉腫における融合遺伝子の検出

佐藤浩平, 中田英二, 近藤宏也, 畑利彰, たき平将太, 藤原智洋, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 95 ( 6 ) S1269 - S1269 2021.6

がんゲノム中核拠点病院における肉腫のがんゲノム医療

中田英二, 国定俊之, 藤原智洋, 尾崎敏文

日本整形外科学会雑誌 95 ( 6 ) S1252 - S1252 2021.6

肉腫における免疫療法

たき平将太, 佐藤浩平, 畑利彰, 近藤宏也, 中田英二, 藤原智洋, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 95 ( 6 ) S1338 - S1338 2021.6

寛骨臼を含む骨盤発生Ewing肉腫に対する英国集約化施設における治療変遷とその成績

藤原智洋, Stevenson Jonathan, Parry Michael, 津田祐輔, 中田英二, 国定俊之, 尾崎敏文, Grimer Robert, Jeys Lee

日本整形外科学会雑誌 95 ( 6 ) S1272 - S1272 2021.6

NICE軟部肉腫ガイドラインは英国における軟部肉腫患者の診療体制や生存予後にどのような影響を与えたか

藤原智洋, Grimer Robert, Evans Scott, 津田祐輔, 中田英二, 国定俊之, 尾崎敏文, Abudu Adesegun

日本整形外科学会雑誌 95 ( 6 ) S1371 - S1371 2021.6

Postoperative computed tomography assessment of anteromedial cortex reduction is a predictor for reoperation after intramedullary nail fixation for pertrochanteric fractures. International journal

Norio Yamamoto, Takahiro Imaizumi, Tomoyuki Noda, Tomoo Inoue, Keisuke Kawasaki, Toshifumi Ozaki

European journal of trauma and emergency surgery : official publication of the European Trauma Society 2021.5

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Postoperative radiographs are routinely used to assess fracture reduction following intramedullary nail fixation for pertrochanteric fractures, even though computed tomography (CT) is a superior modality. We aimed to determine the association between reduction quality assessed by CT and rates of reoperation and to evaluate the association of reoperation and reduction quality according to the assessment modality (plain radiographs vs. CT). METHODS: A retrospective analysis of 299 consecutive patients treated with intramedullary nail fixation for pertrochanteric fractures was conducted. Fracture reduction measured by postoperative radiographs and CT was categorized as anatomical type, extramedullary type, or intramedullary type. Postoperative data for analysis included reduction status, tip-apex distance (TAD), screw position in the femoral head, sliding distance, and conditions associated with reoperation. RESULTS: Of the 299 patients included with a mean age of 83.1 ± 8.2 years, there were six patients who required reoperation (2.0%). According to the CT assessments, there were 42 intramedullary reductions (14.0%). Patients with a non-intramedullary reduction based on postoperative CT images were significantly more likely to have proper placement of the screw, a reduced TAD, a reduced sliding distance, and a lower reoperation rate than those with an intramedullary reduction (P < 0.05). The reduction quality assessed by postoperative CT was significantly associated with reoperation (95% CI, 1.45-29.31). CONCLUSIONS: Intramedullary reduction assessed by CT was associated with reoperation. The reduction quality based on CT findings was more predictive for reoperation than that from plain radiographs.

DOI： 10.1007/s00068-021-01718-9

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