Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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下肢長幹骨発生の原発性悪性骨腫瘍に対する広範切除術後の機能回復は再建法によりどのように異なるか?

藤原智洋, 中田英二, 堅山佳美, 濱田全紀, 国定俊之, 尾崎敏文, 千田益生

The Japanese Journal of Rehabilitation Medicine 59 ( 秋季特別号 ) S364 - S364 2022.10

骨盤悪性腫瘍に対するHip transposition法の術後機能・歩行能力

国定俊之, 中田英二, 藤原智洋, 尾崎敏文, 堅山佳美, 濱田全紀, 千田益生

The Japanese Journal of Rehabilitation Medicine 59 ( 秋季特別号 ) S364 - S364 2022.10

60歳以上の術前がん患者のがんロコモとサルコペニア,フレイルの有病率

堅山佳美, 中田英二, 藤原智洋, 國定俊之, 濱田全紀, 千田益生, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 59 ( 秋季特別号 ) S363 - S363 2022.10

THA後の腸腰筋障害に対する股関節鏡下腸腰筋腱部分切離術の治療経験

安藤輝彦, 山田和希, 鉄永智紀, 佐藤嘉洋, 廣瀬一樹, 小浦卓, 井上智博, 尾崎敏文

中国・四国整形外科学会雑誌 34 ( 3 ) 392 - 392 2022.10

踵骨関節内骨折に対する低侵襲ロッキングプレート固定は早期荷重を可能とさせる

國富康資, 依光正則, 上原健敬, 福岡史朗, 佐藤浩平, 尾崎敏文

中部日本整形外科災害外科学会雑誌 65 ( 秋季学会 ) 194 - 194 2022.10

生理的インピーダンス法におけるPhase angleは運動器慢性疼痛患者においてサルコペニア検出に有用である

辻寛謙, 三澤治夫, 鉄永智紀, 濱田全紀, 堅山佳美, 小田孔明, 西田圭一朗, 千田益生, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 59 ( 秋季特別号 ) S343 - S343 2022.10

ポータブル筋音筋電計を用いた膝蓋腱反射の定量化

辻寛謙, 三澤治夫, 小田孔明, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 59 ( 秋季特別号 ) S392 - S392 2022.10

岡山大学病院における頸椎損傷の急性期手術介入のタイミングに関する検討

魚谷弘二, 植田昌敬, 志渡澤央和, 小田孔明, 鉄永倫子, 三澤治夫, 尾崎敏文

中国・四国整形外科学会雑誌 34 ( 3 ) 437 - 437 2022.10

踵骨関節内骨折の固定法の変化と術後荷重開始時期の短縮

依光正則, 上原健敬, 佐藤浩平, 福岡史朗, 濱田全紀, 千田益生, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 59 ( 秋季特別号 ) S353 - S353 2022.10

大腿骨頸部骨折を合併した寛骨臼両柱骨折の1例

福岡史朗, 依光正則, 畑利彰, 佐藤浩平, 上原健敬, 尾崎敏文

中国・四国整形外科学会雑誌 34 ( 3 ) 417 - 417 2022.10

Factors influencing caregiver burden in chronic pain patients: A retrospective study International journal

Hironori Tsuji, Tomoko Tetsunaga, Tomonori Tetsunaga, Haruo Misawa, Yoshiaki Oda, Shinichiro Takao, Keiichiro Nishida, Toshifumi Ozaki

Medicine 101 ( 39 ) e30802 - e30802 2022.9

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)

Chronic pain coexists with disability, anxiety, depression, and sleep disturbances, which are factors of pain chronicity in the fear-avoidance model. Self-efficacy for managing pain plays a protective role against pain chronicity. For chronic pain sufferers, social support from caregivers is important. However, such caregivers face enormous physical and mental burdens. This study aimed to assess how self-efficacy and factors related to the fear-avoidance model affect caregiver burden. Participants were 135 chronic pain patients and their caregivers who visited our outpatient pain special clinic. In clinical assessments, numeric rating scale (NRS), pain catastrophizing scale (PCS), hospital anxiety and depression scale (HADS), Athens insomnia scale (AIS), pain disability assessment scale (PDAS), pain self-efficacy questionnaire (PSEQ) for the patients and Zarit Burden Interview (ZBI) for their caregivers were evaluated. Participants were divided into 2 groups (L group ZBI < 24 points and H group ZBI ≥ 24 points) and compared. Regression analyses were conducted to identify factors correlated with the ZBI scores. Compared to L group, H group showed significantly higher NRS and HADs depression scores, and lower PSEQ scores. In univariate regression analysis, ZBI scores were significantly correlated with NRS, PCS, HADS anxiety, HADS depression, PDAS and PSEQ. Multiple linear regression analysis revealed that ZBI scores were significantly correlated with PSEQ. The caregivers who perceived high caregiver burden had significantly higher patients' pain intensity, depression, and lower self-efficacy than those who perceived low caregiver burden. Caregiver burden correlated with the pain intensity, pain catastrophizing, anxiety, depression, disability, and self-efficacy of chronic pain patients. Among these factors, self-efficacy was the most negatively correlated with caregiver burden. Treatments focused on increasing self-efficacy for managing pain have the potential to reduce caregiver burden.

DOI： 10.1097/md.0000000000030802

PubMed

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DevOpsを用いた機械学習・医療アプリケーションの開発効率の改善

中原龍一, 西田圭一郎, 高橋康, 那須義久, 原田遼三, 堀田佳史, 浪花崇一, 尾崎敏文

日本整形外科学会雑誌 96 ( 8 ) S1796 - S1796 2022.9

Clinicopathological and histological analysis of secondary malignant giant cell tumors of bone without radiotherapy. International journal

Eiji Nakata, Hotaka Kawai, Tomohiro Fujiwara, Toshiyuki Kunisada, Hirofumi Inoue, Mashu Futagawa, Haruyoshi Katayama, Takuto Itano, Toshifumi Ozaki

Oncology letters 24 ( 3 ) 319 - 319 2022.9

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Giant cell tumor of bone (GCTB) is an intermediate bone tumor that rarely undergoes malignant transformation. Secondary malignant GCTB (SMGCTB) is defined as a lesion in which high-grade sarcoma occurs at the site of previously treated GCTB. The present study retrospectively reviewed the medical records of patients with GCTB treated at Okayama University Hospital between April 1986 and April 2020. The clinicopathological and histological features of patients with SMGCTB without prior radiotherapy were investigated. A total of three patients (4%) with SMGCTB were detected, and the tumor sites were the distal ulna, distal femur and sacrum. Two of the patients had been treated with curettage and bone graft, and one had been treated with denosumab. In all cases, the lesions were made up of two components, the conventional GCTB component and the malignant component. The Ki67 labeling index was higher in the malignant components of SMGCTB and metastatic lesions compared with that in primary and recurrent conventional GCTB, or the conventional GCTB component of SMGCTB. Moreover, p53 expression was higher in these same components in patients who underwent curettage and bone grafting; however, there was no difference in the patient that received denosumab treatment. In this patient, clinical cancer genomic profiling revealed loss of CDKN2A, CDKN2B and MTAP expression. All three patients developed distant metastasis. The patients with SMGCTB in the ulna and femur died 13 and 54 months after detection of malignant transformation, respectively. The patient with SMGCTB in the sacrum received carbon-ion radiotherapy to the sacrum and pazopanib; the treatment was effective and the patient was alive at the last follow-up 3 years later. In conclusion, p53 may be associated with malignant transformation in GCTB. Future studies should investigate the association of between denosumab treatment and malignant transformation, as well as molecular targeted therapy to improve the clinical outcomes of SMGCTB.

DOI： 10.3892/ol.2022.13439

PubMed

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骨・軟部腫瘍の基礎科学のトピックスクリニカルシークエンスによる肉腫のゲノム医療

中田英二, 藤原智洋, 国定俊之, 二川摩周, 遠西大輔, 久保寿夫, 平沢晃, 尾崎敏文

日本整形外科学会雑誌 96 ( 8 ) S1533 - S1533 2022.9

骨・軟部肉腫に対するがんゲノムプロファイリング検査から検出されるpresumed germline pathogenic variantsの意義

二川摩周, 中田英二, 十川麗美, 加藤芙美乃, 浦川優作, 河内麻里子, 山本英喜, 藤原智洋, 国定俊之, 平沢晃, 尾崎敏文

日本整形外科学会雑誌 96 ( 8 ) S1770 - S1770 2022.9

The stability of repaired meniscal root can affect postoperative cartilage status following medial meniscus posterior root repair

Ximing Zhang, Takayuki Furumatsu, Takaaki Hiranaka, Yuki Okazaki, Haowei Xue, Keisuke Kintaka, Shinichi Miyazawa, Toshifumi Ozaki

Journal of Orthopaedic Science 2022.9

腫瘍随伴マクロファージの浸潤割合および予後を予測する血中バイオマーカーの特定浸潤性軟部肉腫患者における検討

畑利彰, 藤原智洋, 吉田晶, 近藤彩奈, 近藤宏也, 佐藤浩平, たき平将太, 中田英二, 国定俊之, 箱崎道之, 尾崎敏文

日本整形外科学会雑誌 96 ( 8 ) S1766 - S1766 2022.9

浸潤型軟部肉腫におけるCathepsin Proteaseの発現の臨床病理学的意義(Clinicopathological significance of cathepsin protease expression in infiltrative soft-tissue sarcomas)

藤原智洋, Zhang Lingxin, Chandler Andrew, Yakoub Mohamed, Hameed Meera, 中田英二, 国定俊之, 尾崎敏文, Healey John

日本癌学会総会記事 81回 P - 1275 2022.9

浸潤性軟部肉腫患者における腫瘍随伴マクロファージの浸潤および予後を予測する血中バイオマーカーの特定(Circulating cytokines as blood biomarker predictive of TAM infiltration and prognosis in patients with infiltrative STS)

畑利彰, 藤原智洋, 吉田晶, 近藤彩奈, 近藤宏也, 国定俊之, 尾崎敏文

日本癌学会総会記事 81回 J - 1065 2022.9

変形性股関節症とCCN3発現の相関

廣瀬一樹, 中田英二, 鉄永智紀, 山田和希, 佐藤嘉洋, 小浦卓, 服部高子, 桑原実穂, 滝川正春, 久保田聡, 尾崎敏文

日本整形外科学会雑誌 96 ( 8 ) S1583 - S1583 2022.9

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