Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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他院THA術後5年で鼠径部腫瘤を生じた1例

魚谷弘二, 岡田芳樹, 香川洋平, 尾崎敏文, 遠藤裕介, 藤原一夫

中国・四国整形外科学会雑誌 26 ( 1 ) 187 - 188 2014.4

Outcomes of pregabalin in lumbar-disease patients with depression Reviewed

Tomoko Tetsunaga, Tomonori Tetsunaga, Masato Tanaka, Yoshihisa Sugimoto, Tomoyuki Takigawa, Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC SCIENCE 19 ( 2 ) 229 - 234 2014.3

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER JAPAN KK

The anti-seizure drug pregabalin is currently used for peripheral neuropathic pain, including degenerative lumbar disease with a neuropathic component. Although there are many reports associated with pregabalin, treatment outcome in low back pain (LBP) patients with depression remains uncertain. This study investigated the outcomes of pregabalin in LBP patients with depression.
We assessed 64 patients (29 men and 35 women) using a Visual Analogue Scale, a Self-Rating Depression Scale (SDS) and the Oswestry Disability Index (ODI). Mean age was 63.3 years (range 20-81), and mean duration of disease was 69.8 months (range 3-576). The patients were divided into two groups according to SDS: normal (n = 37) and depressed group (n = 27).
Pregabalin significantly reduced both SDS and ODI in the depressed group (p < 0.05). Effect size was larger for both SDS and ODI in the depressed group than in the normal group. Pain was significantly relieved, even in the depressed group (p < 0.01). Pain reduction was achieved by the direct effect of pregabalin, as well as indirect effects attributed to change in depressive symptoms. Although both somnolence and dizziness were detected, the use of hypnotic agents was decreased in half of cases. Somnolence did not influence the analgesic effects of the drug or psychotic state.
This investigation indicated that pregabalin is safe and effective for reducing both LBP and mood disturbance in patients with depression.

DOI： 10.1007/s00776-013-0529-4

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A novel, visible light-induced, rapidly cross-linkable gelatin scaffold for osteochondral tissue engineering Reviewed

Tetsuro Mazaki, Yasuyuki Shiozaki, Kentaro Yamane, Aki Yoshida, Mariko Nakamura, Yasuhiro Yoshida, Di Zhou, Takashi Kitajima, Masato Tanaka, Yoshihiro Ito, Toshifumi Ozaki, Akihiro Matsukawa

SCIENTIFIC REPORTS 4 2014.3

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Osteochondral injuries remain difficult to repair. We developed a novel photo-cross-linkable furfurylamine-conjugated gelatin (gelatin-FA). Gelatin-FA was rapidly cross-linked by visible light with Rose Bengal, a light sensitizer, and was kept gelled for 3 weeks submerged in saline at 37 degrees C. When bone marrow-derived stromal cells (BMSCs) were suspended in gelatin-FA with 0.05% Rose Bengal, approximately 87% of the cells were viable in the hydrogel at 24 h after photo-cross-linking, and the chondrogenic differentiation of BMSCs was maintained for up to 3 weeks. BMP4 fusion protein with a collagen binding domain (CBD) was retained in the hydrogels at higher levels than unmodified BMP4. Gelatin-FA was subsequently employed as a scaffold for BMSCs and CBD-BMP4 in a rabbit osteochondral defect model. In both cases, the defect was repaired with articular cartilage-like tissue and regenerated subchondral bone. This novel, photo-cross-linkable gelatin appears to be a promising scaffold for the treatment of osteochondral injury.

DOI： 10.1038/srep04457

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大腿骨骨孔モデルを用いた前十字靱帯再建術における骨孔内での再建靱帯の偏位についての検討

藤井政孝, 佐々木祐介, 荒木大輔, Monica Rosen, Patrick Smolinski, 尾崎敏文, Fu Freddie

日本整形外科学会雑誌 88 ( 2 ) S278 - S278 2014.3

Kaplan extensile lateral approachを用いた尺骨鈎状突起骨折の手術的治療

今谷潤也, 森谷史朗, 前田和茂, 桐田亜希子, 林正典, 尾崎敏文, 秋田恵一

日本整形外科学会雑誌 88 ( 3 ) S779 - S779 2014.3

骨肉腫患者治療後の長期的問題点

武田健, 国定俊之, 長谷井嬢, 上原健敬, 大森敏規, 尾崎敏文

日本整形外科学会雑誌 88 ( 2 ) S131 - S131 2014.3

脛骨・腓骨の骨折高位の違いにより下腿骨幹部骨折は治療成績に差があるか

山川泰明, 野田知之, 上原健敬, 中原龍一, 木浪陽, 島村安則, 尾崎敏文

日本整形外科学会雑誌 88 ( 3 ) S655 - S655 2014.3

不安定型骨盤輪骨折に対するnavigation systemを利用したiliosacral screwの有用性

上原健敬, 木浪陽, 野田知之, 山川泰明, 井上円加, 中原龍一, 島村安則, 尾崎敏文

日本整形外科学会雑誌 88 ( 2 ) S410 - S410 2014.3

家兎骨軟骨欠損モデルにおける可視光硬化ゼラチンおよび結合性改変成長因子CBD-BMP4による組織修復効果

馬崎哲朗, 山根健太郎, 吉田晶, 松川昭博, 伊藤嘉浩, 尾崎敏文

中部日本整形外科災害外科学会雑誌 57 ( 春季学会 ) 124 - 124 2014.3

岡山大学病院における難治性慢性痛に対する集学的治療脱落症例の検討

鉄永倫子, 田中雅人, 杉本佳久, 荒瀧慎也, 瀧川朋亨, 尾崎敏文, 西江宏行, 石川慎一, 井上真一郎, 小田幸治, 太田晴之

日本整形外科学会雑誌 88 ( 3 ) S786 - S786 2014.3

思春期特発性側彎症(Lenke type 1、2)に対する後方矯正固定術後の肩バランスの変化

荒瀧慎也, 田中雅人, 杉本佳久, 瀧川朋亨, 鉄永倫子, 馬崎哲朗, 尾崎修平, 山根健太郎, 篠原健介, 魚谷弘二, 渡邉典行, 尾崎敏文

Journal of Spine Research 5 ( 3 ) 249 - 249 2014.3

思春期特発性側彎症における後方固定術前後の矢状面バランスと骨盤パラメーターの検討

魚谷弘二, 田中雅人, 杉本佳久, 荒瀧慎也, 瀧川朋亨, 鉄永倫子, 馬崎哲朗, 尾崎修平, 山根健太郎, 篠原健介, 尾崎敏文

日本整形外科学会雑誌 88 ( 3 ) S718 - S718 2014.3

In vitro and in vivo enhanced osteogenesis by kaempferol found by a high-throughput assay using human mesenchymal stromal cells Reviewed

Tetsuro Mazaki, Takashi Kitajima, Yasuyuki Shiozaki, Miwa Sato, Megumi Mino, Aki Yoshida, Mariko Nakamura, Yasuhiro Yoshida, Masato Tanaka, Toshifumi Ozaki, Akihiro Matsukawa, Yoshihiro Ito

JOURNAL OF FUNCTIONAL FOODS 6 241 - 247 2014.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

High-throughput screening was performed as a phenotypic screening on clinically relevant human mesenchymal stem cells to identify small molecules that affect stem cell fate. From a library of pharmacologically active small molecules, we identified kaempferol, which is a natural flavonol, with a high osteogenic activity. Kaempferol achieved the highest levels of bone-specific markers among the chemicals tested in vitro. The osteogenic activity of kaempferol was the same as that of ipriflavone, which is a synthetic isoflavone, in ovariectomized mouse experiments. Considering that kaempferol is present in various foods such as vegetables and fruits, it will be useful as a new preventive medicine for osteoporosis. (C) 2013 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jff.2013.10.013

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A 5-22-year follow-up study of stemmed alumina ceramic total elbow arthroplasties with cement fixation for patients with rheumatoid arthritis Reviewed

Keiichiro Nishida, Kenzo Hashizume, Yoshihisa Nasu, Makoto Kishimoto, Toshifumi Ozaki, Hajime Inoue

JOURNAL OF ORTHOPAEDIC SCIENCE 19 ( 1 ) 55 - 63 2014.1

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER JAPAN KK

We determined mid to long-term results of total elbow arthroplasty (TEA) by use of unlinked elbow prostheses with solid alumina ceramic trochleae, and ceramic ulnar stems (stemmed Kyocera type I; SKC-I) for patients with rheumatoid arthritis.
Fifty-four elbows of 39 patients were available for detailed clinical and radiographic review after a follow-up period of at least 5 years. The mean follow-up period was 12.6 years (range 5-22 years). Clinical condition before and after surgery was assessed by use of a modified version of the Mayo Elbow Performance Score (MEPS; 0-100 points) and a Japan Orthopaedic Association Elbow score (JOA score; 0-100 points). The radiographs were reviewed and loosening was defined as a progressive radiolucent line > 1 mm wide that was completely circumferential around the prosthesis. Clinical records of post-operative events affecting the elbows were used for survival analysis of the prostheses using the Kaplan-Meier method.
The average modified MEPS and JOA scores improved significantly from 39.7 +/- A 14.3 to 44.7 +/- A 9.4, respectively, pre-operatively, to 89.7 +/- A 15.4 and 83.1 +/- A 12.8, respectively, post-operatively (P < 0.0001). The functional assessment score also improved from 4.9 +/- A 2.8 to 8.5 +/- A 3.3 points (P < 0.0001). With loosening or implant revision defined as end points, the likelihood of survival of the prosthesis for up to 20 years was 92.6 % (95 % confidence interval (CI), 85.6-100.0) or 86.3 % (95 % CI 75.0-97.6), respectively.
Satisfactory clinical results were obtained after TEA using SKC-I prostheses, which provided excellent pain relief and functional range of motion. The results of our study reveal the high reliability over a long period of the cemented SKC-I prosthesis with an alumina ceramic component.

DOI： 10.1007/s00776-013-0492-0

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3Dナビゲーションを用いたIS screw固定術の経験

木浪陽, 野田知之, 上原健敬, 井上円加, 中原龍一, 尾崎敏文

骨折 36 ( 1 ) 61 - 63 2014.1

Language：Japanese Publisher：(一社)日本骨折治療学会

当院では、仙腸関節脱臼骨折および仙骨骨折に対しiliosacral(IS)screwを挿入する場合、3Dナビゲーションを使用しており、その安全性について検討した。2011年4月〜2012年12月の期間、IS screw手技を用いた5症例(男性2例、女性3例)・7本を対象とした。平均年齢は43歳であった。全例、術後1週以内にCTでスクリュー位置を調査した。セッティング時間を除いた挿入時間は1本につき平均20分であった。全例、脊柱管・神経管への迷入や前方骨皮質穿破はなく、スクリュー位置は良好であった。通常透視下でのIS screw挿入は、神経管への迷入や前方骨皮質穿破などの危険があり、安全性には限界がある。3DナビゲーションでのIS screw挿入は、被曝量を軽減しつつ、脊柱管・神経管を確認しながらスクリュー挿入方向と深度を決定でき、正確で安全性が高く有用であった。(著者抄録)

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Favorable outcome after complete resection in elderly soft tissue sarcoma patients: Japanese Musculoskeletal Oncology Group study Reviewed

Y. Yoneda, T. Kunisada, N. Naka, Y. Nishida, A. Kawai, T. Morii, K. Takeda, J. Hasei, Y. Yamakawa, T. Ozaki

EJSO 40 ( 1 ) 49 - 54 2014.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI LTD

Background: The surgical management of soft tissue sarcoma (STS) in elderly patients has only been addressed in a few studies. The objective of the current study was to assess surgical outcomes in patients with STS aged 70 years and older and the association of older age with the survival after complete resection.
Methods: A retrospective analysis was conducted in 158 elderly patients with localized STS who visited 11 institutions participating in Japanese Musculoskeletal Oncology Group between 1995 and 2006 and were treated by surgical resection. Univariate and multivariate analyses were performed to identify prognostic factors.
Results: Median follow-up period was 38 months. Histologically high-grade tumors were detected in 71% of the patients. Wide resection with adequate margins was performed in 66% of the cases. Systemic chemotherapy was performed in only 5 patients. Univariate analysis identified histological grade and gender as statistically significant prognostic factors for sarcoma-specific survival. Multivariate analysis did not identify significant prognostic factors for sarcoma-specific survival, although high grade sarcoma emerged as a potentially significant prognostic factor (P = 0.050). Local recurrence was detected in 19% of the patients. Multivariate analysis of local recurrence-free survival showed that tumor site and surgical margins were statistically significant prognostic factors.
Conclusions: Older age was not identified as a prognostic factor for sarcoma-specific survival, which is not consistent with the findings of previous studies showing that older age was associated with decreased sarcoma-specific survival. Complete resection should be indicated and can lead to optimal treatment outcome for properly selected elderly patients. (C) 2013 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.ejso.2013.09.004

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Outcome of Conservative Treatment for SRE (Skeletal Related Events) of the Spine

Nakata Eiji, Sugihara Shinsuke, Ozaki Toshifumi

The Journal of the Chugoku-Shikoku Orthopaedic Association 26 ( 2 ) 279 - 283 2014

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

We evaluated the outcome of conservative treatment for SRE (skeletal related events) of the spine. Fifty-eight patients (32 men and 26 women, mean age 68 years) were treated at our institution between August 2012 and September 2013. The site of the primary tumor was the lung in 20 patients, breast in 11, prostate in 9, and other sites in 18. Instability of the spine was evaluated using the Spine Instability Neoplastic Score (SINS). Early mobilization was performed based on the stability of the spine estimated by SINS. Pain (Numerical Rating Scale (NRS)), imaging studies of the vertebral body, SINS, and ADL (Barthel Index (BI)) were evaluated at the start and at 1, 2, 3, 4, 6 months. NRS improved over time and in the imaging studies, bone formation was gradually observed in almost all cases after three months. SINS improved over time and about 90% of the patients were considered stable after three months. Although mean BI was 71 initially, it gradually improved and at the time of the last observation the mean BI was 82. Our data suggest that early mobilisation is safe and efficient for selected patients who have received conservative treatment for SRE (skeletal related events) of the spine.

DOI： 10.11360/jcsoa.26.279

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Total Hip Arthroplasty Without Blood Transfusion in a Jehovah's Witness : A Case Report

Tanaka Takaaki, Okada Yoshiki, Ozaki Toshifumi, Fujiwara Kazuo, Endo Hirosuke, Nishida Keiichiro

The Journal of the Chugoku-Shikoku Orthopaedic Association 26 ( 2 ) 255 - 259 2014

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

Jehovah's Witnesses refuse blood transfusions on the basis of their religious belief. We report our experience with total hip arthroplasty without blood transfusion in a Jehovah's Witness.<br>The patient was a 70-year-old woman who had been receiving treatment for rheumatoid arthritis for 34 year and had been taking anti-platelet agents for atrial fibrillation and hypertension. Plain radiographs revealed severe erosions (Larsen Grade 4) in the right hip. We used a cemented femoral component and reamed the acetabulum gently to minimize any bleeding, while performing intraoperative blood-salvaging autotransfusion.<br>We carried out hybrid total hip arthroplasty with a cementless acetabular component and a cemented femoral component. The operation time was 62 minutes, intraoperative blood loss was 50ml, and postoperative blood loss was 90ml. The preoperative hemoglobin level was 9.9g/dl, and the lowest hemoglobin level was 6.8g/dl after surgery. At the final follow-up, the patient was able to walk with a T-shaped walking stick, and her Japanese Orthopaedics Association score (right/left) was 80 points/81 points on.<br>We considered that the use of a cemented femoral component and gentle reaming of the acetabulum were factors that reduced bleeding during total hip arthroplasty.

DOI： 10.11360/jcsoa.26.255

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Clinical Results of Total Shoulder Arthroplasty for Osteoarthritis and Rheumatoid Arthritis

KANAZAWA Tomoko

Japanese Journal of Joint Diseases 33 ( 4 ) 479 - 485 2014

Language：English Publisher：Japanese Society for Joint Diseases

Objective: To investigate the clinical and radiographic results of total shoulder arthroplasty (TSA) for damaged shoulder joints with osteoarthritis (OA) and rheumatoid arthritis (RA).Patients and Methods: From 1999 to 2012 inclusive, we performed 19 total shoulder arthroplasties in 17 patients. A total of sixteen shoulders, five with OA and 11 with RA, from 15 patients were followed up for more than six months. All patients were female, with an average age of 71 years, and an average follow-up period of three years. Preoperative magnetic resonance imaging showed that the supraspinatus tendon was intact in five shoulders (intact group), and torn or thin in 11 shoulders (damaged group), respectively. Clinical outcomes were assessed using the Japanese Orthopedic Association (JOA) score, Disabilities of the Arm, Shoulder and Hand (DASH) score and range of motion (ROM). Radiographic loosening of the humeral stem and glenoid component was evaluated according to the criteria described by Stewart.Results: The average JOA score improved from 39.9 points preoperatively to 80.3 points at the final follow-up. The average DASH score improved from 70.1 points to 56.0 points. The range of active flexion, abduction and external rotation significantly improved postoperatively. Radiolucent line evaluation around the glenoid component was observed in two shoulders. There was no significant difference in the improvement of the JOA score between the intact group and the damaged group. In both groups, pain relief was experienced postoperatively, but the improvement in ROM consisting of flexion, abduction and external rotation, was significantly greater in the intact group than in the damaged group. The postoperative JOA score showed a strong inverse correlation with the preoperative DASH score.Conclusion: The results of the current study showed satisfactory clinical outcomes of TSA for OA and RA, particularly with the treatment effect of good postoperative pain relief. Clinical outcome may depend on the preoperative status of the rotator cuff and the function of the upper extremity.

DOI： 10.11551/jsjd.33.479

CiNii Article

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Other Link： https://jlc.jst.go.jp/DN/JLC/20002300823?from=CiNii

MicroRNAs in Soft Tissue Sarcomas: Overview of the Accumulating Evidence and Importance as Novel Biomarkers Reviewed

Tomohiro Fujiwara, Toshiyuki Kunisada, Ken Takeda, Koji Uotani, Aki Yoshida, Takahiro Ochiya, Toshifumi Ozaki

BIOMED RESEARCH INTERNATIONAL 2014 592868 2014

Language：English Publisher：HINDAWI PUBLISHING CORPORATION

Sarcomas are distinctly heterogeneous tumors and a variety of subtypes have been described. Although several diagnostic explorations in the past three decades, such as identification of chromosomal translocation, have greatly improved the diagnosis of soft tissue sarcomas, the unsolved issues, including the limited useful biomarkers, remain. Emerging reports on miRNAs in soft tissue sarcomas have provided clues to solving these problems. Evidence of circulating miRNAs in patients with soft tissue sarcomas and healthy individuals has been accumulated and is accelerating their potential to develop into clinical applications. Moreover, miRNAs that function as novel prognostic factors have been identified, thereby facilitating their use in miRNA-targeted therapy. In this review, we provide an overview of the current knowledge on miRNA deregulation in soft tissue sarcomas, and discuss their potential as novel biomarkers and therapeutics.

DOI： 10.1155/2014/592868

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