Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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骨盤骨腫瘍

武田健, 上原健敬, 大森敏規, 原田遼三, 長谷井嬢, 吉田晶, 尾崎敏文, 国定俊之

中国・四国整形外科学会雑誌 25 ( 1 ) 239 - 239 2013.4

再発した手関節尺側部痛の1例

金澤智子, 島村安則, 大森敏規, 篠原健介, 原田遼三, 山川泰明, 小澤正嗣, 井上円加, 斉藤太一, 中原龍一, 野田知之, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 25 ( 1 ) 245 - 245 2013.4

Dupuytren拘縮の術後成績

斎藤太一, 島村安則, 井上円加, 小澤正嗣, 尾崎敏文

日本手外科学会雑誌 30 ( 1 ) 2 - 25 2013.4

橈骨遠位端骨折に対するMIPO法による治療成績

島村安則, 野田知之, 斉藤太一, 中原龍一, 尾崎敏文

日本手外科学会雑誌 30 ( 1 ) 1 - 6 2013.4

Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells Reviewed

Joe Hasei, Tsuyoshi Sasaki, Hiroshi Tazawa, Shuhei Osaki, Yasuaki Yamakawa, Toshiyuki Kunisada, Aki Yoshida, Yuuri Hashimoto, Teppei Onishi, Futoshi Uno, Shunsuke Kagawa, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara

MOLECULAR CANCER THERAPEUTICS 12 ( 3 ) 314 - 325 2013.3

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER ASSOC CANCER RESEARCH

Tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. p53 overexpression enhances the antitumor activity of oncolytic adenoviruses; however, the molecular mechanism of this occurrence remains unclear. We previously developed a tumor-specific replication-competent oncolytic adenovirus, OBP-301, that kills human osteosarcoma cells, but some human osteosarcoma cells were OBP-301-resistant. In this study, we investigated the antitumor activity of a p53-expressing oncolytic adenovirus, OBP-702, and the molecular mechanism of the p53-mediated cell death pathway in OBP-301-resistant human osteosarcoma cells. The cytopathic activity of OBP-702 was examined in OBP-301-sensitive (U2OS and HOS) and OBP-301-resistant (SaOS-2 and MNNG/HOS) human osteosarcoma cells. The molecular mechanism in the OBP-702-mediated induction of two cell death pathways, apoptosis and autophagy, was investigated in OBP-301-resistant osteosarcoma cells. The antitumor effect of OBP-702 was further assessed using an orthotopic OBP-301-resistant MNNG/HOS osteosarcoma xenograft tumor model. OBP-702 suppressed the viability of OBP-301-sensitive and -resistant osteosarcoma cells more efficiently than OBP-301 or a replication-deficient p53-expressing adenovirus (Ad-p53). OBP-702 induced more profound apoptosis and autophagy when compared with OBP-301 or Ad-p53. E1A-mediated miR-93/106b upregulation induced p21 suppression, leading to p53-mediated apoptosis and autophagy in OBP-702-infected cells. p53 overexpression enhanced adenovirus-mediated autophagy through activation of damage-regulated autophagy modulator (DRAM). Moreover, OBP-702 suppressed tumor growth in an orthotopic OBP-301-resistant MNNG/HOS xenograft tumor model. These results suggest that OBP-702-mediated p53 transactivation is a promising antitumor strategy to induce dual apoptotic and autophagic cell death pathways via regulation of miRNA and DRAM in human osteosarcoma cells. Mol Cancer Ther; 12(3); 314-25. (C)2012 AACR.

DOI： 10.1158/1535-7163.MCT-12-0869

Web of Science

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[A case of synovial sarcoma with brain metastasis treated with surgical resection and stereotactic radiosurgery]. Reviewed

Otani Y, Ichikawa T, Kurozumi K, Yanai H, Kunisada T, Ozaki T, Date I

No shinkei geka. Neurological surgery 41 ( 3 ) 255 - 262 2013.3

Language：Japanese Publishing type：Research paper (scientific journal)

Synovial sarcomas compromise between 5 to 10% of all soft tissue sarcomas in adults. Synovial sarcoma commonly occurs in the vicinity of the large joints and cranial metastasis is rare. Here, we describe a case with intracranial metastases of a synovial sarcoma. A 41-year-old woman was admitted to our department with sensory aphasia. She had a history of a left inguinal synovial sarcoma and underwent surgery and chemotherapy for primary and metastatic lesions. Head MRI revealed three gadolinium-enhancing lesions in the left frontal, parietal and parietotemporal lobe. Gross total resection was achieved in the left parietotemporal lesion and pathological diagnosis was synovial sarcoma. Two weeks after surgery, she received cyber-knife radiosurgery and her neurological deficit was almost completely resolved. Intracranial metastatic synovial sarcoma is rare. Surgical resection and stereotaxic radiosurgery was very effective in the present case.

PubMed

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[Update on microRNAs research in sarcoma: review the literature and proposal of the clinical application].

Tomohiro Fujiwara, Akira Kawai, N Kosaka, Toshifumi Ozaki, Takahiro Ochiya

Gan to kagaku ryoho. Cancer & chemotherapy 40 ( 3 ) 305 - 13 2013.3