Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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トラブルから学ぶ骨折治療トラブルから学ぶ骨盤・寛骨臼骨折治療

野田知之, 上原健敬, 山川泰明, 島村安則, 尾崎敏文, 木浪陽

骨折 36 ( Suppl. ) S32 - S32 2014.6

ICU管理における小児四肢骨幹部骨折に対するelastic nailingの有用性

木浪陽, 野田知之, 杉生和久, 山川泰明, 上原健敬, 井上円加, 中原龍一, 雑賀建多, 島村安則, 尾崎敏文

骨折 36 ( Suppl. ) S467 - S467 2014.6

足関節開放脱臼骨折に対してVAF flapを用いて治療した2例

堀田昌宏, 雑賀建多, 野田知之, 井上円加, 中原龍一, 島村安則, 尾崎敏文, 木浪陽, 斎藤太一

骨折 36 ( Suppl. ) S432 - S432 2014.6

骨肉腫におけるribophorin II(RPN2)の機能解析

藤原智洋, 根津悠, 川井章, 武田健, 国定俊之, 尾崎敏文, 落谷孝広

日本整形外科学会雑誌 88 ( 6 ) S1172 - S1172 2014.6

がん治療の個別化における形成外科の役割、期待と現状骨軟部悪性腫瘍の治療診断・切除・再建

尾崎敏文, 国定俊之, 武田健, 藤原智洋, 長谷川健二郎, 木股敬裕

日本癌治療学会誌 49 ( 3 ) 678 - 678 2014.6

Phase II study of eribulin mesylate in patients (pts) with advanced soft tissue sarcoma (STS). Reviewed

Yoichi Naito, Akira Kawai, Nobuhito Araki, Toshifumi Ozaki, Hideshi Sugiura, Yasuo Yazawa, Hideo Morioka, Akihiko Matsumine, Masahide Hiraiwa, Shun Asami, Kazuo Isu

JOURNAL OF CLINICAL ONCOLOGY 32 ( 15 ) 2014.5

Prognostic factors for high-grade soft tissue sarcomas (STS) in the extremities treated by perioperative chemotherapy with ifosfamide (IFO) and doxorubicin hydrochloride (ADM): Using the data from Japan Clinical Oncology Group trial (JCOG0304). Reviewed

Kazuhiro Tanaka, Tadashi Hasegawa, Junki Mizusawa, Nobuhito Araki, Hirokazu Chuuman, Mitsuru Takahashi, Toshifumi Ozaki, Toru Hiruma, Hiroyuki Tsuchiya, Hideo Morioka, Hiroshi Hatano, Takuro Wada, Masami Hosaka, Yukihiro Yoshida, Junya Toguchida, Satoshi Abe, Akihiko Matsumine, Koichiro Yokoyama, Haruhiko Fukuda, Yukihide Iwamoto

JOURNAL OF CLINICAL ONCOLOGY 32 ( 15 ) 2014.5

人工筋肉を用いた手指痙縮に対するアプローチ

馬崎哲朗, 千田益生, 堅山佳美, 上原健敬, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 51 ( Suppl. ) S347 - S347 2014.5

家兎骨軟骨欠損モデルにおける可視光硬化ゼラチンおよび骨髄間質細胞の組織修復効果

馬崎哲朗, 塩崎泰之, 山根健太郎, 吉田晶, 松川昭博, 中村真理子, 吉田靖弘, 北嶋隆, 伊藤嘉浩, 尾崎敏文

移植 49 ( 1 ) 178 - 178 2014.5

ROCK inhibition enhances aggrecan deposition and suppresses matrix metalloproteinase-3 production in human articular chondrocytes Reviewed

Takayuki Furumatsu, Emi Matsumoto-Ogawa, Takaaki Tanaka, Zhichao Lu, Toshifumi Ozaki

CONNECTIVE TISSUE RESEARCH 55 ( 2 ) 89 - 95 2014.4

Language：English Publishing type：Research paper (scientific journal) Publisher：INFORMA HEALTHCARE

Homeostasis of articular cartilage is maintained by a balance between catabolism and anabolism. Matrix metalloproteinase-3 (MMP-3) catabolism of cartilaginous extracellular matrix (ECM), including aggrecan (AGN), is an important factor in osteoarthritis progression. We previously reported that inhibition of Rho-associated coiled-coil forming kinase (ROCK), an effector of Rho family GTPases, activates the chondrogenic transcription factor SRY-type high-mobility-group box (SOX) 9 and prevents dedifferentiation of monolayer-cultured chondrocytes. We hypothesized that ROCK inhibition prevents chondrocyte dedifferentiation by altering the transcriptional balance between MMP-3 and AGN. Normal human articular chondrocytes were cultured in the presence or absence of ROCK inhibitor (ROCKi, Y-27632). Expression of MMP-3 and AGN during monolayer cultivation was assessed by quantitative real-time PCR and western blot analysis. Chondrogenic redifferentiation potential of ROCKi-treated chondrocytes was evaluated by immunohistological analysis of pellet cultures. ROCKi treatment suppressed MMP-3 expression in monolayer-and pellet-cultured chondrocytes but increased AGN expression. Chromatin immunoprecipitation revealed that the association between transcription factors E26 transformation specific (ETS)-1 and SOX9 and their target genes MMP-3 and AGN, respectively, was affected by ROCKi treatment. ROCKi decreased the association between ETS-1 and its binding sites on the MMP-3 promoter, whereas ROCKi promoted the interaction between SOX9 and the AGN promoter. Our results suggest that ROCK inhibition may have an important role in modulating the balance between degradation and synthesis of cartilaginous ECM, a finding that may facilitate development of techniques to prepare differentiated chondrocytes for cartilage regeneration therapy.

DOI： 10.3109/03008207.2013.852544

Web of Science

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Clinical Relevance and Therapeutic Significance of MicroRNA-133a Expression Profiles and Functions in Malignant Osteosarcoma-Initiating Cells Reviewed

Tomohiro Fujiwara, Takeshi Katsuda, Keitaro Hagiwara, Nobuyoshi Kosaka, Yusuke Yoshioka, Ryou-U Takahashi, Fumitaka Takeshita, Daisuke Kubota, Tadashi Kondo, Hitoshi Ichikawa, Akihiko Yoshida, Eisuke Kobayashi, Akira Kawai, Toshifumi Ozaki, Takahiro Ochiya

STEM CELLS 32 ( 4 ) 959 - 973 2014.4

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Novel strategies against treatment-resistant tumor cells remain a challenging but promising therapeutic approach. Despite accumulated evidence suggesting the presence of highly malignant cell populations within tumors, the unsolved issues such as in vivo targeting and clinical relevance remain. Here, we report a preclinical trial based on the identified molecular mechanisms underlying osteosarcoma-initiating cells and their clinical relevance. We identified key microRNAs (miRNAs) that were deregulated in a highly malignant CD133(high) population and found that miR-133a regulated the cell invasion that characterizes a lethal tumor phenotype. Silencing of miR-133a with locked nucleic acid (LNA) reduced cell invasion of this cell population, and systemic administration of LNA along with chemotherapy suppressed lung metastasis and prolonged the survival of osteosarcoma-bearing mice. Furthermore, in a clinical study, high expression levels of CD133 and miR-133a were significantly correlated with poor prognosis, whereas high expression levels of the four miR-133a target genes were correlated with good prognosis. Overall, silencing of miR-133a with concurrent chemotherapy would represent a novel strategy that targets multiple regulatory pathways associated with metastasis of the malignant cell population within osteosarcoma. Stem Cells 2014;32:959-973

DOI： 10.1002/stem.1618

Web of Science

PubMed

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内果骨折を合併したアキレス腱断裂(アキレス腱付着部踵骨裂離骨折)の治療経験

山川泰明, 野田知之, 上原健敬, 井上円加, 斎藤太一, 金澤智子, 長谷井嬢, 中原龍一, 島村安則, 尾崎敏文, 木浪陽, 遠藤裕介

中国・四国整形外科学会雑誌 26 ( 1 ) 162 - 163 2014.4

耕耘機による両下肢開放骨折の一例

上原健敬, 山川泰明, 井上円加, 金澤智子, 斉藤太一, 中原龍一, 島村安則, 野田知之, 尾崎敏文, 木浪陽

中国・四国整形外科学会雑誌 26 ( 1 ) 162 - 162 2014.4

大腿骨遠位骨幹部骨折偽関節(infraisthmal fracture nonunion)の治療経験

山川泰明, 野田知之, 井上円加, 金澤智子, 長谷井嬢, 斎藤太一, 中原龍一, 島村安則, 尾崎敏文

中国・四国整形外科学会雑誌 26 ( 1 ) 155 - 155 2014.4

前方小皮切slipped planting法による上腕骨骨幹部骨折の治療経験

金澤智子, 島村安則, 中原龍一, 斉藤太一, 小澤正嗣, 山川泰明, 原田遼三, 中道亮, 井上円加, 木浪陽, 野田知之, 尾崎敏文

中国・四国整形外科学会雑誌 26 ( 1 ) 154 - 154 2014.4

前方プレートによる手術を行った鎖骨遠位端骨折の治療経験

島村好信, 島村安則, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 井上円加, 野田知之, 尾崎敏文

中国・四国整形外科学会雑誌 26 ( 1 ) 150 - 150 2014.4

橈骨遠位部骨折に対するMIPO法による治療成績

島村安則, 野田知之, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 井上円加, 尾崎敏文, 西田圭一郎

中国・四国整形外科学会雑誌 26 ( 1 ) 149 - 149 2014.4

タクロリムス使用下の整形外科手術

町田崇博, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 原田遼三, 尾崎敏文, 那須義久

岡山医学会雑誌 126 ( 1 ) 76 - 77 2014.4

岡山大学病院における難治性慢性痛に対する新しい試み痛みリエゾン外来

鉄永倫子, 田中雅人, 尾崎敏文, 西江宏行, 石川慎一, 溝渕知司, 井上真一郎, 小田幸治, 流王雄太, 宮脇卓也, 太田晴之

中国・四国整形外科学会雑誌 26 ( 1 ) 23 - 29 2014.4

Language：Japanese Publisher：中国・四国整形外科学会

当院では平成24年4月から痛みリエゾン外来(難治性慢性痛に対する多角的集学的外来)を開設した。その概要を紹介し、これまでに診療した32例の短期成績を報告した。32例の内訳は腰痛11例、下肢痛5例、頸部痛5例、全身痛5例、足底部痛2例、前胸部痛2例、腋窩部痛1例、背部痛1例で、成績の評価指標は「Pain Disability Assessment Scale(PDAS)」「Pain Catastrophizing Scale(PCS)」「Hospital Anxiety Depression Scale(HADS)」「日本整形外科学会腰痛疾患質問票(JOABPEQ)」「日本整形外科学会頸部脊髄症評価質問票(JOACMEQ)」とした。PDASの得点は、初診時平均29.7±13.5点、1ヵ月後25.6±12.9点、3ヵ月後25.3±12.8点であり、有意な改善は認められなかった。PCSは初診時39.7±8.1点、1ヵ月後33.7±9.0点、3ヵ月後34.7±9.9点であり、有意な改善が認められた。HADSの抑うつスコアは初診時11.2±4.7点、1ヵ月後9.8±5.5点、3ヵ月後12.0±4.5点で有意な改善は認められず、不安スコアは初診時11.6±5.7点、1ヵ月後9.2±5.1点、3ヵ月後8.6±4.9点で有意な改善が認められた。JOABPEQは初診時46.3±35.1点、1ヵ月後37.5±28.5点、3ヵ月後35.5±28.5点で有意な改善が認められた。JOACMEQは全ての項目において有意な改善は認められなかった。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J02438&link_issn=&doc_id=20140626110004&doc_link_id=%2Fcm4ortho%2F2014%2F002601%2F004%2F0023-0029%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcm4ortho%2F2014%2F002601%2F004%2F0023-0029%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

IBGによる大腿骨再建を行ったTHA再置換術の1例

遠藤裕介, 藤原一夫, 三宅由晃, 岡田芳樹, 中道亮, 尾崎敏文

中国・四国整形外科学会雑誌 26 ( 1 ) 182 - 182 2014.4

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