Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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RNA干渉による原発性および転移性骨腫瘍の制御

藤原智洋, 竹下文隆, 川井章, 尾崎敏文, 落谷孝広

日本骨代謝学会学術集会プログラム抄録集 30回 146 - 146 2012.7

岡山大学病院における、初期研修医アンケートの結果

小比賀美香子, 片岡仁美, 渡辺文恵, 三好智子, 金澤右, 尾崎敏文

医学教育 43 ( Suppl. ) 171 - 171 2012.7

Early Rehabilitation with Weight-bearing Standing-shaking-board Exercise in Combination with Electrical Muscle Stimulation after Anterior Cruciate Ligament Reconstruction Reviewed

Kingo Takahashi, Masamichi Hayashi, Toshihiro Fujii, Kenji Kawamura, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 66 ( 3 ) 231 - 237 2012.6

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

The objective of early rehabilitation after anterior cruciate ligament (ACL) reconstruction is to increase the muscle strength of the lower extremities. Closed kinetic chain (CRC) exercise induces co-contraction of the agonist and antagonist muscles. The purpose of this study was to compare the postoperative muscle strength/mass of subjects who performed our new CKC exercise (new rehabilitation group: group N) from week 4, and subjects who received traditional rehabilitation alone (traditional rehabilitation group: group T). The subjects stood on the device and maintained balance. Then, low-frequency stimulation waves were applied to 2 points each in the anterior and posterior region of the injured thigh 3 times a week for 3 months. Measurement of muscle strength was performed 4 times (before the start, and then once a month). Muscle mass was evaluated in CT images of the extensor and flexor muscles of 10 knees (10 subjects) in each group. The injured legs of group N showed significant improvement after one month compared to group T. The cross-sectional area of the extensor muscles of the injured legs tended to a show a greater increase at 3 months in group N. This rehabilitation method makes it possible to contract fast-twitch muscles, which may be a useful for improving extensor muscle strength after ACL reconstruction.

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Statistical Analysis of Prognostic Factors for Survival in Patients with Spinal Metastasis Reviewed

Masaki Kataoka, Toshiyuki Kunisada, Masato Tanaka, Ken Takeda, Satoru Itani, Yoshihisa Sugimoto, Haruo Misawa, Masuo Senda, Shinnosuke Nakahara, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 66 ( 3 ) 213 - 219 2012.6

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

There are a variety of treatment options for patients with spinal metastasis, and predicting prognosis is essential for selecting the proper treatment. The purpose of the present study was to identify the significant prognostic factors for the survival of patients with spinal metastasis. We retrospectively reviewed 143 patients with spinal metastasis. The median age was 61 years. Eleven factors reported previously were analyzed using the Cox proportional hazards model: gender, age, performance status, neurological deficits, pain, type of primary tumor, metastasis to major organs, previous chemotherapy, disease-free interval before spinal metastasis, multiple spinal metastases, and extra-spinal bone metastasis. The average survival of study patients after the first visit to our clinic was 22 months. Multivariate survival analysis demonstrated that type of primary tumor (hazard ratio [HR] = 6.80, p < 0.001), metastasis to major organs (HR = 2.01, p = 0.005), disease-free interval before spinal metastasis (HR = 1.77, p = 0.028), and extra-spinal bone metastasis (HR = 1.75, p = 0.017) were significant prognostic factors. Type of primary tumor was the most powerful prognostic factor. Other prognostic factors may differ among the types of primary tumor and may also be closely associated with primary disease activity. Further analysis of factors predicting prognosis should be conducted with respect to each type of primary tumor to help accurately predict prognosis.

DOI： 10.18926/AMO/48560

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Modified posterolateral approachによる脛骨近位部関節内骨折の治療経験

金澤智子, 野田知之, 島村安則, 木浪陽, 中原龍一, 斉藤太一, 井上円加, 小澤正嗣, 山川泰明, 皆川寛, 尾崎敏文

骨折 34 ( Suppl. ) S293 - S293 2012.6

鎖骨骨幹部骨折に対するMIPO法による治療成績(第2報)

島村安則, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 井上円加, 山川泰明, 原田遼三, 中道亮, 島村好信, 国定俊之, 野田知之, 尾崎敏文

骨折 34 ( Suppl. ) S120 - S120 2012.6

開放性骨盤骨折の治療経験

斎藤太一, 野田知之, 島村安則, 木浪陽, 皆川寛, 中原龍一, 小澤正嗣, 井上円加, 金澤智子, 山川泰明, 尾崎敏文

骨折 34 ( Suppl. ) S106 - S106 2012.6

同側骨幹部骨折を伴った脛骨高原陥没骨折に対する外側MIPO法の治療経験

木浪陽, 野田知之, 島村安則, 中原龍一, 斎藤太一, 金澤智子, 井上円加, 山川泰明, 山名圭哉, 臼井正明, 尾崎敏文

骨折 34 ( Suppl. ) S144 - S144 2012.6

CTを使用した脛骨近位端の外側プレート設置に関する三次元的解剖

山川泰明, 中原龍一, 井上円加, 小澤正嗣, 金澤智子, 斎藤太一, 木浪陽, 島村安則, 野田知之, 尾崎敏文

骨折 34 ( Suppl. ) S143 - S143 2012.6

後内側剪断骨片を有する脛骨近位部関節内骨折に対する固定方法の検討

小澤正嗣, 野田知之, 山川泰明, 金澤智子, 長谷井嬢, 齋藤太一, 中原龍一, 木浪陽, 島村安則, 国定俊之, 尾崎敏文

骨折 34 ( Suppl. ) S170 - S170 2012.6

関節内骨折の克服治療成績の向上を目指して関節内骨折の克服治療成績の向上を目指して足関節内骨折

野田知之, 島村安則, 中原龍一, 齋藤太一, 金澤智子, 長谷井嬢, 井上円加, 山川泰明, 国定俊之, 尾崎敏文, 木浪陽

骨折 34 ( Suppl. ) S9 - S9 2012.6

RNA干渉による骨肉腫の幹細胞性の制御

藤原智洋, 小坂展慶, 吉岡祐亮, 高橋陵宇, 竹下文隆, 窪田大介, 川井章, 尾崎敏文, 落谷孝広

日本整形外科学会雑誌 86 ( 6 ) S837 - S837 2012.6

鎖骨骨折後に遅発性腕神経叢麻痺を合併した一例

中道亮, 木浪陽, 杉生和久, 野田知之, 山名圭哉, 臼井正明, 尾崎敏文

骨折 34 ( Suppl. ) S146 - S146 2012.6

A multidisciplinary treatment comprising standard chemotherapy with vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide for Ewing sarcoma family of tumor (ESFT) in Japan: Results of the first Japan Ewing Sarcoma Study (JESS) 04.

Atsushi Makimoto, Motoaki Chin, Minako Sumi, Ryohei Yokoyama, Tsuyoshi Ishida, Hajime Okita, Akinobu Matsuzaki, Atsushi Kikuta, Hiroyoshi Watanabe, Toshifumi Ozaki, Kazuo Isu, Michihiro Yano, Masahito Hatori, Masahito Tsurusawa, Hideaki Ohta, Yoshifumi Kawano, Takeshi Ishii, Hiroshi Kawamoto, Satoshi Morita, Hideo Mugishima

JOURNAL OF CLINICAL ONCOLOGY 30 ( 15 ) 2012.5

多発外傷に伴うfloating shoulderの1例

金澤智子, 島村安則, 野田知之, 西山武, 斎藤太一, 尾崎敏文

骨折 34 ( 2 ) 272 - 274 2012.5

Language：Japanese Publisher：(一社)日本骨折治療学会

【目的】両側floating shoulderは極めて稀であるが、その治療経験を報告する。【症例】49歳、男性。バイク走行中に転倒し、受傷。初療時の単純X線写真、CTで両鎖骨骨折、肩甲骨骨折(右:頸部骨折、左:関節窩骨折、肩峰骨折)を合併したfloating shoulderと診断された。他に第7頸椎椎弓骨折、胸椎破裂骨折、右橈骨尺骨骨幹部開放骨折、右脛骨近位端骨折を合併していた。【手術】全身麻酔下に両側鎖骨に対しプレート固定を行った後に左肩甲骨はスクリューとワイヤーで固定。右側は保存加療とした。【考察】Floating shoulderは高エネルギー外傷によるものが多く、保存療法を選択せざるを得ない症例も多数存在し、良好な治療成績が得にくい。しかし特に今回の症例のように関節窩の転位を伴うような骨折の場合は、患者の状態の許す限り積極的な観血的治療を行い、より良好な機能回復を目指すべきであると考える。(著者抄録)

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RA生物学的製剤治療の最前線寛解を目指して生物製剤の登場による手術療法の動向と適応の変化について

西田圭一郎, 中原龍一, 橋詰謙三, 斎藤太一, 金澤智子, 小澤正嗣, 那須義久, 尾崎敏文

日本整形外科学会雑誌 86 ( 5 ) 394 - 400 2012.5

3D-CADシステムを用いた鎖骨の三次元形状比較

中原龍一, 野田知之, 島村安則, 橋詰謙三, 西田圭一郎, 尾崎敏文

骨折 34 ( 2 ) 265 - 268 2012.5

Language：Japanese Publisher：(一社)日本骨折治療学会

【目的】当院では骨折症例に対してCT画像をもとに健側鏡像の立体模型か実寸大の左右反転図を作成し、プレベンディングを行っている。この方法は骨の左右差が少ないことを前提としているが、どの程度骨の左右差があるかは不明であった。そこでCADソフトを用いてCT画像を三次元的に比較するシステムを構築し、プレベンディング法を最も利用している鎖骨を対象に左右差を検討した。【方法と対象】解剖実習で摘出した屍体の左右の鎖骨16対をCTで撮影し、CADソフトを用いて三次元的な左右差を検討した。【結果】骨幹部のカーブ形状に左右差は少なかったが、径の左右差は認められた。【考察】径の左右差はあるがカーブ形状に左右差はなかったため、鎖骨に関してプレベンディングは有用であると考えられた。(著者抄録)

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CTを併用した脛骨遠位部関節内骨折の転位様式に関するX線学的検討

岡田芳樹, 野田知之, 金澤智子, 齋藤太一, 中原龍一, 島村安則, 尾崎敏文, 寺田忠司

骨折 34 ( 2 ) 367 - 370 2012.5

Language：Japanese Publisher：(一社)日本骨折治療学会

脛骨遠位部骨折、とりわけpilon骨折は関節内骨折の中でも治療に難渋し未解決の多い骨折である。今回我々が経験したpilon骨折を単純X線とCTにて評価し、その特徴につき検討した。症例は66例で、17〜89歳(平均55歳)である。AO分類でB1が6例、B2が5例、B3が9例、C1が8例、C2が10例、C3が21例であった。腓骨骨折の形態分類が内反変形22例、外反変形25例、intact 12例であった。腓骨骨折が外反変形・intactでは、内反変形よりCTによる評価でcoronal family fracturesのY-type、V-typeに分類されるものが多くみられた。本研究により、単純X線写真と関節面の骨折型、および腓骨骨折の有無が骨折の重傷度を評価する一助となり、今後の手術治療アプローチ選択、固定法選択に有用である可能性が示唆された。(著者抄録)

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ROCK inhibitor prevents the dedifferentiation of human articular chondrocytes Reviewed

Emi Matsumoto, Takayuki Furumatsu, Tomoko Kanazawa, Masanori Tamura, Toshifumi Ozaki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 420 ( 1 ) 124 - 129 2012.3

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE

Chondrocytes lose their chondrocytic phenotypes in vitro. The Rho family GTPase ROCK, involved in organizing the actin cytoskeleton, modulates the differentiation status of chondrocytic cells. However, the optimum method to prepare a large number of un-dedifferentiated chondrocytes is still unclear. In this study, we investigated the effect of ROCK inhibitor (ROCKi) on the chondrogenic property of monolayer-cultured articular chondrocytes. Human articular chondrocytes were subcultured in the presence or absence of ROCKi (Y-27632). The expression of chondrocytic marker genes such as SOX9 and COL2A1 was assessed by quantitative real-time PCR analysis. Cellular morphology and viability were evaluated. Chondrogenic redifferentiation potential was examined by a pellet culture procedure. The expression level of SOX9 and COL2A1 was higher in ROCKi-treated chondrocytes than in untreated cells. Chondrocyte morphology varied from a spreading form to a round shape in a ROCKi-dependent manner. In addition, ROCKi treatment stimulated the proliferation of chondrocytes. The deposition of safranin O-stained proteoglycans and type II collagen was highly detected in chondrogenic pellets derived from ROCKi-pretreated chondrocytes. Our results suggest that ROCKi prevents the dedifferentiation of monolayer-cultured chondrocytes, and may be a useful reagent to maintain chondrocytic phenotypes in vitro for chondrocyte-based regeneration therapy. (C) 2012 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.bbrc.2012.02.127

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Mechanical stretch enhances COL2A1 expression on chromatin by inducing SOX9 nuclear translocalization in inner meniscus cells. Reviewed International journal

Tomoko Kanazawa, Takayuki Furumatsu, Motomi Hachioji, Toshitaka Oohashi, Yoshifumi Ninomiya, Toshifumi Ozaki

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 30 ( 3 ) 468 - 74 2012.3

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

The meniscus plays an important role in controlling the biomechanics of the knee. However, the mechanical stress-related response in meniscus cells remains unclear. We investigated mechanical stretch-regulated gene expression in human meniscus cells. Human inner and outer meniscus cells were prepared from the inner and outer halves of the lateral meniscus. The gene expressions of Sry-type HMG box (SOX) 9 and α1(II) collagen (COL2A1) were assessed by real-time PCR analyses after cyclic tensile strain (CTS) treatment (0.5 Hz, 5% stretch). The localization and phosphorylation of SOX9 were evaluated by immunohistochemical and Western blot (WB) analyses. Chromatin immunoprecipitation (IP) analysis was performed to assess the stretch-related protein-DNA complex formation between SOX9 and the COL2A1 enhancer on chromatin. Type II collagen deposition and SOX9 production were detected only in inner menisci. CTS treatments increased expression of the COL2A1 and SOX9 genes in inner meniscus cells, but not in outer meniscus cells. In addition, CTS treatments stimulated nuclear translocalization and phosphorylation of SOX9 in inner meniscus cells. Chromatin IP analyses revealed that CTS increased the association between SOX9 and its DNA-binding site, included in the COL2A1 enhancer, on chromatin. Our results indicate that inner and outer meniscus cells have different properties in mechanical stretch-induced COL2A1 expression. In inner meniscus cells, mechanical stretch may have an essential role in the epigenetic regulation of COL2A1 expression.

DOI： 10.1002/jor.21528

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Papers - OZAKI Toshifumi