Faculty Profiles - OZAKI Toshifumi

Papers - OZAKI Toshifumi

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Letter regarding "Clinical outcomes and trans-syndesmotic screw frequency after posterior malleolar fracture osteosynthesis". International journal

Norio Yamamoto, Yosuke Tomita, Tomoyuki Noda, Kohei Iwamoto, Toshifumi Ozaki

Injury 52 ( 8 ) 2479 - 2480 2021.8

Two simple stitches for medial meniscus posterior root repair prevents the progression of meniscal extrusion and reduces intrameniscal signal intensity better than modified Mason-Allen sutures. International journal

Yuki Okazaki, Takayuki Furumatsu, Takaaki Hiranaka, Yuya Kodama, Yusuke Kamatsuki, Keisuke Kintaka, Toshifumi Ozaki

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 31 ( 6 ) 1005 - 1013 2021.8

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Medial meniscus posterior root tears (MMPRTs) can cause severe medial extrusion of the medial meniscus (MMME) and the progression of knee degenerative changes, inducing a high signal intensity of the meniscus on magnetic resonance imaging (MRI). Although MMME and intrameniscal signal intensity (IMSI) reportedly decreased within 3 months after MMPRT repair, no previous studies have reported these changes after a 1-year follow-up. This study aimed to investigate the 1-year postoperative changes in MMME and IMSI on MRI after using different suture techniques. METHODS: Overall, 33 patients with MMPRT were evaluated, 22 underwent FasT-Fix-dependent modified Mason-Allen suture (F-MMA) repair, and 11 underwent two simple stitches (TSS) repair. MRI examinations were performed preoperatively and 1 year postoperatively. MMME and IMSI were determined using MRI. RESULTS: A significant decrease in postoperative MMME was observed in the TSS group (4.1 ± 1.0) relative to that in the F-MMA group (5.1 ± 1.4, P = 0.03). A significant decrease in postoperative IMSI (0.75 ± 0.14) was observed relative to preoperative IMSI in the TSS group (P < 0.01), whereas postoperative IMSI (0.94 ± 0.25) was similar to preoperative IMSI in the F-MMA group (P = 0.06). Furthermore, a significant decrease in postoperative IMSI was observed in the TSS group relative to that in the F-MMA group (P < 0.01). CONCLUSIONS: The most important finding of this study is that TSS repair yielded a greater decrease in MMME and IMSI than F-MMA repair in patients with MMPRT. These results suggest that TSS repair is more useful for restoring loading stress to the posterior horn of the medial meniscus.

DOI： 10.1007/s00590-020-02830-z

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Assessment of the concordance rate between intraoperative pathological diagnosis and the final pathological diagnosis of spinal cord tumors

Muraoka S, Yamane K, Misawa H, Takigawa T, Tetsunaga T, Oda Y, Nakanishi K, Ozaki T, Tanaka T

Acta Med Okayama 75 ( 4 ) 455 - 460 2021.8

Language：English Publishing type：Research paper (scientific journal)

The intraoperative pathological diagnosis (IPD) plays an important role in determining the optimal surgical treatment for spinal cord tumors. The final pathological diagnosis (FPD) is sometimes different from the IPD. Here, we sought to identify the accuracy of the IPD of spinal cord tumors compared to the FPD. We retrospec-tively analyzed the cases of 108 patients with spinal cord tumors treated surgically in our institute; the IPD, FPD, mismatched cases, and concordance rate between the IPD and FPD were investigated. Five cases involved a mismatch between the IPD and FPD. The overall concordance rate was 95.4%, with 90.9% for extra-dural lesions, 98.5% for intradural extramedullary lesions, 84.2% for intramedullary lesions, and 100% for dumbbell-type tumors. The concordance rate of intramedullary lesions tended to be lower than that of other lesions (p = 0.096). A lower concordance rate was revealed for intramedullary lesions compared to the other lesions. Despite the IPD clearly remaining a valuable tool during operative procedures, surgeons should recog-nize the limitations of IPDs and make comprehensive decisions about surgical treatments.

DOI： 10.18926/AMO/62397

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Medial meniscus posterior root repair using a modified Mason-Allen suture can prevent the progression of cartilage degeneration on the loading surface of the medial compartment: a second-look arthroscopic evaluation

Takihira S, Furumatsu T, Okazaki Yuki, Hiranaka T, Kintaka K, Kodama Y, Kamatsuki Y, Miyazawa S, Ozaki T

Acta Med Okayama 75 ( 4 ) 423 - 430 2021.8

変形性肩関節症とCCN3発現上昇との相関について

廣瀬一樹, 中田英二, 服部高子, 鉄永智紀, 山田和希, 佐藤嘉洋, 桑原実穂, 滝川正春, 久保田聡, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1506 - S1506 2021.8

がん患者における周術期のがんロコモの発生率とそのリスクファクター

堅山佳美, 中田英二, 明崎禎輝, 千田益生, 国定俊之, 濱田全紀, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1580 - S1580 2021.8

ISB座標系と後顆平面座標系を用いた3D-CT計測と従来法による大腿骨骨幹部骨折術後の回旋変形の比較

佐藤浩平, 上原健敬, 福岡史朗, 近藤宏也, 畑利彰, 齋藤太一, 島村安則, 野田知之, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1688 - S1688 2021.8

移植腱固定法の違いとmicrofracture手技が腱骨接合部癒合に与える影響

根津智史, 齋藤太一, 吉田晶, 島村安則, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1828 - S1828 2021.8

ISB座標系と後顆平面座標系を用いた3D-CT計測と従来法による大腿骨骨幹部骨折術後の回旋変形の比較

佐藤浩平, 上原健敬, 福岡史朗, 近藤宏也, 畑利彰, 齋藤太一, 島村安則, 野田知之, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1688 - S1688 2021.8

教師なし学習を用いたAIによる超音波画像撮像部位自動検出

中原龍一, 高橋康, 西田圭一郎, 那須義久, 渡辺雅仁, 松橋美波, 堀田佳史, 品岡玲, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1726 - S1726 2021.8

人工知能を用いた骨肉腫X線像読影ツールの開発

長谷井嬢, 中原龍一, 沖田駿治, 三宅孝昌, 木浪陽, 藤原一夫, 臼井正明, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1475 - S1475 2021.8

移植腱固定法の違いとmicrofracture手技が腱骨接合部癒合に与える影響

根津智史, 齋藤太一, 吉田晶, 島村安則, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1828 - S1828 2021.8

変形性肩関節症とCCN3発現上昇との相関について

廣瀬一樹, 中田英二, 服部高子, 鉄永智紀, 山田和希, 佐藤嘉洋, 桑原実穂, 滝川正春, 久保田聡, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1506 - S1506 2021.8

Pexidartinibの骨肉腫に対する前臨床的検討 CSF-1/CSF-1R阻害は肉腫微小環境の免疫細胞構成分画を変化させ抗腫瘍効果を発揮する

藤原智洋, Yakoub Mohamed, 吉田晶, 近藤宏也, 畑利彰, 佐藤浩平, たき平将太, 中田英二, 国定俊之, 尾崎敏文, Healey John

日本整形外科学会雑誌 95 ( 8 ) S1557 - S1557 2021.8

肉腫におけるがんゲノム医療の意義

中田英二, 国定俊之, 藤原智洋, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1549 - S1549 2021.8

悪性末梢神経鞘腫瘍におけるPRRX1の悪性化因子としての役割

たき平将太, 山田大祐, 高尾知佳, 中田英二, 近藤宏也, 佐藤浩平, 畑利彰, 藤原智洋, 国定俊之, 尾崎敏文, 宝田剛志

日本整形外科学会雑誌 95 ( 8 ) S1554 - S1554 2021.8

畑利彰, 藤原智洋, 吉田晶, 近藤彩奈, 片山晴喜, 佐藤浩平, 近藤宏也, たき平将太, 中田英二, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1552 - S1552 2021.8

骨肉腫における腫瘍関連マクロファージの役割とin vitro実験による検証

近藤宏也, 田澤大, 久禮美穂, 藤原智洋, 佐藤浩平, 畑利彰, 中田英二, 国定俊之, 藤原俊義, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1556 - S1556 2021.8

がん患者における周術期のがんロコモの発生率とそのリスクファクター

堅山佳美, 中田英二, 明崎禎輝, 千田益生, 国定俊之, 濱田全紀, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1580 - S1580 2021.8

Adjuvant and neoadjuvant chemotherapy for osteosarcoma: JCOG Bone and Soft Tissue Tumor Study Group. International journal

Hiroaki Hiraga, Toshifumi Ozaki

Japanese journal of clinical oncology 2021.7

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

The usefulness of adjuvant chemotherapy for high-grade osteosarcoma was established by two randomized, controlled trials conducted in the 1980s, which used six drugs, doxorubicin, cisplatin, high-dose methotrexate, bleomycin, cyclophosphamide and actinomycin D. Since then, development has been promoted in the direction of introducing preoperative chemotherapy, changing post-operative adjuvant chemotherapy according to histological effects, adding ifosfamide as a key drug and strengthening adjuvant chemotherapy. No clinical trials, however, have shown the effectiveness of study treatment, and the improvement of treatment results during that time has been slight, although the JCOG0905 study is now going to verify the effectiveness of introducing ifosfamide for patients who experienced limited preoperative therapeutic effects. We are desperately looking for a breakthrough.

DOI： 10.1093/jjco/hyab120

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