Faculty Profiles - KUBOKI Takuo

MISC - KUBOKI Takuo

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口腔インプラントの予後に関するリスク評価歯周病の分子生物学的リスク検査の応用

荒川光, 小島俊司, 鈴木秀典, 岡本壮一郎, 園山亘, 完山学, 窪木拓男, 山下敦

日本口腔インプラント学会誌 13 ( 1 ) 163 - 164 2000.3

口腔インプラント患者と接着ブリッジ患者の満足度ならびにQOLについての短期予後調査少数歯中間欠損症例における検討

園山亘, 鈴木秀典, 岡本壮一郎, 助政安伸, 荒川光, 完山学, 窪木拓男, 山下敦

日本口腔インプラント学会誌 13 ( 1 ) 236 - 236 2000.3

欠損歯列を有する患者の治療におけるevidenceに基づいたアプローチ-下顎片測遊離端症側をベースにした考察-(共著)

窪木拓男, 山下敦

歯界展望 95 ( 1 ) 65 - 80 2000.1

Four-Year Longitudinal Course of TMD Symptoms in an Adult Population and the Estimation of Risk Factors in Relation to Symptoms

Manabu Kamisaka, Hirofumi Yatani, Takuo Kuboki, Yoshizo Matsuka, Hajime Minakuchi

Journal of Orofacial Pain 14 ( 3 ) 224 - 232 2000

Language：English

Aims: To investigate the natural course of symptoms of temporomandibular disorders (TMD) in a non-patient population and to estimate the strength of the relationship between several hypothesized risk factors and precipitation and perpetuation of the symptoms. Methods: A total of 672 randomly selected citizens of Okayama City was requested to answer the same self-administered questionnaire that they had answered 4 years earlier. The mailed questionnaire failed to reach 58 subjects at the second survey, and 367 of the remaining subjects (59.8%) responded. The fluctuation of TMD symptoms was assessed by comparison of 6 pairs of answers for questions regarding temporomandibular joint (TMJ) pain, limitation of mouth opening, TMJ noise, headache, neck pain, and shoulder stiffness. Six factors (age under 40, female, clenching habit, history of extrinsic trauma, sleep disturbance, and family history of TMD) were tested for their relative risk in precipitating and perpetuating each TMD symptom by the use of its confidence interval to define significance. Results: The incidence of TMD symptoms ranged from 6.1% (TMJ pain) to 12.9% (TMJ noise). More than half of the subjects who had reported TMJ and neck pain at the initial survey no longer reported these symptoms at the second survey, whereas TMJ noise and shoulder stiffness remained in more than 70% of the subjects. Individuals under 40 years old had a 3.3:1 increased risk of precipitating TMJ noise (P &lt
0.01), individuals with a history of extrinsic trauma had a 2.85:1 increased risk of precipitating limited mouth opening (P &lt
0.01), and females had a 2.81:1 increased risk of perpetuating TMJ pain (P &lt
0.01). Conclusion: The possible etiologic significance of these factors in TMD should be validated hv future research.

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Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Synovial Fluids of Patients with Temporomandibular Joint Osteoarthritis

Manabu Kanyama, Takuo Kuboki, Shunji Kojima, Takuo Fujisawa, Takako Hattori, Masaharu Takigawa, Atsushi Yamashita

Journal of Orofacial Pain 14 ( 1 ) 20 - 30 2000

Language：English

Aims: Imbalance between matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) may be involved in the breakdown of articular cartilage matrix of the temporomandibular joint (TMJ). Aims: In this study, MMPs, TIMPs, and MMP-1/TIMP-1 complex levels were examined in TMJ synovial fluid samples aspirated from TMJ osteoarthritis (OA) patients (2 males, 8 females
mean age, 29.7 years) and asymptomatic control subjects (2 males, 8 females
mean age, 23.6 years) to determine the likelihood of increased proteolytic activity in the OA joints. Methods: The various types of MMPs and TIMPs were detected by Western blotting with monoclonal antibodies and gelatin zymography. The MMP-1/ TIMP-1 complex level was measured by an enzyme-linked immunosorbent assay kit. All aspirates were first analyzed for total protein content and then individually diluted to make the total protein levels equivalent. Results: The mean MMP-1/TIMP-1 complex concentration in the synovial fluids of the OA patients was 3.92 ± 1.39 ng/mL
this value was significantly lower (P &lt
0.05) than the value from control subjects (5.46 ± 1.32 ng/mL). Matrix metalloproteinase-1 (52 kDa), MMP-3 (57 kDa), TIMP-1 (28 kDa), and TIMP-2 (26 kDa) were detected in all of the normal and the OA samples. However, MMP-1 (28 kDa), MMP-2 (72 kDa), MMP-3 (45 kDa), and MMP-9 (83 kDa) were detected in higher concentration in the OA samples. Conclusion: These findings suggest a strong association between the OA-active joints and the presence of biologically active forms of known tissue degradation enzymes (MMP-1, MMP-3, and MMP-9).

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EBM and dental medical care. Approach based on evidence in treatment for patients with anodontia. Consideration based on lower unilateral free edge coloboma cases.

窪木拓男, 山下敦

歯界展望 95(1),66-80 ( 1 ) 2000

第102回日本補綴歯科学会開催される(共著)

補綴臨床 33 116 - 117 2000

筋筋膜疼痛—そのメカニズムと新しい診断、治療法—

窪木拓男, 前川賢治

日本歯科評論 694,89-94 ( 694 ) 2000

RCT of initial therapy for anterior disc displacement without reduction.

H Minakuchi, T Kuboki, Y Matsuka, K Maekawa, H Yatani, Y Yamashita

JOURNAL OF DENTAL RESEARCH 79 587 - 587 2000

Validation of near-infrared spectroscopy with MRI in human masseter muscle.

K Suzuki, K Maekawa, T Kuboki, M Inoue, A Yamashita, K Kishi, GT Clark

JOURNAL OF DENTAL RESEARCH 79 492 - 492 2000

岡山大学歯学部における問題発見解決型教育法（チュートリアル教育）導入の試み

窪木拓男, 石川邦夫, 新井英雄, 吉田登志子, 平田あずみ, 市川博之, 船橋誠, 久保田聡, 井上正久, 谷本一郎, 十川紀夫, 入江正郎, 濱和洋, 伊東孝介, 明貝文夫, 完山学

岡山歯学会雑誌 19 ( 2 ) 295 - 304 2000

Language：Japanese Publisher：岡山歯学会

平成11年度に採用されたチュートリアル教育の内容を記述し,その自己評価と新年度のシステムに向けての改革案について論じた.チュートリアル教育が6年間の断続性のある一貫的な歯科教育システムの中で,どのような意味付けがあるかを考え,各学年個々に目的意識を持って挑む必要がある.目的がはっきりすれば,評価方法に関してもその目的にそった方法がとられるものと考えられる.又,歯学教育システムの中でのタイミングについては,特に考慮が必要で,第1,2,3年次という連続した3年間をチュートリアルのスケジュールにあてがうこと自体も再考の余地があると思われた

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第102回日本補綴歯科学会開催される．

大西栄史, 窪木拓男

補綴臨床 33:116-117 2000

QOL assessment of dental implant patients with bounded edentulous spaces.

W Sonoyama, S Okamoto, H Suzuki, H Arakawa, M Kanyama, T Kuboki, H Yatani, A Yamashita

JOURNAL OF DENTAL RESEARCH 79 466 - 466 2000

Intramuscular hemodynamic responses to sustained masseter muscle extension in humans

M Inoue, K Maekawa, T Kuboki, K Suzuki, GT Clark

JOURNAL OF DENTAL RESEARCH 79 492 - 492 2000

Biomechanical modeling of human TM joint loading with jaw opening

T.Kuboki, Y.Takenami, M.Shinoda, M.G.Orsini, A.Yamashita, G.T.Clark

J Oral Rehabil 2000

在宅患者のTDMを目的とした基礎的検討カルバマゼピンの唾液中濃度による投与計画への試み

川上英治, 安部瑞江, 古野勝志, 荒木博陽, 五味田裕, 窪木拓男, 矢谷博文, 菅原利夫

日本病院薬学会年会講演要旨集 10th 2000

アデノウイルスベクターによる培養骨芽細胞と骨組織への結合組織成長因子の遺伝子導入

完山学, 窪木拓男, 江口傑徳, 縄稚久美子, 上原淳二, 水島恒尚, 園山亘, 藤沢拓生, 矢谷博文

日本補綴歯科学会学術大会プログラム・抄録集 104th 2000

市販のカリエスリスクテストを用いた唾液中う蝕原性細菌に対するクロルヘキシジンの殺菌効果に関する臨床的研究

杉山英樹, 水口一, 上原淳二, 大西栄史, 畑中乾志, 吉田栄介, 窪木拓男, 矢谷博文, 山下敦

日本補綴歯科学会雑誌 44 ( 6 ) 2000

ヒト軟骨細胞様培養細胞株HCS-2/8における結合組織成長因子ctgf/ecogenin遺伝子発現制御機構

江口傑徳, 久保田聡, 近藤誠二, 服部高子, 中西徹, 窪木拓男, 矢谷博文, 滝川正春

日本分子生物学会年会プログラム・講演要旨集 23rd 2000

オクルーザルポーセレンアンレーの臨床成績

吉田栄介, 矢谷博文, 水口一, 神坂学, 畑中乾志, 窪木拓男

日本補綴歯科学会学術大会プログラム・抄録集 104th 2000

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