Faculty Profiles - KUBOKI Takuo

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超音波洗浄や滅菌処置が歯科用金属アレルギーの非破壊的原因金属同定結果に及ぼす影響

峯篤史, 窪木拓男, 長岡紀幸, 土本洋平, 園山亘, 前川賢治, 矢谷博文

日本補綴歯科学会雑誌 47 ( 5 ) 902 - 902 2003.12

Er:YAGレーザー照射象牙質の脆弱層(レーザースメア層)と接着強さ

峯篤史, 鈴木一臣, 矢谷博文, 吉田靖弘, 窪木拓男

日本補綴歯科学会雑誌 47 ( 110回特別 ) 69 - 69 2003.10

顎関節内障患者の細病態分類と日常生活障害度

黒井建志, 前川賢治, 中澤義人, 窪木拓男

日本補綴歯科学会雑誌 47 ( 110回特別 ) 63 - 63 2003.10

歯牙削除量の少ないピンテクニック

山下敦, 矢谷博文, 窪木拓男, 峯篤史, 土本洋平

日本補綴歯科学会雑誌 47 ( 110回特別 ) 157 - 157 2003.10

比例ハザード回帰を用いた口腔インプラント上部構造体のトラブルに関する遠隔予後調査

杉山英樹, 荒川光, 山崎聖也, 園山亘, 小島俊司, 完山学, 窪木拓男

日本補綴歯科学会雑誌 47 ( 110回特別 ) 72 - 72 2003.10

A repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint

T Fujisawa, T Kuboki, T Kasai, W Sonoyama, S Kojima, J Uehara, C Komori, H Yatani, Hattori, I, M Takigawa

JOURNAL OF DENTAL RESEARCH 82 ( 9 ) 731 - 735 2003.9

Language：English Publisher：INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R

Although excessive mechanical stress is assumed to be one of the factors contributing to pathogenesis of temporomandibular joint (TMJ) osteoarthritis (OA), no pure mechanical-stress-induced OA model has been developed without surgical manipulation or puncture of the joint cavity. The purpose of this study was to establish a genuine mechanical-stress-induced OA model of the rabbit TMJ. In the experimental rabbits, repetitive, forced jaw-opening, 3 hrs/day for 5 days, was applied with the use of a general anesthesia protocol. By histological assessment of the TMJ articular tissues, partial eburnation of the articular cartilage, reactive marginal proliferation of the articular cartilage chondrocytes, and nested proliferation of chondrocytes in the subchondral bone area were observed at 7 days after the repetitive, forced-jaw-opening period. These results suggest that the repetitive, forced-jaw-opening protocol without surgical intervention can induce evident OA-like lesions in the rabbit TMJ, and this OA model may greatly contribute to the elucidation of the cartilage degradation mechanism in TMJ OA.

Web of Science

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チタンの接着に適した表面改質法の検討

土本洋平, 吉田靖弘, 峯篤史, 窪木拓男, 矢谷博文, 鈴木一臣

歯科材料・器械 22 ( 5 ) 343 - 343 2003.8

歯科治療に関連した難治性疼痛補綴学的な立場から

窪木拓男

日本歯科麻酔学会雑誌 31 ( 4 ) 401 - 402 2003.8

Cbfa1/Runx2 gene expression in articular chondrocytes of the mice temporomandibular and knee joints in vivo. International journal

Takuo Kuboki, Manabu Kanyama, Tohru Nakanishi, Kentaro Akiyama, Kumiko Nawachi, Hirofumi Yatani, Kazuo Yamashita, Teruko Takano-Yamamoto, Masaharu Takigawa

Archives of oral biology 48 ( 7 ) 519 - 25 2003.7

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Healthy articular cartilage is thought to be maintained by the modulation of Cbfa1 expression, although little is currently known about Cbfa1 expression in such tissues. Therefore, we examined in vivo Cbfa1 transcript levels in the temporomandibular (TM) and knee joints of 3- and 10-week-old male ICR mice (weighing 50-70 g). A digoxigenin-11-UTP-labeled single-stranded RNA probe (0.6 kbp PstI-HindIII fragment of the 3' of untranslated region in exon 8 of mouse Cbfa1 cDNA) was prepared and in situ hybridization was performed on paraffin-embedded TM and knee joint sections. The antisense probe detected Cbfa1 transcripts in prehypertrophic chondrocytes, but not in the articular surface layer chondrocytes of 3- and 10-week-old mice TMJs. Despite the intense Cbfa1 expression in prehypertrophic chondrocytes, articular surface layer chondrocytes of the knee joints expressed low and undetectable level of Cbfa1 in the 3- and 10-week-old mice, respectively. These results indicate that Cbfa1 are highly expressed in the prehypertrophic chondrocytes presumably for articular tissue remodeling during the entire lifespan of the mouse, whereas Cbfa1 expression is suppressed in the articular surface chondrocytes in the adult mouse TM and knee joints to obtain the permanent cartilage phenotype.

DOI： 10.1016/S0003-9969(03)00088-8

Web of Science

PubMed

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超音波洗浄や滅菌処置が歯科用金属アレルギーの非破壊的原因金属同定結果に及ぼす影響

峯篤史, 窪木拓男, 長岡紀幸, 土本洋平, 園山亘, 前川賢治, 矢谷博文

岡山歯学会雑誌 22 ( 1 ) 183 - 188 2003.6

Language：Japanese Publisher：岡山歯学会

研磨用ポイント(WP)で歯科鋳造用銀合金及び陶材焼付用白色合金を研磨し,WPの表面を走査型電子顕微鏡で観察した.表面には金属付着が観察され,元素分析により銀合金においてはC,O,Al,Zn,Agが,白色合金ではC,O,Al,Cr,Niが検出された.又,試料を無処理群,蒸留水浸漬群,超音波処理群に分け,同様に金属分析を行ったところ,超音波処理群で銀合金の主成分であるAg,白色合金の主成分のNi,Crが検出され,無処理群,蒸留水浸漬群と同等の結果であった.銀合金でのZnは超音波処理群で全試料の1/3に,他の2群では2/3に検出された.次に試料を薬液滅菌群とオートクレーブ群に分け,超音波洗浄後金属分析を行った.両群とも主成分が検出されたが,銀合金のZnはオートクレーブ群で1/3のみ検出され,薬液滅菌群では検出されなかった.又,両群とも無処理及び蒸留水浸漬に比較してCが検出されにくかった

J-GLOBAL

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Tyrosine kinase-type receptors erbB4 and m-csfr/c-fms gene expression in chondrocytes.

K. Nawachi, S. Kubota, M. Inoue, T. Nishida, T. Kuboki, T. Nakanishi, H. Yatani, M. Takigawa

JOURNAL OF DENTAL RESEARCH 82 B357 - B357 2003.6

Effect of Er : YAG laser irradiation on compressive properties of dental hard tissues.

A. Mine, K. Suzuki, T. Kuboki, H. Yatani

JOURNAL OF DENTAL RESEARCH 82 B377 - B377 2003.6

Responses of hypothalamic-pituitary-adrenal axis to cold pressor stimulation.

K. Suzuki, K. Maekawa, T. Kuboki, H. Yatani

JOURNAL OF DENTAL RESEARCH 82 B296 - B296 2003.6

Daily activity limitation and subcategories of TMJ internal derangements.

T. Kuroi, Y. Nakazawa, K. Maekawa, T. Kuboki, H. Yatani

JOURNAL OF DENTAL RESEARCH 82 B231 - B231 2003.6

Plasma beta-endorphin concentration and pain threshold changes upon CP stimulation.

K. Maekawa, K. Suzuki, Y. Nakazawa, T. Kuboki, H. Yatani

JOURNAL OF DENTAL RESEARCH 82 B160 - B160 2003.6

オッセオインテグレーション獲得を阻害するリスク因子に関する臨床疫学的検討

縄稚梢, 荒川光, 窪木拓男, 杉山英樹, 小島俊司, 園山亘, 矢谷博文, 植野高章, 高木慎, 真野隆充, 菅原利夫

岡山歯学会雑誌 22 ( 1 ) 242 - 242 2003.6

Regeneration of defects in the articular cartilage in rat knee joints by connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24)

T Nishida, S Kubota, S Kojima, T Kuboki, T Kushibiki, Y Tabata, M Takigawa

BONE 32 ( 5 ) S101 - S101 2003.5

チタン製補綴物の接着特性に及ぼす表面処理の影響

土本洋平, 吉田靖弘, 峯篤史, 窪木拓男, 矢谷博文, 鈴木一臣

日本補綴歯科学会雑誌 47 ( 109回特別 ) 85 - 85 2003.5

片側臼歯部交叉こう合患者の顎関節空隙について

荒木佳子, 宮脇正一, 谷本裕子, 片山朗, 窪木拓男, 山本照子

日本顎関節学会雑誌 15 ( 1 ) 137 - 137 2003.4

正常こう合者のそしゃく運動時における下顎頭内外側極点の運動について

片山朗, 宮脇正一, 谷本裕子, 荒木佳子, 窪木拓男, 山本照子

日本顎関節学会雑誌 15 ( 1 ) 136 - 136 2003.4

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