Faculty Profiles - KUBOKI Takuo

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Effect of prosthetic restoration on masticatory function in patients with shortened dental arches: a multicentre study

K. Fueki, Y. Igarashi, Y. Maeda, K. Baba, K. Koyano, K. Sasaki, Y. Akagawa, T. Kuboki, S. Kasugai, N. R. Garrett

JOURNAL OF ORAL REHABILITATION 43 ( 7 ) 534 - 542 2016.7

Language：English Publisher：WILEY-BLACKWELL

The aim of this multicentre study was to investigate the effect of prosthetic restoration for missing posterior teeth on mastication in patients with shortened dental arches (SDAs). Partially dentate patients who had an intact teeth in anterior region and missed distal molar(s) (2-12 missing occlusal units) classified as Kennedy Class I or Class II were recruited from seven university-based dental hospitals in Japan. Of the 125 subjects who underwent baseline (pre-treatment) and follow-up/post-treatment evaluation, 53 chose no replacement of missing teeth and 72 chose treatment with removable partial dentures (n = 53) or implant-supported fixed partial dentures (n = 19). Objective masticatory performance (MP) was evaluated using a gummy jelly test. Perception of chewing ability (CA) was rated using a food intake questionnaire. In the no-treatment group, mean MP and CA scores at baseline were similar to those at follow-up evaluation (P > 005). In the treatment group, mean MP after treatment was significantly greater than the pre-treatment mean MP (P < 005). However, the mean perceived CA in the treatment groups was similar at pre- and post-treatment (P > 005). In a subgroup analysis of subjects in the treatment group, subjects with lower pre-treatment CA showed a significant CA increase after treatment (P = 0004), but those with higher pre-treatment CA showed a significant decrease in CA (P = 0001). These results suggest that prosthetic restoration for SDAs may benefit objective masticatory performance in patients needing replacement of missing posterior teeth, but the benefit in subjective chewing ability seems to be limited in subjects with perceived impairment in chewing ability before treatment.

DOI： 10.1111/joor.12387

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平成27年度にODAPUSプログラムで岡山大学に留学をした5か国6校の学生の意識調査

藤田麻里子, 柳文修, 久富美紀, 此内浩信, 村上純, 前田あずさ, 窪木拓男, 宮脇卓也, 仲野道代, 皆木省吾, 浅海淳一

日本歯科医学教育学会総会・学術大会プログラム・抄録集 35回 97 - 97 2016.7

要支援・要介護高齢者における生命予後および低体重発生のリスク因子の検討

小山絵理, 大野彩, 山本道代, 三野卓哉, 黒崎陽子, 中川晋輔, 逢坂卓, 沼本賢, 縄稚久美子, 水口真実, 水口一, 前川賢治, 窪木拓男

日本補綴歯科学会誌 8 ( 特別号 ) 117 - 117 2016.7

5年次歯学生を対象とした周術期チーム医療の現場を体験させる演習が多職種連携の認識に及ぼした影響

園井教裕, 曽我賢彦, 山中玲子, 室美里, 前田あずさ, 川瀬明子, 杉本恭子, 飯田征二, 窪木拓男, 浅海淳一

日本歯科医学教育学会総会・学術大会プログラム・抄録集 35回 78 - 78 2016.7

岡山大学における在宅・訪問歯科診療実習の実績報告

杉本恭子, 宮脇卓也, 原哲也, 武田宏明, 曽我賢彦, 鳥井康弘, 窪木拓男, 浅海淳一

日本歯科医学教育学会総会・学術大会プログラム・抄録集 35回 80 - 80 2016.7

在宅歯科診療用シミュレーターを用いたシミュレーション教育の有効性の検討

杉本恭子, 宮脇卓也, 武田宏明, 前田茂, 窪木拓男, 浅海淳一

日本歯科医学教育学会総会・学術大会プログラム・抄録集 35回 86 - 86 2016.7

岡山大学歯学部で行ったCODAによる教育認証評価に基づいた外部評価の試み

川瀬明子, 前田あずさ, 園井教裕, 宮脇卓也, 窪木拓男, 浅海淳一

日本歯科医学教育学会総会・学術大会プログラム・抄録集 35回 91 - 91 2016.7

在宅歯科医療に対する歯科研修医の意識調査

村田尚道, 江草正彦, 杉本恭子, 武田宏明, 川瀬明子, 前田あずさ, 園井教裕, 曽我賢彦, 浅海淳一, 窪木拓男

日本歯科医学教育学会総会・学術大会プログラム・抄録集 35回 127 - 127 2016.7

岡山大学病院歯科医師臨床研修における在宅歯科医療研修の改善に向けて

武田宏明, 白井肇, 塩津範子, 鈴木康司, 河野隆幸, 杉本恭子, 吉田登志子, 浅海淳一, 窪木拓男, 鳥井康弘

日本歯科医学教育学会総会・学術大会プログラム・抄録集 35回 139 - 139 2016.7

変形性顎関節症への取り組み小児から高齢者まで顎関節OAによる咬合変化に対する補綴治療安定する咬合位は?

窪木拓男

日本顎関節学会雑誌 28 ( Suppl. ) 71 - 71 2016.7

口腔粘膜上皮における角化因子の探索

植田淳二, 大野充昭, 小盛大志, 吉岡裕也, 園山亘, 前川賢治, 窪木拓男

日本補綴歯科学会誌 8 ( 特別号 ) 120 - 120 2016.7

創傷治癒過程における宿主骨髄由来間葉系幹細胞がもたらす免疫寛容性とそのメカニズム

古味佳子, 秋山謙太郎, 吉岡裕也, 國友雅義, 小盛大志, 國友由理, 大野充昭, 前川賢治, 窪木拓男

日本補綴歯科学会誌 8 ( 特別号 ) 150 - 150 2016.7

固定性ブリッジおよび部分床義歯患者の口腔関連QOL評価における最小有効差の検討

中川晋輔, 大野彩, 黒崎陽子, 小山絵理, 逢坂卓, 沼本賢, 三野卓哉, 水口一, 前川賢治, 窪木拓男

日本補綴歯科学会誌 8 ( 特別号 ) 173 - 173 2016.7

インターディシプリナリーデンティストリー補綴歯科専門医は他分野から何を求められているか歯周、歯内療法の立場から高度な軟組織マネージメントやエンド治療とのコラボレーション

窪木拓男

日本補綴歯科学会誌 8 ( 特別号 ) 95 - 95 2016.7

皮膚創傷治癒過程におけるCCN4/WISP-1の役割

大野充昭, 正木明日香, 前田あずさ, Hara Emilio S., 小盛大志, 久保田聡, Young Marian F., 大橋俊孝, 窪木拓男

日本結合組織学会学術大会プログラム・抄録集 48回 88 - 88 2016.6

前歯部歯根破折に対し歯根の矯正的挺出と結合組織移植の後インプラント治療を行った1症例

佐藤毅, 園山亘, 窪木拓男

日本口腔インプラント学会誌 29 ( 2 ) E52 - E52 2016.6

インプラント治療後に来院が途絶えた要介護高齢者の口腔・全身状態および介護環境に関する報告

黒崎陽子, 沼本賢, 大野彩, 三野卓哉, 山本道代, 小山絵理, 前川賢治, 窪木拓男

日本老年歯科医学会総会・学術大会プログラム・抄録集 27回 213 - 213 2016.6

Sleep bruxism frequency and platelet serotonin transporter activities in young adult subjects. International journal

Hajime Minakuchi, Chiharu Sogawa, Haruna Miki, Emilio S Hara, Kenji Maekawa, Norio Sogawa, Shigeo Kitayama, Yoshizo Matsuka, Glenn Thomas Clark, Takuo Kuboki

Sleep & breathing = Schlaf & Atmung 20 ( 1 ) 271 - 6 2016.3

Language：English Publisher：SPRINGER HEIDELBERG

PURPOSE: To evaluate correlations between serotonin transporter (SERT) uptake ability in human peripheral platelets and sleep bruxism (SB) frequency. METHODS: Subjects were consecutively recruited from sixth-year students at Okayama University Dental School. Subjects were excluded if they (1) were receiving orthodontic treatment, (2) had a dermatological disease, (3) had taken an antidepressant within 6 months, or (4) had used an oral appliance within 6 months. SB frequency was determined as the summary score of three consecutive night assessments using a self-contained electromyography detector/analyzer in their home. Fasting peripheral venous blood samples were collected in the morning following the final SB assessment. SERT amount and platelet number were quantified via an ELISA assay and flow cytometry, respectively. Functional SERT characterization, 5-hydroxytryptamine (5-HT) uptake, maximum velocity (V max), and an affinity constant (K m ) were assessed with a [(3)H] 5-HT uptake assay. The correlations between these variables and SB level were evaluated. RESULTS: Among 50 eligible subjects (26 males, mean age 25.4 ± 2.41 years), 7 were excluded because of venipuncture failure, smoking, and alcohol intake during the experimental period. A small but significant negative correlation between SB level and [(3)H] 5-HT uptake was observed (Spearman's correlation R (2) = 0.063, p = 0.04). However, there were no significant correlations between SB level and total platelet amount, SERT, V max, and K m values (p = 0.08, 0.12, 0.71, and 0.68, respectively). CONCLUSIONS: Platelet serotonin uptake is significantly associated with SB frequency, yet only explains a small amount of SB variability.

DOI： 10.1007/s11325-015-1281-0

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CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function. International journal

Yuya Yoshioka, Mitsuaki Ono, Azusa Maeda, Tina M Kilts, Emilio Satoshi Hara, Hany Khattab, Junji Ueda, Eriko Aoyama, Toshitaka Oohashi, Masaharu Takigawa, Marian F Young, Takuo Kuboki

Bone 83 162 - 170 2016.2

Language：English Publisher：ELSEVIER SCIENCE INC

The CCN family of proteins plays important roles in development and homeostasis of bone and cartilage. To understand the role of CCN4 in chondrogenesis, human bone marrow stromal cells (hBMSCs) were transduced with CCN4 adenovirus (adCCN4) or siRNA to CCN4 (siCCN4) in the presence or absence of transforming growth factor-β3 (TGF-β3). Overexpression of CCN4 enhanced TGF-β3-induced SMAD2/3 phosphorylation and chondrogenesis of hBMSCs in an in vitro assay using a micromass culture model. On the other hand, knockdown of CCN4 inhibited the TGF-β3-induced SMAD2/3 phosphorylation and synthesis of cartilage matrix in micromass cultures of hBMSCs. Immunoprecipitation-western blot analysis revealed that CCN4 bound to TGF-β3 and regulated the ability of TGF-β3 to bind to hBMSCs. In vivo analysis confirmed there was a significant decrease in the gene expression levels of chondrocyte markers in cartilage samples from Ccn4-knock out (KO) mice, compared to those from wild type (WT) control. In order to investigate the regenerative properties of the articular cartilage in Ccn4-KO mice, articular cartilage defects were surgically performed in the knee joints of young mice, and the results showed that the cartilage was partially repaired in WT mice, but not in Ccn4-KO mice. In conclusion, these results show, for the first time, that CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-β3.

DOI： 10.1016/j.bone.2015.11.007

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Cellular Reprogramming Using Defined Factors and MicroRNAs. International journal

Takanori Eguchi, Takuo Kuboki

Stem cells international 2016 7530942 - 7530942 2016

Language：English Publisher：Hindawi Publishing Corporation

Development of human bodies, organs, and tissues contains numerous steps of cellular differentiation including an initial zygote, embryonic stem (ES) cells, three germ layers, and multiple expertized lineages of cells. Induced pluripotent stem (iPS) cells have been recently developed using defined reprogramming factors such as Nanog, Klf5, Oct3/4 (Pou5f1), Sox2, and Myc. This outstanding innovation is largely changing life science and medicine. Methods of direct reprogramming of cells into myocytes, neurons, chondrocytes, and osteoblasts have been further developed using modified combination of factors such as N-myc, L-myc, Sox9, and microRNAs in defined cell/tissue culture conditions. Mesenchymal stem cells (MSCs) and dental pulp stem cells (DPSCs) are also emerging multipotent stem cells with particular microRNA expression signatures. It was shown that miRNA-720 had a role in cellular reprogramming through targeting the pluripotency factor Nanog and induction of DNA methyltransferases (DNMTs). This review reports histories, topics, and idea of cellular reprogramming.

DOI： 10.1155/2016/7530942

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