Faculty Profiles - KUBOKI Takuo

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植松宏, 戸原玄, 中島純子, 菊谷武, 高橋浩二, 野原幹司, 前田芳信, 小野高裕, 吉田光由, 大野友久, 佐々木啓一, 高橋裕, 田中貴信, 鈴木哲也, 谷口尚, 小正裕, 岡崎定司, 津賀一弘, 吉川峰加, 西恭宏, 飯沼利光, 川良美佐雄, 皆木省吾, 古屋純一, 小山重人, 木本統, 飯島守雄, 乙丸貴史, 隅田由香, 猪原健, 中根綾子, 若杉葉子, 大内ゆかり, 都島千明, 田村文誉, 尾澤昌悟, 吉岡文, 堀一浩, 城下尚子, 洲脇道弘, 難波謙介, 清水博史, 津江文武, 今井崎太一, 加地彰人, 長岡英一, 佐藤裕二, 高井良招, 赤川安正, 井上農夫男, 服部正己, 森戸光彦, 北川昇, 窪木拓男, 藤澤政紀, 玉置勝司, 築山能大, 永尾寛, 萩原芳幸, 松香芳三, 宮城敦, 重枝昭広, 中村全宏, 日本老年歯科医学会

老年歯科医学 24 ( 2 ) 104 - 116 2009.9

インプラント義歯を装着した少数歯中間欠損患者の隣在歯の予後調査(第2報) 隣在歯の補綴状態が同等なブリッジ群との比較

山崎聖也, 荒川光, 野田欣志, 完山学, 松香芳三, 窪木拓男

日本口腔インプラント学会誌 22 ( 特別号 ) 121 - 121 2009.8

成長因子を用いた骨増生法の臨床効果に関するSystematic Review

荒川光, 下野賢吾, 大島正充, 縄稚久美子, 窪木拓男

日本口腔インプラント学会誌 22 ( 特別号 ) 255 - 255 2009.8

歯科治療に対する不安や恐怖の程度を測定できる簡易型質問票の信頼性・妥当性の検討

三野卓哉, 木村彩, 荒川光, 松香芳三, 窪木拓男

日本口腔インプラント学会誌 22 ( 特別号 ) 278 - 278 2009.8

臨床エビデンスに基づく顎関節症の診断と治療口腔顔面痛や口腔運動器疾患を治療する立場から

窪木拓男

日本顎関節学会雑誌 21 ( 2 ) vi - vi 2009.8

岡山大学病院周術期管理センター受診患者における手術前プラークフリーの実施状況

三浦留美, 木南美香, 住吉由季子, 羽川操, 下野勉, 縄稚久美子, 山中玲子, 曽我賢彦, 中塚秀輝, 窪木拓男, 森田学, 森田潔

日本歯科衛生学会雑誌 4 ( 1 ) 108 - 108 2009.8

口腔インプラントの臨床エビデンスはどのくらい整ったのか診療ガイドラインの策定に向けて臨床エビデンスに基づく欠損補綴治療をアシストするための診療ガイドライン患者の視点に立ったインプラント治療を行うために

窪木拓男

日本口腔インプラント学会誌 22 ( 特別号 ) 71 - 71 2009.8

顎関節症の教育カリキュラムの立案補綴歯科の立場から

窪木拓男

日本顎関節学会雑誌 21 ( Suppl. ) 60 - 60 2009.7

携帯電話を用いたEMAシステムの歯科領域への応用の試み

黒井隆太, 水口一, 坂口千代美, 川上彩, 松香芳三, 岡田宏基, 窪木拓男

岡山歯学会雑誌 28 ( 1 ) 87 - 87 2009.6

全身疾患を有する患者を対象にした問題発見解決型教育法(チュートリアル教育)

礒兼衣里, 松香芳三, 完山学, 水口一, 上原淳二, 縄稚久美子, 上枝麻友, 笈田育尚, 三野卓哉, 新川重彦, 前川賢治, 荒川光, 園山亘, 窪木拓男

岡山歯学会雑誌 28 ( 1 ) 87 - 88 2009.6

第二世代BMP-2を用いた歯槽骨再生療法確実かつ質の高いインプラント治療をめざして

窪木拓男

日本口腔インプラント学会誌 22 ( 2 ) 199 - 199 2009.6

口腔インプラント治療を受けた高齢者の長期予後評価

荒川光, 山崎聖也, 野田欣志, 木村彩, 完山学, 松香芳三, 窪木拓男

日本口腔インプラント学会誌 22 ( 2 ) 204 - 205 2009.6

Polyphosphoric acid treatment promotes bone regeneration around titanium implants

K. Maekawa, K. Shimono, M. Oshima, Y. Yoshida, B. Van Meerbeek, K. Suzuki, T. Kuboki

JOURNAL OF ORAL REHABILITATION 36 ( 5 ) 362 - 367 2009.5

Language：English Publisher：WILEY-BLACKWELL PUBLISHING, INC

This study was conducted to evaluate the effect of polyphosphoric acid (PPA) treatment on bone regeneration around titanium (Ti) implants in vivo. Adsorption of PPA by Ti was achieved by immersing Ti implants (2 mm in diameter, 4 mm in length) in different concentrations of PPA solution (0, 1 and 10 wt%) for 24 h at 37 degrees C after proper Ti surface cleaning. The treated Ti implants were implanted on 8-week-old-male rat (n = 30) tibiae. Two or four weeks after implantation, all animals were deeply anaesthetized and underwent perfusion fixation. Ten specimens in each condition were further immersed in the same fixative for 1 week and eventually embedded in polyester resin. Afterwards, undecalcified sections were ground to a thickness of approximately 70 mu m parallel to the long axis of the implant. The sections were stained with basic fuchsine and methylene blue and then examined by light microscopy. For quantitative evaluation of bone regeneration around the implants, the bone-implant contact ratio (BICR) was determined. Polyphosphoric acid treatment of the Ti implant surface significantly enhanced direct bone contact to the Ti surface. Especially, the BICRs of the 1 wt% PPA-treated Ti implants were significantly higher than those of the control untreated Ti implants, both 2 and 4 weeks after implantation. At 4 weeks, 10 wt% PPA-treated implants also significantly increased the BICR as compared to that of the untreated Ti implants. These results suggest that PPA treatment promotes osteoconductivity of Ti in vivo.

DOI： 10.1111/j.1365-2842.2008.01928.x

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BOTULINUM TOXIN TYPE A (150 kDa) DECREASES EXAGGERATED NEUROTRANSMITTER RELEASE FROM TRIGEMINAL GANGLION NEURONS AND RELIEVES NEUROPATHY BEHAVIORS INDUCED BY INFRAORBITAL NERVE CONSTRICTION

Y. Kitamura, Y. Matsuka, I. Spigelman, Y. Ishihara, Y. Yamamoto, W. Sonoyama, T. Kuboki, K. Oguma

NEUROSCIENCE 159 ( 4 ) 1422 - 1429 2009.4

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Many patients with trigeminal neuropathies suffer severe chronic pain which is inadequately alleviated with centrally-acting drugs. These drugs also possess severe side effects making compliance difficult. One strategy is to develop new treatments without central side effects by targeting peripheral sensory neurons, since sensory neuron excitability and neurotransmitter release increase in chronic pain states. Such treatments may include the highly purified botulinum toxin type A 150 kDa (BoNT/A) which reportedly blocks vesicular neurotransmitter release. We set out to determine if experimental trigeminal neuropathy induced by infraorbital nerve constriction (IoNC) in rats could alter neurotransmitter release from somata of trigeminal sensory neurons and if it could be aften-uated by BoNT/A. Thus, we monitored the secretory activity of acutely dissociated trigeminal ganglion (TRG) neurons from naive and IoNC rats by measuring the fluorescence intensity of the membrane-uptake marker (N-(3-triethylammoniumpropyl)-4-(6-(4-(diethylamino)phenyl)hexatrienyl)pyridinium dibromide (FM4-64). FM4-64 staining showed that neurons possess a pool of recycled vesicles which could be released by high KCl (75 mM) application. BoNT/A pre-treatment of acutely dissociated TRG neurons from naive rats significantly reduced the rate of FM4-64 dye release. Neurons isolated from TRG ipsilateral to IoNC exhibited significantly faster onset of FM4-64 release than neurons contralateral to

DOI： 10.1016/j.neuroscience.2009.01.066

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補綴歯科診療ガイドライン歯の欠損の補綴歯科診療ガイドライン2008

市川哲雄, 窪木拓男, 小林博, 津賀一弘, 秀島雅之, 志賀博, 永尾寛, 石井拓男, 江里口彰, 吉田雅博, 川添堯彬, 社団法人日本補綴歯科学会

日本補綴歯科学会誌 1 ( 2 ) i,E85 - E201 2009.4

【現在、そしてこれからの補綴を考える】補綴装置別これからの補綴はどう変わっていくか? クラウン・ブリッジ編

窪木拓男

Quintessence of Dental Technology 34 ( 4 ) 398 - 409 2009.4

Simvastatin induces the odontogenic differentiation of human dental pulp stem cells in vitro and in vivo. International journal

Yosuke Okamoto, Wataru Sonoyama, Mitsuaki Ono, Kentaro Akiyama, Takuo Fujisawa, Masamitsu Oshima, Yohei Tsuchimoto, Yoshizo Matsuka, Tatsuji Yasuda, Songtao Shi, Takuo Kuboki

Journal of endodontics 35 ( 3 ) 367 - 72 2009.3

Language：English Publisher：ELSEVIER SCIENCE INC

Statin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, is known to promote bone formation. However, it is not clear whether statin affects the differentiation of pulp cells. This study used a cell proliferation assay, cell cycle analysis, quantitative reverse transcriptase polymerase chain reaction (RT-PCR) and in vivo transplantation to examine the effects of simvastatin on human dental pulp stem cells (DPSCs) in vitro and in vivo. Simvastatin at 1 mumol/L was able to significantly suppress the proliferation of DPSCs without inducing apoptosis. Quantitative RT-PCR revealed both osteocalcin and dentin sialophosphoprotein to be significantly up-regulated when DPSCs were cultured with simvastatin in comparison to bone morphogenetic protein-2 treatment. The in vivo transplantation data showed that simvastatin treatment promoted mineralized tissue formation. Taken together, these results suggest that statin might be an ideal active ingredient to accelerate the differentiation of DPSCs.

DOI： 10.1016/j.joen.2008.11.024

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CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. International journal

Azusa Maeda, Takashi Nishida, Eriko Aoyama, Satoshi Kubota, Karen M Lyons, Takuo Kuboki, Masaharu Takigawa

Journal of biochemistry 145 ( 2 ) 207 - 16 2009.2

Language：English Publisher：OXFORD UNIV PRESS

Both CCN family 2/connective tissue growth factor (CCN2/CTGF) and bone morphogenetic protein (BMP)-2 play an important role in cartilage metabolism. We evaluated whether or not CCN2 would interact with BMP-2, and examined the combination effect of CCN2 with BMP-2 (CCN2-BMP-2) on the proliferation and differentiation of chondrocytes. Immunoprecipitation-western blotting analysis, solid-phase binding assay and surface plasmon resonance (SPR) spectroscopy showed that CCN2 directly interacted with BMP-2 with a dissociation constant of 0.77 nM as evaluated by SPR. An in vivo study revealed that CCN2 was co-localized with BMP-2 at the pre-hypertrophic region in the E18.5 mouse growth plate. Interestingly, CCN2-BMP-2 did not affect the BMP-2/CCN2-induced phosphorylation of p38 MAPK but caused less phosphorylation of ERK1/2 in cultured chondrocytes. Consistent with these results, cell proliferation assay showed that CCN2-BMP-2 stimulated cell growth to a lesser degree than by either CCN2 or BMP-2 alone, whereas the expression of chondrocyte marker genes and proteoglycan synthesis, representing the mature chondrocytic phenotype, was increased collaboratively by CCN2-BMP-2 treatment in cultured chondrocytes. These findings suggest that CCN2 may regulate the proliferating and differentiation of chondrocytes by forming a complex with BMP-2 as a novel modulator of BMP signalling.

DOI： 10.1093/jb/mvn159

Web of Science

PubMed

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携帯電話を用いたEMAシステムの歯科領域への応用の試み

黒井隆太, 水口一, 坂口千代美, 川上彩, 松香芳三, 岡田宏基, 窪木拓男

日本補綴歯科学会誌 1 ( 1 ) E10 - E10 2009.1

歯周病原性細菌に対する歯科表面滑沢硬化材の影響

熊田愛, 上原淳二, 大野充昭, 松香芳三, 窪木拓男

日本補綴歯科学会誌 1 ( 1 ) E2 - E2 2009.1

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