Faculty Profiles - KUBOKI Takuo

MISC - KUBOKI Takuo

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三叉神経節細胞の神経伝達物質遊離・取り込みに及ぼす改良A型ボツリヌス毒素の影響

北村洋一, 松香芳三, 福田朋樹, 小熊惠二, 窪木拓男

日本補綴歯科学会雑誌 51 ( 116回特別 ) 190 - 190 2007.5

Etanerceptは炎症環境下の軟骨細胞におけるMMPs産生を抑制する

上原淳二, 藤澤拓生, 大野充昭, 窪木拓男

日本補綴歯科学会雑誌 51 ( 116回特別 ) 220 - 220 2007.5

持続反復筋収縮はラット咬筋組織におけるIL-6遺伝子の発現を亢進する

小野剛, 前川賢治, 窪木拓男

日本補綴歯科学会雑誌 51 ( 116回特別 ) 88 - 88 2007.5

被験者の自覚や家族の指摘のみで睡眠時ブラキシズムは診断できるか?

永松千代美, 水口一, Clark Glenn T., 窪木拓男

日本補綴歯科学会雑誌 51 ( 116回特別 ) 90 - 90 2007.5

bFGF製剤の骨髄腔内注入によるインプラント埋入部位歯槽骨の骨密度改善

大島正充, 大野充昭, 下野賢吾, 園山亘, 窪木拓男

日本補綴歯科学会雑誌 51 ( 116回特別 ) 183 - 183 2007.5

接着性レジンセメントを用いた支台築造の臨床予後に関する15年間の前向きコホート調査

暈貴行, 峯篤史, 松香芳三, 今井誠, 藤田栄伸, 矢谷博文, 山下敦, 窪木拓男

接着歯学 24 ( 4 ) 235 - 235 2007.4

接着性レジンセメントを用いたコアに関する15年間の前向きコホート調査

暈貴行, 松香芳三, 水口一, 峯篤史, 荒川光, 前田健志, 三輪隆宏, 窪木拓男

日本補綴歯科学会雑誌 51 ( 2 ) 359 - 359 2007.4

犬歯隣在歯保護のための接着技法によるカスプライズ法

山下敦, 窪木拓男, 近藤康弘, 今井誠, 水口一

日本補綴歯科学会雑誌 51 ( 2 ) 361 - 361 2007.4

咬合感覚異常症患者における歯根膜メカノレセプターの関与

松香芳三, 小川匠, 重田優子, 平林里大, 井川知子, 安藤栄里子, 前川賢治, 水口一, 藤澤拓生, 小野剛, 福島俊士, Clark Glenn T., 窪木拓男

日本補綴歯科学会雑誌 51 ( 2 ) 364 - 364 2007.4

生体活性型口腔インプラントを目指したリン酸化糖処理チタンの検討

田中力, 吉田靖弘, 土本洋平, 鈴木一臣, 窪木拓男

歯科材料・器械 26 ( 2 ) 172 - 172 2007.4

金属アレルギー患者に対するインプラント治療チタン製修復物による暴露試験でチタンの安全性を確認した一症例

完山学, 真野隆充, 荒川光, 峯篤史, 上山吉哉, 窪木拓男

日本口腔インプラント学会誌 20 ( 1 ) 197 - 198 2007.3

インプラント義歯装着患者のQOLレベル測定におけるレスポンスシフトの影響

荒川光, 木村彩, 野田欣志, 完山学, 窪木拓男

日本口腔インプラント学会誌 20 ( 1 ) 78 - 78 2007.3

Comparison of inter-twin concordance in symptoms of temporomandibular disorders: a preliminary investigation in an adolescent twin population. International journal

Yoshizo Matsuka, Chiyomi Nagamatsu, Shingo Itoh, Takayuki Tomonari, Ali Makki, Hajime Minakuchi, Kenji Maekawa, Manabu Kanyama, Takuo Kuboki

Cranio : the journal of craniomandibular practice 25 ( 1 ) 23 - 9 2007.1

Language：English Publisher：CHROMA INC

There is controversy as to the genetic contribution to the pathogenesis of temporo-mandibular disorders (TMD). Several reports reveal a marked familial aggregation in the signs and symptoms of TMD, while others do not. Therefore, our goal was to investigate the hypothesis using a sophisticated research design, which was a well-known genetic survey inter-twin concordance assessment in the symptoms of TMD. This study is the first step to survey TMD symptoms of a twin group in junior and high schools as a preliminary trial. The 63 twins were asked to participate in this study in junior and senior high schools affiliated with the University of Tokyo, Japan, schools which kept ten twins in each grade for the purpose of several genetic survey programs. After excluding incomplete filling out of questionnaire sheets and data from male-female pairs, 43 monozygotic (MZ) (15.3+/-1.7 yrs, male/female = 17/26 pairs) and nine dyzygotic (DZ) (15.2+/-1.8 yrs, male/female = 6/3 pairs) twins were studied. Outcomes consisted of a prevalidated 14-item self-administered questionnaire, which assessed proband- and pair-wise concordance levels in the MZ and DZ twins. These results demonstrated that the MZ twins had a higher tendency of inter-twin concordance than DZ twins in terms of jaw pain in wide mouth opening (proband-wise concordance = 66.7% in MZ, 0% in DZ), difficulty in mouth opening (20% in MZ, 0% in DZ) and difficulty in mouth closing (50.0% in MZ, 33.3% in DZ), while there was no significant difference between the MZ and DZ concordance levels in other general health-related and behavior-related items, except toothache. However, the pair-wise concordance rates of jaw pain in wide mouth opening and difficulty in mouth opening in the MZ twins were not significantly higher compared to the DZ rate. Possibly, a genetic factor contributed to the pathogenesis of TMD in an adolescent population. The sample size needs to be increased, and there are plans to survey the next sample in the same schools.

DOI： 10.1179/crn.2007.005

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Comparison of inter-twin concordance in symptoms of temporomandibular disorders: A preliminary investigation in an adolescent twin population International journal

Yoshizo Matsuka, Chiyomi Nagamatsu, Shingo Itoh, Takayuki Tomonari, Ali Makki, Hajime Minakuchi, Kenji Mackawa, Manabu Kanyama, Takuo Kuboki

CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE 25 ( 1 ) 23 - 29 2007.1

Language：English Publisher：CHROMA INC

There is controversy as to the genetic contribution to the pathogenesis of temporomandibular disorders (TMD). Several reports reveal a marked familial aggregation in the signs and symptoms of TMD, while others do not. Therefore, our goal was to investigate the hypothesis using a sophisticated research design, which was a well-known genetic survey inter-twin concordance assessment in the symptoms of TMD. This study is the first step to survey TMD symptoms of a twin group in junior and high schools as a preliminary trial. The 63 twins were asked to participate in this study in junior and senior high schools affiliated with the University of Tokyo, Japan, schools which kept ten twins in each grade for the purpose of several genetic survey programs. After excluding incomplete filling out of questionnaire sheets and data from male-female pairs, 43 monozygotic (MZ) (15.3 +/- 1.7 yrs, male/female = 17/26 pairs) and nine dyzygotic (DZ) (15.2 +/- 1.8 yrs, male/female = 6/3 pairs) twins were studied. Outcomes consisted of a prevaliclated 14-item self-administered questionnaire, which assessed proband- and pair-wise concordance levels in the MZ and DZ twins. These results demonstrated that the MZ twins had a higher tendency of inter-twin concordance than DZ twins in terms of jaw pain in wide mouth opening (proband-wise concordance = 66.7% in MZ, 0% in DZ), difficulty in mouth opening (20% in MZ, 0% in DZ) and difficulty in mouth closing (50.0% in MZ, 33.3% in DZ), while there was no significant difference between the MZ and DZ concordance levels in other general health-related and behavior-related items, except toothache. However, the pair-wise concordance rates of jawpain in wide mouth opening and difficulty in mouth opening in the MZ twins were not significantly higher compared to the DZ rate. Possibly, a genetic factor contributed to the pathogenesis of TMD in an adolescent population. The sample size needs to be increased, and there are plans to survey the next sample in the same schools.

DOI： 10.1179/crn.2007.005

Web of Science

PubMed

researchmap

Cell proliferation on Titania layer with in vitro apatite forming ability

S. Yabe, K. Tsuru, S. Hayakawa, A. Osaka, Y. Yoshida, K. Suzuki, T. Kuboki

BIOCERAMICS, VOL 19, PTS 1 AND 2 330-332 131 - + 2007

Language：English Publisher：TRANS TECH PUBLICATIONS LTD

Titania layer was fabricated on the titanium substrates with chemical treatment with 20ml or 40ml of hydrogen peroxide solution and subsequent heat treatment at 400 degrees C, coded as CHT20 and CHT40, respectively. CHT20 spontaneously deposited apatite on the surface in a simulated body fluid (SBF), while CHT40 did not. TF-XRD patterns showed that the diffraction intensity of anatase of CHT20 was higher than that of CHT40. It was suggested that the thicker titania layer indicated in vitro apatite forming ability. The cell proliferation of CHT20 and CHT40 were lower than NT and HT. Since the surface of titania layers became hydrophobic after autoclaving, we can suppose that the cell proliferation on CHT20 and CHT40 were lower than NT and HT due to their surface hydrophobicity.

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附属病院の歯科系広報誌から，附属病院，研究科，学部をまとめた岡山大学歯学部総合情報交換誌「歯学だより」へ

窪木拓男

歯学だより 3 7 2007

今年の夏は岡山歯学会に集合しよう

窪木拓男

岡山大学歯学部広報 2007

Current research directions and management innovations for temporomandibular disorders and orofacial pain.

窪木拓男

The Twelfth Scientific Meeting Asian Academy of Craniomandibular Disorders.Program and Abstracts, 21 2007

目指せ，日本一の医学部・歯学部附属病院