Faculty Profiles - KUBOKI Takuo

MISC - KUBOKI Takuo

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Cold Pressor刺激により誘発されるストレス関連ホルモンの唾液中濃度変化

鈴木康司, 上原淳二, 井上真実, 前川賢治, 完山学, 窪木拓男, 矢谷博文

日本顎関節学会雑誌 13 ( 1 ) 151 - 152 2001.4

顎関節リモデリングの寄与因子とリモデリングの長期予後に及ぼす影響

水口一, 神坂学, 吉田栄介, 畑中乾志, 窪木拓男, 矢谷博文

日本顎関節学会雑誌 13 ( 1 ) 134 - 134 2001.4

Randomized controlled evaluation on non-surgical treatments for temporomandibular joint anterior disk displacement without reduction

H Minakuchi, T Kuboki, Y Matsuka, K Maekawa, H Yatani, A Yamashita

JOURNAL OF DENTAL RESEARCH 80 ( 3 ) 924 - 928 2001.3

Language：English Publisher：AMER ASSOC DENTAL RESEARCH

The common methods for treating anterior disk displacement without reduction (ADDwor) are not based on randomized controlled clinical trials. Our study evaluated non-surgical treatments in 69 MRI-confirmed ADDwor subjects (m/f = 6/63). Subjects were randomly assigned to a control group and one of two treatment groups. Outcomes included maximum mouth opening, visual analogue scale of pain, and daily activity limitation. Calibrated examiners collected data at the initial interview and at 0, 2, 4, and 8 weeks of treatment. At the eight-week point, within-group improvements were present for all variables, for all groups. Between-group differences were not highly evident, with only mean daily activity limitation for the self-careiNSAID group being significantly lower than that of the occlusal appliance/jaw mobilization + self-care/NSAID group at the two- and four-week time-points. These results suggest that ADDwor subjects will improve with only minimal treatment intervention, and no significant difference was evident for the treatments tested and the control condition.

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口腔インプラントの患者の分子生物学的マーカーによるリスク評価口腔インプラント周囲歯肉溝滲出液中のMMPsの検出

荒川光, 上原淳二, 半井雅昭, 小島俊司, 水島恒尚, 園山亘, 完山学, 窪木拓男, 矢谷博文

日本口腔インプラント学会誌 14 ( 1 ) 99 - 99 2001.3

A trigeminal neuralgia-like paroxysmal pain condition presumably due to buccal nerve compression in the temporalis muscle

S Maeda, T Miyawaki, T Kuboki, M Shimada

CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE 19 ( 1 ) 56 - 60 2001.1

Language：English Publisher：CHROMA INC

We encountered three patients with trigeminal neuralgia-like paroxysmal pain in the buccal nerve region. In all cases, paroxysmal pain was felt spreading to the receptive field of the ipsilateral buccal nerve, and clear tenderness was observed during intraoral palpation at the inner side of the mandibular ramus where the temporalis muscle runs and attaches. It was assumed that the paroxysmal pain might be caused by nerve compression related to temporalis muscle hyperactivity. To lend support to this hypothesis, we also studied the anatomical relationship between the buccal nerve and the masticatory muscles. In this autopsy study, the buccal nerve pierced the temporalis muscle in six (12%) of 52 specimens from 26 cadavers. These findings support the hypothesis that peripheral buccal nerve compression could be an etiology of paroxysmal neuropathic pain in the unilateral orofacial region.

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Management of testicular intraepithelial neoplasia (TIN) - a review on the foundation of evidence based medicine (EBM)

KP Dieckmann, J Classen, R Souchon, Loy, V

WIENER KLINISCHE WOCHENSCHRIFT 113 ( 1-2 ) 7 - 14 2001.1

Language：German Publishing type：Book review, literature introduction, etc. Publisher：SPRINGER-VERLAG WIEN

Testicular intraepithelial neoplasia (TIN; also called carcinoma in situ of the testis) is the uniform precursor of testicular germ cell tumors. There is general agreement on the biological significance of TIN, however, the treatment is still a matter of dispute. The present review summarizes the treatment options currently available.
In general, the management of TIN has to be adapted to the particular clinical situation of the patient.
Eradication of TIN usually implies the loss of fertility. Therefore, fertility aspects should be considered before any kind of treatment is employed. Usually, patients with TIN have only small residual potential of fertility. Nonetheless, individual patients may qualify for sperm banking or cryopreservation of testicular tissue for future sperm extraction (TESE) and assisted fertilization.
The most common clinical situation is the case of contralateral TIN in the presence of unilateral testicular cancer. Low dose radiotherapy to the testis with 18 Gy is the standard management option in these patients. The same procedure may be applied to solitary testicles after partial orchiectomy for germ cell tumors. During followup, testosterone levels should be evaluated every six months.
If chemotherapy is required due to metastatic disease of the primary tumor management of TIN should be deferred. After chemotherapy 30% of TIN cases will persist and approximately 42% will recur in the later course. Repeat biopsy should be done six months after completion of chemotherapy or later. Only in cases with persistent TIN additional radiotherapy should be administered.
If one testicle is afflicted with TIN while the other testis is in healthy condition (conceivable in infertility cases or patients with primary extragonadal germ cell tumors), then the TIN-bearing testis should be excised. Radiotherapy is not feasible in these cases because of shielding problems with the healthy testis.

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結合組織成長因子（CTGF/Hcs24）を応用した関節軟骨再生療法の可能性の検討－in vitroおよびin vivoにおける検討－

西田崇, 小島俊司, 窪木拓男, 中西徹, 久保田聡, 滝川正春

第３回生体組織工学シンポジウム 2001

卒後臨床研修における顎関節MRI読影トレーニングの一方法

山下和夫, 宮脇正一, 井上雅秀, 片山朗, 窪木拓男, 前川賢治, 水口一, 矢谷博文, 山本照子

日本矯正歯科学会雑誌 14 ( 1 ) 129 - 129 2001

Language：Japanese Publisher：(一社)日本顎関節学会

研修医及び大学院生12名を被験者として,臨床所見と関連の深いOrisiniらの読影基準に基づいて,顎関節症患者の連続サンプルから20関節を選び,被験者ごとにその開閉口位のMRIから顎関節円板動態を診断する読影テストを行った.読影時間は各関節30秒以内とし,読影テスト終了後,各被験者の正答率及び正解との一致度を計算してその結果を公表した.その後,各被験者の間違いを関節ごとに明らかにし,正しい読影方法を教授した.異なる資料を用いて2週間毎に読影テストとその解説を計3回行った.平均正答率と一致度は読影トレーニングを繰り返すごとに向上し,3回目の読影テストの平均値は1,2回目と比べて有意に高い値を示すと共に,臨床上十分許容できる範囲に達した.本法はMRI読影能力を効率的に向上できることが示唆された

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2001&ichushi_jid=J03125&link_issn=&doc_id=20010904370007&doc_link_id=https%3A%2F%2Fprojects.repo.nii.ac.jp%2F%3Faction%3Drepository_uri%26item_id%3D198453&url=https%3A%2F%2Fprojects.repo.nii.ac.jp%2F%3Faction%3Drepository_uri%26item_id%3D198453&type=%8D%91%97%A7%8F%EE%95%F1%8Aw%8C%A4%8B%86%8F%8A%81FNii%83v%83%8D%83W%83F%83N%83g%83%8A%83%7C%83W%83g%83%8A&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80182_3.gif

顎関節物語．初診時の患者の見方と初期にしてはいけない治療は

窪木拓男

日本歯科評論 ( 702 ) 173 - 175 2001

中心咬合位付近で下顎の左方偏位を示した顎関節症患者の顎関節形態と顎口腔機能分析所見

谷本裕子, 宮脇正一, 荒木佳子, 片山朗, 山本照子, 前川賢治, 窪木拓男, 矢谷博文

岡山歯学会雑誌 21 ( 1 ) 180 - 181 2001

Language：Japanese Publisher：岡山歯学会

23歳8ヵ月女.主訴は開口時下顎骨の左方偏位,下顎前突感,咀嚼時の右側顎関節部疼痛.顎口腔機能検査により,著しい右側での偏咀嚼癖が明確となった.その後,反対側の左側での咀嚼を心がけたところ,再び左側顎関節に疼痛が発現した.顎顔面形態と顎口腔機能を解析した結果,矢状面観において顎関節に異常を認めなかったが,前頭面観において顎関節の断層X線写真所見とナソヘキサグラフ所見により下顎頭運動の異常を認め,側方向における下顎頭と関節円板の位置異常が疑われた

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外傷による歯牙欠損に対しインプラント治療を施行した症例の検討

田村彰規, 真野隆充, 上山吉哉, 岸本晃治, 山田庸介, 完山学, 荒川光, 園山亘, 窪木拓男, 矢谷博文

岡山歯学会雑誌 20 ( 2 ) 201 - 208 2001

Language：Japanese Publisher：岡山歯学会

外傷による歯牙欠損に対するインプラントを施行した4例(平均24.8歳)について検討を行った.可撤性義歯の使用では機能的,審美的に問題があり患者の満足が得られなかった.そのため外傷による前歯部歯牙欠損に対してインプラントを施行したが,これにより機能的にも審美的にも患者の満足が得られた

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Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis

T Shimo, T Nakanishi, T Nishida, M Asano, A Sasaki, M Kanyama, T Kuboki, T Matsumura, M Takigawa

ONCOLOGY 61 ( 4 ) 315 - 322 2001

Language：English Publisher：KARGER

Connective tissue growth factor (CTGF) is a potent secreted signaling factor which functions in multiple stages of angiogenesis. In the present study, we examined the role of CTGF in tumor angiogenesis and made the following observations: (1) Histological analysis of human breast cancer (MDA231) cell and human fibrosarcoma (HT1080) cell xenografts in BALB/c nude mice showed a high level of neovascularization. Human squamous cell carcinoma (A431) xenografts induced only a low level of neovascularization. (2) CTGF mRNA was strongly expressed in MDA231 and in HT1080 cells in vivo and in vitro, but not in A431 cells. (3) CTGF protein was markedly produced in MDA231 cells and HT1080 cells and secreted into culture medium, and its production was greater during phases of growth rather than confluency. (4) Production of CTGF in bovine aorta endothelial cells was induced by CTGF, VEGF, bFGF and TGF-beta. (5) Neovascularization induced by HT1080 cells or MDA231 cells on chicken chorioallantoic membrane was suppressed in the presence of neutralizing CTGF-specific polyclonal antibody. These results suggest that CTGF regulates progression in tumor angiogenesis and the release or secretion of CTGF from tumor cells is essential for the angiogenesis. Copyright (C) 2001 S. Karger AG, Basel.

DOI： 10.1159/000055339

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Relationship between signal intensity in T2-wighted MR images and near-infrared spectroscopy signals of the human masseter muscle.

T.Kuboki, K.Suzuki, K.Maekawa, M.Inoue, C.O.Acero Jr, Y.Yanagi, T.Wakasa, K.Kishi, H.Yatani, G.T.Cla

Arch Oral Biol 2001

Supportive Periodontal Treatment（SPT）期にある歯周病患者の根面う蝕症の実態

清水明美, 大橋敏雄, 山崎太士, 杉典子, 塩見伸行, 竹内加珠, 村内利光, 岡本慎治, 前田武将, 窪木拓男, 矢谷博文, 山下敦, 高柴正悟, 村山洋二

岡山歯学会雑誌 20 ( 1 ) 119 - 127 2001

Language：Japanese Publisher：岡山歯学会

Supportive Periodontal Treatment(SPT)期にある歯周病患者の根面う蝕の実態を報告した.SPT患者群と非SPT患者群間ではう蝕罹患経験,う蝕リスク因子による有意差はなく,う蝕罹患の危険性に差はなかった.露出根面に対してう蝕や修復の多いSPT患者はう蝕リスクが大きく,更にう蝕を引き起こす可能性が高いことが示唆された

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エビデンスを「創る」治療効果を明らかにするための研究デザイン

窪木拓男

日本補綴歯科学会学術大会プログラム・抄録集 106th 2001

Residency program training for proper reading of the results of magnetic resonance imaging of the TMJ.

山下和夫, 宮脇正一, 井上雅秀, 片山朗, 窪木拓男, 前川賢治, 水口一, 矢谷博文, 山本照子

Orthodontic Waves 60 ( 4 ) 2001

Supportive Periodontal Treatment(SPT)期にある歯周病患者の根面う蝕症の実態

清水明美, 大橋敏雄, 山崎太士, 杉典子, 塩見信行, 窪木拓男, 矢谷博文, 山下敦, 村山洋二

岡山歯学会雑誌 20 ( 1 ) 2001

修復象牙質形成促進時における結合組織成長因子の局在とその発現制御機構

園山亘, 窪木拓男, 江口傑徳, 小森千尋, 藤沢拓生, 完山学, 矢谷博文

日本補綴歯科学会学術大会プログラム・抄録集 106th 2001

中心こう合位付近で下顎の左方偏位を示した顎関節症患者の顎関節形態と顎口腔機能分析所見

谷本裕子, 宮脇正一, 荒木佳子, 片山朗, 山本照子, 前川賢治, 窪木拓男, 矢谷博文

岡山歯学会雑誌 20 ( 2 ) 2001

オッセオインテグレーションの獲得と維持からみたオッセオインテグレーテッドインプラントの予後

完山学, 荒川光, 園山亘, 小島俊司, 秋山謙太郎, 窪木拓男, 矢谷博文

日本口腔インプラント学会学術大会抄録集 31st 2001

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