Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

Division display 1,181 - 1,200 of about 1,411 ／ All the affair displays >>

マウス抗II型コラーゲン抗体関節炎におけるTh1/2/17反応とSOCS3・SOCS5による制御

高畑智宏, 松川昭博, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 52回・17回 385 - 385 2008.4

Comparison of two MIS lumbar interbody fusion procedures for degenerative spondylolisthesis

MISAWA H.

19 ( 2 ) 213 - 213 2008.3

Surgical Treatment of Neuromuscular Scoliosis

TANAKA M.

19 ( 2 ) 455 - 455 2008.3

The subaxial alignment change after atlantoaxial fusion

TANAKA M.

19 ( 1 ) 51 - 51 2008.3

Application of laminar screws to posterior fusion of cervical spine

Kazuo Nakanishi, Masato Tanaka, Yoshihisa Sugimoto, Haruo Misawa, Tomoyuki Takigawa, Kazuo Fujiwara, Keiichiro Nishida, Toshifumi Ozaki

SPINE 33 ( 6 ) 620 - 623 2008.3

Language：English Publisher：LIPPINCOTT WILLIAMS & WILKINS

Study Design. Morphometric analysis.
Objective. For safe and solid fixation, it is necessary to measure the diameter of the vertebral arch to ascertain whether or not screws can be used and if so, the appropriate size of screws to be used.
Summary of Background Data. Cervical pedicle screws are the most biomechanically stable screws. However, their use carries a high risk of neurovascular complications during screw insertion. In 2004, a new method to avoid such vertebral artery injuries was reported by insertion of screws with crosswise to the lamina of C2. For safe and solid fixation, it is necessary to measure the diameter of the vertebral arch to ascertain whether or not screws can be used and if so, the appropriate size of screws to be used. There is no report of the diameter of the vertebral arch by a navigation system.
Methods. Morphometric analysis was performed on 42 patients who had undergone a CT scan of the cervical spine for either surgery or diagnostic purposes. To examine the possibilities to insert laminar screws, the diameter of the vertebral arch was measured using a navigation system.
Results. The diameter of the vertebral arch in C2 was the largest in the cervical spine, individual differences ranging between 0.8 and 8.4 mm. In C2, insertion of screws with a diameter of 3 mm was possible in 80% of males and 63% of females. As for screws with a diameter of 4 mm, insertion was possible in 50% of the males and 24% of the females in C2. In C2, gender had a significant effect, but left-right differences and height did not.
Conclusion. Laminar screws are useful as they can prevent vascular injuries, but a preoperative evaluation is necessary.

Web of Science

researchmap

2.特発性側弯症におけるCobb角の進行と重心動揺(第20回日本リハビリテーション医学会中国・四国地方会)

迫間巧将, 千田益生, 堅山佳美, 田中雅人, 中西一夫, 三澤治夫, 尾崎敏文

リハビリテーション医学 : 日本リハビリテーション医学会誌 45 ( 2 ) 129 - 129 2008.2

Prognostic implication of SYT-SSX fusion type in synovial sarcoma: A multi-institutional retrospective analysis in Japan

Satoshi Takenaka, Takafumi Ueda, Norifumi Naka, Nobuhito Araki, Nobuyuki Hashimoto, Akira Myoui, Toshifumi Ozaki, Tomitaka Nakayama, Junya Toguchida, Kazuhiro Tanaka, Yukihide Iwamoto, Akihiko Matsumine, Atsumasa Uchida, Makoto Ieguchi, Mitsunori Kaya, Takuro Wada, Ichiro Baba, Ikuo Kudawara, Yasuaki Aoki, Hideki Yoshikawa

ONCOLOGY REPORTS 19 ( 2 ) 467 - 476 2008.2

Language：English Publisher：PROFESSOR D A SPANDIDOS

The prognostic implication of SYT-SSX fusion type in synovial sarcomas is still controversial. The aim of this study is to clarify the prognostic impact of fusion type, in association with other clinical factors, in patients with synovial sarcoma in Japan. Data on 108 SYT-SSX fusion transcript-positive patients with synovial sarcoma, treated in I I tertiary referral cancer centers in Japan, were retrospectively analyzed. The following parameters were examined for their potential prognostic impact: SYT-SSX fusion type, patient age at presentation, sex, primary tumor location, tumor size, histological subtype, histological grade, treatment modalities and disease stage at presentation. Among the patients with localized disease at presentation, 5-year overall survival (OS) for SYT-SSX1 and -2 subgroups were 84.4 and 74.9%, respectively (P=0.244). Five-year metastasis-free survival (MFS) rates were 67.8% for SYT-SSX1 and 68.5% for SYT-SSX2 (P=0.949). Univariate survival analyses for 91 patients with localized disease at presentation showed that tumor size was the only significant prognostic factor for OS (P=0.0033) and MFS (P=0.0029) and the histological grade was marginally significant for MFS (P=0.0785), whereas the SYT-SSX fusion type and other variables were not. Multivariate survival analyses further indicated that tumor size was the most significant independent prognostic factor for OS and MFS and the histological grade was also significant for MFS. In conclusion, the SYT-SSX fusion type is not a significant prognostic factor unlike tumor size, followed by histological grade for patients with localized synovial sarcoma in Japan.

Web of Science

researchmap

Treatment result of pathological fractures of bone metastases

NAKATA Eiji

51 ( 1 ) 83 - 84 2008.1

Inhibition of histone deacetylase down-regulates the expression of hypoxia-induced vascular endothelial growth factor by rheumatoid synovial fibroblasts

H. Manabe, Y. Nasu, T. Komiyama, T. Furumatsu, A. Kitamura, S. Miyazawa, Y. Ninomiya, T. Ozaki, H. Asahara, K. Nishida

INFLAMMATION RESEARCH 57 ( 1 ) 4 - 10 2008.1

Language：English Publisher：BIRKHAUSER VERLAG AG

Objective: To investigate the effect of FK228 on the in vitro expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) by rheumatoid arthritis synovial fibroblasts (RASFs), and on the in vivo expression of VEGF and angiogenesis in the synovial tissue of mice with collagen-antibody-induced arthritis (CAIA).
Methods: RASFs were stimulated with IL-1 beta and TNF alpha and then incubated under hypoxia (1 % O-2) with various concentrations of FK228. The effects of FK228 on the expression of HIF-1 alpha and VEGF mRNA were examined by quantitative real-time PCR. Changes in HIF-1 alpha protein expression and the secretion of VEGF protein into the culture medium were examined by Western blot analysis and ELISA, respectively. Immunohistochemical analysis was carried out to investigate the expression and distribution of VEGF in synovial tissues of CAIA mice.
Results: The cytokine-stimulated expression of HIF-1 alpha and VEGF mRNA was inhibited by FK228 in a dose-dependent manner. FK228 also reduced the expression of HIF-1 alpha and VEGF protein. Intravenous administration of FK228 (2.5 mg/kg) suppressed VEGF expression, and also blocked angiogenesis in the synovial tissue of CAIA.
Conclusion: FK228 may exhibit a therapeutic effect on RA by inhibition of angiogenesis through down-regulation of angiogenesis related factors, HIF-1 alpha and VEGF.

DOI： 10.1007/s00011-007-7036-z

Web of Science

researchmap

半月板縫合術における FasT-Fix の使用経験 -適応と限界-.

古松毅之, 阿部信寛, 伊達宏和, 迫間巧将, 尾﨑敏文

中・四整会誌 20 ( 1 ) 69 - 74 2008

P.F.C Sigma RP-F 人工膝関節置換術後 Patellar Clunk Syndrome を呈した 1 例.

阿部信寛, 吉鷹輝仁, 林智樹, 伊達宏和, 迫間巧将, 尾﨑敏文

中・四整会誌 20 ( 1 ) 17 - 21 2008

Giant Cell Tumor of Bone with Malignant Transformation : A Case Report

Sasaki Tsuyoshi, Morimoto Yuki, Ohata Norihide, Yoneda Yasushi, Ozaki Toshifumi, Kunisada Toshiyuki, Sugihara Shinsuke, Nakata Eiji

The Journal of the Chugoku-Shikoku Orthopaedic Association 20 ( 2 ) 261 - 265 2008

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

We present a case of malignant giant cell tumor of bone (GCT) that developed after surgery alone. Malignancy develops in approximately 1-2% of patients with giant cell tumors of bone, and is classified as either primary or secondary. Primary malignant GCT is extremely rare, and secondary malignant GCT typically occurs after radiotherapy, but can rarely occurs without radiotherapy. A 27-year-old male with GCT of bone in the left distal femur was treated by curettage and autologous bone grafting. One year later, the tumor recurred and reoperation was performed. Two years after the second surgery, malignant change and pulmonary metastasis occurred. Despite chemotherapy, the patient died one year after development of malignant GCT. This patient was younger than is usual for cases of this type, and the period between recurrences was shorter than usual. Clinicians should be mindful about malignant transformation in cases with giant cell tumor of bone showing repeated recurrence.

DOI： 10.11360/jcsoa.20.261

CiNii Article

researchmap

Navigation 下の側臥位セメントレス MIS-THAにおける工夫.

鉄永智紀, 三谷茂, 藤原一夫, 遠藤裕介, 皆川寛, 尾﨑敏文

中・四整会誌 20 ( 1 ) 101 - 107 2008

Language：Japanese Publisher：中国・四国整形外科学会

著者らの施設においてCTベースナビゲーション下に施行したMIS-THAのうち、2006年1月〜8月の30例(前期群)と2007年1月〜5月の30例(後期群)を比較検討した。レジストレーションの方法と術中操作は前期群と後期群で以下の4点が変更された。1)腸骨稜のレジステーションは、前期群では腸骨稜全体を行ったが、後期群では腸骨稜の外側縁に変更した。2)臼底のレジステーションは、前期群では臼底全体に行ったが、後期群では臼底下部中心へ変更した。3)臼蓋縁のレジステーションは、前期群では骨棘の影響が少ない臼蓋縁の上方のみであったが、後期群ではなるべく広範囲に臼蓋全周に変更した。4)前期群ではナビゲーションを設置するためのピンを創外の腸骨稜に刺入していたが、後期群では創内上方に設置した。以上、これらの結果、術中verification値と術後CT計測値との誤差は後期群で有意に減少し、より正確で安全なナビゲーション手術が可能となることが示唆された。

DOI： 10.11360/jcsoa.20.101

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J02438&link_issn=&doc_id=20080509040019&doc_link_id=%2Fcm4ortho%2F2008%2F002001%2F019%2F0101-0107%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcm4ortho%2F2008%2F002001%2F019%2F0101-0107%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

化膿性脊椎炎に対する治療経験.

中西一夫, 田中雅人, 三澤治夫, 瀧川朋亨, 尾﨑敏文

西日本脊椎研究会誌 34 ( 1 ) 50 2008

MRI 画像による後十字靱帯損傷膝の修復過程の解析.

林智樹, 阿部信寛, 吉鷹輝仁, 迫間巧将, 伊達宏和, 尾﨑敏文

中・四整会誌 20 ( 1 ) 13 - 16 2008

Insall 変法にて治療した骨端線閉鎖前習慣性膝蓋骨脱臼の 1 例.

伊達宏和, 阿部信寛, 古松毅之, 迫間巧将, 尾﨑敏文

中・四整会誌 20 ( 1 ) 127 - 132 2008

大腿骨頭すべり症で大腿骨頭壊死を生じた 1 例.

鉄永智紀, 三谷茂, 遠藤裕介, 皆川寛, 尾﨑敏文

整形外科 59 ( 2 ) 164 - 168 2008

Language：Japanese Publisher：(株)南江堂

12歳男児。患者はスキー中に転倒し、右股関節痛の出現で歩行不能となり近医を受診、右大腿骨頭すべり症と診断され、著者らの施設へ紹介となった。X線ではみかけの頸体角は右127°でTrethowan徴候が認められ、側面像では右股後方傾斜角(PTA)55°でanterior physeal separationを認めた。更に45日間の介達牽引後、X線ですべり部の線維性癒合と骨頭の輝度変化を認め、入院45日目に手術を行なうこととなった。手術内容は右側は3次元転子骨切り術でPTAを30°以下に矯正し、左側は現位置ピン固定(in situ pinning)を行った。だが、骨シンチで右大腿骨頭に集積がなく骨頭壊死が疑われ、X線で骨頭の陥凹を認めたため、術後6ヵ月間松葉杖歩行の完全免荷とした。その結果、徐々に壊死領域の修復を認め、術後7ヵ月に骨切り部と骨端線の癒合を認めた。以後、1年経過で右側のプレートを抜去して部分荷重歩行を開始、目下、術後8年経過で関節適合性は良好で、関節裂隙は保たれている。

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J00764&link_issn=&doc_id=20080128240014&doc_link_id=issn%3D0030-5901%26volume%3D59%26issue%3D2%26spage%3D164&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0030-5901%26volume%3D59%26issue%3D2%26spage%3D164&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

MIPO technique with the locking compression plate for lower leg lengthening

Orthopaedic surgery and traumatology 51 ( 11 ) 1507 - 1511 2008

MRI において転移性脊椎腫瘍と鑑別を要した再生不良性の貧血の 1 例.

杉本佳久, 田中雅人, 中西一夫, 三澤治夫, 瀧川朋亨, 尾﨑敏文

整形外科 59 ( 5 ) 489 - 491 2008

基礎研究に意欲を持った整形外科医の育成と環境の整備.

古松毅之, 尾﨑敏文

日整会誌 82 ( 5 ) 428 - 430 2008

　 PREV - NEXT 　

< OZAKI Toshifumi >

MISC - OZAKI Toshifumi