Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

Division display 1,181 - 1,200 of about 1,444 ／ All the affair displays >>

特発性側弯症における頚椎 MRI の有用性

高畑智宏, 田中雅人, 三澤治夫, 越宗幸一郎, 尾﨑敏文

西日本脊椎研究会誌第35巻 ( 1 ) 89 - 89 2009

腰椎疾患初診患者における臨床症状と自己評価抑うつ尺度の検討

三澤治夫, 田中雅人, 越宗幸一郎, 中西一夫, 尾﨑敏文

西日本脊椎研究会誌第35巻 ( 1 ) 58 - 62 2009

Treatment of long bone fractures using locking plate

SAIGA Kenta

The Central Japan Journal of Orthopaedic Surgery & Traumatology 第52巻 ( 3 ) 663 - 664 2009

仙骨骨盤部巨大神経鞘腫の検討

三澤治夫, 田中雅人, 越宗幸一郎, 尾﨑敏文

西日本脊椎研究会誌第35巻 ( 2 ) 209 - 209 2009

当科における脊髄腫瘍の手術成績

田中雅人, 三澤治夫, 越宗幸一郎, 尾﨑敏文

西日本脊椎研究会誌第35巻 ( 2 ) 153 - 160 2009

股関節手術時の出血と血管内止血

藤原一夫, 三谷茂, 遠藤裕介, 鉄永智紀, 皆川寛, 迫間巧将, 中原龍一, 尾﨑敏文, 三村秀文

関節外科第28巻 ( 6 ) 695 - 701 2009

脊髄原発 High grade astrocytoma の 2 例

三澤治夫, 田中雅人, 越宗幸一郎, 尾﨑敏文

西日本脊椎研究会誌第35巻 ( 2 ) 232 - 232 2009

Short-Term Results of Metal-on-Metal Total Hip Arthroplasty

Tetsunaga Tomonori, Mitani Shigeru, Endo Hirosuke, Minagawa Hiroshi, Ozaki Toshifumi, Fujiwara Kazuo

The Journal of the Chugoku-Shikoku Orthopaedic Association 第21巻 ( 1 ) 53 - 57 2009

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

Metal-on-metal total hip arthroplasty (THA) is characterized by low wear and a wide range of motion. We performed metal-on-metal THA with limitations in young males with alcoholic avascular necrosis of the femoral head, and studied the short-term outcome of the procedure. Five patients were treated during the period from September 2007 to July 2008. All of the patients were males engaged in manual labor. The average age at the time of surgery was 39 years, and the average postoperative follow-up period was 5.2 months. The average period until return to work was 57 days, and no particular postoperative complications were observed. With regard to postoperative range of motion, more than 100 degrees of flexion was obtained. The average Japanese Orthopaedic Association hip score, which was 42 points before surgery, improved significantly to 93 points after surgery. In particular, pain was disappeared completely, and it was possible for the patients to return to heavy manual labor. As metal-on-metal THA might be involved with some problems, such as the metal ion concentration, its application to patients with renal dysfunction or gravida should be limited.

DOI： 10.11360/jcsoa.21.53

CiNii Article

researchmap

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. International journal

Tatsuo Ito, Neelu Yadav, Jaeho Lee, Takayuki Furumatsu, Satoshi Yamashita, Kenji Yoshida, Noboru Taniguchi, Megumi Hashimoto, Megumi Tsuchiya, Toshifumi Ozaki, Martin Lotz, Mark T Bedford, Hiroshi Asahara

BMC developmental biology Vol.9 47 - 47 2009

Language：English

BACKGROUND: Chondrogenesis and subsequent endochondral ossification are processes tightly regulated by the transcription factor Sox9 (SRY-related high mobility group-Box gene 9), but molecular mechanisms underlying this activity remain unclear. Here we report that coactivator-associated arginine methyltransferase 1 (CARM1) regulates chondrocyte proliferation via arginine methylation of Sox9. RESULTS: CARM1-null mice display delayed endochondral ossification and decreased chondrocyte proliferation. Conversely, cartilage development of CARM1 transgenic mice was accelerated. CARM1 specifically methylates Sox9 at its HMG domain in vivo and in vitro. Arg-methylation of Sox9 by CARM1 disrupts interaction of Sox9 with beta-catenin, regulating Cyclin D1 expression and cell cycle progression of chondrocytes. CONCLUSION: These results establish a role for CARM1 as an important regulator of chondrocyte proliferation during embryogenesis.

DOI： 10.1186/1471-213X-9-47

PubMed

researchmap

Computer navigation-assisted spinal fusion with segmental pedicle screw instrumentation for scoliosis with Rett syndrome: a case report.

Masato Tanaka, Kazuo Nakanishi, Yoshihisa Sugimoto, Haruo Misawa, Tomoyuki Takigawa, Keiichiro Nishida, Toshifumi Ozaki

Acta medica Okayama 63 ( 6 ) 373 - 377 2009

Language：English

Scoliosis is a common clinical manifestation of Rett syndrome, a neurodevelopmental disorder that almost exclusively affects females. The spinal curve in patients with Rett syndrome is typically a long C curve of a neuromuscular type. As the onset of the scoliosis is very early and shows rapid progression, early surgical intervention has been recommended to prevent a life-threatening collapsing spine syndrome. However, there are high perioperative risks in Rett syndrome patients who undergo spinal surgery, such as neurological compromise and respiratory dysfunction due to rigid spinal curve. We herein report the surgical result of treating severe rapid progressive thoracic scoliosis in a 16-year-old girl with Rett syndrome. Posterior segmental pedicle screw fixation was performed from T1 to L3 using a computer-assisted technique. Post-operative radiography demonstrated a good correction of the curve in both the sagittal and coronal alignment. There were no postoperative complications such as neurological compromise. The patient had maintained satisfactory spinal balance as of the 3-year follow-up examination.

DOI： 10.18926/AMO/31823

PubMed

researchmap

Frequent methylation of RASSF1A in synovial sarcoma and the anti-tumor effects of 5-aza-2'-deoxycytidine against synovial sarcoma cell lines. International journal

Kunihiko Numoto, Aki Yoshida, Shinsuke Sugihara, Toshiyuki Kunisada, Yuki Morimoto, Yasushi Yoneda, Yasuko Fujita, Keiichiro Nishida, Mamoru Ouchida, Toshifumi Ozaki

Journal of cancer research and clinical oncology 136 ( 1 ) 17 - 25 2009

Language：English

PURPOSE: In this study, the methylation status of RASSF1A in synovial sarcomas and the effect of demethylation on synovial sarcoma were examined. METHODS: The methylation status in 74 soft tissue sarcomas (STSs) including 21 synovial sarcomas was determined by methylation specific PCR. The effect of the de-methylating agent 5-aza-20-deoxycytidine (5-Aza-dC) on synovial sarcoma was examined using synovial sarcoma cell lines (SYO-1 and HS-SY-II). RESULTS: RASSF1A methylation was observed in 10 (47.6%) of 21 synovial sarcomas and in 10 (18.9%) of 53 the other STSs (P = 0.0295). De-methylation of the cells by treatment with 5-Aza-dC induced re-expression of RASSF1A and growth suppression of the cells. The calculated IC50 of 5-Aza-dC against the SYO-1 and the HS-SYII cells were 0.9 and 1.3 lM (96 h), respectively. With twice weekly administration of 1 or 10 mg/kg 5-Aza-dC, the growth of the mouse xenograft tumors of SYO-1 was significantly suppressed in comparison to the controls (P\0.01). CONCLUSION: This is the first report showing the anti-tumor effect of 5-Aza-dC on synovial sarcoma. 5-Aza-dC is suggested to have a good therapeutic potential against synovial sarcoma.

DOI： 10.1007/s00432-009-0632-2

PubMed

researchmap

低侵襲型人工膝関節置換術支援ロボットの精度評価

藤原一夫, 阿部信寛, 遠藤裕介, 西田圭一郎, 尾崎敏文, 鈴木昌彦, 斎藤季, 杉田直彦, 中島義和, 光石衛

日本整形外科学会雑誌 83 ( 8 ) 2009

X-ray dark field imaging of human articular cartilage: Possible clinical application to orthopedic surgery

Toshiyuki Kunisada, Daisuke Shimao, Hiroshi Sugiyama, Ken Takeda, Toshifumi Ozaki, Masami Ando

EUROPEAN JOURNAL OF RADIOLOGY 68 ( 3 ) S18 - S21 2008.12

Language：English Publisher：ELSEVIER IRELAND LTD

Despite its convenience and non-invasiveness on daily clinical use, standard X-ray radiography cannot show articular cartilage. We developed a novel type of X-ray dark field imaging (DFI), which forms images only by a refracted beam with very low background illumination. We examined a disarticulated distal femur and a shoulder joint with surrounding soft tissue and skin, both excised from a human cadaver at the BL20B2 synchrotron beamline at SPring-8. The field was 90 mm wide and 90 mm high. Articular cartilage of the disarticulated distal femur was obvious on DFI, but not on standard X-ray images. Furthermore, DFI allowed visualization in situ of articular cartilage of the shoulder while covered with soft tissue and skin. The gross appearance of the articular cartilage on the dissected section of the proximal humerus was identical to the cartilage shown on the DFI image. These results suggested that DFI could provide a clinically accurate method of assessing articular cartilage. Hence, DFI would be a useful imaging tool for diagnosing joint disease such as osteoarthritis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2008.04.034

Web of Science

researchmap

Subluxation after internal fixation of a femoral neck fracture in the presence of hip dysplasia: A case report

Tomonori Tetsunaga, Tomoyuki Noda, Hirosuke Endo, Kazuo Fujiwara, Hiroshi Minagawa, Shigeru Mitani, Toshifumi Ozaki

Injury Extra 39 ( 12 ) 380 - 383 2008.12

The step up cannulated guide and cannula for hip scopy

ENDO Hirosuke

34 712 - 714 2008.11

Advantage of arthroscopy in preoperative planning of femoral osteotomy combined with pelvic osteotomy for osteoarthritis of the hip

MITANI Shigeru

33 ( 3 ) 215 - 215 2008.10

The Minimally Invasive Plate Osteosynthesis (MIPO) Technique with a Locking Compression Plate for Femoral Lengthening

Hirosuke Endo, Koji Asaumi, Shigeru Mitani, Tomoyuki Noda, Hiroshi Minagawa, Tomonori Tetsunaga, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 62 ( 5 ) 333 - 339 2008.10

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

A minimally invasive plate osteosynthesis technique using a locking compression plate (LCP) has been used widely in trauma cases. Its advantages are that the MIPO technique does not interfere with the fracture site and thus provides improved biological healing, and that the UP has excellent angular stability. Its use in bone lengthening, however, has not been established. In such cases, it is desirable to shorten the external skeletal fixation period as much as possible. Here, the MIPO technique using an UP was applied to femoral distraction osteogenesis in an attempt to shorten the external skeletal fixation period. For femoral lengthening, the MIPO technique was performed in 2 stages. Orthofix external fixators (Ortholix, England) were used to insert screws from the anterolateral side rather than from the lateral side of the femur for bone lengthening. When sufficient callus formation was detected postoperatively at the site of bone lengthening, and the absence of infection was ensured, limb draping was performed, including a whole external fixator, and then the MIPO technique was applied with an LCP.
In 3 cases (5 limbs), the average duration of external skeletal fixation was 134 days, the average external-fixation index was 24 days/cm, and the average consolidation index was 22 days/cm. The MIPO technique using an LCP made it possible to shorten the external skeletal fixation-wearing period in femoral lengthening.

DOI： 10.18926/AMO/30972

Web of Science

researchmap

E‐PASS scoring systemを用いた転移性骨腫瘍の術前リスク予測

中田英二, 大森貴夫, 黒住健人, 西山武, 菊地剛, 阿部光伸, 福田昇司, 時岡孝光, 森本裕樹, 尾崎敏文

中国・四国整形外科学会雑誌 20 ( 3 ) 358 - 358 2008.10

Spinal cord herniation into pseudomeningocele after traumatic nerve root avulsion: case report and review of the literature

Masato Tanaka, Hisanori Ikuma, Kazuo Nakanishi, Yoshihisa Sugimoto, Haruo Misawa, Tomoaki Takigawa, Toshifumi Ozaki

EUROPEAN SPINE JOURNAL 17 ( Suppl 2 ) S263 - S266 2008.9

Language：English Publishing type：Book review, literature introduction, etc. Publisher：SPRINGER

We present an extremely rare case of traumatic spinal cord herniation due to a brachial plexus avulsion injury and provide a review of the literature of spinal cord herniation. Spinal cord herniation is an uncommon condition that can occur spontaneously or as a result of surgery or trauma. This condition often presents with symptoms and signs as Brown-Sequard syndrome. Traumatic pseudomeningoceles after a brachial plexus avulsion injury have been reported. But transdural herniation of the spinal cord into this pseudomeningocele is an extremely rare and poorly documented condition. There is only two reports of this condition in a thoracic case. The authors report the case of a 22-year-old man presented with a 2-year history of quadriplegia. He was involved in a motorcycle accident, 3 years prior to his presentation. Four years after the initial right brachial plexus injury, he was not able to walk independently. Magnetic resonance imaging (MRI) and computerized tomography (CT) myelography revealed a lateral pseudomeningocele arising from the right C6-7 and C7-T1 intervetebral foramen and cervical spinal cord herniation into this pseudomeningocele. The patient underwent primary closure of pseudomeningocele to prevent spinal cord reherniation. He can walk with cane and use left arm unrestrictedly at the 2-year follow-up examination. Spinal cord herniation following traumatic nerve root avulsion is extremely rare but it should be considered in the differential diagnosis of patients presenting with delayed myelopathy or Brown-Sequard syndrome.

DOI： 10.1007/s00586-007-0537-1

Web of Science

researchmap

Disease-specific screening for deep venous thrombosis and pulmonary thromboembolism using plasma D-dimer values after total knee arthroplasty

Teruhito Yoshitaka, Nobuhiro Abe, Hiroshi Minagawa, Hirokazu Date, Yoshimasa Sakoma, Keiichiro Nishida, Toshifumi Ozaki

MODERN RHEUMATOLOGY 18 ( 4 ) 359 - 365 2008.8

Language：English Publisher：SPRINGER

We prospectively evaluated the disease-specific features of the early postoperative plasma D-dimer value and the relationship with deep venous thrombosis and/or pulmonary thromboembolism (DVT/PE) in 95 patients following total knee arthroplasty. Patients in whom DVT/PE was highly suspected were diagnosed by high-resolution multi-detector row computed tomography scanning (MDCT). Forty-nine knees in 46 patients with rheumatoid arthritis (RA, 24 knees) or osteoarthritis (OA, 25 knees) were finally recruited. DVT/PE was detected in 28 (57.1%) of the 49 cases examined by diagnostic MDCT: 12 (50.0%) of the 24 cases of RA, and 16 (64.0%) of the 25 cases of OA. Of these, PE was found in 11 cases (39.2%), but none of them showed clinical symptomatic signs of dyspnea or chest pain. In both RA and OA cases, there were statistically significant differences in the D-dimer value on postoperative day 3 (P = 0.027) and after day 28 (P = 0.037) between the groups with and without DVT/PE. In OA cases, there were significant differences between the two groups on postoperative days 1 (P = 0.034), 3 (P = 0.020), 5 (P = 0.005), and 7 (P = 0.045), respectively. At the baseline, perioperative D-dimer levels in the RA group without DVT/PE were higher than in the OA group. However, multivariate logistic regression analysis showed that RA was not a significant risk factor of DVT/PE in comparison with OA. In conclusion, individual evaluation of the D-dimer level between RA and OA should provide a more precise predictive indicator of early postoperative DVT/PE.

DOI： 10.1007/s10165-008-0068-6

Web of Science

researchmap

　 PREV - NEXT 　

< OZAKI Toshifumi >

MISC - OZAKI Toshifumi