Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

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悪性軟部腫瘍に対するパゾパニブ投与例の後方視的検討

妹尾賢, 久保寿夫, 田端雅弘, 西森久和, 冨田秀太, 国定俊之, 尾崎敏文, 谷本光音, 谷本光音, 木浦勝行

日本臨床腫瘍学会学術集会(CD-ROM) 15th 2017

低出力パルス超音波(LIPUS)が半月板中のCCN2,CCN3に与える効果

釜付祐輔, 青山絵理子, 古松毅之, 前原亜美, 山中信康, 西田崇, 久保田聡, 久保田聡, 尾崎敏文, 滝川正春

日本骨代謝学会学術集会プログラム抄録集 35th 2017

半月板におけるCCN2,CCN3に与える低出力パルス超音波(LIPUS)の効果

釜付祐輔, 釜付祐輔, 青山絵理子, 古松毅之, 前原亜美, 山中信康, 西田崇, 久保田聡, 久保田聡, 尾崎敏文, 滝川正春

日本結合組織学会学術大会抄録集 49th 2017

3-2LIPUSにより半月板でのCCN2の発現・産生は増加する

釜付祐輔, 釜付祐輔, 青山絵理子, 古松毅之, 前原亜美, 山中信康, 西田崇, 久保田聡, 久保田聡, 尾崎敏文, 滝川正春

移植(Web) 52 ( 6 ) 2017

Neurological Recovery after Posterior Spinal Surgery in Patients with Metastatic Epidural Spinal Cord Compression

Noriyuki Watanabe, Yoshihisa Sugimoto, Masato Tanaka, Tetsuro Mazaki, Shinya Arataki, Tomoyuki Takigawa, Masaki Kataoka, Toshiyuki Kunisada, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 70 ( 6 ) 449 - 453 2016.12

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

Metastatic epidural spinal cord compression (MESCC) is a common complication in patients with a malignant tumor, but it is difficult to decide the proper time to perform the necessary surgery. Here we analyzed the prognostic factors for postoperative walking ability. We retrospectively reviewed the cases of 112 MESCC patients treated surgically at our institute and divided them into ambulatory (n = 88) and non-ambulatory (n = 24) groups based on their American Spinal Injury Association (ASIA) Impairment Scale grades at the final follow-up. We also classified the patients preoperatively using the revised Tokuhashi score. We assessed the correlation between preoperative or intraoperative factors and postoperative walking ability in both groups. Of the 10 patients classified preoperatively as grade A or B, 2 (20) were ambulatory at the final follow-up. Of the 102 patients classified preoperatively as grade C, D or E, 86 (84) were ambulatory at the final follow-up (p < 0.001). There were no significant differences between the groups in the average total Tokuhashi score. Our analysis revealed that the severity of paralysis significantly affects neurological recovery in patients with MESCC. Patients with MESCC should receive surgery before the preoperative ASIA Impairment Scale grade falls below grade C.

DOI： 10.18926/AMO/54807

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Pseudoaneurysm of the Perforating Branch of the Deep Femoral Artery Following Anterior Cruciate Ligament Reconstruction

Masataka Fujii, Takayuki Furumatsu, Yasutaka Kadota, Yoshinobu Shimamura, Shigeyuki Tsuchimochi, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 70 ( 6 ) 515 - 518 2016.12

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

The present report describes the first known, case of a pseudoaneurysm of the perforating branch of the deep femoral artery following anterior cruciate ligament (ACL) reconstruction. A 19-year-old man underwent ACL reconstruction using the outside-in femoral tunnel-creation method. Seven days after the surgery, he complained of abnormal thigh pain and had swelling with local heat on the distal lateral thigh. Magnetic resonance imaging, computed tomography, and color Doppler ultrasonography showed the pseudoaneurysm in the thigh. Resection surgery was successfully performed by a vascular surgeon 12 days after ACL reconstruction. Careful examination and awareness of postoperative symptoms such as thigh pain and swelling after ACL reconstruction were critical for the early diagnosis of pseudoaneurysm.

DOI： 10.18926/AMO/54818

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Concurrent Lateral Meniscal Repair with Anterior Cruciate Ligament Reconstruction Induces the Extrusion of the Lateral Meniscus: Assessments of Magnetic Resonance Images

Naoko Kashihara, Takayuki Furumatsu, Yuya Kodama, Takaaki Tanaka, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 70 ( 6 ) 441 - 448 2016.12

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

Concurrent meniscal repair with anterior cruciate ligament (ACL) reconstruction has shown good clinical outcomes, but it has a considerable risk of progressing to post-traumatic osteoarthritis of the knee. Here we investigated postoperative changes in the position of the lateral meniscus (LM) and assessed the short-term clinical results after concurrent LM repair with ACL reconstruction. Twentyseven patients underwent LM repair of a peripheral longitudinal tear concomitant with ACL reconstruction. We evaluated the preoperative and postoperative values of the Lysholm score and anteroposterior instability. The length and width of the lateral tibial plateau were determined by radiographic images. The length, width, body width, extrusion, and height of the LM were measured in magnetic resonance images and compared between the preoperative and postoperative measurements. Our analysis revealed that concurrent LM repair with ACL reconstruction improved the short-term clinical outcomes. Although the body width and height of the LM did not change, the postoperative LM extrusion and LM width were significantly increased after the surgery. The post-traumatic transposition of the LM may not be completely prevented by LM repair concomitant with ACL reconstruction.

DOI： 10.18926/AMO/54806

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Shortening Oblique Osteotomy with Screw Fixation for Correction of the Lesser Metatarsophalangeal Joints of Rheumatoid Forefoot

Keiichiro Nishida, Takahiro Machida, Masahiro Horita, Kenzo Hashizume, Ryuichi Nakahara, Yoshihisa Nasu, Hideki Ohashi, Kenta Saiga, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 70 ( 6 ) 477 - 483 2016.12

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

The metatarsophalangeal (MTP) joints are often and predominantly affected in rheumatoid arthritis. The aim of the current study was to describe surgical techniques of shortening oblique osteotomy for lesser metatarsal bone with screw fixation at the osteotomy site, and to investigate the short-term clinical outcomes of our procedure. Twenty-seven feet (78 toes) of 24 RA patients underwent the shortening oblique osteotomy for the correction of deformity at the lesser MTP joints. The average Japanese Society of Surgery of the Foot (JSSF) standard rating system for the RA foot and ankle scale improved significantly from 59.6 points preoperatively to 88.3 points postoperatively (p < 0.001). Twenty-four feet (89) were free from metatarsalgia and symptomatic callosities at the lesser MTP joint after surgery. Our present findings showed satisfactory early clinical outcomes of the shortening oblique osteotomy of the metatarsal bone with screw fixation for RA forefoot.

DOI： 10.18926/AMO/54811

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Features of human autologous hamstring graft elongation after pre-tensioning in anterior cruciate ligament reconstruction

Masataka Fujii, Takayuki Furumatsu, Shinichi Miyazawa, Takaaki Tanaka, Hiroto Inoue, Yuya Kodama, Kenji Masuda, Noritaka Seno, Toshifumi Ozaki

INTERNATIONAL ORTHOPAEDICS 40 ( 12 ) 2553 - 2558 2016.12

Language：English Publisher：SPRINGER

Precise pre-tensioning protocol of the graft has not been determined in anterior cruciate ligament (ACL) reconstruction. The aims of this study are to measure the human autologous graft elongation, and to reveal what portion of the graft elongated greater after pre-tensioning in ACL reconstruction.
Twenty-four hamstring tendon grafts which were harvested from patients were included. A continuous load of 150 N was applied to the graft twice for 30 seconds each (150 N-1 minute), and the same loading was repeatedly applied (150 N-2 minute). The amount of elongation of the tendon portion (Length T) and the stitched portion (Length S) were measured after each pre-tensioning.
Length S gradually increased by 1.57 +/- 0.67 mm after the 150 N-1 minute pre-tensioning and by 2.12 +/- 0.76 mm after the 150 N-2 minute pre-tensioning, respectively. Length T was not significantly elongated after 150 N-1 min (p = 0.66) and 150 N-2 min (p = 0.59).
Graft elongation of the approximately 2 mm was observed, particularly in the stitched portion. It is necessary for a surgeon to focus on careful removal of slack from each stitch during suturing.

DOI： 10.1007/s00264-016-3298-9

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Acetabular development after open reduction to treat dislocation of the hip after walking age

Yohei Kagawa, Hirosuke Endo, Tomonori Tetsunaga, Yosuke Fujii, Takamasa Miyake, Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC SCIENCE 21 ( 6 ) 815 - 820 2016.11

Language：English Publisher：SPRINGER JAPAN KK

Background: Treatment of hip dislocation diagnosed after walking age is often difficult. We report the surgical treatment of these patients by open reduction with a soft tissue surgical procedure without osteotomy.
Methods: Thirty-eight children (43 hips) diagnosed with complete dislocation of the hip after walking age were included in this study. We radiographically analysed postoperative hip joint development up to 6 years of age. To assess the predictors of acetabular development, we evaluated the radiographs, using an acetabular index of <= 35 degrees and a centre-edge angle of >5 degrees at 6 years of age as satisfactory outcomes, and evaluated the advance of acetabular development over time.
Results: AI on the affected side was improved with time after open reduction. The diameter of the capital femoral ossific nucleus on the affected side was almost equivalent to that on the unaffected side at 6-12 months after surgery, after which the centre -edge angle improved gradually from one year after surgery. We compared hips classified as satisfactory to unsatisfactory at 6 years of age, and found that the centre -edge angle at one year after open reduction was significantly associated with acetabular development (P = 0.044). The cut-off value was -2 degrees with sensitivity of 0.909 and specificity of 0.677.
Conclusions: The results of the current study suggest that initial development of the capital femoral ossific nucleus after open reduction would be followed by improved joint congruity, and that this would facilitate acetabular development. The centre -edge angle at one year after surgery could be regarded as a potential predictor of acetabular development in open reduction surgery for late -diagnosed developmental dysplasia of the hip cases. (C) 2016 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jos.2016.07.007

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Pullout repair of a medial meniscus posterior root tear using a FasT-Fix (R) all-inside suture technique

Y. Kodama, T. Furumatsu, M. Fujii, T. Tanaka, S. Miyazawa, T. Ozaki

ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH 102 ( 7 ) 951 - 954 2016.11

Language：English Publisher：ELSEVIER MASSON

A medial meniscus posterior root tear (MMPRT) may increase the tibiofemoral contact pressure by decreasing the tibiofemoral contact area. Meniscal dysfunction induced by posterior root injury may lead to the development of osteoarthritic knees. Repair of a MMPRT can restore medial meniscus (MM) function and prevent knee osteoarthritis progression. Several surgical procedures have been reported for treating a MMPRT. However, these procedures are associated with several technical difficulties. Here, we describe a technique to stabilize a torn MM posterior root using the FasT-Fix (R) all-inside meniscal suture device and a new aiming device. The uncut free-end of the FasT-Fix (R) suture can be used as a thread for transtibial pullout repair. Our procedure might help overcome the technical difficulties in arthroscopic treatment of a MMPRT. (C) 2016 Elsevier Masson SAS. All rights reserved.

DOI： 10.1016/j.otsr.2016.06.013

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Histological and biological comparisons between complete and incomplete discoid lateral meniscus

Hiroto Inoue, Takayuki Furumatsu, Ami Maehara, Takaaki Tanaka, Toshifumi Ozaki

CONNECTIVE TISSUE RESEARCH 57 ( 5 ) 408 - 416 2016.9

Language：English Publisher：TAYLOR & FRANCIS INC

The discoid lateral meniscus (DLM) is an anatomically abnormal meniscus that covers a greater area of the tibial plateau than the normal meniscus. The DLM is classified into two types: complete (CDLM) and incomplete (ICDLM) types. In this study, we investigated the histological and cell biological characteristics of CDLM and ICDLM. The number of blood vessels, proteoglycan deposition, and collagen distribution were assessed using meniscal tissues. Collagen production was also investigated in CDLM and ICDLM cells. The intercondylar region of the CDLM had a higher number of blood vessels than the inner region of the ICDLM. Safranin O staining density and type II collagen deposition in ICDLM were higher than those in CDLM. Type II collagen-positive cells were higher in ICLDM than in CDLM. CDLM cells showed slender fibroblastic morphology, while ICDLM cells were triangular chondrocytic in shape. This study demonstrated that the intercondylar region of the CDLM showed similar properties to the outer region of the meniscus. The inner region of the ICDLM, on the other hand, differed from the intercondylar region of the CDLM. Our results suggest that the intercondylar region of the CDLM may have a high healing potential like the outer meniscus.

DOI： 10.1080/03008207.2016.1195827

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Evaluation of the semitendinosus tendon graft shift in the bone tunnel: an experimental study

Masataka Fujii, Yusuke Sasaki, Daisuke Araki, Takayuki Furumatsu, Shinichi Miyazawa, Toshifumi Ozaki, Monica Linde-Rosen, Patrick Smolinski, Freddie H. Fu

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 24 ( 9 ) 2773 - 2777 2016.9

Language：English Publisher：SPRINGER

The purpose of this study was to measure the semitendinosus tendon graft shift at the tunnel aperture with graft bending using a simulated femoral bone tunnel.
Eight semitendinosus tendon grafts were used in this study. The median age of the specimen was 53 years (range 46-63). After stripping excess soft tissue, the semitendinosus tendon was doubled over the loop of the EndoButton CL (Smith and Nephew Inc.). The diameter of the graft was measured using a graft-sizing tube (Smith and Nephew Inc.) and verified to be 7.0 mm. A custom-made aluminium fixture, the size was 40.0 mm(3), with 7.0-mm-diameter hole was used as a simulated femoral bone tunnel. The graft was inserted to the tunnel, and EndoButton was positioned to the outside of the tunnel on the fixture. The distal end of the graft was tensioned with 30 N at an angle of 15A degrees, 30A degrees, 45A degrees, 60A degrees, 75A degrees that reproduced the graft bending angle during knee range of motion. The photograph of the tunnel aperture was taken at each graft bending angle using a digital camera, and the graft shift amount in the simulated tunnel was analysed using the computer software (ImageJ).
The amount of the graft shift significantly increased when the graft bending angle was increased (P < 0.05). The biggest shift was observed when the graft bending angle was 75A degrees in all specimens, and the value was 1.10 mm +/- 0.12.
The present study suggests that even if the femoral tunnel was created in the centre of the ACL insertion site, the graft shifted within the tunnel in the direction of the tension applied to the graft during knee range of motion. Surgeons may have to consider the graft shift within the bone tunnel as well as the tunnel position in the restoration of the native ACL anatomy.

DOI： 10.1007/s00167-014-3461-z

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大腿骨頸部病的骨折に骨幹部の骨欠損を伴った3例

中田英二, 杉原進介, 尾崎敏文

中部日本整形外科災害外科学会雑誌 59 ( 秋季学会 ) 152 - 152 2016.9

多糖複合体を基材とした感染制御能と生体吸収性を有する抗菌薬含有骨セメントの開発

渡邉典行, 香川洋平, 張偉, 吉村将秀, 吉田晶, 田中雅人, 吉田靖弘, 松川昭博, 尾崎敏文

日本整形外科学会雑誌 90 ( 8 ) S1819 - S1819 2016.8

新規生体材料リン酸化プルランによるインプラントコーティング技術の開発

香川洋平, 渡邉典行, 張偉, 吉村将秀, 吉田晶, 吉田靖弘, 尾崎敏文, 松川昭博

日本整形外科学会雑誌 90 ( 8 ) S1813 - S1813 2016.8

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs

Ryo Nakamichi, Yoshiaki Ito, Masafumi Inui, Naoko Onizuka, Tomohiro Kayama, Kensuke Kataoka, Hidetsugu Suzuki, Masaki Mori, Masayo Inagawa, Shizuko Ichinose, Martin K. Lotz, Daisuke Sakai, Koichi Masuda, Toshifumi Ozaki, Hiroshi Asahara

NATURE COMMUNICATIONS 7 2016.8

Language：English Publisher：NATURE PUBLISHING GROUP

The main pathogenesis of intervertebral disc (IVD) herniation involves disruption of the annulus fibrosus (AF) caused by ageing or excessive mechanical stress and the resulting prolapse of the nucleus pulposus. Owing to the avascular nature of the IVD and lack of understanding the mechanisms that maintain the IVD, current therapies do not lead to tissue regeneration. Here we show that homeobox protein Mohawk (Mkx) is a key transcription factor that regulates AF development, maintenance and regeneration. Mkx is mainly expressed in the outer AF (OAF) of humans and mice. In Mkx(-/-) mice, the OAF displays a deficiency of multiple tendon/ligament-related genes, a smaller OAF collagen fibril diameter and a more rapid progression of IVD degeneration compared with the wild type. Mesenchymal stem cells overexpressing Mkx promote functional AF regeneration in a mouse AF defect model, with abundant collagen fibril formation. Our results indicate a therapeutic strategy for AF regeneration.

DOI： 10.1038/ncomms12503

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Minimally invasive plate osteosynthesis using posterolateral approach for distal tibial and tibial shaft fractures

Norio Yamamoto, Kenichi Ogawa, Chuji Terada, Yoshiki Okazaki, Kazuo Munetomo, Tomoyuki Noda, Toshifumi Ozaki

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED 47 ( 8 ) 1862 - 1866 2016.8

Language：English Publisher：ELSEVIER SCI LTD

Objective: The objective of the study was to evaluate the effectiveness of the posterolateral minimally invasive plate osteosynthesis (MIPO) method for managing distal tibial or tibial shaft fractures with severe anterior and medial soft tissue injuries.
Materials and methods: Five consecutive patients with three distal tibial and two tibial shaft fractures (three open fractures) at a level-1 trauma and tertiary referral center were retrospectively reviewed. All patients were definitively treated and followed to bone union. Main outcome was measured by American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, complications, and bone union on radiographs.
Results: The average follow-up period was 15.8 months (range, 12-24 months). The average AOFAS score was 88.2 (range, 81-90). There were no complications, such as incision breakdown, deep infection, or impingement of the flexor hallucis longus tendon. Bone union was achieved in all cases.
Conclusions: Posterolateral MIPO is a feasible option when treating these fractures, especially in cases with severe anterior and medial soft tissue injuries. (C) 2016 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.injury.2016.06.017

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Circulating cell-free microRNA as a novel biomarker for synovial sarcoma patients

Koji Uotani, Tomohiro Fujiwara, Aki Yoshida, Takuya Morita, Yutaka Nezu, Tadashi Komatsubara, Kazuhisa Sugiu, Takenori Uehara, Toshinori Omani, Ken Takeda, Toshiyuki Kunisada, Junya Toguchida, Akira Kawai, Takahiro Ochiya, Toshifumi Ozaki

CANCER RESEARCH 76 2016.7

Identification of circulating tumor derived microRNA signatures in osteosarcoma

Tomohiro Fujiwara, Koji Uotani, Aki Yoshida, Takuya Morita, Tadashi Komatsubara, Kazuhisa Sugiu, Toshinori Oman, Ken Takeda, Toshiyuki Kunisada, Yutaka Nezu, Akira Kawai, Hirotaka Kanzaki, Takahiro Ochiya, Toshifumi Ozaki

CANCER RESEARCH 76 2016.7

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