Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

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P1-246 腎機能低下MRSA患者に対するバンコマイシン含有セメントビーズの有用性(一般演題ポスター発表,薬物動態・TDM・投与設計,臨床から学び臨床へと還元する医療薬学)

川上恭弘, 浅海浩二, 尾崎敏文, 千堂年昭

日本医療薬学会年会講演要旨集 20 328 - 328 2010.10

Open Reduction for Residual Subluxation after Developmental Dislocation of the Hip

ENDO Hirosuke

19 ( 2 ) 367 - 373 2010.10

Evaluation for the short-term results and the operative indication of Chiari pelvic osteotomy

ENDO Hirosuke

36 54 - 59 2010.10

Less invasive intrapelvic approach (Stoppa modification) in the treatment of acetabular fractures and pelvic ring injuries

NODA T., OZAKI T., TAKAGI Y., OGAWA K., YAGATA Y., UEDA Y.

32 ( 3 ) 522 - 526 2010.9

T細胞特異的SOCS5過剰発現はマウス抗II型コラーゲン抗体関節炎において関節炎を遷延させる

高畑智宏, 松川昭博, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 84 ( 8 ) S1145 - S1145 2010.8

The role of thallium-201 and pentavalent dimercapto succinic acid (DMSA) for staging cartilaginous tumors

Orthopedic surgery 61 ( 8 ) 787 - 792 2010.7

Surgical treatment of metastatic bone tumors

Orthopedic surgery 61 ( 8 ) 919 - 926 2010.7

Epigenetic Regulation in Chondrogenesis

Takayuki Furumatsu, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 64 ( 3 ) 155 - 161 2010.6

Language：English Publishing type：Book review, literature introduction, etc. Publisher：OKAYAMA UNIV MED SCHOOL

Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis.

Web of Science

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Evaluation of venous return of proximal femoral fractures using fracture table

TERAMOTO H., INOUE A., NAKANISHI K., NARAZAKI S., YAMANE K., NODA T., OZAKI T.

32 ( 2 ) 377 - 380 2010.5

Surgical treatment of LCP clavicle hook plate for distal clavicle fracture

WATANABE M., OZAKI T., NODA T., MORISHITA T., TAKAGI T., HAYASHI T., KURODA T.

32 ( 2 ) 438 - 442 2010.5

Cerebral hemorrhage during the anticoagulant therapy after the total hip arthroplasty : a case report

MIYAKE Yoshiaki

53 ( 2 ) 443 - 444 2010.3

Epigenetic regulation of chondrogenesis by TGF-β-Smad3 pathway

FURUMATSU Takayuki

53 ( 2 ) 403 - 404 2010.3

Bilateral acetabular fracture fixation via a modified Stoppa approach ; a case report

YOKOYAMA Y., NODA T., KADOTA Y., OZAKI T., YAGATA Y., UEDA Y.

32 ( 1 ) 91 - 94 2010.2

Evaluation of fracture line separation for PFNA blade insertion in femoral trochanteric fractures

TERAMOTO H., INOUE A., NAKANISHI K., NARAZAKI S., YAMANE K., NODA T., OZAKI T.

32 ( 1 ) 136 - 138 2010.2

Surgical Treatment for Vertical Talus Combined with Polysyndactyly : A Case Report

ENDO Hirosuke

19 ( 1 ) 16 - 20 2010.2

GDF-5/7 and bFGF Activate Integrin alpha 2-Mediated Cellular Migration in Rabbit Ligament Fibroblasts

Hirokazu Date, Takayuki Furumatsu, Yoshimasa Sakoma, Aki Yoshida, Yuko Hayashi, Nobuhiro Abe, Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC RESEARCH 28 ( 2 ) 225 - 231 2010.2

Language：English Publisher：JOHN WILEY & SONS INC

Cellular activities responding to growth factors are important in ligament healing. The anterior cruciate ligament (ACL) has poor healing potential compared to the medial collateral ligament (MCL). To assess the differences, we investigated the proliferation, migration, adhesion, and matrix synthesis responding to growth factors in rabbit ACL and MCL fibroblasts. ACL cell proliferation to basic fibroblast growth factor (bFGF), bone morphogenetic protein-2, growth and differentiation factor (GDF)-5, and GDF-7 treatment was similar to that of MCL cells. GDF-5 enhanced Colla1 expression in ACL and MCL fibroblasts up to 4.7- and 17-fold levels of control, respectively. MCL fibroblasts showed stronger migration activities in response to bFGF and GDF-5 than ACL cells. GDF-5/7 and bFGF also changed the stress fiber formation and cellular adhesion by modulating the distribution of integrin alpha 2. Functional blocking analyses using anti-integrin alpha 2 antibodies revealed that cellular migration responding to growth factors depended on the integrin alpha 2-mediated adhesion on type I collagen. The expression of integrin alpha 2 was also increased by growth factors in both cells. Our results demonstrate that GDF-5/7 and bFGF stimulate cellular migration by modulating integrin alpha 2 expression and integrin alpha 2-dependent adhesion, especially in MCL fibroblasts. These findings suggest that the different healing potential between ACL and MCL may be caused by different cellular behavior in the integrin alpha 2-mediated cellular migration in response to growth factors. (C) 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:225-231, 20.10

DOI： 10.1002/jor.20981

Web of Science

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創外固定を用いて加療した手関節否定型抗酸菌症の1例

島村安則, 野田知之, 雑賀建多, 門田康孝, 西田圭一郎, 尾﨑敏文

日本創外固定・骨延長学会誌 21 186 - 186 2010

Interventional radiology for vascular anomalies

三村秀文, 藤原寛康, 平木隆夫, 郷原英夫, 芝本健太郎, 木股敬裕, 尾崎敏文, 佐々木了, 金澤右

岡山医学会雑誌 122 ( 1 ) 2010

Biomechanical evaluation of the fixation methods for transcondylar fracture of the humerus:ONI plate versus conventional plates and screws.

Yasunori Shimamura, Keiichiro Nishida, Junya Imatani, Tomoyuki Noda, Hiroyuki Hashizume, Aiji Ohtsuka, Toshifumi Ozaki

Acta medica Okayama 64 ( 2 ) 115 - 120 2010

Language：English

We biomechanically evaluated the bone fixation rigidity of an ONI plate (Group I) during fixation of experimentally created transcondylar humerus fractures in cadaveric elbows, which are the most frequently observed humeral fractures in the elderly, and compared it with the rigidity achieved by 3 conventional fixation methods:an LCP reconstruction plate 3.5 using a locking mechanism (Group II), a conventional reconstruction plate 3.5 (CRP) with a cannulated cancellous screw (Group III), and a CRP with 2 cannulated cancellous screws (CS) in a crisscross orientation (Group IV). In the axial loading test, the mean failure loads were:Group I, 98.9+/-32.6;Group II, 108.5+/-27.2;Group III, 50.0+/-7.5;and Group IV, 34.5+/-12.2 (N). Group I fixations failed at a significantly higher load than those of Groups III and IV (p<0.05). In the extension loading test, the mean failure loads were:Group I, 34.0+/-12.4;Group II, 51.0+/-14.8;Group III, 19.3+/-6.0;and Group IV, 14.7+/-3.1 (N). Group IV fixations showed a significantly lower failure load than those of Group I (p<0.05). The fixation rigidities against mechanical loading by the ONI plate and LCP plate were comparable. These results suggested that an ONI system might be superior to the CRP and CS method, and comparable to the LCP method in terms of fixation rigidity for distal humerus fractures.

PubMed

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Time-concentration profile of serum etanercept in Japanese patients with rheumatoid arthritis after treatment discontinuation before orthopedic surgery

NISHIDA Keiichiro, HASHIZUME Kenzo, KADOTA Yasutaka, NATSUMEDA Masamitsu, NAKAHARA Ryuichi, SAITO Taichi, KANAZAWA Tomoko, EZAWA Kazuhiko, OZAKI Toshihumi

20 ( 6 ) 637 - 639 2010

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