Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

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マウス抗II型コラーゲン抗体関節炎におけるTh1/2反応とSOCS3・SOCS5による制御

高畑智宏, 松川昭博, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 83 ( 8 ) S1120 - S1120 2009.8

Radiographic Prediction of the Results of Long-term Treatment with the Pavlik Harness for Developmental Dislocation of the Hip

Takao Ohmori, Hirosuke Endo, Shigeru Mitani, Hiroshi Minagawa, Tomonori Tetsunaga, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 63 ( 3 ) 123 - 128 2009.6

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

In 1957, Pavlik introduced the Pavlik harness as a useful treatment for developmental dislocation of the hip (DDH), and subsequent studies have documented favorable outcomes among patients treated with this device. However, there are only a few articles reporting how early radiographic measurements can be used to determine the prognosis after treatment with the Pavlik harness. In this study, 217 hips from 192 patients whose DDH treatment with the Pavlik harness was initiated before they were 6 months old and whose follow-up lasted at least 14 years (rate, 63.8%) were analyzed using measurements from radiographs taken immediately before and after harness treatment, and at 1, 2, and 3 years of age. Severin's classification at the final follow-up was I or II in 71.9% and III or IV in 28.1% of the hips, respectively. Avascular necrosis of the femoral head (AVN) was seen in 10% of the hips. Stepwise multiple regression analysis was performed to retrospectively determine whether any radiographic factors were related to the final classification as Severin I/II or III/IV. Receiver operating characteristic (ROC) curves were drawn for these factors, and a Wiberg OE angle (Point 0 was the middle point of the proximal metaphyseal border of the femur) of 2 degrees on the 3-year radiographs was found to be the most useful screening value for judging the acetabular development of DDH cases after treatment with a Pavlik harness, with a sensitivity of 71% a specificity of 93%, and a likelihood ratio of 10.1.

DOI： 10.18926/AMO/31850

Web of Science

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Surgical Treatment of Metastatic Vertebral Tumors

Masato Tanaka, Shinnosuke Nakahara, Yasuo Ito, Toshiyuki Kunisada, Haruo Misawa, Koichiro Koshimune, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 63 ( 3 ) 145 - 150 2009.6

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

Surgical treatment of metastatic spinal cord compression is controversial. The purpose of this study was to investigate the effectiveness of our current surgical treatments and the use of spinal instrumentation. In this retrospective study covering the years between 1990 and 2006, 100 patients with spinal metastases which were secondary to various cancers underwent posterior and/or anterior decompression with spinal stabilization for the purposes of reduction of pain, and/or to help correct or improve neurological deficits. The group was made up of 60 men and 40 women whose ages ranged from 16 to 83 years (average of 60 years), and the average follow-up period was 14 months. The effect of treatment upon pain relief and neural deficits was assessed, and the cumulative survival rate was calculated by the Kaplan-Meier method. The average surgical time was 185 min. This was calculated based on the following times, listed here with the surgery type: 178 min for posterior surgery; 245 min for anterior surgery; 465 min for combined surgery; and 475 min for total en bloc spondylectomy. Average blood loss during surgery was 1,630 ml for posterior surgery, 1,760 ml for anterior surgery, 1,930 ml for combined surgery, and 3,640 ml for total en bloc spondylectomy. Preoperative pain and paralysis were improved by 88% and 53%, respectively. In regards to surgical complications, postoperative epidural hematoma was observed in 2 patients, and instrumentation-related infection was observed in 1. Only 2 patients died within 2 months of surgery. In conclusion, posterior and/or anterior decompression with spinal stabilization is a safe and effective treatment for patients with spinal metastases, and can improve their quality of life.

DOI： 10.18926/AMO/31849

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大腿骨転移性骨腫瘍の手術療法の検討

中田英二, 大森貴男, 黒住健人, 尾崎敏文

日本整形外科学会雑誌 83 ( 6 ) S948 - S948 2009.6

2A1-K08 Toolpath generation to protect soft tissue for minimally invasive orthopedic surgery

NAKANO Taiga, TORIGOE Yusuke, SUGITA Naohiko, NAKAJIMA Yoshikazu, KATO Takeharu, FUJIWARA Kazuo, ABE Nobuhiro, OZAKI Toshifumi, SUZUKI Masahiko, MITSUISHI Mamoru

2009 "2A1 - K08(1)"-"2A1-K08(3)" 2009.5

Language：Japanese Publisher：The Japan Society of Mechanical Engineers

Tool interference causes serious damage to surrounding soft tissue in minimally invasive orthopedic surgery with a milling robot. The objective of this study is to avoid the collision of cutting tool with soft tissue, and a novel approach of interference-free toolpath generation in a short processing time is proposed. The unknown shape of soft tissue is intraoperatively modeled as interference area, and interference-free tool posture is immediately determined by the preliminary definition of evacuating direction based on the model. The effectiveness of the proposed method is evaluated with artificial models on the system that the authors have developed so far.

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CiNii Books

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Changes in the lateral pillar classification in Perthes' disease

Takayuki Kuroda, Shigeru Mitani, Yoshihisa Sugimoto, Koji Asaumi, Hirosuke Endo, Hirofumi Akazawa, Tadashi Nakagomi, Toshifumi Ozaki

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B 18 ( 3 ) 116 - 119 2009.5

Language：English Publisher：LIPPINCOTT WILLIAMS & WILKINS

The purpose of this study was to examine the correlation between the changes in the lateral pillar grades and the factors influencing such changes. We reviewed 102 patients with Perthes' disease. Changes were observed in 32 (31%) hips. The percentage of the changes in each treatment group showed significant differences. Patients with extensive involvement showed significantly more changes. There was no difference in the age at the onset. We recommend that treatment methods be used that more effectively relieve the mechanical force on the capital femoral epiphysis for patients with extensive involvement regardless of the age at the onset. J Pediatr Orthop B 18:116-119 (c) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

DOI： 10.1097/BPB.0b013e32832b07b1

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Smad3 activates the Sox9-dependent transcription on chromatin

Takayuki Furumatsu, Toshifumi Ozaki, Hiroshi Asahara

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 41 ( 5 ) 1198 - 1204 2009.5

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Transforming growth factor (TGF)-beta has an essential role for the Sry-type high-mobility-group box (Sox)-regulated chondrogenesis. Chondrogenic differentiation is also controlled by chromatin-mediated transcription. We have previously reported that TGF-beta-regulated Smad3 induces chondrogenesis through the activation of Sox9-dependent transcription. However, the cross-talk between TGF-beta signal and Sox9 on chromatin-mediated transcription has not been elucidated. In the present study, we investigated the activity of Smad3, Sox9, and coactivator p300 using an in vitro chromatin assembly model. Luciferase reporter assays revealed that Smad3 stimulated the Sox9-mediated transcription in a TGF-beta-dependent manner. Recombinant Sox9 associated with phosphorylated Smad3/4 and recognized the enhancer region of type 11 collagen gene. In vitro transcription and S1 nuclease assays showed that Smad3 and p300 cooperatively activated the Sox9-dependent transcription on chromatin template. The combination treatment of phosphorylated Smad3, Sox9, and p300 were necessary for the activation of chromatin-mediated transcription. These findings suggest that TGF-beta signal Smad3 plays a key role for chromatin remodeling to induce chondrogenesis via its association with Sox9. (C) 2008 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.biocel.2008.10.032

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Repair of bucket hundle meniscal tear : indication and limitation

DATE Hirokazu, ABE Nobuhiro, FURUMATSU Takayuki, SAIGA Kenta, SAKOMA Yoshimasa, OZAKI Toshifumi

33 ( 2 ) 247 - 250 2009.4

孤立性骨形質細胞腫の1例

井石龍比古, 片山敬久, 吉尾浩太郎, 尾形毅, 武本充広, 金澤右, 黒田昌宏, 尾崎敏文, 品川克至, 姫井健吾

Japanese Journal of Radiology 27 ( Suppl. ) 69 - 69 2009.4

Gene therapy with Scleraxis for modulating differentiation potentials of anterior cruciate ligament cells

FURUMATSU Takayuki, SAKOMA Yoshimasa, DATE Hirokazu, ABE Nobuhiro, OZAKI Toshifumi

33 ( 1 ) 7 - 10 2009.3

悪性骨腫瘍切除後の再建手術

尾崎敏文

関東整形災害外科学会雑誌 40 40 - 40 2009.3

5.生体肺移植におけるリハビリテーション(第22回日本リハビリテーション医学会中国・四国地方会)

堅山佳美, 千田益生, 雑賀建多, 尾崎敏文

リハビリテーション医学 : 日本リハビリテーション医学会誌 46 ( 2 ) 132 - 132 2009.2

2.頸髄症と胸髄症のバランス障害(第22回日本リハビリテーション医学会中国・四国地方会)

雑賀建多, 田中雅人, 三澤治夫, 越宗幸一郎, 尾崎敏文, 千田益生, 堅山佳美

リハビリテーション医学 : 日本リハビリテーション医学会誌 46 ( 2 ) 131 - 131 2009.2

Muscular Torticollis with Traction Spur : A Case Report

MINAGAWA Hiroshi

18 ( 1 ) 36 - 39 2009.2

神経・筋原性側彎症の手術成績

田中雅人, 中西一夫, 三澤治夫, 迫間巧将, 高畑智宏, 尾﨑敏文

脊柱変形第23巻 ( 1 ) 122 - 127 2009

CT ベースナビゲーションシステムでの骨盤傾斜角を考慮した前方開角設定

藤原一夫, 三谷茂, 遠藤裕介, 鉄永智紀, 皆川寛, 尾﨑敏文

Hip Joint 第35巻 578 - 582 2009

Language：Japanese Publisher：日本股関節学会

著者らが人工股関節全置換術を行った39例を対象に、CTベースナビケーションシステムにより提示される術前骨盤傾斜角について検討した。その結果、1)骨盤傾斜角は年齢とともに後傾し、臥位から立位で有意な後傾が認められた。2)術前の姿勢変化による骨盤傾斜の変化は10度以内の誤差はあるが95%の症例で術後にも反映され、術前の骨盤傾斜角は98%の症例で術前と比べ10度以内に収まるため、術前APPの傾斜とPIA変化量はカップ設置の指標として有用であると考えられた。

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Revision Total Knee Arthroplasty for an Elderly Patient with Many Complications : Application of the Shoelace Technique

Date Hirokazu, Abe Nobuhiro, Furumatsu Takayuki, Saiga Kenta, Takata Naoki, Yokoyama Yusuke, Ozaki Toshifumi

The Journal of the Chugoku-Shikoku Orthopaedic Association 第21巻 ( 2 ) 289 - 294 2009

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

In revision total knee arthroplasty, there are often several problems, including extensor mechanism disruption, intraoperative fracture, infection or delayed wound healing. We report a 76-year-old woman who sustained both tibial and fibular fractures after total knee arthroplasty (TKA). She was undergone revision TKA with the shoelace skin closure technique. She had severe swelling, fracture blisters, and ulcers because of many complications such as diabetes mellitus, liver cirrhosis and anemia. At revision TKA, we made an additional skin incision on the medial side of the knee joint for the shoelace technique to avoid any compartment syndrome including skin trouble. The additional incision was tightened and completely closed on postoperative day 8. We suggest that this option would be a good one in TKA when primary skin closure is difficult because of soft tissue damage.

DOI： 10.11360/jcsoa.21.289

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Tumor prosthesis for malignant bone tumor of distal fumur

SASAKI Tshuyoshi

The Central Japan Journal of Orthopaedic Surgery & Traumatology 第52巻 ( 2 ) 317 - 318 2009

指節骨用創外固定器を用いて治療した外傷後化膿性 DIP 関節炎・骨髄炎の 1 例

島村安則, 野田知之, 雑賀建多, 中原龍一, 皆川寛, 尾﨑敏文

日本創外固定・骨延長学会雑誌第20巻 196 - 196 2009

Are iliac screws stronger than S1 pedicle screws for lumbosacral fusion?

TANAKA Masato

第52巻 ( 1 ) 73 - 74 2009

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