Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

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Clinical and radiographic study of partial arthrodesis for rheumatoid wrists

Taichi Saito, Keiichiro Nishida, Kenzo Hashizume, Ryuichi Nakahara, Ryozo Harada, Takahiro Machida, Masahiro Horita, Toshifumi Ozaki

MODERN RHEUMATOLOGY 26 ( 1 ) 57 - 61 2016.1

Language：English Publisher：SPRINGER

Objectives. To retrospectively investigate the clinical and radiographic results of partial arthrodesis for the wrists with rheumatoid arthritis (RA).Methods. Forty-one wrists with RA were treated by radiolunate (RL) or radiolunotriquetral (RLT) arthrodesis with ulnar head resection. The average follow-up period after surgery was 7.1 years. Preoperative radiographs of all wrists were classified according to Schulthess classification. We performed RL arthrodesis for all Type II (n = 26) and Type III wrists (n = 7), and RLT arthrodesis for Type III wrists (n = 8). Pre- and postoperative pain score (visual analog scale), grip strength, range of motion, and radiographic parameters were statistically compared.Results. Pain scores in all groups were significantly improved at final follow-up (P < 0.05). Grip strength increased from 5.9 to 12.4 (kg) significantly in Type II wrists (P < 0.01), from 7.2 to 9.1 in Type III wrists after RLT arthrodesis, but decreased from 6.9 to 6.0 in Type III wrists after RL arthrodesis. In all groups, the arc of pronation and supination improved significantly (P < 0.05), and all radiographic parameters improved.Conclusions. RL arthrodesis for Type II wrists showed satisfactory clinical results. RLT arthrodesis would be a reliable method in case of unstable wrist joint.

DOI： 10.3109/14397595.2015.1072293

Web of Science

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Risk factors for surgical site infection and delayed wound healing after orthopedic surgery in rheumatoid arthritis patients

Yasutaka Kadota, Keiichiro Nishida, Kenzo Hashizume, Yoshihisa Nasu, Ryuichi Nakahara, Tomoko Kanazawa, Masatsugu Ozawa, Ryozo Harada, Takahiro Machida, Toshifumi Ozaki

MODERN RHEUMATOLOGY 26 ( 1 ) 68 - 74 2016.1

Language：English Publisher：SPRINGER

Objective: To investigate the prevalence and the risk factors of surgical-site infection (SSI) and delayed wound healing (DWH) in patients with rheumatoid arthritis (RA) underwent orthopedic surgery.Methods: We reviewed the records of 1036 elective orthopedic procedures undertaken in RA patients. Risk factors for SSI and DWH were assessed by logistic regression analysis using age, body mass index, disease duration, pre-operative laboratory data, surgical procedure, corticosteroid use, co-morbidity, and use of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and biological DMARDs (bDMARDs) as variables.Results: SSI and DWH were identified in 19 cases and 15 cases, respectively. One case of SSI and three cases of DWH were recorded among 196 procedures in patients using bDMARDs. Foot and ankle surgery was associated with an increased risk of SSI (odds ratio (OR), 3.167; 95% confidence interval (CI), 1.256-7.986; p=0.015). Total knee arthroplasty (TKA; OR, 4.044; 95% CI, 1.436-11.389; p=0.008) and disease duration (OR, 1.004; 95% CI, 1.000-1.007; p=0.029) were associated with an increased risk of DWH.Conclusions: Our results indicated foot and ankle surgery, and TKA and disease duration as risk factors for SSI and DWH, respectively. bDMARDs was not associated with an increased risk of SSI and DWH.

DOI： 10.3109/14397595.2015.1073133

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骨盤・股関節悪性骨腫瘍の手術療法

59 ( 8 ) 1059 - 1064 2016

人工股関節周囲感染に対する3 phase 骨シンチグラフィの有用性

藤井洋佑, 藤原一夫, 遠藤裕介, 鉄永智紀, 香川洋平, 三宅孝昌, 尾﨑敏文

Hip Joint 42 ( 2 ) 775 - 778 2016

Language：Japanese Publisher：日本股関節学会

過去8年3ヵ月間に、人工股関節全置換術後感染が疑われた7例7関節(男性2関節、女性5関節、再手術時平均年齢68.5歳)を対象に、3 phase骨シンチグラフィの有用性について検討した。骨シンチグラフィ検査陽性は動脈相、血流プール相で対側と比較して集積の亢進を認めた場合に陽性とし、感染の診断は関節液・組織培養陽性例、術中迅速病理で好中球分葉核球5個/400倍視野以上を陽性とした。その結果、非感染性の弛みと考えられた3関節に対して一期的再置換術を行い、感染と診断した4関節(コアグラーゼ陰性ブドウ球菌3関節、MRSA1関節)に二期的再置換術を行った。骨シンチグラフィは、感染例4例で動脈相と血流プール相で集積が亢進し、非感染例3例は2例で集積の亢進を認め、1例は亢進なしであった。なお、感度100%、特異度33%、陽性予測値67%、陰性予測値100%であったことより、骨シンチグラフィ陰性の場合は高い精度で感染を否定できると考えられた。

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診察法と診断ピットフォール-腫瘍-

長谷井嬢, 藤原智洋, 尾﨑敏文

関節外科 35 ( 増刊号 ) 110 - 114 2016

30年来の大腿骨遠位部偽関節に対して手術を施行した1例

三宅昌孝, 遠藤裕介, 野田知之, 吉村将秀, 藤井洋佑, 尾﨑敏文

中部整災誌 59 ( 2 ) 819 - 820 2016

High grade spondylolisthesis の１例

小田孔明, 杉本佳久, 瀧川朋亨, 荒瀧慎也, 田中雅人, 尾﨑敏文

中部整災誌 59 ( 2 ) 497 - 498 2016

Risk factors of skeletal related events in non-small cell lung cancer with bone metastases

NAKATA Eiji

The Central Japan Journal of Orthopaedic Surgery & Traumatology 59 ( 2 ) 225 - 226 2016

3D実体モデルを利用した骨・軟部腫瘍手術

武田健, 中原龍一, 原田遼三, 国定俊之, 尾﨑敏文

関節外科 35 ( 2 ) 94 - 100 2016

整形外科外傷治療における3Dモデル・3Dプリンターの応用

杉生和久, 中原龍一, 吉村将秀, 山川泰明, 雑賀建多, 島村安則, 野田知之, 尾﨑敏文

関節外科 35 ( 2 ) 76 - 85 2016

Combination Therapy with Continuous Three-in-One Femoral Nerve Block and Periarticular Multimodal Drug Infiltration after Total Hip Arthroplasty

Tomonori Tetsunaga, Tomoko Tetsunaga, Kazuo Fujiwara, Hirosuke Endo, Toshifumi Ozaki

PAIN RESEARCH & MANAGEMENT 2016 1 - 6 2016

Language：English Publisher：HINDAWI PUBLISHING CORP

Background. Various postoperative pain relief modalities, including continuous femoral nerve block (CFNB), local infiltration analgesia (LIA), and combination therapy, have been reported for total knee arthroplasty. However, no studies have compared CFNB with LIA for total hip arthroplasty (THA). The aim of this study was to compare the efficacy of CFNB versus LIA after THA. Methods. We retrospectively reviewed the postoperative outcomes of 93 THA patients (20 men, 73 women; mean age 69.2 years). Patients were divided into three groups according to postoperative analgesic technique: CFNB, LIA, or combined CFNB+LIA. We measured the following postoperative outcome parameters: visual analog scale (VAS) for pain at rest, supplemental analgesia, side effects, mobilization, length of hospital stay, and Harris Hip Score (HHS). Results. The CFNB+LIA group had significantly lower VAS pain scores than the CFNB and LIA groups on postoperative day 1. There were no significant differences among the three groups in use of supplemental analgesia, side effects, mobilization, length of hospital stay, or HHS at 3 months after THA. Conclusions. Although there were no clinically significant differences in outcomes among the three groups, combination therapy with CFNB and LIA provided better pain relief after THA than CFNB or LIA alone, with few side effects.

DOI： 10.1155/2016/1425201

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Impact of rotation correction after brace treatment on prognosis in adolescent idiopathic scoliosis

Kentaro Yamane, Tomoyuki Takigawa, Masato Tanaka, Yoshihisa Sugimoto, Shinya Arataki, Toshifumi Ozaki

Asian Spine Journal 10 ( 5 ) 893 - 900 2016

Language：English Publisher：Korean Society of Spine Surgery

Study Design: Level 4 retrospective review. Purpose: Brace treatment is the standard nonoperative treatment for adolescent idiopathic scoliosis (AIS). Rotation correction is also important, because AIS involves a rotation deformity. The purpose of this study was to evaluate the impact of rotation correction after Osaka Medical College (OMC) brace treatment on clinical outcomes in AIS. Overview of Literature: Brace treatment has a significant effect on the progression of AIS. However, few reports have examined rotation correction after brace treatment. Methods: A total of 46 patients who wore the OMC brace were retrospectively reviewed. The curve magnitude was determined according to the Cobb method, and the rotation angle of the apical vertebrae was measured by the modified Nash-Moe method. Based on the difference in the rotation angle before and after the initial brace treatment, patients were divided into two groups. Group A (n=33) was defined as no change or improvement of the rotation angle
group B (n=13) was defined as deterioration of the rotation angle. If the patients had curve or rotation progression of 5° or more at skeletal maturity, or had undergone surgery, the treatment was considered a failure. Results: Differences of rotation angle between before and after the initial brace treatment were 2°±2° in group A and -3°±2° in group B (p &lt
0.001). The rates of treatment failure were 42% in group A and 77% in group B (p &lt
0.05). This study included 25 patients with Lenke type 1 (54%). Group A (24%) with Lenke type 1 also had a significantly better success rate of brace treatment than group B (75%) (p &lt
0.05). Conclusions: Insufficient rotation correction increased brace treatment failure. Better rotation correction resulted in a higher success rate of brace treatment in patients with Lenke type 1.

DOI： 10.4184/asj.2016.10.5.893

Scopus

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Microgeodic Disease Affecting the Fingers and Toes in Childhood: A Case Report. International journal

Tomonori Tetsunaga, Hirosuke Endo, Kazuo Fujiwara, Tomoko Tetsunaga, Toshifumi Ozaki

The open orthopaedics journal 14 ( 10 ) 500 - 504 2016

Language：English

Microgeodic disease is a disease of unknown etiology that affects the fingers and toes of children, with ≥ 90% of cases involving the fingers alone. We present a rare case of microgeodic disease affecting an index finger and two toes simultaneously in a 7-year-old girl. X-ray and magnetic resonance imaging (MRI) showed multiple small areas of osteolysis in the middle phalanges of the left index finger, hallux, and second toe. Microgeodic disease was diagnosed from X-ray and MRI findings, and conservative therapy involving rest and avoidance of cold stimuli was provided. Although pathological fractures occurred in the course of conservative treatment, the affected finger healed under splinting without any deformity of the finger.

PubMed

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claw toe に対して後足部鏡視下長母趾屈筋腱切離術を施行した2例

大橋秀基, 雑賀建多, 吉村将秀, 堀田昌宏, 尾﨑敏文

日足外会誌 37 ( 1 ) 288 - 291 2016

外傷後の著明な尖足に対して Taylor Spatial Frame を用いて変形矯正を施行した1例

望月雄介, 雑賀建多, 大橋秀基, 兼田大輔, 吉村将秀, 堀田昌宏, 尾﨑敏文

中・四整学誌 28 ( 2 ) 313 - 316 2016

Minimally Invasive Cervical Pedicle Screw Fixation by a Posterolateral Approach for Acute Cervical Injury.

Komatsubara T, Tokioka T, Sugimoto Y, Ozaki T

Clin Spine Surg. 1 - 4 2016

Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain

Tomoko Tetsunaga, Tomonori Tetsunaga, Masato Tanaka, Keiichiro Nishida, Yoshitaka Takei, Toshifumi Ozaki

PAIN RESEARCH & MANAGEMENT 7458534 2016

Language：English Publisher：HINDAWI LTD

Background. The contribution of apathy, frequently recognized in individuals with neurodegenerative diseases, to chronic low back pain (LBP) remains unclear. Objectives. To investigate levels of apathy and clinical outcomes in patients with chronic LBP treated with tramadol-acetaminophen. Methods. A retrospective case-control study involving 73 patients with chronic LBP (23 male, 50 female; mean age 71 years) treated with tramadol-acetaminophen (n = 36) and celecoxib (n = 37) was performed. All patients were assessed using the self-reported questionnaires. A mediation model was constructed using a bootstrapping method to evaluate the mediating effects of pain relief after treatment. Results. A total of 35 (55.6%) patients met the criteria for apathy. A four-week treatment regimen in the tramadol group conferred significant improvements in the Apathy scale and numerical rating scale but not in the Rolland-Morris Disability Questionnaire, Pain Disability Assessment Scale, or Pain Catastrophizing Scale. The depression component of the Hospital Anxiety and Depression Scale was lower in the tramadol group than in the celecoxib group. The mediation analysis found that the impact of tramadol-acetaminophen on the change in apathy was not mediated by the pain relief. Conclusions. Tramadol-acetaminophen was effective at reducing chronic LBP and conferred a prophylactic motivational effect in patients with chronic LBP.

DOI： 10.1155/2016/7458534

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膝前十字靭帯再建術後に仮性動脈瘤を生じた1例

門田康孝, 古松毅之, 尾﨑敏文

JOSKAS 41 ( 1 ) 164 - 165 2016

解剖学的二重束前十字靭帯再建術後の再鏡視による軟骨損傷評価

杉生和久, 古松毅之, 宮澤慎一, 田中孝明, 井上博登, 児玉有弥, 阿部信寛, 尾﨑敏文

JOSKAS 41 ( 1 ) 110 - 111 2016

Overcoming Therapeutic Resistance of Bone Sarcomas: Overview of the Molecular Mechanisms and Therapeutic Targets for Bone Sarcoma Stem Cells

Tomohiro Fujiwara, Toshifumi Ozaki

STEM CELLS INTERNATIONAL 2016 2603092 2016

Language：English Publishing type：Book review, literature introduction, etc. Publisher：HINDAWI PUBLISHING CORP

Bone sarcomas are heterogeneous malignant tumors that exhibit clinical, histological, and molecular heterogeneity. Recent progress in their multimodal treatment has gradually improved patient prognosis; however, drug resistance and distant metastasis remain unresolved clinical problems. Recent investigations have suggested the existence of cancer stem-like cells (CSCs) in bone sarcomas, which represent a subpopulation of tumor cells with high tumor-forming ability. The hallmarks of CSCs include tumor-and metastasis-forming potential and drug resistance, which are responsible for poor prognoses of bone sarcoma patients. Therefore, elucidation of the molecular mechanisms of CSCs and identification of therapeutic targets could contribute to novel treatment strategies for bone sarcomas and improve patient prognosis. This paper provides an overview of the accumulating knowledge on bone sarcoma stem cells and preclinical analyses to overcome their lethal phenotypes, in addition to a discussion of their potential for novel therapeutics for bone sarcomas.

DOI： 10.1155/2016/2603092

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