Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

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Cyclops lesion after reconstruction of the anterior cruciate ligament

FUJII Masataka

38 ( 1 ) 94 - 95 2013.3

[I. Current status and challenge to clinical usage of microRNA for sarcoma treatment].

Tomohiro Fujiwara, Akira Kawai, N. Kosaka, Toshifumi Ozaki, Takahiro Ochiai

Gan to kagaku ryoho. Cancer & chemotherapy 40 305 - 313 2013.3

Truncated SSX protein suppresses synovial sarcoma cell proliferation by inhibiting the localization of SS18-SSX fusion protein. International journal

Yasushi Yoneda, Sachio Ito, Toshiyuki Kunisada, Yuki Morimoto, Hirotaka Kanzaki, Aki Yoshida, Kenji Shimizu, Toshifumi Ozaki, Mamoru Ouchida

PloS one 8 ( 10 ) e77564-e77564 2013

Language：English

Synovial sarcoma is a relatively rare high-grade soft tissue sarcoma that often develops in the limbs of young people and induces the lung and the lymph node metastasis resulting in poor prognosis. In patients with synovial sarcoma, specific chromosomal translocation of t(X; 18) (p11.2;q11.2) is observed, and SS18-SSX fusion protein expressed by this translocation is reported to be associated with pathogenesis. However, role of the fusion protein in the pathogenesis of synovial sarcoma has not yet been completely clarified. In this study, we focused on the localization patterns of SS18-SSX fusion protein. We constructed expression plasmids coding for the full length SS18-SSX, the truncated SS18 moiety (tSS18) and the truncated SSX moiety (tSSX) of SS18-SSX, tagged with fluorescent proteins. These plasmids were transfected in synovial sarcoma SYO-1 cells and we observed the expression of these proteins using a fluorescence microscope. The SS18-SSX fusion protein showed a characteristic speckle pattern in the nucleus. However, when SS18-SSX was co-expressed with tSSX, localization of SS18-SSX changed from speckle patterns to the diffused pattern similar to the localization pattern of tSSX and SSX. Furthermore, cell proliferation and colony formation of synovial sarcoma SYO-1 and YaFuSS cells were suppressed by exogenous tSSX expression. Our results suggest that the characteristic speckle localization pattern of SS18-SSX is strongly involved in the tumorigenesis through the SSX moiety of the SS18-SSX fusion protein. These findings could be applied to further understand the pathogenic mechanisms, and towards the development of molecular targeting approach for synovial sarcoma.

DOI： 10.1371/journal.pone.0077564

PubMed

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実物大臓器立体モデルを活用した手術支援の実際と歯科技工士の関わり

竹内哲男, 有地秀裕, 松本洋, 中原龍一, 水川展吉, 吉岡徳枝, 木股敬裕, 尾崎敏文, 飯田征二, 佐々木朗, 三野卓哉, 前川賢治, 森田学, 槇野博史, 窪木拓男

QDT別冊 CAD/CAM YEAR BOOK 2013 別冊 22 - 31 2013

軟部腫瘍と分子生物学的解析の臨床応用特に補助診断法としての有用性について

国定俊之, 吉田晶, 武田健, 長谷井嬢, 柳井広之, 尾崎敏文

関節外科 32 ( 6 ) 656 - 661 2013

A simple detection system for adenovirus receptor expression using a telomerase-specific replication-competent adenovirus.

Sasaki T, Tazawa H, Hasei J, Osaki S, Kunisada T, Yoshida A, Hashimoto Y, Yano S, Yoshida R, Kagawa S, Uno F, Urata Y, Ozaki T, Fujiwara T

Gene Ther 2013

Chronic Pedal Osteomyelitis with Spina Bifida : A Case Report

27 12 - 16 2013

Efficacy of temporary external fixator as staged operations in the treatment of distal tibial fracture

24 91 - 96 2013

Application of external fixator for treatment of Lisfranc's fracture dislocation with comminuted fracture of the 1st cuneiform bone

24 31 - 36 2013

マウスにおける改変型成長因子Collagen binding domain BMP4の効果

塩崎泰之, 馬崎哲朗, 吉田晶, 山根健太郎, 田中雅人, 松川昭博, 尾崎敏文

移植 47 ( 6 ) 498 - 498 2012.12

コラーゲン結合性骨形成蛋白質BMP4の骨芽細胞に対する影響

吉田晶, 古松毅之, 塩崎泰之, 馬崎哲朗, 松川昭博, 中村真理子, 吉田靖弘, 北嶋隆, 伊藤嘉浩, 尾崎敏文

移植 47 ( 6 ) 498 - 498 2012.12

知ってますか? 整形外科手術の変遷(8)いわゆる先天性股関節脱臼に対する観血的整復術

遠藤裕介, 三谷茂, 尾﨑敏文

臨床整形外科 47 ( 11 ) 1108 - 1112 2012.11

マウスを用いた遺伝子改変成長因子Collagen binding domain BMP4の効果

塩崎泰之, 馬崎哲郎, 山根健太郎, 吉田靖弘, 中村真理子, 北嶋隆, 伊藤嘉浩, 尾崎敏文, 松川昭博

日本バイオマテリアル学会大会予稿集シンポジウム2012 269 - 269 2012.11

ウサギの骨欠損モデルにおいてコラーゲン結合性骨形成蛋白質は骨形成を促進する

吉田晶, 塩崎泰之, 馬崎哲朗, 古松毅之, 松川昭博, 中村真理子, 吉田靖弘, 北島隆, 伊藤嘉浩, 尾崎敏文

日本バイオマテリアル学会大会予稿集シンポジウム2012 270 - 270 2012.11

家兎骨軟骨欠損モデルにおける可視光硬化ゼラチンの骨軟骨組織修復の効果

馬崎哲朗, 塩崎泰之, 吉田晶, 松川昭博, 中村真理子, 吉田靖弘, 北嶋隆, 伊藤嘉浩, 尾崎敏文

日本バイオマテリアル学会大会予稿集シンポジウム2012 325 - 325 2012.11

J241024 Minimalization of Skin Incision by Presenting Optimal Opening Area for Multi-Axis Medical Machine Tool

NAWATA Wataru, YOKOO Syunsuke, SUGITA Naohiko, NAKAJIMA Yoshikazu, KATO Takeharu, ABE Nobuhiro, FUJIWARA Kazuo, YOKOYAMA Yuusuke, OZAKI Toshifumi, SUZUKI Masahiko, MITSUISHI Mamoru

Mechanical Engineering Congress, Japan 2012 "J241024 - 1"-"J241024-5" 2012.9

Language：Japanese Publisher：The Japan Society of Mechanical Engineers

J241024In Total Knee Arthroplasty (TKA), bone cuting is needed to make several planes for insesrtion of artificial joint, and the cutting presicion is important for the long-term result TKA by means of Minimally Invasive Surgery (MIS) is a challenging surgery because bone cutting accuracy tend to worse due to the small incision A robotic system has developed to achieve high accuracy with MIS In robotic MIS, the location of incision is a critical issue because it is extremely difficult for surgery to make the shortest incision which allows bone cutting tool to resect every plane of bone Therefore, the system which calculates the optimal incision and presents it visually was developed to make the best incision The optimal incision is calculated based on the position of bone and skin And the calculated optimal incision is presented on camera display by use of Augmented Reality so that surgeons can know the optimal incision easily The experiments with bone models and swine legs showed that the surgery could be successfully implemented within 80 mm in clinical use

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Surgical treatment for bone tumors using novel aligned connected porous artificial bone graft

KUNISADA Toshiyuki

55 ( 5 ) 1167 - 1168 2012.9

Arthroscopic treatment for the soft-tissue impingement after total knee arthroplasty -a case report-

FUJII Masataka

55 ( 5 ) 1097 - 1098 2012.9

ウサギ尺骨骨欠損モデルを用いたリン酸化プルランの骨再生能の検討

山根健太郎, 塩崎泰之, 馬崎哲朗, 吉田晶, 杉本佳久, 瀧川朋亨, 田中雅人, 松川昭博, 尾崎敏文

日本整形外科学会雑誌 86 ( 8 ) S1349 - S1349 2012.8

ウサギの骨欠損モデルにおけるコラーゲン結合性骨形成蛋白質の有効性

馬崎哲朗, 塩崎泰之, 吉田晶, 松川昭博, 中村真理子, 吉田靖弘, 北嶋隆, 伊藤嘉浩, 尾崎敏文

日本整形外科学会雑誌 86 ( 8 ) S1071 - S1071 2012.8

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