Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

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後腹膜脂肪肉腫の治療における問題点

杉原進介, 中田英二, 魚谷弘二, 尾崎敏文

日本整形外科学会雑誌 91 ( 6 ) S1276 - S1276 2017.6

麻痺のない脊椎の骨関連事象(SRE)に対するRTの治療成績

中田英二, 杉原進介, 尾崎敏文

日本整形外科学会雑誌 91 ( 6 ) S1261 - S1261 2017.6

Sauve-Kapandji法術後掌屈可動域減少例の検討

竹下歩, 西田圭一郎, 島村安則, 那須義久, 尾崎敏文

日本手外科学会雑誌 34 ( 1 ) S415 - S415 2017.4

大腿骨近位部病的骨折の治療成績

中田英二, 杉原進介, 尾崎敏文

中部日本整形外科災害外科学会雑誌 60 ( 春季学会 ) 198 - 198 2017.4

本邦のさまざまな医療機関における倫理委員会の現状と課題臨床研究が効率よく実施されるために

藤原智洋, 藤井政孝, 吉原久美子, 大野彩, 三橋利晴, 丸山貴之, 桑木健司, 伊東孝, 難波志穂子, 尾崎敏文, 樋之津史郎

日本整形外科学会雑誌 91 ( 2 ) S303 - S303 2017.3

TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes

Joe Hasei, Takeshi Teramura, Toshiyuki Takehara, Yuta Onodera, Takuro Horii, Merissa Olmer, Izuho Hatada, Kanji Fukuda, Toshifumi Ozaki, Martin K. Lotz, Hiroshi Asahara

SCIENTIFIC REPORTS 7 42990 2017.2

Language：English Publisher：NATURE PUBLISHING GROUP

The objective was to investigate the levels of TWIST1 in normal and OA cartilage and examine its role in regulating gene expression in chondrocytes. Human cartilage tissues and chondrocytes were obtained at autopsy from normal knee joints and from OA-affected joints at the time of total knee arthroplasty. TWIST1 expression was increased in human OA knee cartilage compared to normal knee cartilage. TWIST1 induced matrix metalloproteinase 3 (MMP3) expression without direct binding to MMP3 promoter and increased the 5-hydroxymethylcytosine (5hmC) level at the MMP3 promoter. The effect of TWIST1 on expression of TET family (TET1, 2 and 3) was measured in stable TWIST1 transfected TC28 cells, and TET1 expression was up-regulated. TWIST1 dependent upregulation of Mmp3 expression was suppressed in Tet triple KO fibroblast derived from mouse ES cells. Increased TWIST1 expression is a feature of OA-affected cartilage. We identified a novel mechanism of catabolic reaction where TWIST1 up-regulates MMP3 expression by enriching 5hmC levels at the MMP3 promoter via TET1 induction. These findings implicate TWIST1 as an important factor regulating OA related gene expression. Clarifying epigenetic mechanisms of 5hmC induced by TWIST1 is a critical molecule to understanding OA pathogenesis.

DOI： 10.1038/srep42990

Web of Science

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The epidemiology of developmental dysplasia of the hip in Japan: Findings from a nationwide multi-center survey

Tadashi Hattori, Yutaka Inaba, Sadafumi Ichinohe, Toshio Kitano, Daisuke Kobayashi, Takashi Saisu, Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC SCIENCE 22 ( 1 ) 121 - 126 2017.1

Language：English Publisher：SPRINGER JAPAN KK

Background: It has been reported that the national incidence of developmental dysplasia of the hip (DDH) has decreased in Japan. This is because of prevention activities after birth since around 1970. However, cases of late-diagnosed DDH have still been noted in some children's hospitals. There has been no recent survey of DDH in Japan. The purpose of this study was to investigate the current epidemiology of DDH using a comprehensive nationwide survey.
Methods: A questionnaire was sent to orthopedic surgeons in 1987 facilities nationwide, who were asked to complete and return a survey card on each DDH patient treated between April 2011 and March 2013.
Results: A total of 783 (39%) facilities completed and returned the card. Of these, 79% reported no cases of DDH-related dislocation over the 2-year period, while the remaining facilities reported 1295 cases. The characteristics of children diagnosed with DDH-related dislocation were as follows: girls (89%), left side involvement (69%), bilateral involvement (4%), positive family history (27%), first-born (56%), and pelvic position at birth (15%). Seasonal variation showed an increase in DDH incidence among those born in the winter. Overall, 199 cases (15%) were diagnosed at >1 year of age, and these included 36 cases diagnosed very late, at >3 years of age. The majority of the 199 cases of late diagnosis had received earlier routine screening at <1 year of age.
Conclusion: The characteristics of the children diagnosed with DDH nationwide were similar to past data from local regions. However, many children were diagnosed late (>1 year of age), particularly in the more populous regions. The findings identify a need for improved early routine screening for DDH in Japan. (C) 2016 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jos.2016.08.009

Web of Science

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ラット脊椎固定モデルにおけるrhBMP2添加リン酸化プルランフィルムの有用性の検討

宇川諒, 塩崎泰之, 村岡聡介, 池田吉弘, 内野崇彦, 小田孔明, 吉村将秀, 吉田晶, 瀧川朋亨, 三澤治夫, 尾崎敏文, 松川昭博

移植 52 ( 6 ) 582 - 582 2017

施設入所中の脳性麻痺児における健康関連QOL調査の試み

小田孔明, 堅山佳美, 赤澤啓史, 田中雅人, 千田益生, 尾崎敏文

Japanese Journal of Rehabilitation Medicine 54 ( Supplement ) 2017

臓器移植とリハビリテーション

千田益生, 堅山佳美, 兼田大輔, 尾崎敏文

Japanese Journal of Rehabilitation Medicine 54 ( Supplement ) 2017

椎間板線維輪の転写因子制御

中道亮, 浅原弘嗣, 尾崎敏文

日本骨代謝学会学術集会プログラム抄録集 35th 2017

半月板変性断裂におけるクラスター形成と細胞外器質構成成分の検討

児玉有弥, 古松毅之, 前原亜美, 釜付祐輔, 尾崎敏文

日本結合組織学会学術大会抄録集 49th 2017

ラット脊椎固定モデルにおけるrhBMP2添加リン酸化プルランフィルムの有用性の検討

宇川諒, 塩崎泰之, 村岡聡介, 池田吉弘, 内野崇彦, 小田孔明, 吉村将秀, 吉田晶, 瀧川朋亨, 三澤治夫, 尾崎敏文, 松川昭博

整形外科バイオマテリアル研究会プログラム・抄録集 37th 2017

Calcar femorale in patients with osteoarthritis of the hip secondary to developmental dysplasia

Tomonori Tetsunaga, Kazuo Fujiwara, Hirosuke Endo, Tomoko Tetsunaga, Naofumi Shiota, Toru Sato, Toshifumi Ozaki

CiOS Clinics in Orthopedic Surgery 9 ( 4 ) 413 - 419 2017

Language：English Publisher：Korean Orthopaedic Association

Background: We investigated whether the calcar femorale, a cortical septum in the region of the lesser trochanter of the femur, correlates with results of femoral stem implantation in patients with osteoarthritis of the hip secondary to developmental dysplasia using computed tomography. Methods: This retrospective study included 277 hips (41 males and 236 females
age, 37 to 92 years) of patients who had presented to Okayama Medical Center with hip pain. Of these, a total of 219 hips (31 males and 188 females) had previously undergone total hip arthroplasty. According to the Crowe classification, 147 hips were classified as Crowe grade I, 72 hips as Crowe grade II– IV, and 58 hips as normal. Results: The calcar femorale was identified in 267 hips (96.4%). The calcar femorale was significantly shorter and more ante-verted in Crowe grade II–IV hips than in Crowe grade I or normal hips. Significant differences in the shape of the calcar femorale were found according to the severity of hip deformity. Three stem designs were analyzed: single-wedge (59 hips), double-wedge metaphyseal filling (147 hips), and modular (13 hips). Single-wedge stems were inserted more parallel to the calcar femorale rather than femoral neck anteversion, while other types of stems scraped the calcar femorale. Conclusions: The angle of the calcar femorale differs according to the severity of hip deformity, and the calcar femorale might thus serve as a more useful reference for stem insertion than femoral neck anteversion in total hip arthroplasty using a single-wedge stem.

DOI： 10.4055/cios.2017.9.4.413

Scopus

PubMed

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強直股に対する人工股関節全置換術の治療経験

鉄永智紀, 藤原一夫, 遠藤裕介, 藤井洋佑, 三宅孝昌, 山田和希, 塩田直史, 佐藤徹, 尾﨑敏文

日本人工関節学会誌 47 675 - 676 2017

Language：Japanese Publisher：(一社)日本人工関節学会

強直股に対して THA(人工股関節全置換術)を行った11例12股(男性5股、女性7股、手術時平均年齢64歳)の術後成績について検討した。手術はCT basedナビゲーションシステム使用例が5例、非使用例が7例であった。術後平均観察期間35ヵ月の結果、手術に伴う合併症は異所性骨化が2例、ナビゲーションを使用しなかった1例で術中骨折、Hardingeで行った1例で中殿筋部の疼痛を認めた。隣接関節痛である腰痛や膝関節痛は術前に6例で認められていたが、最終調査時には5例で軽減していた。JOAスコアは術前平均46点から最終調査時平均79点へ改善していた。

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Fixation transtibiale des l?sions de la racine post?rieure du m?nisque m?dial. Un guide de vis?e sp?cifique am?liore le positionnement du tunnel tibial

T. Furumatsu, Y. Kodama, M. Fujii, T. Tanaka, T. Hino, Y. Kamatsuki, K. Yamada, S. Miyazawa, T. Ozaki

Revue de Chirurgie Orthopedique et Traumatologique, Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil Moteur, Revue d'orthope?die et de chirurgie de l'appareil moteur 103 ( 3 ) 1 - 50 2017

THA再置換術後に遅発性Bacteroides感染を生じた1例

三宅孝昌, 遠藤裕介, 鉄永智紀, 藤井洋佑, 山田和希, 尾﨑敏文

日本人工関節学会誌 47 735 - 736 2017

岡山大学病院における外国人患者受入れ医療機関認証制度（JMIP）受審までの取り組み

尾﨑敏文

岡山医学会雑誌 129 ( 3 ) 199 - 200 2017

非接触三次元計測器を用いた新たな可動域計測法の考案

兼田大輔, 西田圭一郎, 竹下歩, 大橋秀基, 尾﨑敏文, 堅山佳美, 千田益生, 中原龍一, 那須義久, 堀田昌宏

日本関節病学会誌 36 ( 4 ) 481 - 487 2017

Language：Japanese Publisher：(一社)日本関節病学会

健常者8名(男性6名、女性2名、20歳代)を対象とし、2種類の計測法によって関節可動域(ROM)を計測した。理学療法士(PT)により角度計を用いて徒手的にROM計測を行った(徒手計測法)。考案した新しい計測法として、3Dスキャナーによって体表の撮像を行い、そこから得られた三次元データを用いてコンピューター上でROM計測を行った(3Dスキャナー計測法)。被験者ごとのROMの標準偏差は、全ての関節肢位において3Dスキャナー計測法では徒手計測法と比較し検者間における標準偏差は有意に小さかった。平均最大測定値差は、標準偏差と同様に全ての関節肢位において3Dスキャナー計測法では徒手計測法と比較して有意に小さかった。徒手計測法、3Dスキャナー計測法の級内相関係数(ICC)は、全ての関節において3Dスキャナー計測法のほうが高く、検者間誤差は小さかった。平均計測時間は、肘関節、足関節ともに3Dスキャナー計測法のほうが有意に計測に時間を要した。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J05177&link_issn=&doc_id=20171221080011&doc_link_id=%2Ffd8kanse%2F2017%2F003604%2F011%2F0481-0487%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffd8kanse%2F2017%2F003604%2F011%2F0481-0487%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

発育性股関節形成不全（脱臼）の全国多施設調査の結果報告

服部義, 稲葉裕, 一戸貞文, 北野利夫, 小林大介, 西須孝, 尾﨑敏文

日小整会誌 26 ( 2 ) 343 - 351 2017

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