Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

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指神経に発生した巨指症を伴わない fibrolipomatous hamartoma の1例

清野正普, 武田健, 藤原智洋, 国定俊之, 尾﨑敏文

中部整災誌 59 ( 2 ) 563 - 564 2016

Language：Japanese Publisher：(一社)中部日本整形外科災害外科学会

31歳男。10年前より右環指の腫瘤、同部DIP関節の可動域制限を自覚していた。巨指症は伴わず、肉眼、単純X線、MRI各所見、針生検、切開生検で確定診断を得られなかった。切除生検を行い右環指橈側から進入したところ、皮膚直下に境界明瞭で指神経と連続する黄色の結節状腫瘍を認めた。指神経の腫瘍と判断し、指神経合併切除による腫瘍辺縁切除を行った。病理診断はfibrolipomatous hamartoma(FLH)であった。術後、指の腫脹、巧緻性障害は消失し患者の満足度は高いが、右環指橈側DIP遠位に軽度の知覚障害が認められた。

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J00831&link_issn=&doc_id=20160815090067&doc_link_id=10.11359%2Fchubu.2016.563&url=https%3A%2F%2Fdoi.org%2F10.11359%2Fchubu.2016.563&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

可視光硬化型ゼラチンとコラーゲン結合性肝細胞増殖因子を用いた脊髄損傷治療

山根健太郎, 吉田晶, 松川昭博, 伊藤嘉浩, 尾崎敏文

移植 51 ( 6 ) 517 - 517 2016

Ewing肉腫の診断と治療

尾崎敏文

日本小児血液・がん学会雑誌(Web) 53 ( 4 ) 2016

Overcoming Therapeutic Resistance of Bone Sarcomas: Overview of the Molecular Mechanisms and Therapeutic Targets for Bone Sarcoma Stem Cells

Tomohiro Fujiwara, Toshifumi Ozaki

Stem Cells International 2016 2016

Language：English Publishing type：Book review, literature introduction, etc. Publisher：Hindawi Limited

Bone sarcomas are heterogeneous malignant tumors that exhibit clinical, histological, and molecular heterogeneity. Recent progress in their multimodal treatment has gradually improved patient prognosis
however, drug resistance and distant metastasis remain unresolved clinical problems. Recent investigations have suggested the existence of cancer stem-like cells (CSCs) in bone sarcomas, which represent a subpopulation of tumor cells with high tumor-forming ability. The hallmarks of CSCs include tumor-and metastasis-forming potential and drug resistance, which are responsible for poor prognoses of bone sarcoma patients. Therefore, elucidation of the molecular mechanisms of CSCs and identification of therapeutic targets could contribute to novel treatment strategies for bone sarcomas and improve patient prognosis. This paper provides an overview of the accumulating knowledge on bone sarcoma stem cells and preclinical analyses to overcome their lethal phenotypes, in addition to a discussion of their potential for novel therapeutics for bone sarcomas.

DOI： 10.1155/2016/2603092

Scopus

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Interprosthetic fractureの治療経験

望月雄介, 野田知之, 上原健敬, 杉生和久, 吉村将秀, 清野正普, 島村安則, 尾崎敏文, 山川泰明

骨折 38 ( Supplement ) 2016

変形性膝関節症のリハビリテーション

千田益生, 堅山佳美, 上原健敬, 兼田大輔, 尾崎敏文

日本腎臓リハビリテーション学会学術集会プログラム・抄録集 6th 2016

Lesion de la racine posterieure du menisque medial?

Y. Kodama, T. Furumatsu, M. Fujii, T. Tanaka, S. Miyazawa, T. Ozaki

Revue de Chirurgie Orthopedique et Traumatologique, Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil Moteur, Revue d'orthope?die et de chirurgie de l'appareil moteur 102 ( 7 ) 2016

骨腫瘍切除後の骨欠損に対する配向連通気孔構造を有する人工骨移植の治療経験

清野正普, 国定俊之, 藤原智洋, 長谷井嬢, 杉生和久, 魚谷弘二, 森田卓也, 小松原将, 望月雄介, 尾崎敏文

移植(Web) 51 ( 6 ) 2016

岡山大学病院における難治性慢性痛に対する薬剤師の介入意義について

神崎浩孝, 北村佳久, 千堂年昭, 鉄永倫子, 鉄永智紀, 尾崎敏文, 西江宏行, 太田晴之, 井上真一郎, 小田幸治, 流王雄太, 宮脇卓也, 西田圭一郎

日本運動器疼痛学会誌 7 ( 3 ) S71 - S71 2015.11

Postgraduate orthopaedic trauma education : Effort of Okayama University

89 ( 11 ) 932 - 936 2015.11

新規生体吸収性骨セメントの細胞動態の検討

ZHANG W, 吉田晶, 山根健太郎, 香川洋平, 篠原健介, 吉田靖弘, 松川昭博, 尾崎敏文

日本整形外科学会雑誌 89 ( 8 ) S1575 - S1575 2015.9

肺がん骨転移の骨関連事象の解析

中田英二, 杉原進介, 尾崎敏文

中部日本整形外科災害外科学会雑誌 58 ( 秋季学会 ) 149 - 149 2015.9

骨軟部骨軟部腫瘍の診断・バイオマーカー初診時原発不明癌骨転移の原発巣の診断と予後

中田英二, 杉原進介, 尾崎敏文

日本癌治療学会誌 50 ( 3 ) 1446 - 1446 2015.9

Preclinical evaluation of radiotherapy in combination with radio-sensitizing telomerase-specific oncolytic virus for human bone and soft tissue sarcomas

Toshinori Omori, Yasuaki Yamakawa, Joe Hasei, Hiroshi Tazawa, Shuhei Osaki, Tusyoshi Sasaki, Kazuhisa Sugiu, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara

CANCER RESEARCH 75 2015.8

肺がん脊椎転移に対するRT後の骨硬化像の出現時期の検討

中田英二, 杉原進介, 尾崎敏文

日本整形外科学会雑誌 89 ( 6 ) S1315 - S1315 2015.6

骨肉腫との鑑別を要した術後局所軟部再発大腿骨骨巨細胞腫病的骨折の1例

杉原進介, 中田英二, 尾崎敏文

日本整形外科学会雑誌 89 ( 6 ) S1346 - S1346 2015.6

高齢頚髄症患者の呼吸機能障害 (特集高齢者の脊髄障害)

杉本佳久, 田中雅人, 尾﨑敏文

Monthly book medical rehabilitation ( 181 ) 35 - 37 2015.3

Diagnosis and treatment of Ewing sarcoma of the bone: a review article

Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC SCIENCE 20 ( 2 ) 250 - 263 2015.3

Language：English Publishing type：Book review, literature introduction, etc. Publisher：SPRINGER JAPAN KK

Ewing sarcoma (ES) is rare in Japanese people, and only 30-40 patients develop the disease annually. To diagnose ES, molecular techniques that aim to detect characteristic fusion genes are commonly used in combination with conventional histological and immunohistochemical examinations. The treatment strategy for ES is characterized by multi-disciplinary collaboration between pediatric oncologists, medical oncologists, radiation oncologists, and orthopedic surgeons. In recent years, numerous large-scale national or international multi-institutional studies of ES have been performed. Pre- and postoperative intensive systemic chemotherapy with multiple anticancer drugs is the standard treatment method for ES. Depending on the obtained surgical margin, postoperative radiation might also be performed. If preoperative radiological examinations indicate that surgical excision would be difficult, preoperative radiation can be administered. As the treatment outcomes of ES have improved, late complications and secondary malignancies have become a problem. After treatment, patients with ES require very long-term follow-up in order to detect secondary malignancies and growth-related musculoskeletal complications.

DOI： 10.1007/s00776-014-0687-z

Web of Science

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1A41 Study of kinematics evaluation method for total knee arthroplasty

INOUE Takayuki, ABE Nobuhiro, MIYAZAWA Shinichi, FUJIWARA Kazuo, Nakajima Yoshikazu, SUGITA Naohiko, MITSUISHI Mamoru, OZAKI Toshifumi, CHEN Zhongchun

2015 ( 27 ) 39 - 40 2015.1

特発性膝骨壊死により生じた遊離軟骨の細胞増殖活性と再分化能の検討-膝離断性骨軟骨炎との比較-

古松毅之, 坂田賢一郎, 前原亜美, 田中孝明, 井上博登, 児玉有弥, 尾崎敏文

移植(Web) 50 ( 6 ) 2015

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