Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

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頚椎症性脊髄症の診療ガイドライン

田中雅人, 杉本佳久, 三澤治夫, 高畑智宏, 尾﨑敏文

岡山医誌第122巻 67 - 71 2009

Laminar screw を用いた上位頚椎疾患に対する手術経験

中西一夫, 田中雅人, 三澤治夫, 尾﨑敏文

日本脊椎インストウルメンテーション学会誌第8巻 ( 1 ) 75 - 78 2009

大腿骨骨切りを併用した Chiari 骨盤骨切り術後に股関節鏡を行った 3 例

皆川寛, 三谷茂, 遠藤裕介, 藤原一夫, 鉄永智紀, 尾﨑敏文

関節鏡第34巻 ( 1 ) 18 - 24 2009

Language：Japanese Publisher：日本関節鏡学会

症例1:32歳女。28歳時に両股関節痛が出現し、29歳時に疼痛が増強した。X線所見より進行期の両変形性股関節症と診断し、左キアリ骨盤骨切り術および大腿骨内反伸展骨切り術を施行した。翌年、右股に対し同様の手術を施行した。症例2は:46歳女。30歳時から左股痛が出現し、44歳時に疼痛が増強した。進行期の左変形性股関節症と診断し、左キアリ骨盤骨切り術および大腿骨外反伸展骨切り術を施行した。症例3:43歳女。31歳時から右股痛が出現し、38歳時に疼痛が増強した。末期の右変形性股関節症と診断し、右キアリ骨盤骨切り術および大腿骨外反伸展骨切り術を施行した。3例とも術後JOAスコアは改善し、X線所見で関節裂隙の拡大と関節リモデリングを認めた。抜釘時の股関節鏡視所見では新臼蓋に軟骨様のfibrillationを認めた。症例3に対しX線透視と鏡視を併用して臼蓋移行部の生検を施行したところ、本来軟部組織のみである部分に線維軟骨細胞を認め、線維軟骨化生が生じたと考えられた。

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FasT-Fix を用いた all-inside 半月板縫合術 -適応と限界-

古松毅之, 阿部信寛, 伊達宏和, 尾﨑敏文

スポーツ傷害第14巻 24 - 26 2009

External snapping hip treated by Z plasty: a case report

Orthopaedic surgery and traumatology 第52巻 ( 4 ) 437 - 439 2009

J リーグ入りを目指すサッカークラブにおけるスポーツ外傷・障害

古松毅之, 阿部信寛, 伊達宏和, 雑賀建多, 千田益生, 尾﨑敏文

整スポ会誌第29巻 ( 3 ) 132 - 135 2009

外側小切開による踵骨関節内骨折の治療成績

雑賀建多, 野田知之, 島村安則, 門田康孝, 中原龍一, 尾﨑敏文

骨折第31巻 ( 2 ) 359 - 362 2009

Language：Japanese Publisher：(一社)日本骨折治療学会

著者らは踵骨関節内骨折に対し、後距踵関節面を外側小切開して直視下に整復固定し、関節外アライメントについては間接的に再建する観血的整復固定術を施行してきた。今回、過去4年間に経験した37症例(平均年齢56.8歳)40足を対象に治療成績を検討した。検討項目はBoehler角、Preiss角、後距踵関節面の転位で、それぞれ受傷時、手術直後、最終調査時に測定し臨床成績と比較した。観察期間平均9.3ヵ月の結果、1)臨床成績は34例が成績良好で、合併症としてはpin刺入部感染が1例に認められた。2)治療成績に相関を認めた因子は、受傷時のBoehler角と後距踵関節面の転位、および最終調査時の後距踵関節面の転位であった。3)術前評価としてBoehler角と後距踵関節面の転位は予後予測因子であり、手術においては後距踵関節面の解剖学的整復を得ることが重要であると考えられた。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2009&ichushi_jid=J00496&link_issn=&doc_id=20090622190037&doc_link_id=%2Fdp6fract%2F2009%2F003102%2F037%2F0359-0362%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdp6fract%2F2009%2F003102%2F037%2F0359-0362%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

特発性側弯症における頚椎 MRI の有用性

高畑智宏, 田中雅人, 三澤治夫, 越宗幸一郎, 尾﨑敏文

西日本脊椎研究会誌第35巻 ( 1 ) 89 - 89 2009

腰椎疾患初診患者における臨床症状と自己評価抑うつ尺度の検討

三澤治夫, 田中雅人, 越宗幸一郎, 中西一夫, 尾﨑敏文

西日本脊椎研究会誌第35巻 ( 1 ) 58 - 62 2009

Treatment of long bone fractures using locking plate

SAIGA Kenta

The Central Japan Journal of Orthopaedic Surgery & Traumatology 第52巻 ( 3 ) 663 - 664 2009

仙骨骨盤部巨大神経鞘腫の検討

三澤治夫, 田中雅人, 越宗幸一郎, 尾﨑敏文

西日本脊椎研究会誌第35巻 ( 2 ) 209 - 209 2009

当科における脊髄腫瘍の手術成績

田中雅人, 三澤治夫, 越宗幸一郎, 尾﨑敏文

西日本脊椎研究会誌第35巻 ( 2 ) 153 - 160 2009

股関節手術時の出血と血管内止血

藤原一夫, 三谷茂, 遠藤裕介, 鉄永智紀, 皆川寛, 迫間巧将, 中原龍一, 尾﨑敏文, 三村秀文

関節外科第28巻 ( 6 ) 695 - 701 2009

脊髄原発 High grade astrocytoma の 2 例

三澤治夫, 田中雅人, 越宗幸一郎, 尾﨑敏文

西日本脊椎研究会誌第35巻 ( 2 ) 232 - 232 2009

Short-Term Results of Metal-on-Metal Total Hip Arthroplasty

Tetsunaga Tomonori, Mitani Shigeru, Endo Hirosuke, Minagawa Hiroshi, Ozaki Toshifumi, Fujiwara Kazuo

The Journal of the Chugoku-Shikoku Orthopaedic Association 第21巻 ( 1 ) 53 - 57 2009

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

Metal-on-metal total hip arthroplasty (THA) is characterized by low wear and a wide range of motion. We performed metal-on-metal THA with limitations in young males with alcoholic avascular necrosis of the femoral head, and studied the short-term outcome of the procedure. Five patients were treated during the period from September 2007 to July 2008. All of the patients were males engaged in manual labor. The average age at the time of surgery was 39 years, and the average postoperative follow-up period was 5.2 months. The average period until return to work was 57 days, and no particular postoperative complications were observed. With regard to postoperative range of motion, more than 100 degrees of flexion was obtained. The average Japanese Orthopaedic Association hip score, which was 42 points before surgery, improved significantly to 93 points after surgery. In particular, pain was disappeared completely, and it was possible for the patients to return to heavy manual labor. As metal-on-metal THA might be involved with some problems, such as the metal ion concentration, its application to patients with renal dysfunction or gravida should be limited.

DOI： 10.11360/jcsoa.21.53

CiNii Article

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Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. International journal

Tatsuo Ito, Neelu Yadav, Jaeho Lee, Takayuki Furumatsu, Satoshi Yamashita, Kenji Yoshida, Noboru Taniguchi, Megumi Hashimoto, Megumi Tsuchiya, Toshifumi Ozaki, Martin Lotz, Mark T Bedford, Hiroshi Asahara

BMC developmental biology Vol.9 47 - 47 2009

Language：English

BACKGROUND: Chondrogenesis and subsequent endochondral ossification are processes tightly regulated by the transcription factor Sox9 (SRY-related high mobility group-Box gene 9), but molecular mechanisms underlying this activity remain unclear. Here we report that coactivator-associated arginine methyltransferase 1 (CARM1) regulates chondrocyte proliferation via arginine methylation of Sox9. RESULTS: CARM1-null mice display delayed endochondral ossification and decreased chondrocyte proliferation. Conversely, cartilage development of CARM1 transgenic mice was accelerated. CARM1 specifically methylates Sox9 at its HMG domain in vivo and in vitro. Arg-methylation of Sox9 by CARM1 disrupts interaction of Sox9 with beta-catenin, regulating Cyclin D1 expression and cell cycle progression of chondrocytes. CONCLUSION: These results establish a role for CARM1 as an important regulator of chondrocyte proliferation during embryogenesis.

DOI： 10.1186/1471-213X-9-47

PubMed

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Frequent methylation of RASSF1A in synovial sarcoma and the anti-tumor effects of 5-aza-2'-deoxycytidine against synovial sarcoma cell lines. International journal

Kunihiko Numoto, Aki Yoshida, Shinsuke Sugihara, Toshiyuki Kunisada, Yuki Morimoto, Yasushi Yoneda, Yasuko Fujita, Keiichiro Nishida, Mamoru Ouchida, Toshifumi Ozaki

Journal of cancer research and clinical oncology 136 ( 1 ) 17 - 25 2009

Language：English

PURPOSE: In this study, the methylation status of RASSF1A in synovial sarcomas and the effect of demethylation on synovial sarcoma were examined. METHODS: The methylation status in 74 soft tissue sarcomas (STSs) including 21 synovial sarcomas was determined by methylation specific PCR. The effect of the de-methylating agent 5-aza-20-deoxycytidine (5-Aza-dC) on synovial sarcoma was examined using synovial sarcoma cell lines (SYO-1 and HS-SY-II). RESULTS: RASSF1A methylation was observed in 10 (47.6%) of 21 synovial sarcomas and in 10 (18.9%) of 53 the other STSs (P = 0.0295). De-methylation of the cells by treatment with 5-Aza-dC induced re-expression of RASSF1A and growth suppression of the cells. The calculated IC50 of 5-Aza-dC against the SYO-1 and the HS-SYII cells were 0.9 and 1.3 lM (96 h), respectively. With twice weekly administration of 1 or 10 mg/kg 5-Aza-dC, the growth of the mouse xenograft tumors of SYO-1 was significantly suppressed in comparison to the controls (P\0.01). CONCLUSION: This is the first report showing the anti-tumor effect of 5-Aza-dC on synovial sarcoma. 5-Aza-dC is suggested to have a good therapeutic potential against synovial sarcoma.

DOI： 10.1007/s00432-009-0632-2

PubMed

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Computer navigation-assisted spinal fusion with segmental pedicle screw instrumentation for scoliosis with Rett syndrome: a case report.

Masato Tanaka, Kazuo Nakanishi, Yoshihisa Sugimoto, Haruo Misawa, Tomoyuki Takigawa, Keiichiro Nishida, Toshifumi Ozaki

Acta medica Okayama 63 ( 6 ) 373 - 377 2009

Language：English

Scoliosis is a common clinical manifestation of Rett syndrome, a neurodevelopmental disorder that almost exclusively affects females. The spinal curve in patients with Rett syndrome is typically a long C curve of a neuromuscular type. As the onset of the scoliosis is very early and shows rapid progression, early surgical intervention has been recommended to prevent a life-threatening collapsing spine syndrome. However, there are high perioperative risks in Rett syndrome patients who undergo spinal surgery, such as neurological compromise and respiratory dysfunction due to rigid spinal curve. We herein report the surgical result of treating severe rapid progressive thoracic scoliosis in a 16-year-old girl with Rett syndrome. Posterior segmental pedicle screw fixation was performed from T1 to L3 using a computer-assisted technique. Post-operative radiography demonstrated a good correction of the curve in both the sagittal and coronal alignment. There were no postoperative complications such as neurological compromise. The patient had maintained satisfactory spinal balance as of the 3-year follow-up examination.

DOI： 10.18926/AMO/31823

PubMed

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低侵襲型人工膝関節置換術支援ロボットの精度評価

藤原一夫, 阿部信寛, 遠藤裕介, 西田圭一郎, 尾崎敏文, 鈴木昌彦, 斎藤季, 杉田直彦, 中島義和, 光石衛

日本整形外科学会雑誌 83 ( 8 ) 2009

X-ray dark field imaging of human articular cartilage: Possible clinical application to orthopedic surgery

Toshiyuki Kunisada, Daisuke Shimao, Hiroshi Sugiyama, Ken Takeda, Toshifumi Ozaki, Masami Ando

EUROPEAN JOURNAL OF RADIOLOGY 68 ( 3 ) S18 - S21 2008.12

Language：English Publisher：ELSEVIER IRELAND LTD

Despite its convenience and non-invasiveness on daily clinical use, standard X-ray radiography cannot show articular cartilage. We developed a novel type of X-ray dark field imaging (DFI), which forms images only by a refracted beam with very low background illumination. We examined a disarticulated distal femur and a shoulder joint with surrounding soft tissue and skin, both excised from a human cadaver at the BL20B2 synchrotron beamline at SPring-8. The field was 90 mm wide and 90 mm high. Articular cartilage of the disarticulated distal femur was obvious on DFI, but not on standard X-ray images. Furthermore, DFI allowed visualization in situ of articular cartilage of the shoulder while covered with soft tissue and skin. The gross appearance of the articular cartilage on the dissected section of the proximal humerus was identical to the cartilage shown on the DFI image. These results suggested that DFI could provide a clinically accurate method of assessing articular cartilage. Hence, DFI would be a useful imaging tool for diagnosing joint disease such as osteoarthritis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2008.04.034

Web of Science

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