Faculty Profiles - OZAKI Toshifumi

MISC - OZAKI Toshifumi

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軟部肉腫の治療成績はどこまで改善したか粘液型および脱分化型脂肪肉腫の治療成績年代別治療成績の検討を中心に

穴澤卯圭, 森岡秀夫, 鈴木禎寿, 森井健司, 保坂聖一, 浅野尚文, 岩田慎太郎, 尾崎敏文, 柳川天志, 川井章, 西田佳弘, 保坂泰介, 上田孝文, 矢部啓夫, 戸山芳昭

日本整形外科学会雑誌 86 ( 9 ) 647 - 653 2012

Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas

124 ( 2 ) 105 - 110 2012

The efficacy of external fixation for distal radius fractures

23 1 - 5 2012

Ankle arthrodesis with an external fixator for a large osteochondral defect of the distal tibia

23 131 - 136 2012

整形外科研修施設めぐり(7)岡山大学大学院医歯薬学総合研究科生体機能再生・再建学講座整形外科

尾崎敏文

整形外科surgical technique : 手術が見える・わかる専門誌 2 ( 2 ) 211 - 216 2012

Inner Meniscus Cells Maintain Higher Chondrogenic Phenotype Compared with Outer Meniscus Cells

Takayuki Furumatsu, Tomoko Kanazawa, Yusuke Yokoyama, Nobuhiro Abe, Toshifumi Ozaki

CONNECTIVE TISSUE RESEARCH 52 ( 6 ) 459 - 465 2011.12

Language：English Publishing type：Book review, literature introduction, etc. Publisher：INFORMA HEALTHCARE

Meniscus cells have several distinct properties in cellular morphology and extracellular matrix production. Inner meniscus cells are considered to have more chondrocytic phenotype compared with outer meniscus cells. However, the chondrogenic property of each meniscus cell has not been elucidated in detail. In this study, we investigated the difference between human inner and outer meniscus-derived cells in extracellular matrix deposition and chondrogenic potential. Monolayer-cultured inner meniscus cells showed small and ovoid shapes though slender and fibroblastic cells were obtained from outer half of human meniscus. The syntheses of type II collagen and safranin O-stained proteoglycans were increased in chondrogenic pellets derived from inner meniscus cells, rather than in outer meniscus cell-derived pellets. On the other hand, adipogenic lipid vacuoles were equally accumulated in both inner and outer meniscus cells after adipogenic treatment. Chondrogenic treatments also enhanced the expression of chondrogenic marker genes, such as Sry-type HMG box (SOX) 9, Scleraxis, and alpha 1(II) collagen, in inner meniscus cells. However, SOX9 expression was not increased in outer meniscus cells even after chondrogenic treatment. This study demonstrated that inner meniscus cells maintained higher chondrogenic potential compared with outer meniscus cells. Our results suggest that the difference between inner and outer meniscus cells in chondrogenic property might have an essential role in preserving a zone-specific meniscal feature.

DOI： 10.3109/03008207.2011.562061

Web of Science

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Development of AR Interface on Robotic Surgical System for the Minimally Invasive Knee Arthoplasty

YOKOO S., SUGITA N., NAKAJIMA Y., KATO T., ABE N., FUJIWARA K., YOKOYAMA Y., OZAKI T., SUZUKI M., KURAMOTO K., NAKASHIMA Y., MITSUISHI M.

13 ( 3 ) 340 - 341 2011.11

Mini-incision anterior slipped plating for humeral shaft fracture

KANAZAWA T., SHIMAMURA Y., NODA T., NISHIYAMA T., SAITOU T., OZAKI T.

33 ( 2 ) 318 - 321 2011.5

Surgical treatment for distal femoral fractures after total knee arthroplasty using with the locking plate

SAITO T., NODA T., SHIMAMURA Y., NISHIYAMA T., OZAKI T., TERADA C.

33 ( 2 ) 463 - 467 2011.5

Clinical outcomes and problems of the treatment for traumatic hip dislocations with acetabular fractures

NODA T., SHIMAMURA Y., NISHIYAMA T., NAKAHARA R., OZAKI T., TAKAGI Y.

33 ( 2 ) 352 - 357 2011.5

足関節周囲の骨折 (患者さんといっしょに読める整形外科病態生理32 はじめてマニュアル) -- (膝関節・足部)

野田知之, 島村安則, 尾崎敏文

整形外科看護 16 204 - 211 2011.5

Adjuvant and neoadjuvant chemotherapy (NAC) with ifosfamide (IFO) and doxorubicin hydrochloride (ADM) for high-grade soft tissue sarcomas (STS) in the extremities: Japan Clinical Oncology Group study JCOG030404.

K. Tanaka, J. Mizusawa, H. Fukuda, N. Araki, H. Chuuman, M. Takahashi, T. Ozaki, T. Hiruma, H. Tsuchiya, H. Morioka, T. Morita, T. Wada, M. Hatori, Y. Yoshida, J. Toguchida, S. Abe, A. Matsumine, R. Yokoyama, Y. Iwamoto

JOURNAL OF CLINICAL ONCOLOGY 29 ( 15 ) 2011.5

Biological reconstruction using recycled autogenous bone graft for bone and soft tissue tumors

KUNISADA Toshiyuki, MORIMOTO Yuki, ITANI Satoru, SASAKI Tsuyoshi, HASEI Jo, SUGIHARA Shinsuke, OZAKI Toshifumi

The Journal of the Japanese Orthopaedic Association 85 ( 4 ) 219 - 223 2011.4

Rupture of flexor tendon as the complication of volar distal radius plate

KANAZAWA Tomoko

54 ( 2 ) 385 - 386 2011.3

The use of external fixation during internal fixation for distal radius fractures

HASEI Jo

54 ( 2 ) 387 - 388 2011.3

軟部肉腫の治療成績はどこまで改善したか滑膜肉腫の治療成績と新規治療法の提案

中紀文, 竹中聡, 星学, 松峯昭彦, 戸口田淳也, 和田卓郎, 馬場一郎, 尾崎敏文, 上田孝文, 岩本幸英, 吉川秀樹

日本整形外科学会雑誌 85 ( 2 ) S38 - S38 2011.2

Evaluation of the accuracy of the stem position of cementless total hip arthroplasty with computed tomography-based navigation system

Orthopedic surgery 62 ( 1 ) 13 - 17 2011.1

Separation of the perivascular basement membrane provides a conduit for inflammatory cells in a mouse spinal cord injury model. International journal

Tomoyuki Takigawa, Tomoko Yonezawa, Teruhito Yoshitaka, Jun Minaguchi, Masae Kurosaki, Masato Tanaka, Yoshikazu Sado, Aiji Ohtsuka, Toshifumi Ozaki, Yoshifumi Ninomiya

Journal of neurotrauma 27 ( 4 ) 739 - 51 2011

Language：English

Spinal cord injury results in disruption of the cord microstructure, which is followed by inflammation leading to additional deterioration. Perivascular basement membranes are a component of the spinal cord microstructure that lies between blood vessels and astrocytes. The impact of disrupting the basement membrane structure on the expansion of inflammation has not been fully examined. The objective of this study was to clarify the relationship between damage to basement membranes and inflammation after spinal cord injury. Immunohistochemical analyses of the perivascular extracellular matrix were performed in a mouse spinal cord injury model. In normal tissue, the perivascular basement membrane was a single-layer structure produced by both endothelial cells and surrounding astrocytes. After spinal cord injury, however, the perivascular basement membrane often separated into an inner endothelial basement membrane and an outer parenchymal basement membrane. The altered basement membranes formed during the acute phase (within 7 days after spinal cord injury). During the subacute phase of injury, numerous monocytes and macrophages accumulated in the space between the separated basement membranes and infiltrated into the parenchyma where astrocytic endfeet were displaced. Infiltration of inflammatory cells from the injury core was attenuated coincident with the appearance of the glia limitans and glial scar. Furthermore, the outer parenchymal basement membrane was connected to the basement membrane of the glia limitans surrounding the injury core. Our data suggest that structurally altered basement membranes facilitate expansion of secondary inflammation during the subacute phase of spinal cord injury.

DOI： 10.1089/neu.2009.1111

PubMed

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Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas. International journal

Tsuyoshi Sasaki, Hiroshi Tazawa, Jo Hasei, Toshiyuki Kunisada, Aki Yoshida, Yuuri Hashimoto, Shuya Yano, Ryosuke Yoshida, Futoshi Uno, Shunsuke Kagawa, Yuki Morimoto, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara

Clinical cancer research : an official journal of the American Association for Cancer Research 17 ( 7 ) 1828 - 38 2011

Language：English

PURPOSE: Tumor-specific replication-selective oncolytic virotherapy is a promising antitumor therapy for induction of cell death in tumor cells but not of normal cells. We previously developed an oncolytic adenovirus, OBP-301, that kills human epithelial malignant cells in a telomerase-dependent manner. Recent evidence suggests that nonepithelial malignant cells, which have low telomerase activity, maintain telomere length through alternative lengthening of telomeres (ALT). However, it remains unclear whether OBP-301 is cytopathic for nonepithelial malignant cells. Here, we evaluated the antitumor effect of OBP-301 on human bone and soft tissue sarcoma cells. EXPERIMENTAL DESIGN: The cytopathic activity of OBP-301, coxsackie and adenovirus receptor (CAR) expression, and telomerase activity were examined in 10 bone (OST, U2OS, HOS, HuO9, MNNG/HOS, SaOS-2, NOS-2, NOS-10, NDCS-1, and OUMS-27) and in 4 soft tissue (CCS, NMS-2, SYO-1, and NMFH-1) sarcoma cell lines. OBP-301 antitumor effects were assessed using orthotopic tumor xenograft models. The fiber-modified OBP-301 (termed OBP-405) was used to confirm an antitumor effect on OBP-301-resistant sarcomas. RESULTS: OBP-301 was cytopathic for 12 sarcoma cell lines but not for the non-CAR-expressing OUMS-27 and NMFH-1 cells. Sensitivity to OBP-301 was dependent on CAR expression and not on telomerase activity. ALT-type sarcomas were also sensitive to OBP-301 because of upregulation of human telomerase reverse transcriptase (hTERT) mRNA following virus infection. Intratumoral injection of OBP-301 significantly suppressed the growth of OST and SYO-1 tumors. Furthermore, fiber-modified OBP-405 showed antitumor effects on OBP-301-resistant OUMS-27 and NMFH-1 cells. CONCLUSIONS: A telomerase-specific oncolytic adenovirus is a promising antitumor reagent for the treatment of bone and soft tissue sarcomas.

DOI： 10.1158/1078-0432.CCR-10-2066

PubMed

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屈筋腱障害予防を目的とした橈骨遠位端骨折用掌側ロッキングプレートの設置位置の検討

近藤秀則, 今谷潤也, 清水弘毅, 中道亮, 妹尾則孝, 尾崎敏文

日本手外科学会雑誌 = The journal of Japanese Society for Surgery of the Hand 27 ( 3 ) 252 - 255 2010.12

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