研究者詳細 - 中塚　幹也

MISC - 中塚　幹也

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特集胎児・新生児異常の新しい周産期管理妊娠中毒症・IUGRにおける血管内皮障害一子宮動脈・眼動脈・上腕動脈の血流動態の変化一

中塚幹也, 高田雅代, 工藤尚文

産婦人科の世界 2000年

高速MRIが胎内診断に有用であった片側巨脳症の1例

高田雅代, 多田克彦, 中田高公, 橋本一郎, 熊澤一真, 中塚幹也, 工藤尚文, 上者郁夫

日本産科婦人科学会雑誌 2000年

妊娠初期絨毛,胎盤におけるklotho遺伝子発現と自然流産や常位胎盤早期剥離での変化

羽原俊宏, 中塚幹也, 野口聡一, 浅桐和男, 小西秀樹, 鎌田泰彦, 高田雅代, 木村吉宏, 工藤尚文

日本内分泌学会雑誌 2000年

子宮内膜症の発生と癌発生一環境因子ならびに遺伝子などからのアプローチ)子宮内膜症腹腔内環境における種々の生理活性物質

中塚幹也, 羽原俊宏, 野口聡一, 鎌田泰彦, 浅桐和男, 高田雅代, 小西秀樹, 工藤尚文

エンドメトリオーシス研究会会誌 2000年

妊娠時一過性尿崩症の4症例

川原正行, 中塚幹也, 羽原俊宏, 高田雅代, 木森一吉, 浅桐和男, 野口聡一, 多田克彦, 工藤尚文

内分泌興味ある症例第36集ホルモンと臨床 2000年

Expressions of chemokine receptors, CCR-4 and CCR-5, are altered in chorionic villi from women with embryonal death

Kazuo Asagiri, Mikiya Nakatsuka, Hideki Konishi, Toshihiro Habara, Masayo Takata, Soich Noguchi, Takafumi Kudo

J. Reprod. Immunol. 2000年

岡山大学ジェンダークリニックおける性同一性障害患者の現況

永井敦, 公文裕巳, 中塚幹也, 工藤尚文, 光嶋勲, 佐藤俊樹, 山本文子, 黒田重利

日本性機能学会雑誌 2000年

本態性血小板血症合併妊娠の1症例

舛本明生, 増山寿, 橋本一郎, 熊澤一真, 高田雅代, 中田高公, 中塚幹也, 水谷靖司, 多田克彦, 平松祐司, 工藤尚文

日本産科婦人科学会中国四国合同地方部会雑誌 2000年

超低出生体重児のwell-beingの評価法一胎児心拍数図および胎児血流計測値と分娩時臍帯動脈血ガス分析値との関係一

多田克彦, 工藤尚文, 中田高公, 橋本一郎, 熊澤一真, 増山寿, 中塚幹也

産婦人科の世界 2000年

特集子宮内膜症一その病態を探る一子宮内膜症とNO

中塚幹也, 工藤尚文

Hormone Frontier in Gynecology. 2000年

Elevation of nitrite/nitrate in vaginal secretion precedes premature delivery

Mikiya Nakatsuka, Toshihiro Habara, Yasuhiko Kamada, Katsuhiko Tada, Takafumi Kudo

Am J Obstet Gynecol. 2000年

Fetal hydrocephalus secondary to intraventricular hemorrhage diagnosed by ultrasonography and in utero fast magnetic resonance imaging. A case report

Ichiro Hashimoto, Katsuhiko Tada, Mikiya Nakatsuka, Takakimi Nakata, Nanako Inoue, Masayo Takata, Takafumi Kudo, Ikuo Joja

Fetal Diagnosis and Therapy 14 ( 4 ) 248 - 253 1999年

記述言語：英語出版者・発行元：S. Karger AG

Although fetal hydrocephalus is commonly detected by prenatal ultrasonographic examination, posthemorrhagic hydrocephalus has rarely been observed in the fetus. We report a case of hydrocephalus secondary to intraventricular hemorrhage (IVH) diagnosed by in utero magnetic resonance imaging (MRI) at 37 + 1 weeks of gestation. Ultrasonography revealed enlargement of the bilateral ventricles and an irregular mass measuring 20 x 12 x 10 mm in the right lateral ventricle. T1-weighted images with two-dimensional fast low-angle shot (2D-FLASH) and T2-weighted images with half-Fourier single-shot turbo spin echo (HASTE) demonstrated that an old hemorrhagic clot existed in the right lateral ventricle of the fetus. Hydrocephalus secondary to IVH was confirmed by postnatal MRI and ventriculoscopy. Fast MRI is especially useful for prenatal diagnosis of fetal brain abnormalities because it minimizes the artifact of fetal movement.

DOI： 10.1159/000020931

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Clinical experience of long-term transdermal treatment with nitric oxide donor for women with preeclampsia

Mikiya Nakatsuka, Katsuhiko Tada, Yoshihiro Kimura, Kazuo Asagiri, Yasuhiko Kamada, Masayo Takata, Takakimi Nakata, Nanako Inoue, Takafumi Kudo

Gynecologic and Obstetric Investigation 47 ( 1 ) 13 - 19 1999年

記述言語：英語

Isosorbide dinitrate (ISDN), a nitric oxide donor, was applied transdermally for 4-16 days to 4 preeclamptic women with oligohydramnios, intrauterine fetal growth retardation (IUGR), and elevated resistance of blood flow in the uterine arteries. Pulsed Doppler ultrasonography revealed immediate and drastic improvement of pulsatility index (PI) of uterine arteries following treatment with ISDN. The average PI in uterine arteries of the 4 patients was reduced to approximately 67% of that of the untreated state. In 2 patients the amniotic fluid gradually increased over a few days which suggested improvement of fetoplacental circulation during administration of ISDN. This study suggests that long-term transdermal ISDN is an effective therapy, at least in a portion of preeclamptic women, to avoid maternal hypertension, fetal distress, oligohydramnios, and IUGR, and consequentially to prolong the gestational period.

DOI： 10.1159/000010055

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Generation of peroxynitrite and apoptosis in placenta of patients with chorioamnionitis: Possible implications in placental abruption

Mikiya Nakatsuka, Kazuo Asagiri, Yoshihiro Kimura, Yasuhiko Kamada, Katsuhiko Tada, Takafumi Kudo

Human Reproduction 14 ( 4 ) 1101 - 1106 1999年

記述言語：英語

The reaction of nitric oxide (NO) and superoxide results in the formation of peroxynitrite, a potent and relatively long-lived oxidant. In infectious diseases, these molecules are not only bactericidal but also toxic to host cells. Chorioamnionitis is often complicated by premature rupture of membranes and can be associated with placental abruption. These diseases are significant causes of premature low-birth-weight deliveries and consequently the morbidity and mortality of neonates. Lipopolysaccharide, bacterial endotoxin, is known to be elevated in the amniotic fluid of patients with chorioamnionitis. Lipopolysaccharide is known to induce the formation of NO and superoxide. We report here that nitrite/nitrate, stable metabolites of NO, were increased in serum from patients with chorioamnionitis. Immunohistochemical studies demonstrated enhanced expression of inducible NO synthase and formation of nitrotyrosine, a footprint of peroxynitrite, in the placentae from patients with chorioamnionitis and also in patients with placental abruption. Furthermore, apoptotic cell death was also increased in the placentae from patients with both diseases. These results suggest that chorioamnionitis and a portion of placental abruption may share a common cascade of placental injury. Nitric oxide and its metabolites may play an important role in this cascade.

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Clinical experience of long-term transdermal treatment with NO donor for women with preeclanpsia(共著)

Gynecol Obstet Invest. 47 ( 1 ) 13 - 19 1999年

236 妊娠中毒症症状および胎児発育遅延と母体血漿アルギニン値との関連について

野口聡一, 中塚幹也, 高田雅代, 鎌田泰彦, 羽原俊宏, 浅桐和男, 野口聡一, 木村吉宏, 工藤尚文

日本産科婦人科學會雜誌 51 "S - 252" 1999年

P-306 妊娠時一過性尿崩症の4症例の検討

川原正行, 中塚幹也, 鎌田泰彦, 木森一吉, 高田雅代, 羽原俊宏, 中田高公, 木村吉宏, 多田克彦, 工藤尚文

日本産科婦人科學會雜誌 51 "S - 512" 1999年

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