Faculty Profiles - FUJIWARA Toshiyoshi

Papers - FUJIWARA Toshiyoshi

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GFP発現テロメラーゼ特異的制限増殖型ウイルスTelomelysin-GFPを用いた腫瘍組織ナビゲーション・システム

岸本浩行, 香川俊輔, 滝正樹, 藤原俊哉, 渡辺貴紀, 遠藤芳克, 京哲, 水口裕之, 田中紀章, 藤原俊義

日本癌学会総会記事 63回 454 - 454 2004.9

HDAC阻害剤FR901228によるテロメラーゼ特異的制限増殖型アデノウイルスTelomelysinの選択的抗腫瘍効果の増強

渡邉貴紀, 西崎正彦, 香川俊輔, 滝正樹, 岸本浩行, 藤原俊哉, 遠藤芳克, 京哲, 水口裕之, 田中紀章, 藤原俊義

日本癌学会総会記事 63回 499 - 499 2004.9

A case of advanced non-small lung cancer responding to tumor suppressor p53 gene therapy

Shunsuke Kagawa, Shoichiro Ohtani, Noriaki Tanaka, Toshiyoshi Fujiwara

Gan to kagaku ryoho. Cancer & chemotherapy 31 ( 11 ) 1788 - 1790 2004

Language：Japanese Publishing type：Research paper (scientific journal)

The phase I study of the tumor suppressor p53 gene therapy for advanced lung cancer was performed. A 57-year-old man with locally advanced squamous cell carcinoma at the tracheal bifurcation, clinical stage IIIB, had previously been treated by radiotherapy and chemotherapy. Because of the local recurrence, he was enrolled to the study. He was treated by a local injection of ADVEXIN once every 4 weeks for 14 times without marked adverse events, which resulted in tumor regression and relief of his symptom for a year. In conclusion, gene therapy with ADVEXIN may be an effective treatment for locally advanced non-small lung cancer.

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制限増殖型アデノウイルスによる非増殖型p53遺伝子発現アデノウイルスベクター(Ad5CMV-p53)の腫瘍選択的増殖

谷本光隆, 藤原俊義, 高田佳子, 大谷彰一郎, 川嶋健, 香川俊輔, 西崎正彦, 田中紀章

日本癌学会総会記事 61回 187 - 187 2002.10

Efficient Cre/loxP site-specific recombination in a HepG2 human liver cell line

Naoya Kobayashi, Hirofumi Noguchi, Karen A. Westerman, Toshihisa Matsumura, Takamasa Watanabe, Toshinori Totsugawa, Toshiyoshi Fujiwara, Philippe Leboulch, Noriaki Tanaka

Cell Transplantation 9 ( 5 ) 737 - 742 2000

Language：English Publishing type：Research paper (international conference proceedings) Publisher：Cognizant Communication Corporation

A worldwide shortage of donor livers is a limiting factor of the clinical application of hepatocyte transplantation (HTX). To resolve this issue, we focused on a reversible immortalization system that allows temporary expansion of primary hepatocyte populations by transfer of an oncogene that can be subsequently excised. As a preliminary test toward this goal, we examined the efficacy of Cre/loxP site-specific recombination in a transformed human liver cell line, HepG2. The present study utilized retroviral transfer of a prototypical immortalizing gene, simian virus 40 large T antigen (SV40Tag), flanked by a pair of loxP recombination targets and adenovirus-mediated Cre/loxP recombination. Here we report that complete elimination of the retroviral transferred oncogene was achieved by site-specific recombination using a replication-deficient recombinant adenovirus vector producing Cre recombinase (Ad-Cre).

DOI： 10.1177/096368970000900525

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G162 Vanishing Lungを呈し、手術にて軽快した高IgE症候群の1治験例(胸腔鏡c,示説,第14回日本呼吸器外科学会総会号)

井上文之, 舟木直人, 藤原俊義, 上川康明, 田中紀章

日本呼吸器外科学会雑誌 11 ( 3 ) 453 - 453 1997

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Papers - FUJIWARA Toshiyoshi