Faculty Profiles - FUJIWARA Toshiyoshi

Papers - FUJIWARA Toshiyoshi

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骨・軟部腫瘍の基礎科学のトピックス転移性骨肉腫は臓器指向性サイトカインの分泌を介して微小環境を変化させ前転移ニッチを形成する

近藤宏也, 田澤大, 藤原智洋, 近藤彩奈, 片山晴喜, 佐藤浩平, 畑利彰, 中田英二, 国定俊之, 藤原俊義, 尾崎敏文

日本整形外科学会雑誌 96 ( 8 ) S1532 - S1532 2022.9

転移性骨肉腫細胞はCCL2によるM2マクロファージの腫瘍内浸潤を誘導して肺転移を促進する(Metastatic osteosarcoma cells facilitate lung metastasis by inducing CCL2-mediated tumor infiltration of M2 macrophages)

近藤宏也, 田澤大, 久禮美穂, 藤原智洋, 国定俊之, 尾崎敏文, 藤原俊義

日本癌学会総会記事 81回 J - 2087 2022.9

切除可能膵癌における血中循環腫瘍DNA内Kras遺伝子変異とCA19-9値による予後層別化の試み

宮本耕吉, 吉田龍一, 重安邦俊, 安井和也, 高木弘誠, 藤智和, 楳田祐三, 八木孝二, 藤原俊義

日本分子腫瘍マーカー研究会プログラム・講演抄録 42回 78 - 79 2022.9

食道癌に対するウイルス治療、ワクチン治療の最前線抗腫瘍免疫賦活を介した腫瘍融解アデノウイルス製剤による免疫チェックポイント阻害薬治療増強効果の検討

橋本将志, 黒田新士, 金谷信彦, 田辺俊介, 前田直見, 野間和広, 田澤大, 白川靖博, 浦田泰生, 藤原俊義

日本食道学会学術集会プログラム・抄録集 76回 59 - 59 2022.9

p53搭載テロメラーゼ特異的腫瘍融解アデノウイルスの抗腫瘍効果予測スコアリングシステム(Scoring system to predict antitumor effects of p53-armed telomerase-specific oncolytic adenovirus)

杉本龍馬, 黒田新士, 吉田有佑, 坂本真樹, 濱田侑紀, 八木千晶, 橋本将志, 垣内慶彦, 菊地覚次, 香川俊輔, 田澤大, 浦田泰生, 藤原俊義

日本癌学会総会記事 81回 P - 3347 2022.9

食道癌に対するウイルス治療、ワクチン治療の最前線食道癌に対する腫瘍融解ウイルス併用放射線療法の臨床研究の成果と展望

田辺俊介, 野間和広, 橋本将志, 最所公平, 賀島肇, 前田直見, 菊地覚次, 田澤大, 白川靖博, 藤原俊義

日本食道学会学術集会プログラム・抄録集 76回 59 - 59 2022.9

p53感作樹状細胞ワクチンは大腸癌に対するp53搭載腫瘍融解ウイルスの治療効果を増強する(Ad-p53-transduced dendritic cell vaccine enhances the efficacy of p53-armed oncolytic virotherapy in colorectal cancer)

山田元彦, 田澤大, 庄司良平, 永井康雄, 井上弘章, 菊地覚次, 黒田新士, 浦田泰生, 香川俊輔, 藤原俊義

日本癌学会総会記事 81回 P - 2177 2022.9

血清エクソソームE1A-DNAはテロメラーゼ特異的腫瘍融解アデノウイルスの治療効果予測バイオマーカーとして有用である(Exosomal E1A-DNA in serum as a predictive biomarker of telomerase-specific oncolytic adenovirus)

八木千晶, 黒田新士, 吉田有佑, 坂本真樹, 濱田侑紀, 杉本龍馬, 橋本将志, 垣内慶彦, 菊地覚次, 香川俊輔, 田澤大, 浦田泰生, 藤原俊義

日本癌学会総会記事 81回 E - 3068 2022.9

食道癌に対するサルベージロボット支援下胸腔鏡下食道亜全摘術5症例の検討

門脇大輔, 野間和広, 橋本将志, 最所公平, 賀島肇, 前田直見, 菊地覚次, 田辺俊介, 白川靖博, 藤原俊義

日本食道学会学術集会プログラム・抄録集 76回 186 - 186 2022.9

当院における高齢者進行食道癌に対する治療戦略

竹田泰茂, 野間和広, 橋本将志, 最所公平, 賀島肇, 前田直見, 菊地覚次, 田辺俊介, 白川靖博, 藤原俊義

日本食道学会学術集会プログラム・抄録集 76回 300 - 300 2022.9

喉頭温存を目指した頸部進行食道癌の集学的治療戦略

田辺俊介, 野間和広, 橋本将志, 最所公平, 賀島肇, 前田直見, 菊地覚次, 白川靖博, 藤原俊義

日本食道学会学術集会プログラム・抄録集 76回 302 - 302 2022.9

RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer. International journal

Yasuhiro Komatsu, Kunitoshi Shigeyasu, Shuya Yano, Sho Takeda, Kazutaka Takahashi, Nanako Hata, Hibiki Umeda, Kazuhiro Yoshida, Yoshiko Mori, Kazuya Yasui, Ryuichi Yoshida, Yoshitaka Kondo, Hiroyuki Kishimoto, Fuminori Teraishi, Yuzo Umeda, Shunsuke Kagawa, Hiroyuki Michiue, Hiroshi Tazawa, Ajay Goel, Toshiyoshi Fujiwara

Scientific reports 12 ( 1 ) 13540 - 13540 2022.8

Language：English Publishing type：Research paper (scientific journal)

Most cases of colorectal cancers (CRCs) are microsatellite stable (MSS), which frequently demonstrate lower response rates to immune checkpoint inhibitors (ICIs). RNA editing produces neoantigens by altering amino acid sequences. In this study, RNA editing was induced artificially by chemoradiation therapy (CRT) to generate neoantigens in MSS CRCs. Altogether, 543 CRC specimens were systematically analyzed, and the expression pattern of ADAR1 was investigated. In vitro and in vivo experiments were also performed. The RNA editing enzyme ADAR1 was upregulated in microsatellite instability-high CRCs, leading to their high affinity for ICIs. Although ADAR1 expression was low in MSS CRC, CRT including oxaliplatin (OX) treatment upregulated RNA editing levels by inducing ADAR1. Immunohistochemistry analyses showed the upregulation of ADAR1 in patients with CRC treated with CAPOX (capecitabine + OX) radiation therapy relative to ADAR1 expression in patients with CRC treated only by surgery (p < 0.001). Compared with other regimens, CRT with OX effectively induced RNA editing in MSS CRC cell lines (HT29 and Caco2, p < 0.001) via the induction of type 1 interferon-triggered ADAR1 expression. CRT with OX promoted the RNA editing of cyclin I, a neoantigen candidate. Neoantigens can be artificially induced by RNA editing via an OX-CRT regimen. CRT can promote proteomic diversity via RNA editing.

DOI： 10.1038/s41598-022-17773-0

PubMed

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Verrucous carcinoma of the esophagus with complete response after chemoradiotherapy. International journal

Masashi Hashimoto, Yasuhiro Shirakawa, Shunsuke Tanabe, Takehiro Tanaka, Naoaki Maeda, Kazufumi Sakurama, Kazuhiro Noma, Toshiyoshi Fujiwara

Surgical case reports 8 ( 1 ) 128 - 128 2022.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Verrucous carcinoma of the esophagus (VCE) is a rare tumor that is difficult to diagnose. In most cases, biopsies show nonspecific inflammatory and hyperkeratotic changes and do not show malignant findings. Most VCEs are slowly growing, locally advanced tumors with few metastases. Treatments for VCE are the same as for normal esophageal cancer, involving combined chemotherapy, surgical resection, and radiation therapy. However, it has been reported that VCE has a poor response to radiation or chemoradiotherapy (CRT). A case of VCE with complete response (CR) after CRT is presented. CASE PRESENTATION: A 70-year-old man was found to have white, irregular esophageal mucosa 4 years earlier. He had been followed up as an outpatient as having candidal esophagitis. However, his tumor grew gradually, and biopsy was performed by endoscopic mucosal resection (EMR). He was finally diagnosed with VCE. He had no metastases to distant organs, but some lymph node metastases were suspected. The tumor invaded his left bronchus. The esophagostomy and gastrostomy were constructed as emergent procedures. The patient then underwent definitive CRT. 4 weeks after the end of CRT, two-stage esophagectomy was performed. First, he underwent esophagectomy with thoracic lymph node dissection. A latissimus dorsi flap was patched to the bronchus after primary suture of the hole. 6 weeks later, reconstruction of the gastric tube was performed through the antethoracic route. The pathological findings showed CR to CRT, with no proliferative cancer cells in the specimen. The patient has had no recurrence for three and half years after the resection. CONCLUSIONS: We presented a locally advanced VCE that achieved CR to CRT. In cases that have some difficulty for local resection, CRT might be an appropriate treatment for VCE.

DOI： 10.1186/s40792-022-01486-7

PubMed

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継続的な栄養指導と術後早期アミノ酸投与による胃切除術後の体重・筋肉量減少抑制効果

菊地覚次, 高田暢夫, 黒田新士, 垣内慶彦, 田辺俊介, 前田直見, 野間和広, 楳田祐三, 香川俊輔, 藤原俊義

日本消化器外科学会総会 77回 O4 - 3 2022.7

高度肥満症に対する減量・代謝改善手術の効果と安全性

香川俊輔, 菊地覚次, 黒田新士, 武田正, 垣内慶彦, 寺石文則, 近藤喜太, 重安邦俊, 楳田祐三, 藤原俊義

日本消化器外科学会総会 77回 P276 - 6 2022.7

【上部】噴門側胃切除の手術手技・再建噴門側胃切除術+観音開き法再建を施行した胃癌・食道胃接合部癌症例の長期予後因子に関する検討

垣内慶彦, 黒田新士, 丁田泰宏, 大塚眞哉, 上山聰, 田中則光, 村岡篤, 羽藤慎二, 上川康明, 藤原俊義

日本消化器外科学会総会 77回 WS10 - 4 2022.7

Impact of Amino Acids Nutrition Following Gastrectomy in Gastric Cancer Patients. International journal

Satoru Kikuchi, Nobuo Takata, Shinji Kuroda, Hibiki Umeda, Shunsuke Tanabe, Naoaki Maeda, Kosei Takagi, Kazuhiro Noma, Yuko Hasegawa, Kumiko Nawachi, Shunsuke Kagawa, Yuzo Umeda, Kenichi Shikata, Toshiyoshi Fujiwara

Anticancer research 42 ( 7 ) 3637 - 3643 2022.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIM: Postoperative body weight loss (BWL) and skeletal muscle loss (SML) after gastrectomy are associated with a decline in quality of life and worse longterm prognosis in gastric cancer (GC) patients. This study aimed to evaluate the efficacy of amino acids nutrition on BWL and SML in the early period following gastrectomy. PATIENTS AND METHODS: The parameters of body composition were measured by bioelectrical impedance analysis in the patients undergoing radical gastrectomy for GC and analyzed retrospectively. Patients received either peripheral parenteral nutrition (PPN) of 4.3% glucose fluid with regular diet (control group, n=43) or PPN of 7.5% glucose fluid containing amino acids plus oral nutritional supplement (ONS) rich in protein with regular diet (amino acids group, n=40) following gastrectomy. The percentages of BWL and SML from preoperative values to those at 7 days and 1 month after surgery were compared between the two groups. RESULTS: The %BWL and %SML at 7 days after surgery were significantly lower in the amino acids group than those in the control group (%BWL, -2.4±1.7% vs. -4.2±1.8%; p<0.0001, %SML, -4.1±3.8 vs. -6.5±3.8; p=0.006). Moreover, the %BWL at 1 month after surgery was significantly lower in the amino acids group compared to that in the control group (- 4.6±2.9% vs. -6.1±2.6%; p=0.01); however, the %SML was similar between the two groups. The hematological nutritional parameters were similar between the two groups. CONCLUSION: Amino acids nutrition by PPN and ONS following gastrectomy prevented postoperative BWL and SML in the early period after surgery in GC patients.

DOI： 10.21873/anticanres.15852

PubMed

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狭窄を伴う食道癌患者における術前胃瘻造設と周術期管理チームの有用性

橋本将志, 野間和広, 前田直見, 菊地覚次, 田辺俊介, 黒田新士, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本消化器外科学会総会 77回 P147 - 3 2022.7

T4b食道癌に対する治療戦略についての検討 induction DCF vs.induction DCF-RTを中心に

最所公平, 野間和広, 前田直見, 菊地覚次, 田辺俊介, 黒田新士, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本消化器外科学会総会 77回 P163 - 4 2022.7

【下部】IBDに対するMIS 炎症性腸疾患に対する経肛門的低侵襲手術は患者因子によらない安定した手術を可能にする

近藤喜太, 寺石文則, 菊地覚次, 田邊俊介, 黒田新士, 吉田龍一, 野間和広, 楳田祐三, 香川俊輔, 藤原俊義

日本消化器外科学会総会 77回 WS14 - 5 2022.7

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Papers - FUJIWARA Toshiyoshi