Faculty Profiles - FUJIWARA Toshiyoshi

Papers - FUJIWARA Toshiyoshi

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【消化器疾患に対する機能温存・再建手術】上部消化管領域噴門側胃切除における観音開き法再建

西崎正彦, 黒田新士, 藤原俊義

外科 81 ( 5 ) 417 - 421 2019.4

MELD scoreによる生体肝移植の術後解析生体肝移植におけるMELD/重症度に応じたDonor/Graft選択の重要性

楳田祐三, 八木孝仁, 吉田龍一, 杭瀬崇, 吉田一博, 藤智和, 安井和也, 松田達雄, 白川靖博, 香川俊輔, 藤原俊義

日本外科学会定期学術集会抄録集 119回 PD - 3 2019.4

80歳以上の超高齢者食道癌に対する包括的治療戦略

前田直見, 白川靖博, 西脇紀之, 松田達雄, 田辺俊介, 櫻間教文, 野間和広, 藤原俊義

日本外科学会定期学術集会抄録集 119回 PS - 1 2019.4

肝移植患者の移植後二次発癌

松田達雄, 楳田祐三, 吉田一博, 吉田龍一, 野間和広, 信岡大輔, 田辺俊介, 杭瀬崇, 前田直見, 安井和也, 白川靖博, 八木孝仁, 藤原俊義

日本外科学会定期学術集会抄録集 119回 PS - 2 2019.4

食道外科・頭頸部外科・形成外科の三科合同で行う頸胸部食道癌の拡大切除と消化管・気道再建術におけるチームワークの重要性

橋本将志, 白川靖博, 西脇紀之, 松田達雄, 前田直見, 田辺俊介, 櫻間教文, 野間和広, 楳田祐三, 西崎正彦, 香川俊輔, 藤原俊義

日本外科学会定期学術集会抄録集 119回 SF - 4 2019.4

切除不能T4食道癌に対するDCFを用いた化学放射線療法による集学的治療と最適な救済手術のタイミングの検討

田辺俊介, 白川靖博, 西脇紀之, 松田達雄, 前田直見, 櫻間教文, 野間和広, 楳田祐三, 西崎正彦, 香川俊輔, 藤原俊義

日本外科学会定期学術集会抄録集 119回 SF - 3 2019.4

食道胃接合部癌の外科治療(郭清・再建) 食道胃接合部癌168例の治療経験から導かれる最適な集学的治療

野間和広, 白川靖博, 西脇紀之, 松田達雄, 前田直見, 田辺俊介, 西崎正彦, 香川俊輔, 藤原俊義

日本外科学会定期学術集会抄録集 119回 SY - 4 2019.4

トランスレーショナルリサーチとしての外科治療を補完する新たな集学的治療の開発研究

田澤大, 田辺俊介, 香川俊輔, 白川靖博, 藤原俊義

日本外科学会定期学術集会抄録集 119回 SP - 5 2019.4

血中遊離メチル化DNA測定による早期診断、術後再発予測、病勢予測

戸嶋俊明, 永坂岳司, 入谷光洋, 安井和也, 吉田一博, 稲田涼, 楳田祐三, 藤原俊義

日本外科学会定期学術集会抄録集 119回 SF - 2 2019.4

外科治療成績の向上を目指した感染症対策 IBDセンターにおける外科感染症対策10年の推移、感染率低下のbreakthrough

近藤喜太, 藤原俊義

日本外科学会定期学術集会抄録集 119回 SY - 3 2019.4

PD-L1 expression combined with microsatellite instability/CD8+ tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer. Reviewed International journal

Toshiaki Morihiro, Shinji Kuroda, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Tetsushi Kubota, Katsuyuki Aoyama, Takehiro Tanaka, Satoru Kikuchi, Takeshi Nagasaka, Masahiko Nishizaki, Shunsuke Kagawa, Hiroshi Tazawa, Toshiyoshi Fujiwara

Scientific reports 9 ( 1 ) 4633 - 4633 2019.3

Language：English Publishing type：Research paper (scientific journal)

While the importance of programmed death-ligand 1 (PD-L1), mutation burden caused by microsatellite instability (MSI), and CD8+ tumor infiltrating lymphocytes (TILs) has become evident, the significance of PD-L1 expression on prognosis still remains controversial. We evaluated the usefulness of combined markers of PD-L1 and MSI or CD8+ TILs as a prognostic biomarker in gastric cancer. A total of 283 patients with gastric cancer were reviewed retrospectively. PD-L1 expression on >5% tumor cells was defined as PD-L1-positive. PD-L1-positive rate was 15.5% (44/283). PD-L1 positivity was significantly correlated with invasive and advanced cancer and also significantly correlated with MSI, whereas no significance was observed with CD8+ TILs. Kaplan-Meier analysis showed that PD-L1 positivity significantly correlated with a poor prognosis (p = 0.0025). Multivariate analysis revealed that PD-L1 positivity was an independent poor prognostic factor (hazard ratio [HR]: 1.97, p = 0.0106) along with diffuse histological type and lymph node metastases. Combinations of PD-L1 and MSI (HR: 2.18) or CD8+ TILs (HR: 2.57) were stronger predictive factors for prognosis than PD-L1 alone. In conclusion, combined markers of PD-L1 and MSI or CD8+ TILs may be more useful prognostic biomarkers in gastric cancer, and better clarify the immune status of gastric cancer patients.

DOI： 10.1038/s41598-019-41177-2

PubMed

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Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer. Reviewed

Takeda S, Shigeyasu K, Okugawa Y, Yoshida K, Mori Y, Yano S, Noma K, Umeda Y, Kondo Y, Kishimoto H, Teraishi F, Nagasaka T, Tazawa H, Kagawa S, Fujiwara T, Goel A

Cancer letters 444 127 - 135 2019.3

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

Adenosine-to-inosine (A-to-I) RNA editing is a recently described epigenetic modification, which is believed to constitute a key oncogenic mechanism in human cancers. However, its functional role in cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) and its clinical significance remains unclear. Herein, we systematically analyzed a large cohort of 627 colorectal cancer (CRC) specimens, and investigated the expression pattern of ADAR1 and its biological significance on the antizyme inhIbitor 1 (AZIN1) RNA editing levels. Both ADAR1 expression and AZIN1 RNA editing levels were significantly elevated in CRC tissues vs. normal mucosa, and these findings correlated with the increased expression of mesenchymal markers, Vimentin (p = 0.44) and Fibroblast activation protein (p = 0.38). Intriguingly, ADAR1 expression was specifically upregulated in both cancer cells and fibroblasts from cancerous lesions. Conditioned medium from cancer cells led to induction of ADAR1 expression and activation of AZIN1 RNA editing in fibroblasts (p < 0.05). Additionally, edited AZIN1 enhanced the invasive potential of fibroblasts. In conclusion, we provide novel evidence that hyper-editing of AZIN1 enhances the invasive potential of CAFs within the TME in colon and is an important predictor of tumor invasiveness in CRC.

DOI： 10.1016/j.canlet.2018.12.009

Web of Science

PubMed

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多発筋炎/皮膚筋炎でみつかった直腸癌の一例 Reviewed

重安邦俊, 母里淑子, 三村直毅, 小松泰浩, 戸嶋俊明, 矢野修也, 近藤喜太, 岸本浩行, 寺石文則, 香川俊輔, 藤原俊義

日本臨床外科学会雑誌 80 ( 3 ) 607 - 607 2019.3

腹腔鏡下胃切除術後出血の1例

菊地覚次, 津村朋子, 桑田和也, 黒田新士, 西崎正彦, 香川俊輔, 藤原俊義

日本臨床外科学会雑誌 80 ( 3 ) 606 - 606 2019.3

サルベージ手術としての腹臥位胸腔鏡下食道切除術拡大視効果を最大限に活かして

松田達雄, 西脇紀之, 前田直見, 田辺俊介, 野間和広, 白川靖博, 藤原俊義

日本臨床外科学会雑誌 80 ( 3 ) 605 - 605 2019.3

下大静脈腫瘍栓を有する巨大肝細胞癌に対し積極的な肝切除を施行した2例

岡凌也, 信岡大輔, 小西大輔, 西山岳芳, 田渕幹康, 安井和也, 吉田一博, 杭瀬崇, 吉田龍一, 楳田祐三, 八木孝仁, 藤原俊義

日本臨床外科学会雑誌 80 ( 3 ) 606 - 606 2019.3

A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness. Reviewed International journal

Yuki Katsura, Toshiaki Ohara, Kazuhiro Noma, Takayuki Ninomiya, Hajime Kashima, Takuya Kato, Hiroaki Sato, Satoshi Komoto, Toru Narusaka, Yasuko Tomono, Boyi Xing, Yuehua Chen, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Tomonari Kasai, Masaharu Seno, Akihiro Matsukawa, Toshiyoshi Fujiwara

Cancers 11 ( 2 ) 2019.2

Language：English Publishing type：Research paper (scientific journal)

Excess iron causes cancer and is thought to be related to carcinogenesis and cancer progression including stemness, but the details remain unclear. Here, we hypothesized that stemness in cancer is related to iron metabolism and that regulating iron metabolism in cancer stem cells (CSCs) may be a novel therapy. In this study, we used murine induced pluripotent stem cells that expressed specific stem cell genes such as Nanog, Oct3/4, Sox2, Klf4, and c-Myc, and two human cancer cell lines with similar stem cell gene expression. Deferasirox, an orally available iron chelator, suppressed expression of stemness markers and spherogenesis of cells with high stemness status in vitro. Combination therapy had a marked antitumor effect compared with deferasirox or cisplatin alone. Iron metabolism appears important for maintenance of stemness in CSCs. An iron chelator combined with chemotherapy may be a novel approach via suppressing stemness for CSC targeted therapy.

DOI： 10.3390/cancers11020177

PubMed

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胃癌手術患者における術前・術後サルコペニアの予後に与える影響

桑田和也, 金谷信彦, 菊地覚次, 黒田新士, 吉田龍一, 西崎正彦, 香川俊輔, 藤原俊義

日本胃癌学会総会記事 91回 249 - 249 2019.2

進行胃癌に対するネオアジュバント化学療法の治療成績(Outcomes of neoadjuvant chemotherapy for advanced gastric cancer)

Kagawa Shunsuke, Kuroda Shinji, Kikuchi Satoru, Kuwada Kazuya, Tsumura Tomoko, Nishizaki Masahiko, Fujiwara Toshiyoshi

日本胃癌学会総会記事 91回 464 - 464 2019.2

胃癌の腹膜転移に対する新規の腹腔内ウイルス療法(Novel intraperitoneal virotherapy for the peritoneal metastasis of gastric cancer)

Kikuchi Satoru, Ishikawa Wataru, Ogawa Toshihiro, Kuroda Shinji, Kuwada Kazuya, Nishizaki Masahiko, Kagawa Shunsuke, Fujiwara Toshiyoshi

日本胃癌学会総会記事 91回 337 - 337 2019.2

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Papers - FUJIWARA Toshiyoshi