Faculty Profiles - FUJIWARA Toshiyoshi

Papers - FUJIWARA Toshiyoshi

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高難度手術におけるカダバートレーニングの意義と当科における実際

近藤喜太, 吉岡貴裕, 工藤泰崇, 母里淑子, 岸本浩行, 永坂岳司, 藤原俊義

岡山医学会雑誌 128 ( 1 ) 82 - 82 2016.4

Relative Prognostic and Predictive Value of Gene Signature and Histologic Grade in Estrogen Receptor-Positive, HER2-Negative Breast Cancer. International journal

Takayuki Iwamoto, Catherine Kelly, Taeko Mizoo, Tomohiro Nogami, Takayuki Motoki, Tadahiko Shien, Naruto Taira, Naoki Hayashi, Naoki Niikura, Toshiyoshi Fujiwara, Hiroyoshi Doihara, Junji Matsuoka

Clinical breast cancer 16 ( 2 ) 95 - 100 2016.4

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: In estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer, first-generation genomic signatures serve predominately as prognostic biomarkers and secondarily as predictors of response to chemotherapy. We compared both the prognostic and predictive value of histologic grades and genomic markers. METHODS: We retrieved publicly available cDNA microarray data from 1373 primary ER(+)/HER2(-) breast cancers and developed a genomic signature simulated from Recurrence Online (http://www.recurrenceonline.com/) to calculate the recurrence score and risk using predefined sets of genes in the cDNA microarray. We then compared the prognostic and predictive information provided by histologic grade and genomic signature. RESULTS: Based on genomic signatures, 55%, 28%, and 17% of breast cancers were classified as low, intermediate, and high risk, respectively, whereas the histologic grades were I, II, and III in 22%, 59%, and 19% of breast cancers, respectively. Univariate analysis in the untreated cohort revealed that both histologic grade (overall P = .007) and genomic signature (P < .001) could predict prognosis. Results were similar using the genomic signature, with pathologic complete response rates of 4.6%, 5.7%, and 16.5% for low-, intermediate-, and high-risk cancers, respectively. Neither biomarker was statistically significant in multivariate analysis for predictive response to neoadjuvant chemotherapy (NAC). CONCLUSION: Genomic signature was better at identifying low-risk cases compared to histologic grade alone, but both markers had similar predictive values for NAC response. Better predictive biomarkers for NAC response are still needed.

DOI： 10.1016/j.clbc.2015.10.004

PubMed

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腹腔内播種に対する取り組み外科医の役割腹膜内播種に関する洞察のための胃がん細胞の蛍光誘導によるイメージング(Challenge to peritoneal dissemination: Role of surgeons Fluorescence-guided imaging of gastric cancer cells for an insight into peritoneal dissemination)

Kagawa Shunsuke, Watanabe Megumi, Kuwata Kazuya, Kikuchi Satoru, Kuroda Shinji, Sakamoto Shuichi, Nishizaki Masahiko, Tazawa Hiroshi, Fujiwara Toshiyoshi

日本胃癌学会総会記事 88回 180 - 180 2016.3

スキルス胃癌細胞に対するテロメラーゼ依存的腫瘍融解ウイルス治療の前臨床評価

堀直人, 田澤大, 西崎正彦, 渡邉めぐみ, 田村周太, 國府島健, 黒田新士, 浦田泰生, 香川俊輔, 藤原俊義

日本胃癌学会総会記事 88回 452 - 452 2016.3

腹腔鏡下・ロボット支援下噴門側胃切除後「観音開き法」再建(Esophagogastrostomy with double flap technique after laparoscopic and robotic proximal gastrectomy)

西崎正彦, 黒田新士, 菊地覚次, 渡邉めぐみ, 野間和広, 香川俊輔, 白川靖博, 藤原俊義

日本胃癌学会総会記事 88回 272 - 272 2016.3

低侵襲性と高QOLを追求した腹腔鏡下噴門側胃切除+観音開き法再建の食道胃接合部癌への適応拡大(Laparoscopic proximal gastrectomy with valvuloplastic esophagogastrostomy for EGJ cancer)

黒田新士, 西崎正彦, 野間和広, 菊地覚次, 坂本修一, 香川俊輔, 白川靖博, 藤原俊義

日本胃癌学会総会記事 88回 261 - 261 2016.3

残胃癌手術症例の予後因子の検討

菊地覚次, 黒田新士, 坂本修一, 白川靖博, 西崎正彦, 香川俊輔, 藤原俊義

日本胃癌学会総会記事 88回 198 - 198 2016.3

食道癌手術における鏡視下手術導入による術前後の身体的変化についての検討

田辺俊介, 白川靖博, 前田直見, 野間和広, 藤原俊義

日本静脈経腸栄養学会雑誌 31 ( 1 ) 611 - 611 2016.1

A Case of a Fish Bone Detected in the Upper Bile Duct after Gastrectomy and Choledochoduodenostomy

HORI Naoto, MATSUDA Tadakazu, KATSUBE Ryoichi, LEE JeonUk, KAMIKAWA Yasuaki, FUJIWARA Toshiyoshi

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 77 ( 8 ) 2033 - 2038 2016

Language：Japanese Publisher：Japan Surgical Association

A case of cholangitis of the right hepatic duct caused by an ingested fish bone is reported. A 70-year-old man developed symptoms of acute cholangitis and was admitted to our hospital two times within the space of half a year. Abdominal CT and MRI showed evidence of acute cholangitis with dilatation of the right hepatic duct. Underlying intrahepatic bile duct cancer was considered as the cause of the relapsing cholangitis and dilatation of the right hepatic duct. Under the suspected diagnosis of intrahepatic bile duct cancer, an exploratory laparotomy was performed. The junction between the duodenum and common bile duct was cut, and the intrabiliary wall was observed with a cholangioscope. A foreign body was found to be stuck to the bile duct wall, which was considered to be the cause of the acute cholangitis. The foreign body was removed endoscopically with forceps. Histopathologically, the foreign body was diagnosed as a bone stump, and the needle-shaped appearance suggested that it was a fish bone. This is the first reported case of an ingested fish bone found in the upper bile duct.

DOI： 10.3919/jjsa.77.2033

CiNii Article

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BASIC AND PRACTICAL METHODS FOR SURGICAL CLINICAL STUDY

Fujiwara Toshiyoshi

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 77 ( 5 ) 1288 - 1288 2016

p53 Replacement Therapy for Cancer. Reviewed

Tazawa H, Kagawa S, Fujiwara T

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 209 1 - 15 2016

食道癌への内視鏡外科手術を評価する低侵襲性と長期成績食道癌手術における胸腔鏡手術導入による低侵襲化の検討術後超短期評価と長期評価

田辺俊介, 白川靖博, 九十九悠太, 桂佑貴, 前田直見, 櫻間教文, 野間和広, 西崎正彦, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 20 ( 7 ) SY31 - 8 2015.12

進行胃癌に対する審査腹腔鏡のルチーン化と新たな探索的研究

菊地覚次, 香川俊輔, 坂本修一, 渡邉めぐみ, 黒田新士, 岸本浩行, 西崎正彦, 藤原俊義

日本内視鏡外科学会雑誌 20 ( 7 ) OS312 - 6 2015.12

腹腔鏡下噴門側胃切除後の再建革新を目指して完全体腔内「観音開き法」食道残胃吻合

黒田新士, 西崎正彦, 菊地覚次, 坂本修一, 野間和広, 香川俊輔, 白川靖博, 藤原俊義

日本内視鏡外科学会雑誌 20 ( 7 ) PD10 - 5 2015.12

内視鏡外科のこれからの教育工夫を持ち寄って最善を探るカダバートレーニングにおける指導経験の効用

近藤喜太, 前田直見, 黒田新士, 信岡大輔, 吉田龍一, 藤原俊義

日本内視鏡外科学会雑誌 20 ( 7 ) WS2 - 6 2015.12

腹腔鏡下噴門側胃切除後の再建ベストな再建方法はどれか逆流防止弁形成食道残胃吻合(観音開き法)

西崎正彦, 黒田新士, 菊地覚次, 田邊俊介, 野間和広, 香川俊輔, 白川靖博, 藤原俊義

日本内視鏡外科学会雑誌 20 ( 7 ) DS12 - 1 2015.12

気管周囲微細解剖に留意した左反回神経リンパ節郭清の工夫

白川靖博, 九十九悠太, 桂佑貴, 前田直見, 田辺俊介, 櫻間教文, 野間和広, 西崎正彦, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 20 ( 7 ) OS309 - 4 2015.12

内視鏡視下食道手術のピットフォールとその対策腹臥位胸腔鏡下食道切除における偶発症と当科におけるその対策

野間和広, 白川靖博, 李云成, 九十九悠太, 桂佑貴, 前田直見, 田辺俊介, 櫻間教文, 西崎正彦, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 20 ( 7 ) WS13 - 3 2015.12

腹会陰式直腸切断術の術後会陰感染創に対する局所陰圧閉鎖療法の有用性

近藤喜太, 母里淑子, 岸本浩行, 永坂岳司, 藤原俊義

日本創傷治癒学会プログラム・抄録集 45回 108 - 108 2015.11

[Therapeutic Potential of Targeting Cancer-Associated Fibroblasts in Esophageal Cancer]. Reviewed

Kazuhiro Noma, Hajime Kashima, Takayuki Ninomiya, Ryoichi Katsube, Shinichiro Watanabe, Toshiaki Ohara, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

Gan to kagaku ryoho. Cancer & chemotherapy 42 ( 10 ) 1228 - 30 2015.10

Language：Japanese Publishing type：Research paper (scientific journal)

Advances in molecular and cellular biochemistry, such as the development of targeted cancer therapy, have dramatically improved the prognosis of cancer patients. Emerging data have suggested that bevacizumab treatment may act by controlling the cancer microenvironment. Many reports have examined the interaction of cancer cells with the tumor microenvironment, and cancer-associated fibroblasts (CAFs) are thought to play a central role in this process. We speculated that the cancer microenvironment and in particular, CAFs, strongly influence the development of esophageal cancer. We have analyzed the signaling pathways of molecular targets. However, inhibition of a single signaling pathway is insufficient to treat cancer effectively. Photoimmunotherapy is a molecular-targeted specific cancer therapy using near-infrared radiation, which was introduced by Mitsunaga et al. in 2011. We are using its specific method of killing cells to target CAFs. We will report the results of its effect on cancer cells in the future.

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Papers - FUJIWARA Toshiyoshi