Faculty Profiles - FUJIWARA Toshiyoshi

Papers - FUJIWARA Toshiyoshi

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ESD後急激にリンパ節転移が増大した食道表在癌の1例

白川靖博, 猶本良夫, 田辺俊介, 藤原康宏, 櫻間一史, 山辻知樹, 小林直哉, 藤原俊義, 松原長秀, 羽井佐実, 松岡順治, 田中紀章

岡山医学会雑誌 120 ( 1 ) 111 - 111 2008.5

術前に鑑別診断が困難であった空腸癌の1切除例

櫻間一史, 猶本良夫, 田辺俊介, 藤原康宏, 高岡宗徳, 白川靖博, 山辻知樹, 小林直哉, 藤原俊義, 松原長秀, 岩垣博巳, 松岡順治, 平松聡, 田中紀章

岡山医学会雑誌 119 ( 3 ) 339 - 339 2008.1

食道癌術後に発生した肺小細胞癌の2例

高岡宗徳, 猶本良夫, 田辺俊介, 桜間一史, 藤原康宏, 白川靖博, 山辻知樹, 小林直哉, 藤原俊義, 松原長秀, 岩垣博巳, 松岡順治, 羽井佐実, 田中紀章

岡山医学会雑誌 119 ( 3 ) 337 - 337 2008.1

大腿骨軟骨肉腫術後の巨大腹壁ヘルニア内に発生した大腸癌の1例

田辺俊介, 猶本良夫, 桜間一史, 藤原康宏, 高岡宗徳, 白川靖博, 山辻知樹, 小林直哉, 藤原俊義, 松原長秀, 岩垣博巳, 松岡順治, 羽井佐実, 田中紀章

岡山医学会雑誌 119 ( 3 ) 340 - 340 2008.1

Specific in vivo labeling with GFP retroviruses, lentiviruses, and adenoviruses for imaging

Robert M. Hoffman, Hiroyuki Kishimoto, Toshiyoshi Fujiwara

Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6868 2008

Language：English Publishing type：Research paper (international conference proceedings)

Fluorescent proteins have revolutionized the field of imaging. Our laboratory pioneered in vivo imaging with fluorescent proteins. Fluorescent proteins have enabled imaging at the subcellular level in mice. We review here the use of different vectors carrying fluorescent proteins to selectively label normal and tumor tissue in vivo. We show that a GFP retrovirus and telomerase-driven GFP adenovirus can selectively label tumors in mice. We also show that a GFP lentivirus can selectively label the liver in mice. The practical application of these results are discussed.

DOI： 10.1117/12.773308

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食道癌術前診断におけるPET/CTの有用性ならびに術後病理組織診断との整合性についての検討

田辺俊介, 猶本良夫, 藤原康宏, 櫻間一史, 高岡宗徳, 白川靖博, 山辻知樹, 小林直哉, 藤原俊義, 松原長秀, 羽井佐実, 松岡順治, 田中紀章

日本臨床外科学会雑誌 68 ( 増刊 ) 437 - 437 2007.11

テロメラーゼ依存性腫瘍融解ウイルス療法と放射線療法の相互増感作用(Mutual sensitization with telomerase-specific oncolytic virotherapy and ionizing radiation in antitumor activity)

黒田新士, 藤原俊哉, 児島亨, 渡邊雄一, 橋本悠里, 宇野太, 香川俊輔, 浦田泰生, 田中紀章, 藤原俊義

日本癌学会総会記事 66回 385 - 385 2007.8

リンパ節微小転移を標的としたテロメラーゼ依存性腫瘍融解ウイルス療法(Telomerase-specific virotherapy targeting lymph node micrometastasis of human cancer)

児島亨, 渡辺雄一, 橋本悠里, 黒田新士, 宇野太, 香川俊輔, 浦田泰生, 田中紀章, 藤原俊義

日本癌学会総会記事 66回 91 - 91 2007.8

食道癌化学療法後骨髄異形成症候群の検討

田辺俊介, 猶本良夫, 藤原康宏, 高岡宗徳, 白川靖博, 山辻知樹, 小林直哉, 藤原俊義, 松原長秀, 岩垣博巳, 松岡順治, 羽井佐実, 田中紀章

岡山医学会雑誌 119 ( 1 ) 99 - 99 2007.5

G-CSF産生食道癌の1例

高岡宗徳, 猶本良夫, 田辺俊介, 藤原康宏, 白川靖博, 山辻知樹, 小林直哉, 藤原俊義, 松原長秀, 岩垣博巳, 松岡順治, 羽井佐実, 田中紀章

岡山医学会雑誌 119 ( 1 ) 99 - 99 2007.5

食道癌と甲状腺癌同時切除例の検討

藤原康宏, 猶本良夫, 田辺俊介, 高岡宗徳, 白川靖博, 山辻知樹, 小林直哉, 藤原俊義, 松原長秀, 岩垣博巳, 松岡順治, 羽井佐実, 田中紀章

岡山医学会雑誌 119 ( 1 ) 99 - 99 2007.5

テロメラーゼ特異的GFP発現ナノバイオ・ウイルス製剤(OBP-401)を用いた微小癌組織のin vivoイメージング・システム

児島亨, 藤原俊義, 岸本浩行, 橋本悠里, 香川俊輔, 宇野太, 浦田泰生, 田中紀章

日本癌学会総会記事 65回 258 - 258 2006.9

A case report--The marked response to gemcitabine combined with irinotecan and low-dose cisplatin chemotherapy for advanced gastric cancer with multiple liver metastases.

Fuminori Teraishi, Futoshi Uno, Shunsuke Kagawa, Akira Gochi, Toshiyoshi Fujiwara, Noriaki Tanaka

Gan to kagaku ryoho. Cancer & chemotherapy 33 ( 12 ) 1885 - 1887 2006

Language：English Publishing type：Research paper (scientific journal)

A 69-year-old man with no sign of symptoms was admitted to our hospital for further examination and treatment of gastric cancer. Endoscopy revealed a Borrmann 3-type tumor in the cardia of the stomach. CT of the abdomen demonstrated a marked thickening of the stomach wall near the esophago-gastric junction, multiple liver metastases in bilateral liver lobes, and regional lymph node swelling around the cardia of the stomach. He consented and received systemic chemotherapy consisting of 0.5 h infusion of cisplatin (25 mg/body) followed by 0.5 h infusion of gemcitabine (800 mg/body) and 2.5 h infusion of irinotecan (60 mg/body) every 14 days as described below. Only the initial 1 course was administered with 5-FU (500 mg/body) as an inpatient, and further courses were performed as an outpatient with no severe adverse events. His tumors responded immediately to the chemotherapy, and restaging abdominal CT after 4-cycles of chemotherapy showed almost complete regression of liver metastases, and partial response to lymphadenopathy. The patient currently undergoes regular chemotherapy and remains in remission more than 6 months after the diagnosis of unresectable gastric cancer with liver metastases. It may be possible that the current chemotherapy will be neoadjuvant chemotherapy, and curative surgical resection can be performed.

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Stenting and radiotherapy for malignant tracheal stenosis due to mediastinal lymph node recurrence from gastric cancer--a case report

Shunsuke Kagawa, Toshiyoshi Fujiwara, Masahiko Nishizaki, Naoyuki Tokunaga, Akira Gochi, Noriaki Tanaka

Gan to kagaku ryoho. Cancer & chemotherapy 33 ( 1 ) 91 - 93 2006

Language：Japanese Publishing type：Research paper (scientific journal)

The case is a 74-year-old woman,who underwent curative resection six years earlier for stomach cancer in the cardia extending to the esophagus (Stage IIIA). She noticed hoarseness and cough in September 2004, and CT revealed lymph node metastasis of the cancer in the upper mediastinum. The tumor pressured the SVC, the esophagus,and especially the trachea that narrowed up to a diameter of 5 mm.To secure the air way, first, a self-expandable metallic stent was placed in the narrowed trachea under general anesthesia. Irradiation to the upper mediastinal tumor was further applied for a total of 46 Gy from October to November, 2004.Symptom relief was obtained over the course by a marked reduction in the size of the metastatic tumor, and the disease remained stable for 5 months. In general,a stomach cancer that is mostly adenocarcinoma has been recognized to have low receptivity for radiotherapy. Nevertheless,this case suggests that radiotherapy can play an important role in local control and symptom relief for symptomatic stomach cancer patients.

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A case of advanced gastric cancer with liver metastasis completely responding to CPT-11+low-dose 5-FU+CDDP chemotherapy

Shunsuke Kagawa, Toshiyoshi Fujiwara, Naoyuki Tokunaga, Masahiko Nishizaki, Futoshi Uno, Fuminori Teraishi, Akira Gouchi, Junji Matsuoka, Noriaki Tanaka

Gan to kagaku ryoho. Cancer & chemotherapy 33 ( 9 ) 1317 - 1320 2006

Language：Japanese Publishing type：Research paper (scientific journal)

The case was a 54-year-old man with type-3 gastric cancer in the cardia accompanied by multiple liver metastasis. He received combination chemotherapy consisting of CPT-11 (60 mg/body, day 1 and 8)+low-dose 5-FU and CDDP (5-FU 500 mg/body/day and CDDP 5 mg/body/day, day 1-5 and 8-12, continuous infusion) every 3 weeks. The initial 2 courses were administered on an inpatient basis,and further courses as an outpatient. After 7 courses of therapy without severe adverse events, not only primary lesion but also hepatic metastasis disappeared. He has been free from disease for 4 months, and chemotherapy was further continued with TS-1 (100 mg/body, day 1-14)+CPT-11 60 mg/body, day 1, 8), every 3 weeks. CPT-11 in combination with low-dose 5-FU+CDDP can be one of the most effective regimens for unresectable advanced gastric cancer.

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テロメラーゼ依存性GFP蛍光発現ウイルス製剤OBP-401を用いた微小癌組織ナビゲーション・システムの開発

藤原俊義, 岸本浩行, 香川俊輔, 宇野太, 田中紀章, 河村仁, 浦田泰生

日本癌治療学会誌 40 ( 2 ) 350 - 350 2005.9