Faculty Profiles - FUJIWARA Toshiyoshi

Papers - FUJIWARA Toshiyoshi

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[Development of a detection system for circulating tumor cells in peripheral blood using a next generation conditionally-replicating adenovirus]. Reviewed

Fuminori Sakurai, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 133 ( 3 ) 291 - 6 2013

Language：Japanese

An easy and sensitive detection method for circulating tumor cells (CTC) is expected to be developed because CTC are a promising biomarker for early diagnosis of tumors and prognosis prediction of tumor patients. Our group has already developed a CTC detection method using a conditionally replicating adenovirus (Ad) which efficiently replicates and expresses GFP in telomerase-positive tumor cells. However, malignant tumor cells express much low levels of coxsackievirus and adenovirus receptor (CAR), leading to inefficient infection with a conventional conditionally replicating Ad. In addition, a tiny fraction of normal blood cells, including lymphocytes, express GFP following infection. To overcome these problems, we have developed a next-generation conditionally replicating Ad. The next-generation conditionally replicating Ad possesses the fiber protein derived from Ad serotype 35, leading to efficient infection in both CAR-positive and -negative tumor cells, because the fiber protein of Ad serotype 35 binds to CD46, which is expressed on almost all human cells. Furthermore, sequences complementary to blood cell-specific miRNA (miR-142-3p) were inserted into the 3' untranslated region of the E1 gene and GFP gene, leading to the suppression of GFP expression in normal blood cells. In this symposium, we will not only introduce the importance of CTC as a biomarker and conventional CTC detection methods but also show our data of the novel CTC detection using the next-generation conditionally replicating Ad.

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内視鏡外科におけるチーム医療の在り方食道癌鏡視下手術の周術期におけるチーム医療の関わり Reviewed

白川靖博, 青山克幸, 前田直見, 田辺俊介, 大原利章, 櫻間教文, 野間和広, 藤原俊義

日本内視鏡外科学会雑誌 17 ( 7 ) 313 - 313 2012.12

我々の目指すチーム内視鏡外科当科における腹臥位胸腔鏡下食道亜全摘における術者助手のコラボレーション Reviewed

野間和広, 白川靖博, 青山克幸, 前田直見, 大原利章, 田辺俊介, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 17 ( 7 ) 604 - 604 2012.12

Non-recurrent inferior laryngeal nerveを伴う胸部食道癌に対して胸腔鏡下食道亜全摘を施行した1例 Reviewed

前田直見, 白川靖博, 大原利章, 田辺俊介, 野間和広, 櫻間教文, 藤原俊義

日本内視鏡外科学会雑誌 17 ( 7 ) 696 - 696 2012.12

Robotic Surgeryによる胃切除 Double bipolar techniqueによる術野展開の工夫と郭清手技

西崎正彦, 石田道拡, 黒田新士, 岸本浩行, 宇野太, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 17 ( 7 ) 296 - 296 2012.12

腹腔鏡手術における腹腔内癒着マッピングの有用性と意義

近藤喜太, 稲田涼, 永坂岳司, 西崎正彦, 藤原俊義

日本内視鏡外科学会雑誌 17 ( 7 ) 537 - 537 2012.12

[A case of transverse myelopathy due to spinal bone metastasis of gastric cancer].

Aiko Kono, Shunsuke Kagawa, Hiroyuki Kishimoto, Futoshi Uno, Masahiko Nishizaki, Masahiko Oiwa, Toshiyoshi Fujiwara

Gan to kagaku ryoho. Cancer & chemotherapy 39 ( 12 ) 2357 - 9 2012.11

Language：Japanese Publishing type：Research paper (scientific journal)

We report a case of gastric cancer that presented as transverse myelopathy due to spinal bone metastasis. A 45-year- old man with advanced gastric cancer underwent distal gastrectomy and lymph node dissection for curative intent. However, pathological examination of the specimen revealed positive cytological findings in the peritoneal lavage fluid in addition to serosal invasion and lymph node metastasis(pT4aN3bCY1, stage IV). Three months after the operation, during the second course of chemotherapy with S-1, he began to complain of back pain, and positron emission tomography-computed tomography revealed spinal bone metastasis. Despite immediate radiotherapy for the bone metastasis, he soon suffered from paraplegia in the lower extremities followed by disturbances of bladder and bowel function. We created a sigmoid colostomy, which enabled self-care for defecation, and resumed radiotherapy and chemotherapy. Bone metastasis of gastric cancer is rare but the prognosis is very poor. Because of a rapidly deteriorating clinical course, early diagnosis and multidisciplinary approaches are important for gastric cancer patients with spinal metastasis.

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[Stent placement using a double-balloon endoscope for malignant duodenal obstruction with Roux-en-Y Anastomosis-a case report].

Masahiko Oiwa, Shunsuke Kagawa, Hiroyuki Kishimoto, Futoshi Uno, Masahiko Nishizaki, Aiko Kono, Toshiyoshi Fujiwara

Gan to kagaku ryoho. Cancer & chemotherapy 39 ( 12 ) 2372 - 4 2012.11

Language：Japanese Publishing type：Research paper (scientific journal)

A 79-year-old man who had previously undergone partial resection of the remnant stomach and Roux-en-Y reconstruction was diagnosed as having peritoneal recurrence near the ligament of Treitz. In the course of chemotherapy for recurrent gastric cancer, he complained of colic pain. CT examination revealed a marked dilation of the duodenum suggesting the presence of a distal duodenal stricture resulting from the known recurrent tumor. To palliate this intestinal obstruction, we successfully placed an expandable metal stent(EMS) using a double-balloon enteroscope(DBE), which achieved immediate relief of the obstruction and enabled the resumption of oral intake and chemotherapy. While the endoscopic placement of an EMS is available for malignant gastro-intestinal obstruction, it is considerably more difficult to approach the duodenum with Roux-en-Y anastomosis. A DBE has made it possible to place an EMS deep in the small intestine. In the present case, this minimally invasive procedure avoided the need for surgery and greatly contributed to palliation. Thus, EMS placement using a DBE is a possible palliative treatment for malignant small bowel obstruction.

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当科における食道胃接合部癌に対する再建法の工夫胸腔内観音開き法吻合の経験 Reviewed

野間和広, 白川靖博, 青山克幸, 前田直見, 大原利章, 田辺俊介, 西崎正彦, 香川俊輔, 藤原俊義

日本臨床外科学会雑誌 73 ( 増刊 ) 525 - 525 2012.10

出血性ショックをきたした回腸静脈瘤破裂に対しバルーン下逆行性経静脈的塞栓術(BRTO)が奏功した1例

濱田侑紀, 竹原裕子, 竹原清人, 大原利章, 近藤喜太, 永坂岳司, 香川俊輔, 藤原俊義

日本臨床外科学会雑誌 73 ( 増刊 ) 1084 - 1084 2012.10

低肺機能合併の胸部食道癌症例に対する腹臥位胸腔鏡下食道切除の経験 Reviewed

前田直見, 白川靖博, 青山克幸, 大原利章, 田辺俊介, 野間和広, 櫻間教文, 藤原俊義

日本臨床外科学会雑誌 73 ( 増刊 ) 706 - 706 2012.10

Zenker憩室に合併した頸部食道表在癌の1例 Reviewed

大原利章, 白川靖博, 青山克幸, 前田直見, 田辺俊介, 櫻間教文, 野間和広, 藤原俊義

日本臨床外科学会雑誌 73 ( 増刊 ) 945 - 945 2012.10

食道癌手術における再建法の安全性とQOL 胃が使用できない食道癌症例におけるQOL向上を目指した腸管による食道再建法 Reviewed

田辺俊介, 白川靖博, 青山克幸, 前田直見, 大原利章, 櫻間教文, 野間和広, 藤原俊義

日本臨床外科学会雑誌 73 ( 増刊 ) 383 - 383 2012.10

チームで乗り切る食道癌手術(当院での周術期管理センター:PERIOの取り組み) Reviewed

白川靖博, 青山克幸, 前田直見, 田辺俊介, 大原利章, 櫻間教文, 野間和広, 藤原俊義

日本臨床外科学会雑誌 73 ( 増刊 ) 481 - 481 2012.10

コンポジットメッシュと非吸収性タックを用い腹腔鏡下にて修復した腹壁瘢痕ヘルニアの一例

石田道拡, 香川俊輔, 岸本浩行, 黒田新士, 西崎正彦, 藤原俊義

日本臨床外科学会雑誌 73 ( 増刊 ) 947 - 947 2012.10

腹腔鏡下胃全摘術・噴門切除術とその再建術式腹腔鏡補助下噴門側胃切除術のための「観音開き法」食道残胃吻合の工夫

西崎正彦, 石田道拡, 黒田新士, 岸本浩行, 香川俊輔, 藤原俊義

日本臨床外科学会雑誌 73 ( 増刊 ) 372 - 372 2012.10

大腸癌の悪性度診断と臨床応用 Genetic/epigenetic変異を基盤とした大腸癌個別化治療の構築と臨床応用

永坂岳司, 母里淑子, 森川達也, 久保田暢人, 竹原清人, 稲田涼, 宇野太, 三嶋秀行, 藤原俊義

日本大腸肛門病学会雑誌 65 ( 9 ) 539 - 539 2012.9

消化器がん検診における新しい診断法の展開便中メチル化CpG検出による消化器癌スクリーニング

永坂岳司, 森川達也, 藤原俊義

Gastroenterological Endoscopy 54 ( Suppl.2 ) 2625 - 2625 2012.9

腫瘍特異的制限増殖型アデノウイルスを用いた血液循環腫瘍細胞の遺伝子解析技術の開発(Development of genetic analysis of circulating tumor cells using a telomerase-specific replication-competent adenovirus) Reviewed

重安邦俊, 橋本悠里, 宇野太, 永坂岳司, 田澤大, 香川俊輔, 水口裕之, 浦田泰生, 藤原俊義

日本癌学会総会記事 71回 50 - 50 2012.8

頭頸部表在癌のESDにおける工夫 Reviewed

田辺俊介, 白川靖博, 前田直見, 大原利章, 櫻間教文, 野間和広, 藤原俊義

耳鼻咽喉科展望 55 ( 4 ) 262 - 263 2012.8

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Papers - FUJIWARA Toshiyoshi