Faculty Profiles - FUJIWARA Toshiyoshi

Papers - FUJIWARA Toshiyoshi

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遺伝子情報を用いたStage IV大腸癌の治療戦略の構築

稲田涼, 永坂岳司, 母里淑子, 竹原裕子, 竹原清人, 森川達也, 久保田暢人, 宇野太, 佃和憲, 瀧上隆夫, 嶋村廣視, 森谷行利, 冨岡憲明, 中谷紳, 藤原俊義

日本大腸肛門病学会雑誌 66 ( 9 ) 743 - 743 2013.9

肛門脱出を契機に診断された同時性6多発大腸癌の一例

森谷行利, 高木敏行, 冨岡憲明, 森川達也, 永坂岳司, 白川靖博, 瀧上隆夫, 藤原俊義

日本大腸肛門病学会雑誌 66 ( 9 ) 876 - 876 2013.9

Selectively Replicating Oncolytic Adenoviruses Combined with Chemotherapy, Radiotherapy, or Molecular Targeted Therapy for Treatment of Human Cancers Reviewed

Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara

Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to Clinical Implementation: Third Edition 171 - 183 2013.8

Language：English Publishing type：Part of collection (book) Publisher：Elsevier Inc.

Oncolytic adenovirotherapy presents a novel approach for cancer therapy. Oncolytic adenoviruses are modified to replicate and induce oncolytic cell death in cancer cells but not in normal somatic cells. The first oncolytic adenovirus to be developed was ONYX-015, an E1B-55. kDa gene-deleted oncolytic adenovirus
after which many inventive oncolytic adenoviruses have followed. H101, an oncolytic adenovirus with very similar gene constructs as ONYX-015, was approved in China as the world's first adenovirus cancer treatment in humans in 2005. Many clinical trials have revealed that oncolytic adenoviruses produce synergistic antitumor effects in combination with conventional chemotherapeutic agents, radiation, and some molecular targeted agents, although monotherapy with oncolytic adenoviruses shows limited effects. In this chapter, we discuss the developments of oncolytic adenoviruses, focusing on their synergistic effects when combined with other treatment modalities. Then we discuss the problems that must be overcome for adenoviruses to become more attractive as cancer treatment agents and to expand their clinical applications. © 2014 Elsevier Inc. All rights reserved.

DOI： 10.1016/B978-0-12-394295-1.00012-3

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当科における腹臥位胸腔鏡下食道切除術定型化の工夫 Reviewed

青山克幸, 白川靖博, 勝部亮一, 前田直見, 大原利章, 田辺俊介, 櫻間教文, 野間和広, 藤原俊義

日本消化器外科学会総会 68回 O - 6 2013.7

胃が使用できない食道癌症例における空腸による食道再建術の工夫血管吻合は全例に必要か? Reviewed

渡邊伸一郎, 白川靖博, 勝部亮一, 前田直見, 大原利章, 田辺俊介, 櫻間教文, 野間和広, 藤原俊義

日本消化器外科学会総会 68回 RV - 5 2013.7

当科における低侵襲再建術の試み用手補助的腹腔鏡下胃管作製の60例の検討 Reviewed

前田直見, 白川靖博, 勝部亮一, 大原利章, 田辺俊介, 野間和広, 櫻間教文, 藤原俊義

日本消化器外科学会総会 68回 RV - 3 2013.7

胸部食道癌のよりよい周術期管理を目指して PERIOと鏡視下手術の融合 Reviewed

白川靖博, 勝部亮一, 前田直見, 大原利章, 田辺俊介, 櫻間教文, 野間和広, 藤原俊義

日本消化器外科学会総会 68回 O - 1 2013.7

食道胃接合部癌の外科治療戦略当科における食道胃接合部癌の治療経験下縦隔リンパ節転移症例の検討 Reviewed

野間和広, 白川靖博, 前田直見, 勝部亮一, 大原利章, 田辺俊介, 櫻間教文, 西崎正彦, 香川俊輔, 藤原俊義

日本消化器外科学会総会 68回 PD - 5 2013.7

患者負担軽減のためのPEGを用いた食道癌術前補助栄養療法の現状について Reviewed

勝部亮一, 白川靖博, 前田直見, 大原利章, 田辺俊介, 櫻間教文, 野間和宏, 藤原俊義

日本消化器外科学会総会 68回 RS - 1 2013.7

テロメラーゼ依存性増殖型アデノウイルス製剤を用いた早期大腸癌の低侵襲治療の開発

菊地覚次, 岸本浩行, 田澤大, 橋本悠里, 宇野太, 西崎正彦, 香川俊輔, 浦田泰生, ロバート・ホフマン, 藤原俊義

日本消化器外科学会総会 68回 RS - 2 2013.7

腹腔鏡補助下噴門側胃切除術における郭清手技と「観音開き法」食道残胃吻合

西崎正彦, 黒田新士, 野間和広, 渡邉めぐみ, 岸本浩行, 香川俊輔, 白川靖博, 藤原俊義

日本消化器外科学会総会 68回 O - 6 2013.7

HER2陽性胃癌の臨床病理学的特徴と当院におけるtrastuzumabの使用経験

渡辺めぐみ, 香川俊輔, 石田道拡, 黒田新士, 岸本浩行, 宇野太, 西崎正彦, 藤原俊義

日本消化器外科学会総会 68回 RS - 2 2013.7

LADG、D2における神経解剖を軸とした膵上縁リンパ節郭清

黒田新士, 西崎正彦, 渡邊めぐみ, 石田道拡, 岸本浩行, 宇野太, 香川俊輔, 藤原俊義

日本消化器外科学会総会 68回 RV - 2 2013.7

三次元解剖映像教材を用いた次世代の手術解剖教育

近藤喜太, 稲田涼, 宇野太, 永坂岳司, 武田吉正, 大塚愛二, 藤原俊義

日本消化器外科学会総会 68回 O - 6 2013.7

地域一体型NSTの取り組みと効果について

西川みか, 櫻間教文, 多田仁美, 前田直見, 大原利章, 田辺俊介, 野間和広, 白川靖博, 藤原俊義

日本食道学会学術集会プログラム・抄録集 67回 224 - 224 2013.6

Accumulation of Epigenetic Alteration Could Predict Malignant Formation in Intraductal Papillary Mucinous Neoplasm (IPMN) Reviewed

Yoshida Kazuhiro, Nagasaka Takeshi, Umeda Yuzo, Yokomichi Naosuke, Mori Yoshiko, Kubota Nobuhito, Morikawa Tatsuya, Takehara Yuko, Takehara Kiyoto, Shigeyasu Kunitoshi, Nyuya Akihiro, Shiwaku Rikiya, Suno Manabu, Nishida Naoshi, Fujiwara Toshiyoshi, Goel Ajay

GASTROENTEROLOGY 144 ( 5 ) S98 - S98 2013.5

Fecal DNA Methylation Assay for the Identification of a Multiple Gastrointestinal Cancers Including Pancreatic Caner Reviewed

Morikawa Tatsuya, Nagasaka Takeshi, Yoshida Kazuhiro, Mori Yoshiko, Kubota Nobuhito, Takehara Yuko, Yokomichi Naosuke, Nishida Naoshi, Takehara Kiyoto, Shigeyasu Kunitoshi, Nyuya Akihiro, Shiwaku Rikiya, Suno Manabu, Fujiwara Toshiyoshi, Goel Ajay

GASTROENTEROLOGY 144 ( 5 ) S601 - S602 2013.5

Genetic and Epigenetic Alterations in the Netrin-1 Receptors, UNC5c and DCC, Constitutes a Previously Unrecognized Pathway in Gastric Cancer Progression Reviewed

Kubota Nobuhito, Nagasaka Takeshi, Toda Keisuke, Mori Yoshiko, Morikawa Tatsuya, Umeda Yuzo, Yokomichi Naosuke, Yoshida Kazuhiro, Takehara Yuko, Takehara Kiyoto, Nyuya Akihiro, Shiwaku Rikiya, Shigeyasu Kunitoshi, Suno Manabu, Nishida Naoshi, Fujiwara Toshiyoshi, Goel Ajay

GASTROENTEROLOGY 144 ( 5 ) S527 2013.5

Cytokeratin 19 Staining Is a Novel, Predictive Biomarker for Extra-Hepatic Metastasis in Hepatocellular Carcinoma Reviewed

Yokomichi Naosuke, Nagasaka Takeshi, Nishida Naoshi, Umeda Yuzo, Mori Yoshiko, Morikawa Tatsuya, Kubota Nobuhito, Yoshida Kazuhiro, Takehara Yuko, Takehara Kiyoto, Shigeyasu Kunitoshi, Nyuya Akihiro, Shiwaku Rikiya, Suno Manabu, Fujiwara Toshiyoshi, Goel Ajay

GASTROENTEROLOGY 144 ( 5 ) S719 - S720 2013.5

MGMT Methylation As a Novel Biomarker for the Identification of Stage III Colorectal Cancers At High-Risk of Disease Recurrence Following Curative Surgery Reviewed

Mori Yoshiko, Nagasaka Takeshi, Tazawa Hiroshi, Umeda Yuzo, Morikawa Tatsuya, Kubota Nobuhito, Yoshida Kazuhiro, Takehara Yuko, Yokomichi Naosuke, Takehara Kiyoto, Shigeyasu Kunitoshi, Nyuya Akihiro, Shiwaku Rikiya, Suno Manabu, Nishida Naoshi, Fujiwara Toshiyoshi, Goel Ajay

GASTROENTEROLOGY 144 ( 5 ) S85 - S85 2013.5

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Papers - FUJIWARA Toshiyoshi