Faculty Profiles - FUJIWARA Toshiyoshi

Papers - FUJIWARA Toshiyoshi

Division display 121 - 140 of about 1,586 ／ All the affair displays >>

上部胃癌に対する脾摘と脾門郭清の手技と成績脾門郭清における脾摘の有無によらない脾門アプローチの定型化

黒田新士, 垣内慶彦, 皆木仁志, 庄司良平, 金谷信彦, 賀島肇, 菊地覚次, 香川俊輔, 藤原俊義

日本胃癌学会総会記事 96回 184 - 184 2024.2

高齢者/ハイリスク患者の低侵襲手術肥満症合併胃癌患者に対するロボット支援下胃切除のリンパ節郭清効果

賀島肇, 皆木仁志, 金谷信彦, 垣内慶彦, 菊地覚次, 黒田新士, 香川俊輔, 藤原俊義

日本胃癌学会総会記事 96回 215 - 215 2024.2

術後障害の評価と対策術後継続的な栄養指導による胃切除術後障害の軽減効果

菊地覚次, 半澤俊哉, 賀島肇, 庄司良平, 松三雄騎, 垣内慶彦, 黒田新士, 田辺俊介, 野間和広, 香川俊輔, 藤原俊義

日本胃癌学会総会記事 96回 175 - 175 2024.2

Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles. Reviewed International journal

Kazuya Yasui, Toshiaki Toshima, Ryo Inada, Yuzo Umeda, Shuya Yano, Hiroaki Tanioka, Akihiro Nyuya, Toshiyoshi Fujiwara, Takeshi Yamada, Yoshio Naomoto, Ajay Goel, Takeshi Nagasaka

Molecular cancer 23 ( 1 ) 1 - 1 2024.1

Language：English

This study investigates methylation patterns in circulating cell-free DNA (ccfDNA) for their potential role in colorectal cancer (CRC) detection and the monitoring of treatment response. Through methylation microarrays and quantitative PCR assays, we analyzed 440 samples from The Cancer Genome Atlas (TCGA) and an additional 949 CRC samples. We detected partial or extensive methylation in over 85% of cases within three biomarkers: EFEMP1, SFRP2, and UNC5C. A methylation score for at least one of the six candidate regions within these genes' promoters was present in over 95% of CRC cases, suggesting a viable detection method. In evaluating ccfDNA from 97 CRC patients and 62 control subjects, a difference in methylation and recovery signatures was observed. The combined score, integrating both methylation and recovery metrics, showed high diagnostic accuracy, evidenced by an area under the ROC curve of 0.90 (95% CI = 0.86 to 0.94). While correlating with tumor burden, this score gave early insight into disease progression in a small patient cohort. Our results suggest that DNA methylation in ccfDNA could serve as a sensitive biomarker for CRC, offering a less invasive and potentially more cost-effective approach to augment existing cancer detection and monitoring modalities, possibly supporting comprehensive genetic mutation profiling.

DOI： 10.1186/s12943-023-01910-y

PubMed

researchmap

Epidural versus patient-controlled intravenous analgesia on pain relief and recovery after laparoscopic gastrectomy for gastric cancer: randomized clinical trial. Reviewed International journal

Satoru Kikuchi, Takashi Matsusaki, Toshiharu Mitsuhashi, Shinji Kuroda, Hajime Kashima, Nobuo Takata, Ema Mitsui, Yoshihiko Kakiuchi, Kazuhiro Noma, Yuzo Umeda, Hiroshi Morimatsu, Toshiyoshi Fujiwara

BJS open 8 ( 1 ) 2024.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Epidural analgesia (EDA) is a main modality for postoperative pain relief in major open abdominal surgery within the Enhanced Recovery After Surgery protocol. However, it remains unclear whether EDA is an imperative modality in laparoscopic gastrectomy (LG). This study examined non-inferiority of patient-controlled intravenous analgesia (PCIA) to EDA in terms of postoperative pain and recovery in patients who underwent LG. METHODS: In this open-label, non-inferiority, parallel, individually randomized clinical trial, patients who underwent elective LG for gastric cancer were randomized 1:1 to receive either EDA or PCIA after surgery. The primary endpoint was pain score using the Numerical Rating Scale at rest 24 h after surgery, analysed both according to the intention-to-treat (ITT) principle and per protocol. The non-inferiority margin for pain score was set at 1. Secondary outcomes were postoperative parameters related to recovery and adverse events related to analgesia. RESULTS: Between 3 July 2017 and 29 September 2020, 132 patients were randomized to receive either EDA (n = 66) or PCIA (n = 66). After exclusions, 64 patients were included in the EDA group and 65 patients in the PCIA group for the ITT analysis. Pain score at rest 24 h after surgery was 1.94 (s.d. 2.07) in the EDA group and 2.63 (s.d. 1.76) in the PCIA group (P = 0.043). PCIA was not non-inferior to EDA for the primary endpoint (difference 0.69, one side 95% c.i. 1.25, P = 0.184) in ITT analysis. Postoperative parameters related to recovery were similar between groups. More EDA patients (21 (32.8%) versus 1 (1.5%), P < 0.001) developed postoperative hypotension as an adverse event. CONCLUSIONS: PCIA was not non-inferior to EDA in terms of early-phase pain relief after LG.Registration number: UMIN000027643 (https://www.umin.ac.jp/ctr/index-j.htm).

DOI： 10.1093/bjsopen/zrad161

PubMed

researchmap

Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus. Reviewed International journal

Koji Uotani, Hiroshi Tazawa, Joe Hasei, Tomohiro Fujiwara, Aki Yoshida, Yasuaki Yamakawa, Toshinori Omori, Kazuhisa Sugiu, Tadashi Komatsubara, Hiroya Kondo, Takuya Morita, Masahiro Kiyono, Suguru Yokoo, Toshiaki Hata, Toshiyuki Kunisada, Ken Takeda, Yasuo Urata, Toshiyoshi Fujiwara, Toshifumi Ozaki

PloS one 19 ( 2 ) e0298292 2024

Language：English Publishing type：Research paper (scientific journal)

Bone and soft-tissue sarcomas are rare malignancies with histological diversity and tumor heterogeneity, leading to the lack of a common molecular target. Telomerase is a key enzyme for keeping the telomere length and human telomerase reverse transcriptase (hTERT) expression is often activated in most human cancers, including bone and soft-tissue sarcomas. For targeting of telomerase-positive tumor cells, we developed OBP-301, a telomerase-specific replication-competent oncolytic adenovirus, in which the hTERT promoter regulates adenoviral E1 gene for tumor-specific viral replication. In this study, we present the diagnostic potential of green fluorescent protein (GFP)-expressing oncolytic adenovirus OBP-401 for assessing virotherapy sensitivity using bone and soft-tissue sarcomas. OBP-401-mediated GFP expression was significantly associated with the therapeutic efficacy of OBP-401 in human bone and soft-tissue sarcomas. In the tumor specimens from 68 patients, malignant and intermediate tumors demonstrated significantly higher expression levels of coxsackie and adenovirus receptor (CAR) and hTERT than benign tumors. OBP-401-mediated GFP expression was significantly increased in malignant and intermediate tumors with high expression levels of CAR and hTERT between 24 and 48 h after infection. Our results suggest that the OBP-401-based GFP expression system is a useful tool for predicting the therapeutic efficacy of oncolytic virotherapy on bone and soft-tissue sarcomas.

DOI： 10.1371/journal.pone.0298292

PubMed

researchmap

Perioperative and Postoperative Continuous Nutritional Counseling Improves Quality of Life of Gastric Cancer Patient Undergoing Gastrectomy. Reviewed International journal

Shunya Hanzawa, Satoru Kikuchi, Shinji Kuroda, Ryohei Shoji, Hajime Kashima, Yuki Matsumi, Ayako Takahashi, Yoshihiko Kakiuchi, Kosei Takagi, Shunsuke Tanabe, Kazuhiro Noma, Shunsuke Kagawa, Kenichi Shikata, Toshiyoshi Fujiwara

Nutrition and cancer 76 ( 6 ) 476 - 485 2024

Language：English Publishing type：Research paper (scientific journal)

Post-gastrectomy syndrome (PGS) and body weight loss (BWL) decrease quality of life (QOL) and survival of the patient undergoing gastrectomy. We have introduced perioperative and post-discharge continuous nutritional counseling (CNC) to prevent BWL and improve QOL after gastrectomy. In the present study, we evaluated the effect of CNC on QOL using the Post-gastrectomy Syndrome Assessment Scale-45 (PGSAS-45). Eighty-three patients with gastric cancer (GC) who underwent curative gastrectomy between March 2018 and July 2019 were retrospectively analyzed. Patients received either pre-discharge nutritional counseling alone (control group, n = 45) or CNC (CNC group, n = 38) after gastrectomy. QOL at 12 months after gastrectomy was compared between the two groups. In QOL assessment, change in body weight (-7.98% vs. -12.77%, p = 0.0057), ingested amount of food per meal (7.00 vs. 6.07, p = 0.042) and ability for working (1.89 vs. 2.36, p = 0.049) were significantly better in CNC group than control group. Multiple regression analysis showed that CNC was a significantly beneficial factor for abdominal pain subscale (p = 0.028), diarrhea subscale (p = 0.047), ingested amount of food per meal (p = 0.012), Ability for working (p = 0.031) and dissatisfaction at the meal (p = 0.047). Perioperative and postoperative CNC could improve QOL in the patient undergoing gastrectomy in addition to preventing postoperative BWL.

DOI： 10.1080/01635581.2024.2340782

PubMed

researchmap

ASO Author Reflections: The Role of Robotic Surgery in Patients with Portal Annular Pancreas. International journal

Kosei Takagi, Tomokazu Fuji, Kazuya Yasui, Yuzo Umeda, Toshiyoshi Fujiwara

Annals of surgical oncology 2023.12

Robotic Pancreatoduodenectomy in Portal Annular Pancreas Using a Hanging Maneuver with Indocyanine Green Fluorescence Imaging. Reviewed International journal

Kosei Takagi, Tomokazu Fuji, Motohiko Yamada, Jiro Kimura, Kazuya Yasui, Yuzo Umeda, Toshiyoshi Fujiwara

Annals of surgical oncology 2023.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Sufficient knowledge and surgical management of portal annular pancreas (PAP) are essential for pancreatic surgery. As PAP is a relatively rare pancreatic anomaly, few studies have described surgical techniques for patients with PAP undergoing robotic pancreatoduodenectomy (RPD). PATIENTS AND METHODS: An 82-year-old female patient who underwent RPD presented with distal cholangiocarcinoma and type III PAP (the fusion of the uncinate process with the anteportal main pancreatic duct). After the Kocher maneuver and stomach transection, the pancreas was transected into the neck of the anteportal portion. The retroportal portion was dissected, encircled with hanging tape, and compressed. Blood supply from the mesenteric vessels was confirmed using indocyanine green (ICG) fluorescence imaging. Subsequently, the retroportal portion was stapled. CONCLUSIONS: This study demonstrates a unique surgical technique for type III PAP using the hanging maneuver with ICG fluorescence imaging. Surgeons should decide on the surgical strategy on the basis of the fusion and ductal anatomy of the pancreas.

DOI： 10.1245/s10434-023-14685-9

PubMed

researchmap

【胆道癌・膵臓癌の集学的治療におけるsupportive careの有用性について】胆道癌集学的治療における栄養指標の有用性

楳田祐三, 日置勝義, 吉田一博, 松田達雄, 児島亨, 佐藤太祐, 遠藤芳克, 藤智和, 高木弘誠, 安井和也, 木村真士, 石堂展宏, 大石正博, 稲垣優, 藤原俊義

胆と膵 44 ( 12 ) 1631 - 1637 2023.12

Language：Japanese Publisher：医学図書出版(株)

癌患者は,蛋白質の同化障害や異化亢進を特徴とする栄養不良に陥りやすく,筋肉量も減少しやすい。こうした担癌状態に伴う栄養不良,筋肉量低下・筋肉の質の低下といった二次性サルコペニアは,胆道癌において予後不良因子となることが報告されている。また手術後の感染性合併症の危険因子ともなるため,とくに胆道再建を伴う肝切除や膵頭十二指腸切除を要する胆道癌では注意を要する。胆道癌のさらなる治療予後向上には,腫瘍進行度のみならず,栄養状態を正確に評価し,リハビリ栄養療法を積極的に介入していくことが必要である。今回,肝内胆管癌切除例における栄養指標についての解析結果を踏まえ,胆道癌集学的治療における栄養評価と術前リハビリ栄養療法介入の意義について概説する。(著者抄録)

researchmap

Fontan手術後の肝腺腫に対してロボット支援下肝切除術を施行した2例

山田元彦, 高木弘誠, 楳田祐三, 藤智和, 安井和也, 木村裕司, 木村次郎, 萱野真史, 藤原俊義

日本内視鏡外科学会雑誌 28 ( 7 ) 1281 - 1281 2023.12

Clinical Impact of Prehabilitation on Elective Laparoscopic Surgery in Frail Octogenarians With Colorectal Cancer. Reviewed International journal

Fuminori Teraishi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Shunsuke Kagawa, Rie Tamura, Yoshikazu Matsuoka, Hiroshi Morimatsu, Toshiyoshi Fujiwara

Anticancer research 43 ( 12 ) 5597 - 5604 2023.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIM: The aim of the present study was to clarify the clinical impact of prehabilitation by the perioperative management center (PERIO) at our hospital in severely frail octogenarians with colorectal cancer. PATIENTS AND METHODS: We compared the clinicopathological characteristics of octogenarians who underwent surgery for colorectal cancer before the establishment of PERIO intervention (Control group) with those who received prehabilitation (PERIO group). All patients were classified as American Society of Anesthesiologists (ASA) class 3 or higher. The primary outcome was the incidence of postoperative complications. RESULTS: There were 21 patients in the Control group and 19 patients in the PERIO group. Operative time was significantly longer in the PERIO group (Control group, 200 min vs. PERIO group, 230 min; p=0.03) and blood loss was significantly higher in the PERIO group (Control group, 5 ml vs. PERIO group, 30 ml; p=0.02). Postoperative complications occurred in 10 patients (47.6%) in the Control group and 3 patients (15.8%) in the PERIO group and were significantly lower in the PERIO group (p=0.03). Postoperative hospital stay was 13 days (range=7-31 days) in the Control group and 11 days (range=8-70 days) in the PERIO group (p=0.39). The rate of discharge directly to home was 81% in the Control group and 93.3% in the PERIO group (p=0.29). CONCLUSION: In frail octogenarians with colorectal cancer of ASA class 3 or higher, the incidence of postoperative complications was significantly lower after PERIO intervention.

DOI： 10.21873/anticanres.16762

PubMed

researchmap

Fontan手術後の肝腺腫に対してロボット支援下肝切除術を施行した2例

山田元彦, 高木弘誠, 楳田祐三, 藤智和, 安井和也, 木村裕司, 木村次郎, 萱野真史, 藤原俊義

日本内視鏡外科学会雑誌 28 ( 7 ) 1281 - 1281 2023.12

Double-surgeon techniqueによるロボット支援下肝切除術

高木弘誠, 楳田祐三, 藤智和, 安井和也, 木村裕司, 山田元彦, 木村次郎, 萱野真史, 藤原俊義

日本内視鏡外科学会雑誌 28 ( 7 ) 2336 - 2336 2023.12

鼠径ヘルニア術後、膀胱上窩ヘルニアに対して腹腔鏡下根治術を施行した1例

萱野真史, 高木弘誠, 山田元彦, 近藤喜太, 木村次郎, 木村裕司, 安井和也, 藤智和, 楳田祐三, 藤原俊義

日本内視鏡外科学会雑誌 28 ( 7 ) 1932 - 1932 2023.12

肥満症を伴った大腸癌に対する治療戦略高度肥満症を伴う結腸癌に対する多職種連携周術期管理と手術手技の工夫

松三雄騎, 菊地覚次, 庄司良平, 賀島肇, 重安邦俊, 近藤喜太, 寺石文則, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 28 ( 7 ) 1637 - 1637 2023.12

炎症性腸疾患に対する低侵襲手術の新しい工夫瘻孔形成を伴うクローン病低侵襲手術の効果とバイオ製剤導入時期の腸管機能温存への影響

近藤喜太, 金谷信彦, 庄司良平, 垣内慶彦, 菊地覚次, 重安邦俊, 田辺俊介, 黒田新士, 野間和広, 寺石文則, 楳田祐三, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 28 ( 7 ) 2246 - 2246 2023.12

術者導入期でも安全な当院の鏡視下食道切除コンセプト

橋本将志, 野間和広, 河崎健人, 國友知義, 加藤卓也, 前田直見, 重安邦俊, 菊地覚次, 黒田新士, 近藤喜太, 田辺俊介, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本内視鏡外科学会雑誌 28 ( 7 ) 1535 - 1535 2023.12

食道癌112aoPリンパ節に対する腹腔鏡下経裂孔的アプローチによる系統的郭清

河崎健人, 野間和広, 國友知義, 橋本将志, 加藤卓也, 前田直見, 重安邦俊, 菊地寛次, 黒田新士, 近藤喜太, 田辺俊介, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本内視鏡外科学会雑誌 28 ( 7 ) 1577 - 1577 2023.12

胃癌術後1年目に局所リンパ節再発との鑑別を要した腹腔内デスモイド腫瘍の1例

片山哲也, 垣内慶彦, 黒田新士, 近藤喜太, 菊地覚次, 重安邦俊, 寺石文則, 香川俊輔, 藤原俊義

日本消化器外科学会雑誌 56 ( 12 ) 677 - 684 2023.12

Language：Japanese Publisher：(一社)日本消化器外科学会

症例は44歳の男性で,胃癌に対して腹腔鏡下幽門側胃切除術,D2リンパ節郭清,Billroth-I法再建を施行し,病理組織診断はpT2N0M0 Stage IBであった.術後1年目のCTおよびPET-CTにて,#6リンパ節郭清領域にリンパ節再発を示唆する所見を認めたため腹腔鏡下腫瘤摘出術を施行し,病理組織診断でデスモイド腫瘍であった.デスモイド腫瘍は術前診断が困難であり,その発生機序の一因として手術による機械刺激が挙げられるため,胃癌術後に発生した際は再発との鑑別が困難である.再発リスクの低い症例では化学療法などを施行する前に,診断的治療を目的とした手術を行うことは有用であり,術中迅速検査などで再発が否定できるのであれば,他臓器合併切除は極力避けるべきである.胃癌術後にリンパ節再発との鑑別を要したデスモイド腫瘍の1例を経験した.(著者抄録)

researchmap

　 PREV - NEXT 　

< FUJIWARA Toshiyoshi >

Papers - FUJIWARA Toshiyoshi