Faculty Profiles - FUJIWARA Toshiyoshi

Papers - FUJIWARA Toshiyoshi

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術前化学療法を施行した膵癌患者における代謝栄養学的指標の意義に関する検討

佐藤博紀, 吉田龍一, 安井和也, 楳田祐三, 藤智和, 高木弘誠, 黒田新士, 野間和広, 八木孝仁, 藤原俊義

日本消化器外科学会総会 77回 P224 - 3 2022.7

T4b食道癌に対する治療戦略についての検討 induction DCF vs.induction DCF-RTを中心に

最所公平, 野間和広, 前田直見, 菊地覚次, 田辺俊介, 黒田新士, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本消化器外科学会総会 77回 P163 - 4 2022.7

【下部】IBDに対するMIS 炎症性腸疾患に対する経肛門的低侵襲手術は患者因子によらない安定した手術を可能にする

近藤喜太, 寺石文則, 菊地覚次, 田邊俊介, 黒田新士, 吉田龍一, 野間和広, 楳田祐三, 香川俊輔, 藤原俊義

日本消化器外科学会総会 77回 WS14 - 5 2022.7

食道癌術後肺転移に対して外科的切除を行った16例の検討

大亀正義, 野間和広, 前田直見, 菊地覚次, 田辺俊介, 黒田新士, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本消化器外科学会総会 77回 P195 - 6 2022.7

食道狭窄、食道気道瘻に対する食道バイパス術の成績と新たな術式の構築

陶守貫人, 野間和広, 前田直見, 菊地覚次, 田辺俊介, 黒田新士, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本消化器外科学会総会 77回 P195 - 3 2022.7

高度肥満症に対する減量・代謝改善手術の効果と安全性

香川俊輔, 菊地覚次, 黒田新士, 武田正, 垣内慶彦, 寺石文則, 近藤喜太, 重安邦俊, 楳田祐三, 藤原俊義

日本消化器外科学会総会 77回 P276 - 6 2022.7

根治的CRT後の食道縦隔瘻を伴う食道癌に対してロボット支援下胸腔鏡下食道切除術を施行した1例

門脇大輔, 野間和広, 前田直見, 菊地覚次, 田辺俊介, 黒田新士, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本消化器外科学会総会 77回 P243 - 6 2022.7

【肝胆膵】大腸癌肝転移におけるBRとURの定義 BR大腸癌肝転移に対する肝切除アプローチ Vessel-Skeletonized Parenchyma-sparing Hepatectomyの有用性

楳田祐三, 藤智和, 高木弘誠, 安井和也, 黒田新士, 吉田龍一, 野間和広, 寺石文則, 八木孝仁, 藤原俊義

日本消化器外科学会総会 77回 PD1 - 10 2022.7

術中神経刺激装置が有用であった右鎖骨下動脈起始異常を合併した胸部食道癌の一例

竹田泰茂, 野間和広, 前田直見, 菊地覚次, 田辺俊介, 黒田新士, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本消化器外科学会総会 77回 P065 - 6 2022.7

高齢大腸癌患者の手術および長期予後についての検討

武田正, 寺石文則, 重安邦俊, 菊地覚次, 近藤喜太, 黒田新士, 野間和広, 楳田祐三, 香川俊輔, 藤原俊義

日本消化器外科学会総会 77回 P151 - 1 2022.7

狭窄を伴う食道癌患者における術前胃瘻造設と周術期管理チームの有用性

橋本将志, 野間和広, 前田直見, 菊地覚次, 田辺俊介, 黒田新士, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本消化器外科学会総会 77回 P147 - 3 2022.7

【総論】各臓器サブサブスペシャルティ外科医の育成法食道外科におけるサブサブスペシャリティ取得への取組み

前田直見, 野間和広, 菊地覚次, 田辺俊介, 黒田新士, 吉田龍一, 寺石文則, 楳田祐三, 白川靖博, 藤原俊義

日本消化器外科学会総会 77回 WS15 - 9 2022.7

肝転移に焦点を置いた大腸癌多臓器転移症例の治療戦略

重安邦俊, 楳田祐三, 寺石文則, 武田正, 藤智和, 黒田新士, 近藤喜太, 香川俊輔, 藤原俊義

日本消化器外科学会総会 77回 P009 - 2 2022.7

80歳以上の高齢者に対する術前GS療法の忍容性はあるか?dose intensityの視点から

安井和也, 吉田龍一, 楳田祐三, 藤智和, 高木弘誠, 佐藤博紀, 黒田新士, 野間和広, 八木孝仁, 藤原俊義

日本消化器外科学会総会 77回 RS5 - 3 2022.7

ベーラー大学における膵全摘自家膵島移植200例の検討

熊野健二郎, 藤智和, 高木弘誠, 安井和也, 吉田一博, 吉田龍一, 楳田祐三, 八木孝仁, 藤原俊義, バシュー・ナジルディン

日本消化器外科学会総会 77回 P130 - 7 2022.7

膵癌における術前血中KRAS遺伝子変異情報を用いた予後予測

吉田龍一, 安井和也, 宮本耕吉, 楳田祐三, 藤智和, 高木弘誠, 黒田新士, 野間和宏, 八木孝仁, 藤原俊義

日本消化器外科学会総会 77回 O3 - 4 2022.7

【総論】各臓器サブサブスペシャルティ外科医の育成法肝胆膵外科高度技能専門医の効率的な育成に向けて膵頭十二指腸切除のラーニングカーブ解析

藤智和, 楳田祐三, 高木弘誠, 安井和也, 熊野健二郎, 吉田龍一, 黒田新士, 野間和広, 八木孝仁, 藤原俊義

日本消化器外科学会総会 77回 WS15 - 1 2022.7

Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of gastric cancer. International journal

Toshihiro Ogawa, Satoru Kikuchi, Motoyasu Tabuchi, Ema Mitsui, Yuta Une, Hiroshi Tazawa, Shinji Kuroda, Kazuhiro Noma, Toshiaki Ohara, Shunsuke Kagawa, Yasuo Urata, Toshiyoshi Fujiwara

Molecular therapy oncolytics 25 249 - 261 2022.6

Language：English Publishing type：Research paper (scientific journal)

Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are associated with the establishment and progression of peritoneal metastasis. This study investigated the efficacy of replicative oncolytic adenovirus-mediated p53 gene therapy (OBP-702) against CAFs and peritoneal metastasis of gastric cancer (GC). Higher CAF expression in the primary tumor was associated with poor prognosis of GC, and higher CAF expression was also observed with peritoneal metastasis in immunohistochemical analysis of clinical samples. And, we found transcriptional alteration of p53 in CAFs relative to normal gastric fibroblasts (NGFs). CAFs increased the secretion of cancer-promoting cytokines, including interleukin-6, and gained resistance to chemotherapy relative to NGFs. OBP-702 showed cytotoxicity to both GC cells and CAFs but not to NGFs. Overexpression of wild-type p53 by OBP-702 infection caused apoptosis and autophagy of CAFs and decreased the secretion of cancer-promoting cytokines by CAFs. Combination therapy using intraperitoneal administration of OBP-702 and paclitaxel synergistically inhibited the tumor growth of peritoneal metastases and decreased CAFs in peritoneal metastases. OBP-702, a replicative oncolytic adenovirus-mediated p53 gene therapy, offers a promising biological therapeutic strategy for peritoneal metastasis, modulating CAFs in addition to achieving tumor lysis.

DOI： 10.1016/j.omto.2022.04.009

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Favorable control of hepatocellular carcinoma with peritoneal dissemination by surgical resection using indocyanine green fluorescence imaging: a case report and review of the literature. International journal

Yuma Tani, Hiroki Sato, Ryuichi Yoshida, Kazuya Yasui, Yuzo Umeda, Kazuhiro Yoshida, Tomokazu Fuji, Kenjiro Kumano, Kosei Takagi, Masaaki Kagoura, Takahito Yagi, Toshiyoshi Fujiwara

Journal of medical case reports 16 ( 1 ) 222 - 222 2022.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The optimal management for peritoneal dissemination in patients with hepatocellular carcinoma remains unclear. Although several reports have described the usefulness of surgical resection, the indications should be carefully considered. Herein, we report the case of a patient with hepatocellular carcinoma with peritoneal recurrence who underwent surgical resection using an indocyanine green fluorescence navigation system and achieved favorable disease control. CASE PRESENTATION: A 45-year-old Asian woman underwent left hemihepatectomy for a ruptured hepatocellular carcinoma. Seventeen months after the initial surgery, a single nodule near the cut surface of the liver was detected on computed tomography, along with elevation of tumor markers. The patient was diagnosed with peritoneal metastasis and underwent a surgical resection. Twelve months later, a single nodule on the dorsal side of the right hepatic lobe was detected on computed tomography, and we performed surgical resection. Indocyanine green (0.5 mg/kg) was intravenously administered 3 days before surgery, and the indocyanine green fluorescence imaging system revealed clear green fluorescence in the tumor, which helped us perform complete resection. Indocyanine green fluorescence enabled the detection of additional lesions that could not be identified by preoperative imaging, especially in the second metastasectomy. There was no further recurrence at 3 months postoperatively. CONCLUSION: When considering surgical intervention for peritoneal recurrence in patients with hepatocellular carcinoma, complete resection is mandatory. Given that disseminated nodules are sometimes too small to be detected by preoperative imaging studies, intraoperative indocyanine green fluorescence may be an essential tool for determining the indications for surgical resection.

DOI： 10.1186/s13256-022-03440-5

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[The Chugoku-Shikoku GanPro Produces Advanced Cancer Specialists to Provide Whole Person Medical Care].

Shunsuke Kagawa, Toshiyoshi Fujiwara

Gan to kagaku ryoho. Cancer & chemotherapy 49 ( 6 ) 638 - 641 2022.6

Language：Japanese Publishing type：Research paper (scientific journal)

The 3rd Chugoku-Shikoku GanPro has set a plan to train advanced cancer specialists to provide whole person medical care, and 11 partner universities have formed a consortium, and 18 working groups have been working to provide graduate school education. Through a unique e-learning system and an exercise to learn team medicine, we trained medical professionals who have advanced expertise and can provide cancer care through multidisciplinary team medicine. The project has produced a wide range of personnel including doctors, dentists, pharmacists, nurses, radiologists, medical physicists, and nutritionists. The graduates who have acquired various specialized cancer qualifications practice at regional cancer treatment centers, contributing to the enhancement and improvement of cancer treatment in the Chugoku and Shikoku regions.

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Papers - FUJIWARA Toshiyoshi